6ZXF,4JIN,6FDN,1TQM


Conserved Protein Domain Family
RIO1
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pfam01163: RIO1 (This model is not part of the current CDD release)
RIO domain
This is the atypical serine kinase domain found in RIO family of proteins and related sequences, which is conserved in archaea, bacteria and eukaryotes. Activity of Rio1 is vital in Saccharomyces cerevisiae for the processing of ribosomal RNA, as well as for proper cell cycle progression and chromosome maintenance. The structure of RIO1 has been determined. This domain is also found at the C-terminal of EKC/KEOPS complex subunit BUD32 from Fungi and Kae1/Bud32 from archaea.
Links
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Statistics
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PSSM-Id: 514051
Aligned: 31 rows
Threshold Bit Score: 197.854
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6ZXF_z    193 NVYHASTANGESRAIKIYKTSILVFKDRDKYVSGEFRfrHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRS 272 human
O30245    105 AVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDL--------HFSVLAIRSARNEFRALQKLQGLA--VPKVYAWEG 174 Archaeoglobus fulg...
Q980T1    107 LVYYGYDFNDNKIIVKFHRVGTDSYKKVKFRKSQEKK--------SWLSITVENAKREFEALTCLSNEGGYVPKPLGVEY 178 Saccharolobus solf...
Q9YBJ6    197 DVYVAVSPAGSKLTVKLHRAGRESFRKVRRHRSYALD--LR--PTSWLDVSKALAEREFKILVRLEEEGARIPSPVAWNR 272 Aeropyrum pernix
Q8U3U1    111 DVYVAITPQGEKVAIKFNRIGERTSARKAYYHSDVFA---DKHHKSWLYVSRLIAKKEHEALVLLSSF-AKVPKPIAWNR 186 Pyrococcus furiosus
Q9BVS4    108 DIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKH----RHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNR 183 human
NP_190695 106 DIFEVAQEDGTILAMKLHRLGRTSFRAVKSKRDYLRH----RSSFSWLYLSRLAALKEFAFMKALEEHDFPVPKAIDCNR 181
Q9VBU2    108 NIYVVADEEGTPICLKLHRLGRTCFRNVKAKRDYHGR----RHKASWLYLSRISATREFAYMSALYDRGFPVPKPIDFNR 183 fruit fly
Q9HSL0    107 DVYEVQS--FRPMALKFHREGYTQFREVHRGRDYTSE----KEHTSWQYTARKAAEREYDALEALYPT-VNVPRPVDHNR 179 Halobacterium sali...
6FDN_A    108 DIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKH----RHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNR 183 human

6ZXF_z    273 HVLVMSFIGkDDMPAPLLKNVQ-LSEsKARELYLQVIQyMRRMYQDARLVHADLSEFNMLYHG-G-GVYIIDVSQSVEHD 349 human
O30245    175 NAVLMELID--AKELYRVRVEN-----PDE-VLDMILEeVAKFY-HRGIVHGDLSQYNVLVSE-E-GIWIIDFPQSVEVG 243 Archaeoglobus fulg...
Q980T1    179 NAVAMEYID--GIELYKIPVTNm-DL-NLDEILEKILQtMRIAYTICHITHGDLSPYNVLIDK-NgNPYLIDWPQATK-- 251 Saccharolobus solf...
Q9YBJ6    273 HAVVQRYVE--GVLLADVRVLD--TE-AAASILRDVLEtLRIAYTRVGVVHGDLSEYNVIATT-EgRGVVIDWPQYVYRD 346 Aeropyrum pernix
Q8U3U1    187 HAIVMEFID--GVELAELRDTDlTKE-EAEEILGKVLDeYEKIV-KFGIVHGDMSEFNIVITK-DnDILIIDWAQYLTCA 261 Pyrococcus furiosus
Q9BVS4    184 HAVVMELIN--GYPLCQIHHVE-----DPASVYDEAME-LIVKLANHGLIHGDFNEFNLILDE-SdHITMIDFPQMVSTS 254 human
NP_190695 182 HCVIMSLVQ--GYPMVQVKQLQ-----NPETIFEKIIGi-VVRLAEHGLIHCDFNEFNIMIDD-EeKITMIDFPQMVSVS 252
Q9VBU2    184 HCVLMDLVK--GWPMTQVHELL-----DAPQVYDDLMN-LIVRLGNSGVIHGDFNEFNLMVTD-AgKPILIDFPQMMSTS 254 fruit fly
Q9HSL0    180 HAIVMEKVS--GTELSNAKLNP---E-QASGVLDLILReVAAAY-REGYVHADVSEYNVFVDS-D-GVVLFDWPQATPTD 250 Halobacterium sali...
6FDN_A    184 HAVVMELI--NGYPLCQIHHV----E-DPASVYDEAMe-LIVKLANHGLIHGDFNEFNLILDEsD-HITMIDFPQMVSTS 254 human

6ZXF_z    350 HPHALEFLRKDCANVNDFFMRHSVA--Vm-TVREL 381 human
O30245    244 EEGWREILERDVRNIITYFSRTYRTe---kDINSA 275 Archaeoglobus fulgidus DSM 4304
Q980T1    252 ---SEERLEKDLSNLIIFFRKKGIDv----DTRKI 279 Saccharolobus solfataricus
Q9YBJ6    347 EPHALELLRRDVEYILKYFRRRAGLk---vELASA 378 Aeropyrum pernix
Q8U3U1    262 NPESLGLLKRDISVLLNAFRRRWGVk---rDFEee 293 Pyrococcus furiosus
Q9BVS4    255 HPNAEWYFDRDVKCIKDFFMKRFSY--EseLFPTF 287 human
NP_190695 253 HRNAQMYFDRDIECIFKFFRKRFNMs---fHEdkg 284
Q9VBU2    255 HENAEFFFERDVNCVREMFRRKFGY--EseDYPKF 287 fruit fly
Q9HSL0    251 HENARELLARDVENIVQYFRQKYPSdvPavDHDAV 285 Halobacterium salinarum
6FDN_A    255 HPNAEWYFDRDVKCIKDFFMKRFSY--Eselfptf 287 human
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