5AUN,2KDX


Conserved Protein Domain Family
HypA
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pfam01155: HypA (This model is not part of the current CDD release)
Hydrogenase/urease nickel incorporation, metallochaperone, hypA
HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilise the protein fold.
Links
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Statistics
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PSSM-Id: 514044
Aligned: 353 rows
Threshold Bit Score: 63.707
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5AUN_A          1 MHEWALADAIVRTVLDYA-QR-EGasRVKAVRVVLGELQDVAEDIVKFAMEQLFAG--TiAEgAEIEFVEEEAVFKCRNC 76  Thermococcus k...
CDB43074        1 MHELSIVTYVIEQVEKIA-KE-NEltDIQSVTLEFGEVSGIVPEYLSDCWQWYAKKtpL-IEhAEFKYEIIPAITWCDDC 77 
CCX45945        1 MHELSIVTYVVKQVQEIA-KE-NNltEIESVTLEFGEVSGIVPEYLEDCWNWYTKKepI-IQgTKFLYEIIPAVTWCDDC 77 
WP_021922964    1 MHELGIIVHVMRTVEEVA-AE-NNltEIRSVTCEIGEVSGVVPEYMADCWGYARSRseL-LKdSELKIEIIPGVTMCEDC 77  Roseburia inul...
WP_022425079    1 MHELGIVVHIVRTLEDVA-QE-NSltDIRKVTLQIGKVSGIEPDYLVDCWEYYKKKvpL-LKySTLDYEWIEAITICHNC 77  Catenibacterium
CDC10740        1 MHELGIIIHISKTLKEVA-EE-NEvtKIGSVTLEIGEVSGIVPEYLLDCWDYYRKKsdL-LSeSELRIETLPAVTMCDNC 77 
18_pfamImport   1 MHELGIIVHIAKTLDQVA-AE-NElkKIGSVTLDIGEVSGIVPEYLTECWEFYRKKnpL-IAeCEMKIESLPAVTICEDC 77 
30_pfamImport   1 MHELGIIVHVAKTLKHVA-LQ-ENvsKIGSVTLEIGEVSGIVESYLTDCWEYYRKKdeL-IEdSKLIIEKIEAVTYCDDC 77 
CDD63981        1 MHELGIIVHITKTLNELA-VE-NKltEIGSVTLEIGEVSGIVPDFLTDCWQYYRKKeeL-LKdSELKIEILPATTYCEDC 77 
WP_012543990    1 MHEYYVAKHTIYQVKKELgEVhPS--LVKKVGLEIGKMSGIIPEALEMYLGLIAPEegL-TN-ASFVITLAPVLFRCNDC 76  Coprothermobac...

5AUN_A         77 NYEWklkevkdkfderikedihfipEvvhaflACPKCGSHDFEVVKGRGVYVAGIKI 133 Thermococcus kodakarensis KOD1
CDB43074       78 KSTY---------------------PtvkygkTCPHCGSGRTWLQQGQEMNIKQIEA 113
CCX45945       78 KTTY---------------------PtvqygkTCPHCGNGNTWLQQGNEINIKQIEA 113
WP_021922964   78 GKTY---------------------StvqyakICPHCGSSATYLLEGNGFSIKEIEG 113 Roseburia inulinivorans
WP_022425079   78 QNTY---------------------StidygrECPYCHSGNTVLLQGNECLIKEIEG 113 Catenibacterium
CDC10740       78 KKTY---------------------PtvkfgrQCPYCKSDDTYLLTGNECSIKEMEA 113
18_pfamImport  78 QKTY---------------------EtvtygrQCPHCGSYETYLVTGNECSIKEIEA 113
30_pfamImport  78 EKTY---------------------PtvqygrQCPYCKGYNTWLAVGNECNIKEIEA 113
CDD63981       78 EKTY---------------------PtvkygrECPYCHGPHTYLLEGNECNIKEIEA 113
WP_012543990   77 NTLF---------------------EpsrelfWCPNCNSSNVTFVSGNELKIQYIDV 112 Coprothermobacter proteolyticus
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