2KDX,3A43


Conserved Protein Domain Family
HypA
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pfam01155: HypA 
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Hydrogenase/urease nickel incorporation, metallochaperone, hypA
HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.
Links
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Statistics
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PSSM-Id: 426085
Aligned: 406 rows
Threshold Bit Score: 56.3763
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2KDX_A             3 MHEYSVVSSLIALCEEHA-KKNQa-hKIERVVVGIGERSAMDKSLFVSAFETFREEslvCKDAILDIVDEKVELECKDCS 80  Helicobacte...
Q820F2             1 MHEMSVALAVIDQVEQAA-QQAGdvtAVRSVRLQVGELAGVVPDSLSFCFELACAGt-vLEGADLVTEEVPGRARCAPCA 78  Streptomyce...
EFG05417          63 MHEMSIAAAVVEQVADAA-VRHGa-tAVATVRLEVGELAGVVPEALAFCFALACAGt-vLEGAALETLGVAALARCGPCA 139 Streptomyce...
BAM03493           1 MHELSVAISIVDSLKDVL-EEEDg-gKVSSVSVAVGAHAGVVIEALRYAWGPATCGt-pLEGSVLDVEAVPATVWCGRCA 77  Phycisphaer...
Q9RYJ6             1 MHEASIALALIDVAGDVL-REHGa-aRASALTVRVGQWSSVVPEALAAAFPACAEGt-pLAGARLSIERVPGVGECPQHG 77  Deinococcus...
A9WK98             1 MHELSIAHNIVTIASDAA-AEAGv-dRISAVHLRIGALAGVVADALRFSFAIAAEGt-pLAGAELIIEEVPVVVFCPDCN 77  Chloroflexu...
A5URX3             1 MHELSIAHSLVEIAEEAA-AKAGv-aRVTVVHLRLGTLSGVVRDALLFGFDVASAGt-rLEGARLEIEEVPLQVYCETCD 77  Roseiflexus...
WP_013076023       1 MHELSIAYHMVELAAEAA-EESGm-kRVDVLHMKLGVLSGVVKEALQFAFDVAIQGt-pLEGVRLVIEDVPVKVFCPECQ 77  Kyrpidia tu...
jgi:Acid345_0925   1 MHELSIAMSIIDVAQEEAaQRg---vQVTAVHIKVGALSGVVADALRGSFEMACCDt-pLAGSKLVIEEVPAMIQCPKCG 76  Candidatus ...
jgi:AciX8_4222     1 MHELSIAISMIDQIAEES-ASRGgl-dVEAVHLRLGVFAGVDKNALLFAYELACEGt-pLQGSRLIIETVPLLVYCPVCR 77  Granulicell...

2KDX_A            81 -HVFK-PNALDygV----CEKCHSKNVIITQGNEMRLLSLEM 116 Helicobacter pylori 26695
Q820F2            79 -REWS-VGM----PprlsCPECGGARVDLLSGRELQIVSVHW 114 Streptomyces avermitilis MA-4680 = NBRC 14893
EFG05417         140 -VEWR-PGM----PpdllCPRCGGPDAVLLTGRELRVREVEW 175 Streptomyces clavuligerus ATCC 27064
BAM03493          78 -SESV-LPGvr-----lsCPACGAATPVLLSGKELDLLSFEL 112 Phycisphaera mikurensis NBRC 102666
Q9RYJ6            78 pVELEvWRGL---R----CPLCGAPTPRLLQGDELELDQLEL 112 Deinococcus radiodurans R1
A9WK98            78 -AEVT-LTNPRlfR----CPRCDRPCGQIVHGRELELVALEt 113 Chloroflexus aurantiacus J-10-fl
A5URX3            78 -TVVA-LPDVRyfR----CPQCGAACRRIVTGQEIELAALEY 113 Roseiflexus sp. RS-1
WP_013076023      78 -EAST-LSQPLpmR----CPLCGAKTGNVLEGREMELYALEk 113 Kyrpidia tusciae
jgi:Acid345_0925  77 -VPKP-VSSIQwfC----CAECGSPGHEITQGKELQVTALEV 112 Candidatus Koribacter versatilis Ellin345
jgi:AciX8_4222    78 -QERT-PPS----VyqicCPECLAPTPEILTGREMEVASLEV 113 Granulicella mallensis MP5ACTX8
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