Conserved Protein Domain Family
Caveolin
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pfam01146: Caveolin (This model is not part of the current CDD release)
Caveolin
All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localised and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localisation. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumour suppression.
Links
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Statistics
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PSSM-Id: 514035
Aligned: 31 rows
Threshold Bit Score: 174.317
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007234243  16 EDLFSRSIEPIltkkeklytpepdrDRDPRDINAHL-KVEFEDIIAEPSSTHSFDSVWIWSHAVFELLKYIFYRLLTTLL 94 
XP_003498141  15 KDIHCKEIDLV--------------NRDPKNINEDIvKVDFEDVIAEPEGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLL 80 
EFX82628     107 VQTFTVGLNVL--------------DRDEKHINDTI-NLNFEDVLAEPDVAHGFDPIWRAAFILFTGSRFWIYRLLSAIL 171
XP_003379615  93 QSQMTIGINML--------------DRDEKQLNEHI-KLNFEDILAEPDGYHSWDWVWRGTYHTFNTLRRFIYRFLALLF 157
KAF8373354    84 KQEMTIGIDMQ--------------MRDEKQINNHV-NIQFDDVFAEPETFHSVDCIWRINHRIFESTRTFFYKVFG-IL 147
EGT60057      92 DRDQRMGINFV--------------DRDRNNLATNL-DFSFENVFGENKAQHSWEWSYRINHYVYSAFKEIFYKLFQ-WC 155
Q94051        93 EENIAIGVDLV--------------NRDANSMNNHV-QLNFEDIFGEADSQHSWDCVWRLNHTVFTAVRLFIYRLVS-LL 156 Caenorhabditis ...
XP_002632823  97 EDHIAIGMDFV--------------NRDHNGLNNHV-QHNFDDIFGEADSQHTWEFMWRLNASVFNWVRLFVYRFFT-IL 160
NP_001080174  17 TEALTKEIDLV--------------QRDPKKINQEVvQVDFEDVIAEPDGTHSFDGVWKASSSTFTVTKYWCYRVLSAIF 82  African clawed ...
XP_018114518  19 KDLLTKEIDLV--------------DRDPKRINDSViKVDFEDVIAEPQGTHSFDGVWKASYTTYTVTKFWCYRILSAVI 84  African clawed ...

XP_007234243  95 AIPMAFVAGIVFGLLSCVHIWVVMPLVHSCMMALPSVQVVWASLMDMFTGPFFHSFGKSLSSINIKTV 162
XP_003498141  81 GVPLALIWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSNIKVVLR 148
EFX82628     172 ALPLALVWGITFSLITFFSVWLATPLLRIMDVFLFYIRRVWVALVQTTLEPVANAVGGCFSNVKLTHN 239
XP_003379615 158 AVPCAIVWAMLFALLTSINVWILTPLAIAISIPAVWLAKTWNFIIRSLLDPFFKSCGLMRAAHSESPT 225
KAF8373354   148 SIPIVFIFAILFAFASAVNNFLVMPLAALFTIPLTWIAKTWTFLVSNIFDPVANSIGLCFSKINVRKY 215
EGT60057     156 VLPFTVFFAIFVALFVTLYSWILLPLGKLLIIPGTVVAAVWSWLIHAIFDPIFSSLGLLFSNFNIRKY 223
Q94051       157 ALPFTIIFAIFFGLLASINVFIIVPLGKLLSIPGTLLAKLWNWLIHAIFDPIASAVGLIFSNFNIRKY 224 Caenorhabditis elegans
XP_002632823 161 ALPFTLLFAIFFGFFAAVNVFVIVPFGKLISIPGNLLAKLWNWLVHAVFDPVASAVGLIFSNFNIRKY 228
NP_001080174  83 GLPLALLWGFLFACLSFCQIWAVVPCVKSYLMEVQCLGQFYALCVRTFCDPIFEAMGKVLGGIRVALR 150 African clawed frog
XP_018114518  85 GIPLSIIWGFIFALISFCYIWAAVPCVKSYQIETQCLGRTFSLCIHTFCDPLFEALGKIFGSIKVTLQ 152 African clawed frog
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