5OKZ,5OKZ


Conserved Protein Domain Family
RNase_PH
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pfam01138: RNase_PH 
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3' exoribonuclease family, domain 1
This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components contain a copy of this domain. A hypothetical protein from S. pombe appears to belong to an uncharacterized subfamily. This subfamily is found in both eukaryotes and archaebacteria.
Links
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Statistics
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PSSM-Id: 426074
Aligned: 145 rows
Threshold Bit Score: 48.3571
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5OKZ_W        48 EFRDVAIENNTLSRYAdagnidtknnilGSNVLKSGK--TIVITSITGGIIEetsaA--IKdlDDFGeeelfevtkeEDI 123 Saccharomyces c...
Q24GF7        30 QSREYLIQTGQLKQAN------------GSSFISLNDnsVNIYTGIKVEI---------GEtdNDeg---------kIIL 79  Tetrahymena the...
Q7RLI8        24 TYRTIEINKSILVSAD------------GSSSVMNEE--NNVICGIKLSL---------LPpePHSIde------gfVNL 74  Plasmodium yoel...
Q4UI91        21 QLYSLNIIPNISSIAH------------GSSQVTFGD--NIVQTTVNFSIVS-----------PEDStpd----egiIDL 71  Theileria annulata
XP_001610798  21 DNPKILIEPNVSTGAH------------GSAKVILDD--TVVITTIMFHVTS-----------PNTNspe----egnVEI 71  Babesia bovis T2Bo
Q7URE2        13 QIRPVEIECGYLESNP------------ASVLYKSGK--TIVLCTASVETNV----PpwME--GRGKg--------wVTA 64  Rhodopirellula ...
Q6MJR9        10 QLRNIKITPNVSEYAE------------GSAIVEFGR--TKVLCTATYESKA----PswLL--GTGAg--------wITA 61  Bdellovibrio ba...
Q5NGI2        10 QLRNLKVTHNFTKHAE------------GSVLIEFGD--TKVICTASVVAGV----Pk-FKk-DSGEg--------wLTA 61  Francisella tul...
Q2RL40        11 ELRPVTIERHYLKYAE------------GSALITVGD--TRVICSATVEEKV----PpfLK--NTGKg--------wITA 62  Moorella thermo...
Q6ANS2        12 SLRPISIERGVQLHAD------------ASVLIRMGN--THVICGVSVEESV----PpfMR--GSGKg--------wITA 63  Desulfotalea ps...

5OKZ_W       124 IANYAsvyPVVEVERg-------RvgaCTDEEM----TISQK-------LHDSILHSRIL---------PKKA--LKVKA 174 Saccharomyces c...
Q24GF7        80 KIESA---QRTEQNRdqe---nhI---NSDKNT----LIYLEallnkylIQNICKKSLCI---------VEKKkcWILNI 137 Tetrahymena the...
Q7RLI8        75 QIDCPa--SVASNRI------------KKEHLQ----IMTSI-------IYDLCIKNNIdkkk--lcvlPSKFv-WGIDI 126 Plasmodium yoel...
Q4UI91        72 TITGT---NIFENSE------------LSQRNY----EILCN-------ILYDLEFQHAFldlkslcilPGQLc-WNIRI 124 Theileria annulata
XP_001610798  72 TLGSP---FTLEDSD------------ISQKRD----ERMAH-------ILEMLQFHKQLfnrkllcilSGQYv-WTMRI 124 Babesia bovis T2Bo
Q7URE2        65 EYNML---PGSTSPRkr--------rdRSGKVDgrttEIQRL-------IGRSLRAIVDL---------HALGe-RSITV 116 Rhodopirellula ...
Q6MJR9        62 EYGML---PRSTHTRir---------rdKSMTGgrtqEISRL-------IGRSLRAAVDL---------KQLGe-KQIII 112 Bdellovibrio ba...
Q5NGI2        62 EYGML---PRSTHTRmdreaargK---QSGRTQ----EIQRL-------IGRALRASVDL---------TAIGe-NTIKV 114 Francisella tul...
Q2RL40        63 EYSLL---PRSTKERti----reV---TRGRLTgrtqEIQRL-------IGRSLRSVVDM---------SLLGe-RTIWL 115 Moorella thermo...
Q6ANS2        64 EYGML---PCATDSRyr---------reTNGRSgrtmEIQRL-------IGRSLRMMVDL---------ETIGe-RTLRV 114 Desulfotalea ps...

5OKZ_W       175 GVRSANEDGtfsvlypdeleddtlnetnlkmkrkwsyvlyakivvlsrtgPVFDLCWNSLMYALQSVKLP 244 Saccharomyces cerevisiae ...
Q24GF7       138 DVFILESve----------------------------------------iAYLNLMAAGINAALEDLVLP 167 Tetrahymena thermophila S...
Q7RLI8       127 NVMVLNGGG-----------------------------------------GLLDIISIAIYVALNDMNIP 155 Plasmodium yoelii yoelii
Q4UI91       125 HSTVVKRGG-----------------------------------------CVIDALSIGVLSSLMCSDVP 153 Theileria annulata
XP_001610798 125 HTTVLQRGG-----------------------------------------GVMDAVSVAVICAMLTVSVP 153 Babesia bovis T2Bo
Q7URE2       117 DCDVLQADG-----------------------------------------GTRTASITGGYIALSLAVSQ 145 Rhodopirellula baltica SH 1
Q6MJR9       113 DCDVLNADG-----------------------------------------GTRTASVTGGFVALALALKK 141 Bdellovibrio bacteriovoru...
Q5NGI2       115 DCDVIQADG-----------------------------------------GTRTASITGASLAIADAiey 143 Francisella tularensis su...
Q2RL40       116 DCDVLQADG-----------------------------------------GTRTAAITGSFVALAEALAG 144 Moorella thermoacetica AT...
Q6ANS2       115 DCDVLNADG-----------------------------------------GTRTASITGGALALRDAFTK 143 Desulfotalea psychrophila...
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