1QMH,7MQ8


Conserved Protein Domain Family
RTC

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pfam01137: RTC (This model is not part of the current CDD release)
RNA 3'-terminal phosphate cyclase
RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyze the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids.
Statistics
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PSSM-Id: 514028
Aligned: 147 rows
Threshold Bit Score: 253.595
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1QMH_A        12 QGEGGGQILRSALSLSMITGQPFTITSIRAgraK----PGLLRQHLTAVKAATEICGATvegA-EL---GSqRLLFRPGt 83  Escherichia col...
4_pfamImport   1 MKLKGSQNLRLRLLLATLSATPVLIDDIRH---Ddt-wPGLRPYEVSLLRLFEKICDDC---VvEInetGT-KLKYKPG- 71 
Q9C578         5 KKMKGSQSFRQRLLLSTLSSTPISIDEIRA---Det-iPGLRPHEVNLLRLLEIVTDDA---VvDInetGT-RLKYKPG- 75  thale cress
Q75LH9         7 RRLSGSRHFRQRVVLATLTSTAITIDDIRS---Gga-aPGLRPHEVSLLHLLHKISDHH---SlDLnetGT-KLRYKPG- 77  Japanese rice
Q09870         7 KRFKGCEYLTHRLVLATLSGTPIRVEGIY----PdeadPGVKDYQVSFLRLLEKLTNGS---ViEIsytGT-SFIYRPG- 77  Schizosaccharom...
Q6CHS3         9 IHFSGHNNFRRRLVLATLSGMPVRIDKIR----SddvePGVKDYEVSFLRLLESITNGS---VfEIsytGT-TVVFKPG- 79  Yarrowia lipoly...
XP_013934393   8 ITFQGHKNFRNRLVFATLSGKTIKIEKIR----SddlnPGLKDYEISLLRLIENVTNGS---ViEIsytGT-TVVYRPG- 78 
XP_003955091   8 ITFQGSQNFRIRIVLATLSGKSIKIEKIR----SndlnPGLRDHEISFLRLIESVTNGS---HiEIsytGT-TVIYKPG- 78 
XP_003645374   6 VTFQGALNFRHRIVMATLSGKAIKIEKIR----SddlnPGLKDYEVSFLRLIDGVTNGS---VvEIsytGT-TVIYKPG- 76 
NP_001130728   7 RRLYGSRHFRQRLVLATLTSTAVTIEDIRS---Gda-sPGLRPYEVSLLRLLDKISDHH---TiDLnetGT-KLRYRPG- 77  Zea mays
1QMH_A        84 vrggdyrfaIGSAG-----------SCTLVLQTVLPALWFAdgPSRVEVSGGTDNPS-APPADFIRRVLEPLLAK-IG-I 149 Escherichia col...
4_pfamImport  72 ---------IIMGGknlvhdcgvgrSIGYFLEPLIVLGLFGkkPLSITLKGITNDSK-DPSVDTFQSTTLSILKH-FGvP 140
Q9C578        76 ---------TIVGGknlvhscslsrSIGYYLEPLLLLGLFGkkPLSIRLKGITNDPR-DASVDTFRSTTLNIIKR-FGvP 144 thale cress
Q75LH9        78 ---------VIVGGrdlehdcgvhrGIGYFLEPLILLGLFAraPISIRLKGITNDTK-DPSVDTFRMVTLHMLKQ-FGvP 146 Japanese rice
Q09870        78 ---------NIIGGrvvhd-cpttkGIGYFLEPILILCLFAktPTSLTLTGVTSSNE-DIGVDVLRTSVLPSLQKrFQvG 146 Schizosaccharom...
Q6CHS3        80 ---------IIVGGsvthn-cplsrGVGYFIEPLLLLAPFGkkALTATLRGITSH-SlDPSPDSIRTSVFPVMQK-FGiE 147 Yarrowia lipoly...
XP_013934393  79 ---------LIIGGdfvhq-cpdgvACGYFIEPMLCLAPFSknKFSILFKGLTAS-KeHVGVDFIKWGLLPVMEK-FGvR 146
XP_003955091  79 ---------IIVGGshthn-cppsrAVGYFIEPMLYLAPFSkkKFSIIFRGITAS-HnDAGVEAIKWGLLPVLEK-FGvR 146
XP_003645374  77 ---------IIVGGsythn-cpnskPVGYFVEPLLYLAPFSkkKFSIVFRGMTSS-HgDAGVETIKWGLMPVMEK-FGvR 144
NP_001130728  78 ---------VIIGGkglehdcgvhrGIGYFLEPLILLGLFSraPISIRLKGITNDTK-DPSVDTFRTTTLHMLKH-FGvP 146 Zea mays
1QMH_A       150 H--QQTTLLRHGFYPAGGGVVATevsp-vasFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFS-----LHE 221 Escherichia col...
4_pfamImport 141 SegLKLTIRNRAPPPHGGGEVELkipivqnsLTAVTWIDEGMVKRIRGLTFTSRVSSQFEHTMRYAARGIFNrllpdVHI 220
Q9C578       145 AedLELKIEARGVAPNGGGEVLLtvpn-iktLSAVHWVEEGMVKKIRGTTFSTRVTSDFEHSMRFAARGIFNnllpdVHI 223 thale cress
Q75LH9       147 LegLELKIESRGAPPLGGGEVFLrvpnikstLKAANWADEGMVKRIRGVSFSTRVSPQIENRIIYAARGIFNrfipdVHI 226 Japanese rice
Q09870       147 De-LELRILKRGSAPGGGGEVNFlcpvikesLPPIRLSEFGRVFRIRGIASSTRVSPAFANRLVESARGVLNpfipdVFI 225 Schizosaccharom...
Q6CHS3       148 R--QELKIIQRGATPLGGGEVMLhlphlvlhPKTLHATTTPTISKIRGIAYSCRVSPASVNRLIDGAREELRatgceTFI 225 Yarrowia lipoly...
XP_013934393 147 E--VELHTLKRGSPPLGGGEVHLivnslipqPVTIHVLDYQKISAIRGIAYCTRVSPSVANRLVDSARSVLKatgceVNI 224
XP_003955091 147 E--CALHTLKRGSPPLGGGEVHLivdsliaqPLTMHELERPPIKSIRGVAYSTRVSPSLVNRMIDGSRNVLKdinceVNI 224
XP_003645374 145 E--CALHTLKRGSPPIGGGEVHLvvdsliaqPITMHALEKPVISAITGVAYSTRVSPSMVNRMIDAAKSVLKkvpceVNI 222
NP_001130728 147 LdgFDLNIDSRGSPPLGGGEVFLrvrninstLTAANWVDEGMVKRIRGVSFSTRVSPQLENRIIYAARGIFNrfipdVHI 226 Zea mays
1QMH_A       222 QNIHNLPr---------------dQG---PGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGE 283 Escherichia col...
4_pfamImport 221 STYHSKTgkspgygi--svvaettSGcfiSADTAVSYGRGEESGEDKDEENNELMPPEEVGEQIASVLLGEIEQGGVVDS 298
Q9C578       224 FQDHRAGaqagkspgygislaaetTTgcfISADTTVSCERPDETGELDVEKKERSPAEDTGVEVASWLLQEIEKGGVVDS 303 thale cress
Q75LH9       227 FTDHRSGsaggrsag-ygvsvvaeTTtgcLLSADATVSYPNVDEMNEESENLELTSPEDLGVQVASMLLEEVAQGGVVDS 305 Japanese rice
Q09870       226 YTDVRRGd---------------eCGnspGYSITLVAETNKGCSYAAEHCGEAGETPEDVGSFCAKKLLEVIESGGCVDP 290 Schizosaccharom...
Q6CHS3       226 FSDVARGd---------------eSGkspGFGIVLVGETRPGFCISAESVAVAGSIPEDLGRETAKKLIEEISRAGVFGR 290 Yarrowia lipoly...
XP_013934393 225 TTDVCRGei--------------aGKspgFGLTLFTESKKIPFRYVVEDIGTGGETPEDVGERVALSLLEQIDTSGCLGR 290
XP_003955091 225 TADVWRGe---------------nSGkspGWGITLVGETKKGWCFFSELIGDAGDIPENIGMQVAYHFIEEISKSAAVGR 289
XP_003645374 223 TADVWRGe---------------nSGkspGWGLTLVGETKKGWRYSAEAIGDGGDVPEDIGTKVAYELLEEISKCGVVDR 287
NP_001130728 227 HTDHRSGsaggrspg-ygvslvaeTTtgcLLSVDVTVSYPSVDEINEESEKPELTSPEDLGVQAASMLLEEVAQGGVVDS 305 Zea mays
1QMH_A       284 YLADQLVLPMALA---------GAgeftvAHPSCHLLTNIAVVERFLPVRFSL 327 Escherichia coli K-12
4_pfamImport 299 THQGLLFLLCALCpqdvskirvG-------KLSPNGIETLRHIRDFLGVKFVI 344
Q9C578       304 THQGLLFLLCALSeqdvskvrvG-------TLSPYAVETLRNIKEFLGVKFAI 349 thale cress
Q75LH9       306 AHQGLLFILCALSppdvskvrvG-------QLTPYAIETLRNIRDFLDVKFII 351 Japanese rice
Q09870       291 YTQPSTLTGMLLSsedvntivvGQ-----LGITSQLVVFLRDVKALFNCEYRF 338 Schizosaccharomyces pombe 972h-
Q6CHS3       291 NQLDMAIIFMILGsgdvgrlviGK-----QNIDERFVTLARDIKKFWGVEMRL 338 Yarrowia lipolytica
XP_013934393 291 NQLELAFLYMVIGkedigrlliNK-----AQFDEQLVVFLRDIKTVFGTQFYF 338
XP_003955091 290 NQLPLAIVYMVIGkedigrlriTK-----EQIDENFIHLLRDVKKIFGIEVFL 337
XP_003645374 288 NQLPLALVYMVIGkedigrlriSK-----DQIDERFIRLMRDIKQIFGTEAHL 335
NP_001130728 306 THQGLLFILCALCppdvskvrvG-------QLTPYGIETLRNIRDFLDVKFII 351 Zea mays
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