Conserved Protein Domain Family
Topoisom_bac

?
pfam01131: Topoisom_bac (484677 is an unknown moldel)
DNA topoisomerase
This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Statistics
?
PSSM-Id: 484677
Aligned: 56 rows
Threshold Bit Score: 333.055
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q6AJY0        157 DTMQSLEDAALCRSESDWLIGLNATRALTGf-nSRKgg--ffLT-PCGRVQTPTLSLIVKREAIRNGFTPTDYNCLQA-N 231  Desulfotalea ...
Q1AUL7        155 EVSRELADAGEARQDIDLIWGATLTRWVSRavkRYGs-----AFlSVGRVQSPTLVLIAERELERRAFVPEPYWEVEA-R 228  Rubrobacter x...
WP_011322338  148 DLDFDLAAAGEARQIVDLLWGAALTRFLSLsanQLGd-----DFiSVGRVQSPTLKLIVDREREIEAFDPDDYWELFA-D 221  Natronomonas ...
2_pfamImport    1 EPNENLANKAFARMVVDLTIGASFTRILTLsarRNGgvmprgSFlSYGPCQTPVLYLVVKRELEREQFKKKKYYVLR--- 77  
XP_001388324  165 fpNKNESDAVDVRQELDLKIGVAFSRLQTKylkSKFgdfnksSIiSYGPCQTPTLFFTVQRRDSINSFIPEKYYTISA-T 243 
A0DGW1        189 GPNILESESVDARQIIDLKVGVAFSRFQTLhfqKKYsm---dQMvTFGPCQTPTLGFCVERHEEIVNFVPRAFYTIKlsI 265  Paramecium te...
Q24DD8        701 pPNMNESKAVDARQIIDLKIGAAFTRYQTLf-fRNRypelneNIiSFGPCQTPTLGFCVEREDEIKNFKPRLYFRIRA-T 778  Tetrahymena t...
Q383X7        159 APNRALSEAVEARQELDLRLGAVFTRFQTLkfcSQFkn--fpKVlSFGPCQFPTLGFLVQRGWEQKGFVPEDYFTL---T 233  Trypanosoma b...
XP_001579129  164 PINRNDAAAVKLRQEIDLRIGSAFTRFQSQf-kGMLqn---aELiSFGPCQFPTLGFVVEAFFNHIKHVPESFWKIEp-L 238 
Q8SS31         53 EINEAEAEAVEVRIELDLRIGSAFTRLQtlslgr---arqgkKIlSFGPCQVPTLGFVVERARERESFVPEIFWTLKF-K 128  Encephalitozo...
Q6AJY0        232 FsFETGSYSGkwidpnfkkdpkNSYLRQDrIWDKQKALAILEKC-Qqk-----pAN-ATENSKESRQSAPqLFDLTALQR 304  Desulfotalea ...
Q1AUL7        229 L-QNGGGPFV-------------ARHARGrFKEEAEARRALENLse-------tAVvTEVRQREATRPAPaPFNTTAFLT 287  Rubrobacter x...
WP_011322338  222 L-AREGTTFEaqy------fyrEDGTEQErVWDESGAETAFETLrNag-----tAVvESVRRRRRTDEPPePFNTTQYIS 289  Natronomonas ...
2_pfamImport   78 VrFRSQEG----------------VFTASaTFEDQEKAKSALDSvKrt----gvGVvVSAEFNAVEVEPPvPLNTVYLES 137 
XP_001388324  244 LsKDSQDI--------------NLIWSRSrVFELQVANCFLQLIqNkkp---lsARvVDITSKNSRRIRPlPLNTVSMLK 306 
A0DGW1        266 LnNVGYKQE--------------VEWLGQqIWKEPEAKQVVQQLqKfkqgdvisQQvEQKS-----KPRPeGINTVSLLK 326  Paramecium te...
Q24DD8        779 F-VTEDGMEV------------VSYCDKGhIYDQGESNKIFKDVlNqq-----hIQiTQVSSDFGTKQRPeGLNTVQLLK 840  Tetrahymena t...
Q383X7        234 LqHGDTSF----------------NSVRGpIYDKIAAAVVLQQMfDeart-rpeAEvVEVMKRPNRRRPPfPLSTVMLQK 296  Trypanosoma b...
XP_001579129  239 ItKDNIKVT--------------LKWDRKrLFCKLSAFAIYVDIlDnp-----mAKvLTVDERESLSNKPlPLSTIELQR 299 
Q8SS31        129 a--mHKGFKDe------------FTWRRGpVFDRNCVVCFFNSLsGe------dARiVSREVKEKTKYRPlPLRTVELQK 188  Encephalitozo...
Q6AJY0        305 EANSRFGFSAKNTLGIAQALYEKhKALTYPRTDSRHLP-EDyvDtVKEITQNQTGWEF-------AAIAKTALKeGYIKa 376  Desulfotalea ...
Q1AUL7        288 AAANI-GVSPSRAARIAEDLYTE-GYISYPRTDNTVYP-ESl-Dl-REVLGFLAEVeg------vGDYAGRLL--GAGRl 354  Rubrobacter x...
WP_011322338  290 AANGI-GLSAQRAMSVAEELYTA-GYITYPRTDNTVYP-DDl-Dp-EALLSAFTDHyl------fADDAEMLR--SADDi 356  Natronomonas ...
2_pfamImport  138 RASLFLNLRPKETLSIAEKLYSF-GYISYPRTETTIYP-PT--LnLRGIASMFTR-WEd-----aGWYVAKVLAkGf--- 204 
XP_001388324  307 LSSTILGIGPFQTLNIAEKLYLS-GFTTYPRTETSRYP-KN--FdIKSTIAMFKNNsv------wGSYSSDLLQkGFn-- 374 
A0DGW1        327 FASSYLGLGPQQAMHVAERLYLN-GYISYPRTETTAYP-HE--FpTPKIINNLQK-YKdplisehSKYLKT--N-Ghs-- 396  Paramecium te...
Q24DD8        841 IASSYLHMSPMETMHVAERLYLN-GYITYPRTESTAYP-KA--FqFREILNSLQSDsd------yGKFASNLLQdYKQP- 909  Tetrahymena t...
Q383X7        297 LCTAHLRISSDQCMTWAESLYQE-GYISYPRTETDSFSfTD--NeLLDIVGSQRR-NPe-----vSGFVEAMLAdPnrk- 366  Trypanosoma b...
XP_001579129  300 RCSKYLKISAQRSMEAAEKLYQN-GCISYPRTETDSFS-AD--FkFKDIVNALTRFKGe-----iGQYSNKILQqi---- 366 
Q8SS31        189 KCSSYFRLSGHKVMEIAEGLYNR-GYISYPRTETDVFD-RK--FdFKHILGKLCKDSKvg---eyASKLMGEFNhPRNGk 261  Encephalitozo...
Q6AJY0        377 qtriFnNKKi--SDHHAIIPTnTLP--QNLSEPELk---IYTMVVQRFLAIFFPPAVFHNTKRYSlvegqtFLTEGKILL 449  Desulfotalea ...
Q1AUL7        355 t-ptRgRRQt--TDHPPIYPTgR-AsrAELREDQWk---IYQLVVRRFLATLSGPAKTLRTTLRFesggepLVAGGTVVT 427  Rubrobacter x...
WP_011322338  357 e-ptAgDEEt--TDHPPIHPTgEIPnkDDLSDDEWe---VYELVVRHFFATVADAAEWEHLKVVAdadgcsLKANGKRLV 430  Natronomonas ...
2_pfamImport  205 ---tPtRGReddKAHPPIYPTrSASreEITRRFGEkawkVYEYVVRHFLATISENAVVERQRVVVkvgelsLQSEGRKLV 281 
XP_001388324  375 ---lPrKDGldlGDHPPITPVrSATq-NDLDGDSWr---LYDLITRHFFATISNDIKMINRTIKFdlngeiFIISGNQVI 447 
A0DGW1        397 ---nPkQ-GvdvGDHPPITPTeNVPq-NNLYGEEKt---MYEYVVKMFLAAHSKDCKYENHTLKFfvgdhqFKFQSKYIL 468  Paramecium te...
Q24DD8        910 ----RsGVDm--GDHPPITPTtNYP--NSLGGDERk---LYDYISKHFIASLSEDCKYKKITIQGsicnynFIARGIQMV 978  Tetrahymena t...
Q383X7        367 -frrPlNGGhddKAHPPIYPTkPMPaaNDGRAk------LYNLIVRHFLACTSPDAVASTTSVAVvyggekFTTSGTTID 439  Trypanosoma b...
XP_001579129  367 --vpPrAGKhsdNAHPPIYPIkVp--dKFDTPDQQk---VFEFVCRHFLACCSKDGVSLATRVTFdingeqFHLKGTRVL 439 
Q8SS31        262 ------NND---MAHLPIYPLkEGS---GLSGSDRd---IYDFVSRRFLGCIAKDAKGLETRYELkiglemFDLSGIRVI 326  Encephalitozo...
Q6AJY0        450 EAGWKVVYagaDGSTGKD-KILAPIPT---GSPVTCNKiekeaLTTTPPARYNEATLLSAMENSdkfieneeladamker 525  Desulfotalea ...
Q1AUL7        428 EEGWLAVY---HYGRRRDe-eLPRLSE---GDEVRVAEaellaKETQPPGRYGQGRLIRLMEDL---------------- 484  Rubrobacter x...
WP_011322338  431 EPGYHEVY---PYRSTSEn-hVPAVEE---GEQLAIEDarieeKQTQPPRRRGQSRLIEELESR---------------- 487  Natronomonas ...
2_pfamImport  282 YAGFYNVYk--YSVPKDe--pLPYVVE---GEEVEVEDakieaRTTQPPPYLSESELLALMKKY---------------- 338 
XP_001388324  448 DHGFSVIQ---GRAACHEsNIIPDFTL---NEVVPIKNieilsKETKPPPILSESDLLSLMEKH---------------- 505 
A0DGW1        469 DPGFTKVAt--WLAITEN---KSDLTKfvtNNKVQIGFveyqqGQTSPPDHLTETELITLMDKF---------------- 527  Paramecium te...
Q24DD8        979 NKGFTEVQ---DHISLGEnTIASNLQQ---GKQLKVTSinqeqEYTSAPGYITESELISLMEKN---------------- 1036 Tetrahymena t...
Q383X7        440 EKGWMEVYi--YERWKSt--tLPTYKQ---GERFRPTHadleqHRTSPPPNLTEADLITLMDKH---------------- 496  Trypanosoma b...
XP_001579129  440 EENWHEIYp--YIPFKGt--kIPEFKV---DELISPTNielneGKTTAPPLLTEPDLLKKMNQE---------------- 496 
Q8SS31        327 ERNYLEVY---YYDKWDDk-eVGDFAV---EEIV-SGDleideGETSAPKYLSEAELIGLMDKN---------------- 382  Encephalitozo...
Q6AJY0        526 GLGTPATRATIIEKLIKEKYVVRe----A-KDLVPTGKAFELFSLIEAMkiDTLASPEMTGEWEYKLNQIFKGEMTRDDF 600  Desulfotalea ...
Q1AUL7        485 GLGTKATRPGIIQNLYDRGYIHGd----P---IVPTETGMAVAKALKDFa-SEIASHEMTARLEKSMDAISEGRVSKDSV 556  Rubrobacter x...
WP_011322338  488 GLGTKSTRHNTLQKLYDRGYIESd----P---PRPTKLAMAVVEAAEQFa-DRIVDEEMTAQLESDMQAIVDGEKDLEAV 559  Natronomonas ...
2_pfamImport  339 GIGTDATMQEHIHTNIERRYFVVk---nKr--CIPTPLGRTLALALYETv-pELVLPEVRGKMEASLSKIATGERTPEEV 412 
XP_001388324  506 GIGTDASMPTHIQKIQEREYVKLa----SgRRLEPTKLGIALVHGIMNId-HELVLPKIRSEMEKYVDLIAKGKYNHKAV 580 
A0DGW1        528 KIGTDASMATHINNICERQYVKVegssrK---LKPTDLGLSLVRGYKRId-pDLVAPQLRSSIESQVDQIAKGKLKCQQV 603  Paramecium te...
Q24DD8       1037 SIGTDASMATHIQNIVNRNYVQIn---gSnRSLVPTELGRSLVHGYQKId-PELVQPQIRSKIENMVDQIAKGNKQFADV 1112 Tetrahymena t...
Q383X7        497 GIGTDATISHHIKTVVEREYVKRe---gSs--LVPTHVGNALASAYEVNglVSLLQPQMRAQMELAMADIAAGKATRRDV 571  Trypanosoma b...
XP_001579129  497 GIGTDATYQDHIAKIMERKYIVQe---nNy--FKPTPLGLALNDGYEGMg-fDFMKPRLRAEMEQGLQDISSGRQTYDAV 570 
Q8SS31        383 GIGTDATIHEHIQKIQERGYAVKv----A-EEIRPLNLGTALIEGYERFg-LNVGKPELRKSLEVSLKKISDGEIDGKSV 456  Encephalitozo...
Q6AJY0        601 MQ 602  Desulfotalea psychrophila
Q1AUL7        557 VE 558  Rubrobacter xylanophilus DSM 9941
WP_011322338  560 TE 561  Natronomonas pharaonis
2_pfamImport  413 VN 414 
XP_001388324  581 LK 582 
A0DGW1        604 IQ 605  Paramecium tetraurelia
Q24DD8       1113 In 1114 Tetrahymena thermophila SB210
Q383X7        572 VD 573  Trypanosoma brucei
XP_001579129  571 RN 572 
Q8SS31        457 VY 458  Encephalitozoon cuniculi
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap