Conserved Protein Domain Family
Topoisom_bac

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pfam01131: Topoisom_bac 
DNA topoisomerase
This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Statistics
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PSSM-Id: 426069
Aligned: 61 rows
Threshold Bit Score: 331.515
Created: 16-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6AJY0         157 DTMQSLEDAALCRSESDWLIGLNATRALTGf-nSRKgg--ffLT-PCGRVQTPTLSLIVKREAIRNGFTPTDYNCLQA-N 231  Desulfotalea...
CAI48702       148 DLDFDLAAAGEARQIVDLLWGAALTRFLSLsanQLGd-----DFiSVGRVQSPTLKLIVDREREIEAFDPDDYWELFA-D 221  Natronomonas...
jgi:Tpen_0885  158 EPNENLANKAFARMVVDLTIGASFTRILTLsarRNGgvmprgSFlSYGPCQTPVLYLVVKRELEREQFKKKKYYVLR--- 234  Thermofilum ...
XP_001388324   165 fpNKNESDAVDVRQELDLKIGVAFSRLQTKylkSKFgdfnksSIiSYGPCQTPTLFFTVQRRDSINSFIPEKYYTISA-T 243  Cryptosporid...
A0DGW1         189 GPNILESESVDARQIIDLKVGVAFSRFQTLhfqKKYsm---dQMvTFGPCQTPTLGFCVERHEEIVNFVPRAFYTIKlsI 265  Paramecium t...
Q24DD8         701 pPNMNESKAVDARQIIDLKIGAAFTRYQTLf-fRNRypelneNIiSFGPCQTPTLGFCVEREDEIKNFKPRLYFRIRA-T 778  Tetrahymena ...
Q383X7         159 APNRALSEAVEARQELDLRLGAVFTRFQTLkfcSQFkn--fpKVlSFGPCQFPTLGFLVQRGWEQKGFVPEDYFTL---T 233  Trypanosoma ...
A0CUH3         174 QPDENLSNSVLARQEIDLRIGASFTRFQTLllqQQFhl---qSViSYGPCQIPTLGFVVQRQKEIDSFVKEKFWFIQc-E 249  Paramecium t...
Q7Q111         162 QPDARQNDAVNVRSELDLRIGAAFTRFQTLrlqKSFpqdisnNLvSYGSCQIPTLGFVAQRYKEIENFIPQTFWKIKl-T 240  Anopheles ga...
Q8SS31          53 EINEAEAEAVEVRIELDLRIGSAFTRLQtlslgr---arqgkKIlSFGPCQVPTLGFVVERARERESFVPEIFWTLKF-K 128  Encephalitoz...
Q6AJY0         232 FsFETGSysGkwidpnfkkdpkNSYLRQDRIWDKQKALAILEKC-Q----Qk-PAN-ATENSKESRQSAPQLFDLTALQR 304  Desulfotalea...
CAI48702       222 L-AREGTtfEaqy------fyrEDGTEQERVWDESGAETAFETLrN----Ag-TAVvESVRRRRRTDEPPEPFNTTQYIS 289  Natronomonas...
jgi:Tpen_0885  235 VrFRSQEg----------------VFTASATFEDQEKAKSALDSvKr---Tg-VGVvVSAEFNAVEVEPPVPLNTVYLES 294  Thermofilum ...
XP_001388324   244 LsKDSQDi--------------NLIWSRSRVFELQVANCFLQLIqNk---KplSARvVDITSKNSRRIRPLPLNTVSMLK 306  Cryptosporid...
A0DGW1         266 LnNVGYKq--------------eVEWLGQQIWKEPEAKQVVQQLqKfkqgDviSQQvEQKS-----KPRPEGINTVSLLK 326  Paramecium t...
Q24DD8         779 F-VTEDGmeV------------VSYCDKGHIYDQGESNKIFKDVlN----Qq-HIQiTQVSSDFGTKQRPEGLNTVQLLK 840  Tetrahymena ...
Q383X7         234 LqHGDTSf----------------NSVRGPIYDKIAAAVVLQQMfDeartRp-EAEvVEVMKRPNRRRPPFPLSTVMLQK 296  Trypanosoma ...
A0CUH3         250 ---DQTKc--------------gYNWSRGNIFDEMIVLILFERCfTe---Q---AKiTDVQSKEVQKWKPYPLSTIEFEK 306  Paramecium t...
Q7Q111         241 HtIDDLTv--------------eFHWSRNRLFDKQCCEAYLMLCqTn---P--TAKvVNVTQKPKNKWRPTPMDTVELEK 301  Anopheles ga...
Q8SS31         129 a--mHKGfkDe------------FTWRRGPVFDRNCVVCFFNSLsGe---D---ARiVSREVKEKTKYRPLPLRTVELQK 188  Encephalitoz...
Q6AJY0         305 EANSRFGFSAKNTLGIAQALYEKhKALTYPRTDSRHLP-EDyvDtVKEITQNQTGWEF-------AAIAKTALKeGYika 376  Desulfotalea...
CAI48702       290 AANGI-GLSAQRAMSVAEELYTA-GYITYPRTDNTVYP-DDl-Dp-EALLSAFTDHyl------fADDAEMLR--SAddi 356  Natronomonas...
jgi:Tpen_0885  295 RASLFLNLRPKETLSIAEKLYSF-GYISYPRTETTIYP-PT--LnLRGIASMFTR-WEd-----aGWYVAKVLAkGf--- 361  Thermofilum ...
XP_001388324   307 LSSTILGIGPFQTLNIAEKLYLS-GFTTYPRTETSRYP-KN--FdIKSTIAMFKNNsv------wGSYSSDLLQkGFn-- 374  Cryptosporid...
A0DGW1         327 FASSYLGLGPQQAMHVAERLYLN-GYISYPRTETTAYP-HE--FpTPKIINNLQK-YKdplisehSKYLKT--N-Ghs-- 396  Paramecium t...
Q24DD8         841 IASSYLHMSPMETMHVAERLYLN-GYITYPRTESTAYP-KA--FqFREILNSLQSDsd------yGKFASNLLQdYKq-- 908  Tetrahymena ...
Q383X7         297 LCTAHLRISSDQCMTWAESLYQE-GYISYPRTETDSFSfTD--NeLLDIVGSQRR-NPe-----vSGFVEAMLAdPnrk- 366  Trypanosoma ...
A0CUH3         307 LASKKLKISAHKAMELAEKLYNR-GFISYPRTETNKFP-PT--InLQNIIRDQVN-HPv-----wGEFAQSLINcnf--- 373  Paramecium t...
Q7Q111         302 LGSRKLKMNAKQVMTIAEKLYTQ-GIISYPRTETNMFT-GD--MkLAPLVQAQVA-SDq-----wGSFAEKVLQwg---- 367  Anopheles ga...
Q8SS31         189 KCSSYFRLSGHKVMEIAEGLYNR-GYISYPRTETDVFD-RK--FdFKHILGKLCKDSKvg---eyASKLMGEFNhPRn-- 259  Encephalitoz...
Q6AJY0         377 qtriFNNKKi--SDHHAIIPTNTLP--QNLSEPEL---KIYTMVVQRFLAIFFPPAVFHNTKRYSLV-EGQTFLTEGKIL 448  Desulfotalea...
CAI48702       357 -eptAGDEEt--TDHPPIHPTGEIPnkDDLSDDEW---EVYELVVRHFFATVADAAEWEHLKVVADA-DGCSLKANGKRL 429  Natronomonas...
jgi:Tpen_0885  362 ---tPTRGReddKAHPPIYPTRSASreEITRRFGEkawKVYEYVVRHFLATISENAVVERQRVVVKV-GELSLQSEGRKL 437  Thermofilum ...
XP_001388324   375 ---lPRKDGldlGDHPPITPVRSATq-NDLDGDSW---RLYDLITRHFFATISNDIKMINRTIKFDL-NGEIFIISGNQV 446  Cryptosporid...
A0DGW1         397 ---nPKQ-GvdvGDHPPITPTENVPq-NNLYGEEK---TMYEYVVKMFLAAHSKDCKYENHTLKFFV-GDHQFKFQSKYI 467  Paramecium t...
Q24DD8         909 ---pRSGVDm--GDHPPITPTTNYP--NSLGGDER---KLYDYISKHFIASLSEDCKYKKITIQGSI-CNYNFIARGIQM 977  Tetrahymena ...
Q383X7         367 -frrPLNGGhddKAHPPIYPTKPMPaaNDGRA------KLYNLIVRHFLACTSPDAVASTTSVAVVY-GGEKFTTSGTTI 438  Trypanosoma ...
A0CUH3         374 --dqPRAGNkddKAHPPIHPVKMMResDAQTQQEW---EIYQLITRHFLACCSKNAKGSETTVNLQV-QEESFYKQGLVI 447  Paramecium t...
Q7Q111         368 --vnPRNGKksdQAHPPIHPTKLp---TNLSGDEW---RVYELIARHFLACVSRDATGSETIVNVVVaEEEEFTASGLCI 439  Anopheles ga...
Q8SS31         260 ----gKNND---MAHLPIYPLKEGS---GLSGSDR---DIYDFVSRRFLGCIAKDAKGLETRYELKI-GLEMFDLSGIRV 325  Encephalitoz...
Q6AJY0         449 LEAGWKVVYagaDGSTGKD-KILAPIPT---GSPVTCNKIEKEALTTTPPARYNEATLLSAMENSdkfieneeladamke 524  Desulfotalea...
CAI48702       430 VEPGYHEVY---PYRSTSEn-hVPAVEE---GEQLAIEDARIEEKQTQPPRRRGQSRLIEELESR--------------- 487  Natronomonas...
jgi:Tpen_0885  438 VYAGFYNVYk--YSVPKDe--pLPYVVE---GEEVEVEDAKIEARTTQPPPYLSESELLALMKKY--------------- 495  Thermofilum ...
XP_001388324   447 IDHGFSVIQ---GRAACHEsNIIPDFTL---NEVVPIKNIEILSKETKPPPILSESDLLSLMEKH--------------- 505  Cryptosporid...
A0DGW1         468 LDPGFTKVAt--WLAITEN---KSDLTKfvtNNKVQIGFVEYQQGQTSPPDHLTETELITLMDKF--------------- 527  Paramecium t...
Q24DD8         978 VNKGFTEVQ---DHISLGEnTIASNLQQ---GKQLKVTSINQEQEYTSAPGYITESELISLMEKN--------------- 1036 Tetrahymena ...
Q383X7         439 DEKGWMEVYi--YERWKSt--tLPTYKQ---GERFRPTHADLEQHRTSPPPNLTEADLITLMDKH--------------- 496  Trypanosoma ...
A0CUH3         448 LEKNYLEIYp--YDEWSQs--qVPNYKK---GDMIQIT-LKIQNGKTSPPKPMTESELIGLMDKN--------------- 504  Paramecium t...
Q7Q111         440 HERNYLEVYp--YDRWNAk--eIHSYQV---GHTFEPTELGLHEGSTTAPNMLTEADLIALMEKH--------------- 497  Anopheles ga...
Q8SS31         326 IERNYLEVY---YYDKWDDk-eVGDFAV---EEIV-SGDLEIDEGETSAPKYLSEAELIGLMDKN--------------- 382  Encephalitoz...
Q6AJY0         525 rGLGTPATRATIIEKLIKEKYVVRE----A-KDLVPTGKAFELFSLIEAMkiDTLASPEMTGEWEYKLNQIFKGEMTRDD 599  Desulfotalea...
CAI48702       488 -GLGTKSTRHNTLQKLYDRGYIESD----P---PRPTKLAMAVVEAAEQFa-DRIVDEEMTAQLESDMQAIVDGEKDLEA 558  Natronomonas...
jgi:Tpen_0885  496 -GIGTDATMQEHIHTNIERRYFVVKn---Kr--CIPTPLGRTLALALYETv-pELVLPEVRGKMEASLSKIATGERTPEE 568  Thermofilum ...
XP_001388324   506 -GIGTDASMPTHIQKIQEREYVKLA----SgRRLEPTKLGIALVHGIMNId-HELVLPKIRSEMEKYVDLIAKGKYNHKA 579  Cryptosporid...
A0DGW1         528 -KIGTDASMATHINNICERQYVKVEgssrK---LKPTDLGLSLVRGYKRId-pDLVAPQLRSSIESQVDQIAKGKLKCQQ 602  Paramecium t...
Q24DD8        1037 -SIGTDASMATHIQNIVNRNYVQINg---SnRSLVPTELGRSLVHGYQKId-PELVQPQIRSKIENMVDQIAKGNKQFAD 1111 Tetrahymena ...
Q383X7         497 -GIGTDATISHHIKTVVEREYVKREg---Ss--LVPTHVGNALASAYEVNglVSLLQPQMRAQMELAMADIAAGKATRRD 570  Trypanosoma ...
A0CUH3         505 -GIGTDATIHEHINTIQEREYAIKKg---Qi--IKPTKLGLALVESYEMLg-fTLHKPHLRAVMEQRMNEVAQGTKQKKQ 577  Paramecium t...
Q7Q111         498 -GIGTDATHAEHINTIKERGYIGERd---Rg-fLVPGTLGMGLVEGYEMMe-lRLAHPELRAGLEADLKLVCEGRKNPND 571  Anopheles ga...
Q8SS31         383 -GIGTDATIHEHIQKIQERGYAVKV----A-EEIRPLNLGTALIEGYERFg-LNVGKPELRKSLEVSLKKISDGEIDGKS 455  Encephalitoz...
Q6AJY0         600 FM 601  Desulfotalea psychrophila
CAI48702       559 VT 560  Natronomonas pharaonis DSM 2160
jgi:Tpen_0885  569 VV 570  Thermofilum pendens Hrk 5
XP_001388324   580 VL 581  Cryptosporidium parvum Iowa II
A0DGW1         603 VI 604  Paramecium tetraurelia
Q24DD8        1112 VI 1113 Tetrahymena thermophila SB210
Q383X7         571 VV 572  Trypanosoma brucei
A0CUH3         578 IV 579  Paramecium tetraurelia
Q7Q111         572 VL 573  Anopheles gambiae str. PEST
Q8SS31         456 VV 457  Encephalitozoon cuniculi
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