4BPM,2H8A,6SSR,5HV9


Conserved Protein Domain Family
MAPEG
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pfam01124: MAPEG (This model is not part of the current CDD release)
MAPEG family
This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.
Links
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Statistics
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PSSM-Id: 514018
Aligned: 158 rows
Threshold Bit Score: 37.2738
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4BPM_A  14 FL--LCSTLLVIKMYVVAIITGQVRLrkkaf------anpedALRH----GGPQYCRSDPDVERCLRAHRNDMETIYPFL 81  synthetic construct
Q9I591   6 SA--ICLLGLIAWTLLLVFLLVSQRGllvlggrmavnafaadG-----------SNTPGGFGQRLVRVHANCVENLPLLA 72  Pseudomonas aeruginosa
Q8F0J4   2 NPaiIALLGFIFWTLFLGLCVVSVRSfkvl--------tgsnKSNEfpagIKHGS----EFYWRLNRAHINCIENLPIFG 69  Leptospira interrogans
Q31QW4   4 DL--ICLLILALWTLPLNHIPAIGRAskag---------ldwAMSN-----RDRQPEVPEWVGRADRAQRNHLDNLAMIA 67  Synechococcus elongat...
Q28W95   7 VT--LWNVVLLGVLLLLQPLVRDIVVgfk----------ytiSNF-------DNRVDEGVFARRLAMVRSNQIEALALWV 67  Jannaschia sp. CCS1
Q8P7G3   9 ML--GWAMVLGLVQLLAASTSMTAQRgt------------kwNASA----RDGETKPLTGVAARLDRAFRNFLETFAIFA 70  Xanthomonas campestri...
Q9A7V1   9 MI--AVAVAIGILNLLWASAAAQPQRgl------------kwNVGP-----RDETIELTGMAGRLMRAFANFRETFPFFV 69  Caulobacter vibrioides
Q5NQE5   9 LL--GIVLLLALLQIFLTAHFKTRQYgy------------kwNVSA----RDEALPPLSPMAGRLSRAQANLFETLPLFI 70  Zymomonas mobilis
Q5QUG7   9 MA--YWGVLIALVILLVQWVIASGQKakqpg-------avpgKIDD----SLSHSS----FVFRAHRTLMNSLENYPLML 71  Idiomarina loihiensis
Q3IH31   7 SA--YLAFYLYLIMLLVQWAVATFSKakqpn-------avpgKISD----DLSHDS----FIFRAHRTFHNTLENSALFI 69  Pseudoalteromonas hal...

4BPM_A  82 FLGFVYSFlgP--NPFVAWMHFLVFLVGRVAHTVAY---LGK-LRAP---IRSVTYTLAQLPCASMALQILW 144 synthetic construct
Q9I591  73 GALLYAIAsg---qSSLTDPLAPLVLGARLFQSLMH---LVStSALFv-wLRFAGFFVQLLVLAWWLLLLAG 137 Pseudomonas aeruginosa
Q8F0J4  70 ILVLIGVFag--vFDHRFELATQIILGARIFQTLAH---LSS-GSVFavnARFTGFMIQYGCFLYLLWHILH 135 Leptospira interrogans
Q31QW4  68 SVILIAQItgK--ADGTTAIASIVLLLARIAHSLTY---LAG--LPL---PRSLSYFVSIAALLTIVWRLFA 129 Synechococcus elongatus PCC 7942
Q28W95  68 PVILIAGIavpdlthPHLALIATVFLIARIAYAIMS---LAG--IPL---LRSGAWTVGFAAWACLTWIIRS 131 Jannaschia sp. CCS1
Q8P7G3  71 AAVLAVTVag--rTNAETALGVQLYLWARVAYVPVY---ALG--IPY---LRSAIWVVSFWGIVKLVRALLG 132 Xanthomonas campestris pv. ca...
Q9A7V1  70 ALVIVDYLggR--LGDLTVYGAALYVAARAAYLPLY---AFG--VPY---VRSLVWLASMVGILMLLAALVV 131 Caulobacter vibrioides
Q5NQE5  71 AALLANLYlgH--NGYYSELSAELYVASRLIYLPLY---AFG--VPY---LRSIVWAIGIIGLLGQILLIFC 132 Zymomonas mobilis
Q5QUG7  72 GTVFLAFFig--vSAFWTGIFIWIFAIARLIHMVLYyaiATE-KNPS---PRSYFFMIGLAANVALLILCGV 137 Idiomarina loihiensis
Q3IH31  70 GTVLFAFVin--yQSPIFALCVWIYVIARLIHMVLYyaiATN-KNPS---PRSYFFLIGVLANVVMLVMVGL 135 Pseudoalteromonas haloplankti...
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