5US6,1DIH,5UGJ,5KT0,3IJP,5EER,5WOL,1VM6,7T34,3QY9,2CZC


Conserved Protein Domain Family
DapB_N
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pfam01113: DapB_N (This model is not part of the current CDD release)
Dihydrodipicolinate reductase, N-terminus
Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate. This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both protein and cell wall biosynthesis. The N-terminal domain of DapB binds the dinucleotide NADPH.
Links
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Statistics
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PSSM-Id: 514008
Aligned: 107 rows
Threshold Bit Score: 75.3528
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5US6_A  27 VRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPE---SsLVGVDLG--------ELCGEG-KFDVVVC--DDLAKQID 92  Vibrio vulnificus CMCP6
Q8KBD8   1 MKITLVG-NGRMGRQIADVVAA-SGAHVVNRVLDV-------------------------------------NDTIDAAA 41  Chlorobaculum tepidum...
Q8A2I5   1 MKIALIGY-GKMGKELEKAALS-RGHEIVCIIDVDN------------------------------------QEDFESEA 42  Bacteroides thetaiota...
Q7MTF9   1 MKIVLIGY-GKMGHVIERIACS-RGHEVVLTIDAGE------------------------------------EDRFDSIA 42  Porphyromonas gingivalis
Q9X1K8   1 MKYGIVGYSGRMGQEIQKVFSE-KGHELVLKVDVNG-----------------------------------------VEE 38  Thermotoga maritima MSB8
O80574  73 ISIMVNGCSGKMGKAVIKAADS-AGVNIVPI--SFGs--A-GEDGQRV--------EVCGKEiTVHGPTEreKVLSSVFE 138 thale cress
Q9V1P1   3 VKVGVNGY-GTIGKRVAYAITKQDDMELVGVVKTKPdfeA-YRAKELGipvyaaneEFLSRFeSVGFEVE--GTLNDLLE 78  Pyrococcus abyssi GE5
1VM6_A  13 MKYGIVGYSGRMGQEIQK-VFSEKGHELVLKVDVNG---V------------------------------------EELD 52  Thermotoga maritima
7T34_A  25 ISIMVNGCSGKMGKAVIKAADSA-GVNIVP-ISFGS---A-GEDGQRV--------EVCGKEiTVHGPTEreKVLSSVFE 90  thale cress
3QY9_A   4 MKILLIGY-GAMNQRVARLAEE-KGHEIVGVIENTP------------------------KA-TTPYQQY--QHIADV-K 53  Staphylococcus aureus...

5US6_A  93 Q--FDVIIDFTAPASTLNNLALCQQY-GKSIVIGTTGFTEEQREQIDLVAQQ--VPVVMAPNY 150 Vibrio vulnificus CMCP6
Q8KBD8  42 FsgSDVIIDFTVRSAFLANYPALIAS-GVPVVVGTTGW-DDVMPQVREEVVKarSTMLYSANY 102 Chlorobaculum tepidum TLS
Q8A2I5  43 FksADVAIEFTNPMVAYSNYMKAFKA-GVKLVSGSTGWMAEHGEEIKKLCTEggKTLFWSSNF 104 Bacteroides thetaiotaomicron
Q7MTF9  43 FrsADVAIEFTRPDAAYANCSRCMDK-SVPVVCGTTGW-TERLPELEERCRRegKTLFWASNF 103 Porphyromonas gingivalis
Q9X1K8  39 LdsPDVVIDFSSPEALPKTVDLCKKY-RAGLVLGTTALKEEHLQMLRELSKE--VPVVQAYNF 98  Thermotoga maritima MSB8
O80574 139 KhpELIVVDYTIPSAVNDNAELYSKV-GVPFVMGTTGGDRNKLYETVE-EAK--IYAVISPQM 197 thale cress
Q9V1P1  79 K--VDVIVDAT-PGGVGAKNKPLYEKaGVKAVF-----QGGEKANVAE------VSFVAQANY 127 Pyrococcus abyssi GE5
1VM6_A  53 S--PDVVIDFSSPEALPKTVDLCKKY-RAGLVLGTTALKEEHLQMLRELSKE--VPVVQAYNF 110 Thermotoga maritima
7T34_A  91 KhpELIVVDYTIPSAVNDNAELYSKV-GVPFVMGTTGGDRNKLYETVEEA-K--IYAVISPQM 149 thale cress
3QY9_A  54 G--ADVAIDFSNPNLLFPLLDE--DF-HLPLVVATTGEKEKLLNKLDELSQN--MPVFFSANM 109 Staphylococcus aureus subsp. aureus COL
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