7Y5X


Conserved Protein Domain Family
Presenilin

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pfam01080: Presenilin (This model is not part of the current CDD release)
Presenilin
Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.
Statistics
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PSSM-Id: 513980
Aligned: 50 rows
Threshold Bit Score: 235.543
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7Y5X_B         82 KYGAKHVIMLFVPVTLCMIVVVATIKSVRF-------YTekNGq--------LIYTPFTEDTPSVGQRLLNSVLNTLIMI 146  human
EPB83259       49 QFYVEQLTLLFYPLIVTFALTCWIEITLNI-------DSsqISnp------lMVYDEL--PSDSVGTRLGGSVLNAIIVV 113 
4_pfamImport    1 LNRSSQLKWTLFSVIVNMLLTLSVWIGV---------YGmeVNse-----lsRLYFLDTASNSTTGNPVLDGAINGMFTI 66  
Q01608         11 LVRSSQLRWTLFSVIANMSLTLSIWIGV---------YNmeVNse-----lsKTYFLDPSFEQTTGNLLLDGFINGVGTI 76   Caenorhabditi...
EFO85358        9 FRRSSQLQWTLFSVIVNMSLTLSIWIGI---------YQmqVNse-----lsKLYFLDDSFERTTGNTTLDGLINGFATI 74  
XP_002646243    9 LRRSSQLQWTLFSVVVNMSLTLAIWIGI---------YHmeVNse-----lsKMYFLDDSFNWTTGNPALDGLINGFCTI 74  
XP_020884192   12 DSLGEELIAILTPVSICMFTVVLLVCILN--------SDpsSSsasfssiatAAYAES--DSDSSWDKFVGALLNSVVFV 81  
XP_020436456   96 EDFSNMIIAILKPVTITMFLVVWAVRSINAknnilgqYVggGSmg------mLVYNES--SDDSTGQKIWGSLLNGLVFL 167 
XP_020435220  146 IDYSDQMVSIAIPVFFTMVVVTAVIRAISVpdnqsspPPanRIdip----agFKYD----TDPNIQQVFLNTLINSLIFL 217 
XP_004358443  217 KEYSKAMVSIALPVSISMAIVISAVRLSEEarnfksvSPl------------IQYDVR--EDPATQTLVWGTIINSLILV 282 
7Y5X_B        147 SVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTY-------NVAMDYPTLLLTVWNFGAVGMVCI 219  human
EPB83259      114 CGITLMTFMFVLCFKYRLYKFLFFWLGLSVLSILGVTASALWIEMLNVY-------NMPMDYLTMLFCTWNVAVVGVVAI 186 
4_pfamImport   67 VVLGIVSFVMLGFVLYDFQNLVKTWLIFSCLLILFGVSGQTFYDLFSQLvdqetenGRNLTLVLTILPTLVYGLAGIVAF 146 
Q01608         77 LVLGCVSFIMLAFVLFDFRRIVKAWLTLSCLLILFGVSAQTLHDMFSQVfdqddnnQYYMTIVLIVVPTVVYGFGGIYAF 156  Caenorhabditi...
EFO85358       75 LVLGCVSFVMLAFVLYDFQRVVKAWLTLSCMLILFGVSGQTLYDLFTQIldqndenQYILTVALTVIPTTIYGVLGIYAF 154 
XP_002646243   75 LVLGCVSFVMLAFVLYDFRRIVKSWLTFSCLLILFGVSGQTIYDLFSQIfdqndenQFILTVALTVIPTVVYGCLGIYAF 154 
XP_020884192   82 AAITVATFVLVLLFYLRCVKFLKFYMGFSAFIVLGNLGGEILVLLIDRF-------RFPIDSITFLILLFNFSVVGVFAV 154 
XP_020436456  168 VVIVLTTVAFVLLYKYRCLKAIYAWLFLSVGILLASMGSYVFMAMLEAN-------NLALDYITFAFIMFNFSVGGIIAV 240 
XP_020435220  218 GVVVLSTVIMVILYKFKFMKALYGWLMATSILLLGVFGGFLFILILTYV-------NIALDYLTFVFVVWNFSAGGIVCI 290 
XP_004358443  283 GIIFLSSVIMFALYYFKFMKALYGWLMATSILLLGVFGGFLFILLMTYA-------NVGLDYFTFSFIVWNFSAGGMVCL 355 
7Y5X_B        220 HW-KGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAM 298  human
EPB83259      187 FW-KSPLWVQQVYLVLVSAATSISMLR-MPPWTTWTVLIAVAIYDLFAVLCPAGPLRLLITMAEERQENI-PALVYSAGM 263 
4_pfamImport  147 LA-NGSLLLHQCFVVSNCSLIAVFYLRAFPRHTTWFVLFIVLFWDLFAVLTPMGPLKRVQEKASDYSNNILKFLMFAADD 225 
Q01608        157 FS-NSSLILHQIFVVTNCSLISVFYLRVFPSKTTWFVLWIVLFWDLFAVLAPMGPLKKVQEKASDYSKCVLNLIMFSANE 235  Caenorhabditi...
EFO85358      155 FA-NGSLALHQFFVISNCSLISVFYLRAFPRYTTWFVLWMVLFWDLFAVLAPMGPLKKVQEKASDYSNNILKFLMFAAED 233 
XP_002646243  155 LA-NGSLLLHQFFVVSNCSLIAVFYLRAFPKHTTWFVLWTVLFWDLFAVLAPMGPLKKVQEKASDYSNNILKILMFAAED 233 
XP_020884192  155 FMsKFSILITQGYLVWIGVLVAYFFTL-LPEWTTWVLLVALALYDIAAVLLPVGPLRLLVEMAISRDEDI-PALVYEARP 232 
XP_020436456  241 FW-YAPVLMNQGYLVLISTLMAISISR-LPDWTTWVILSVISIYDLFAVLCPRGPLKVLVETAQERNETI-PALIYNANF 317 
XP_020435220  291 FW-FCPKYLNQAYLICLSAFLALFLAR-FPSWTTWAILVLVSIYDIFAVLCPGGPLQQLIETARKRGESI-PALIYNASV 367 
XP_004358443  356 FW-FCPQYLTRAYLVSISSLMAIFISR-MPEWSTWSILTIVSLYDIFTVLSPGGPLKKLIDLAKERGDEI-PALVYNGSV 432 
7Y5X_B        299 VWT-----------VGMAK--LDPSSqgalq------------------------------------------------- 316  human
EPB83259      264 ASFdteddfiggyrTQESNraSKNHKkwlpftnankg--------------------------------------yrpih 305 
4_pfamImport  226 NRQsagadr---aeevnEGdgTIRRGvkqliamyskqeaqdeefaqkirqrrsawnpdsglteqsplvetepspsvpteh 302 
Q01608        236 KRLtagsnq---eetneGEesTIRRTvkqtieyytkreaqddefyqkirqrraai---npdsvptehsplveaepspiel 309  Caenorhabditi...
EFO85358      234 KREtagidatedssENLNDerKLRKDvkqlielyskkeaqddeflrkirqrrtai--npdsaltetspvhtepsdaliql 311 
XP_002646243  234 KREsagmdmaqdsqENLNDerKLRKDvkeliqlyskqdekddeflqkirqrrnai---npdsgstahspmvttepspivl 310 
XP_020884192  233 VIRndsr----lvqRRVWRerRSNDAenhanrnevravr-----------------------------------seevee 273 
XP_020436456  318 EPPsrpesipkppqQQQQQqsASSSSsqqarsrrnnnngged-----------------------------qqedefgqq 368 
XP_020435220  368 FIG-----------MAESEsiEMNTTttatqqqllqnntnnsqkps--------------------pfptptsipinlps 416 
XP_004358443  433 SIG-----------MASSKnnTTPTTktttnddtmsdtssns----------------------------ssssssssss 473 
7Y5X_B        317 -lpydpEMEEDSYDSFGEPSYPEVFEPPlTGYPGEELee------------------------------eeER------- 358  human
EPB83259      306 nneldeNATLSIALSTLEQSRDVERRNS-NEAGQDEDeeed--------------------------------------- 345 
4_pfamImport  303 qqeekeDKQMDSESSSESCSESAS-IAS-GDSNADDKekeeeddeyqssnietaeecdmetwqqlvneanaKQgdnksnl 380 
Q01608        310 keknstEELSDDESDTSETSSGSSNLSS-SDSSTTvstsdistaeec------------dqkewddlvsnsLPnndkrpa 376  Caenorhabditi...
EFO85358      312 ksknsdEEHTDDESDTTESSTTTS---S-SDvttsevstaeevap------------eewnelmeqqekqaEFdqryvpv 375 
XP_002646243  311 keknsdEELFDNESDTTESSSESS--TS-SESVfsssdvstaaeca-------------peewnelihqqnEFdqndatv 374 
XP_020884192  274 ehvgssERAEISVPLIDRRPEQAENSET-Flegig--------------------------------------------- 307 
XP_020436456  369 qqqqedDAQVDVNNNDEEVPPIEELEPE-QEKR----------------------------------------------- 400 
XP_020435220  417 qsemiePKSSPNSESMSTGVSTSELSES-TDSVTLEKg------------------------------------------ 453 
XP_004358443  474 sssniqKSTSSSSISTGLSTEPSDTPME-VNYST---------------------------------------------- 506 
7Y5X_B        359 ---------------------------GVKLGLGDFIFYSVLVGKAAAtgSGDWNTTLACFVAILIGLCLTLLLLAVFKK 411  human
EPB83259      346 ------------------------elnAIKLGLGDFIFYSVLVGKAAK---TDSVTLCLCIIAILTGLSLTILILTLNRK 398 
4_pfamImport  381 ta-----------------adalndgeTVRLGFGDFVFYSLLIGQAAA--SGCPIAVVFAAAGILFGLLVTLTVLSTEES 441 
Q01608        377 ta-----------------adalndgeVLRLGFGDFVFYSLLIGQAAA--SGCPFAVISAALGILFGLVVTLTVFSTEES 437  Caenorhabditi...
EFO85358      376 ta-----------------adalndgeTVRLGFGDFVFYSLLIGQTAT--GGSALAVACSALGILFGLVATLTVFSSGES 436 
XP_002646243  375 taadalndgvksknsgrlfseicrfpeTVRLGFGDFVFYSLLIGQAAT--GGCPISVGFAAFGILFGLIATLTVLSSEES 452 
XP_020884192  308 ----------------------lgssgAIKLGLGDFIFYSVLVGRAAM---YDLMTVYACYLAIIAGLGITLMLLSVYQK 362 
XP_020436456  401 ---------------------------SLKLGLGDFVFYSVLMGRAAM---FDISTVFTCFVAIITGLFATLFLLAIFRK 450 
XP_020435220  454 --------------------------rGIKLGLGDFVFYSVLVGRAAY---KEIILVFICFVAILTGLFITLLLLAVYKR 504 
XP_004358443  507 ---------------------------KIQLGLGDLVFYSVLLGRAAL---YDLGTIFACFVAILTGLFITLILLIVYKK 556 
7Y5X_B        412 ALPALPISITFGLIFYFSTDNLVRPFM 438  human
EPB83259      399 ALPALPISILLGCITYATAYYMTSPMI 425 
4_pfamImport  442 TTPALPVPVLCGTFCYFTSKFVWENLI 468 
Q01608        438 TTPALPLPVICGTFCYFSSMFFWEQLY 464  Caenorhabditis elegans
EFO85358      437 TTPALPLPVICGTFCYFISKFVVDQVY 463 
XP_002646243  453 TTPALPLPVICGTFCYFVSRFLVDSIQ 479 
XP_020884192  363 ALPALPVSIMLGVVFYFLARLLLEVFV 389 
XP_020436456  451 ALPALPISIAFGILFYFLTRIFLYPFI 477 
XP_020435220  505 ALPALPIKMKFNKLLLVSILLIVHLFH 531 
XP_004358443  557 AIPALPISIFIGILFFFSTSKLICPFL 583 
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