1KFX


Conserved Protein Domain Family
Calpain_III

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pfam01067: Calpain_III (This model is not part of the current CDD release)
Calpain large subunit, domain III
The function of the domain III and I are currently unknown. Domain II is a cysteine protease and domain IV is a calcium binding domain. Calpains are believed to participate in intracellular signaling pathways mediated by calcium ions.
Statistics
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PSSM-Id: 513972
Aligned: 112 rows
Threshold Bit Score: 85.6933
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KFX_L        360 MDGNWRRGS-------------------------TAGGCRNYPNTFWMNPQYLIKLEEededeedgesGCTFLVGLIQK- 413 human
XP_015196228  361 RYGEWSe--------------------------gRCGGCVNHRDSFLHNPQFMLEL-Qr--------eRDEVLICLQQEd 405
40_pfamImport   1 MRGSWRRHDdpl--------------------hnRAGGCSNNKLSFLQNPQYEFDVKKp---------rDEILICLQQKd 51 
XP_006627878  359 MRGAWVRHEdpl--------------------knRTGGCINYKATFLQNPQYVLDVKKp---------eDEVLICLQQKd 409
XP_011408714  357 FHGEWKEKT--------------------------AGGCFNHPDTFTNNPQYLFTLREe----------eEVMVSCMQKd 400
XP_032230471  362 HNYNWTQGQ-------------------------NAGGCVQNQDTFLKNPQYAFSITDn--------eGEDAMVSLMQEd 408
XP_002107604  360 FHGCWSTSAn------------------------RAGGCINNRATFLQNPQYAFDVTDg--------eYGTTVIALMQKd 407 Trichoplax adh...
XP_064422736  358 LRGSWAKHDdpl--------------------mnRSGGCFNNSDTFLQNPQYVFDVTKa---------eDEVLVCLQQQd 408 coelacanth
XP_029696692  360 LYGEWASAPsfqggsqdrttkqaggceaevdkrsRCGGCINHRDTFLHNPQFTFEVGGr---------EEEVLICLQQEd 430 torafugu
XP_006008488  359 LFSQWSSSDvpl--------------------qnRSGGCLNNRETFFQNPQFMFDIFSe---------eDAALLSIQQEd 409 coelacanth
1KFX_L        414 ---HRRRqrKMGE---DmHTIGFGIYEvpeelsGQTNIHLSKNFfLTNRARERSDTFINLREVLNRFKLPPGEYILVPST 487 human
XP_015196228  406 kraRRRE--GAGE---N-LPIGFEVLR------VEANRQSRVQ---RVGEQAASSVYMDSRSVFLRTELSQGRYVIVPTT 470
40_pfamImport  52 rktAQKE--ERGE---N-LPIGFEIQK------VELNRKYRMH---VVQQKAGGSIFINSRSVFLRITLNEGRYVVIPTT 116
XP_006627878  410 rraRPKE--GKGE---N-LAIGFDIHR------VELNRKYRMH---SAQQKVASSIFINSRCVFLRKDLKEGRYVIIPST 474
XP_011408714  401 prmSKKAk-TTGEplpN-FPIGFQIVK------VEDNRTFRIHS-MNFKE-VGRVTYINRRSNFGRFTLGQGRYVIIPST 470
XP_032230471  409 rrkDKSK--GVGN-----LTIGFYIMK------VEENRKYRVH---SMFPKAGDSIFINAREVMNRFFLAAGRYLVVPST 472
XP_002107604  408 krlEKRS--GHGE---N-LSIGYYIMK------VAVNRNYRLH---TVNPKAADVTYSNSREVTGRFELEAGRYVIIPST 472 Trichoplax adh...
XP_064422736  409 rrvHKKE--GKRQ---N-LIVGFEIFK------VEVNRVYRIHL-VQVQQKVATSVYINSRSVFLRKTLKEGRYVIIPTT 475 coelacanth
XP_029696692  431 rriRRKH--GGGE---N-LPIGFEVLK------VEVNRSSRVQ---RVEEKAASSVYMDSRTVTVRATLAPGRYVILPTT 495 torafugu
XP_006008488  410 krlYRKE--GTGD---N-LSIGFEVFR------VEVNREFRMH---RIQEKVAGTDYIGSRSIFLRVDLKQGKYVIIPTT 474 coelacanth
1KFX_L        488 FEPNKDGDFCIRVF 501 human
XP_015196228  471 FNPGGAGRFLLRVF 484
40_pfamImport 117 FDPGLEGEFLLRIF 130
XP_006627878  475 FDPGLQGDFLLRVF 488
XP_011408714  471 FEPNQERQFLLRFF 484
XP_032230471  473 YEPHTPGHFMMRIF 486
XP_002107604  473 FQPGEDGEFLLRMY 486 Trichoplax adhaerens
XP_064422736  476 FDPGVYGEFLLRIF 489 coelacanth
XP_029696692  496 FLPGVAGRFLLRVF 509 torafugu
XP_006008488  475 FTPGQTGRFLIRLF 488 coelacanth
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