Conserved Protein Domain Family
TTR-52
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pfam01060: TTR-52 (This model is not part of the current CDD release)
Transthyretin-like family
TTR-52 was called family 2 , and has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones. The specific function of this protein is as a bridging molecule in apoptosis cross-linking dying cells to phagocytes. TTR-52 bridges by cross-linking surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor, a transmembrane receptor, on phagocytes. TTR-52 has an open beta-barrel-like structure.
Links
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Statistics
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PSSM-Id: 513966
Aligned: 95 rows
Threshold Bit Score: 66.0684
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFP00631      24 SGQLKCNGQPYAEELVQVWEHKFighevwfeew-tdrygnfsitASGHEH----VrrlhpfspitfhyqgfsfSVYPYIW 98 
XP_003093615  29 RGRLVCNGKPFKNEKVELYDKNKvkrdtrilttktdelgnfviqASINEW----Tf----------------fTPNPYIY 88 
XP_002648668  28 RGKLMCNGKPYVDGEISLYEKNWvgrdtklvatktdangnfvlkSSMSEW----Pl----------------fTPNPYIY 87 
O17635        43 RGKLLCNGKPYENAEIELYEKNIigkdthlvttnttslgffsmkAAVSEWi--gF------------------SPNPYIH 102 Caenorhabditis ...
EGT51656      25 RGRLMCNGQPFTNEKVELYEKNWvrqdsrmasirtdnngefsmqGAIEEW----Pl----------------fTPKPYIY 84 
XP_003105212  24 TGRLMCGPSPYRGEKVQIWDPNFligyslwsevstdesgyfsikGAGDDW----S------------------GVNPFLW 81 
EGT49170      27 RGRLMCSSNPYANEKVQVWDPHFliefslwsetqtdesgyfsmkASGNDW----S------------------GVDPFIW 84 
O01517        26 SGRLMCGGKPYANESVSIYEKNYmltdilmeslf----tdedgnfsvkTFgkdwP------------------HFTPYLY 83  Caenorhabditis ...
XP_002635432  28 RGILTCNGNAYSKMPIETFEKNYifkddlltttttnddgsfyikYSGKDL----V------------------FFNPYIY 85 
EFO87925      28 SGSLSCHGRPYSKMPVYIYEKNFlfedkllksaktnddgsfyiqSSGEDL----L------------------SFNPYVY 85 

EFP00631      99 IPNYCGT--EKegd-yrCTKNLVQIYVP 123
XP_003093615  89 FPNYCVLt-TKigs-feCANG-IKIFVP 113
XP_002648668  88 FGNYCDIn-NDlgs-lqCADG-IKIFIP 112
O17635       103 FANFCDPs-NTir--smQCAKTIKIFIP 127 Caenorhabditis elegans
EGT51656      85 IPNFCDIk-NKlgy-feCADS-VQIYVP 109
XP_003105212  82 IPNYCGS--STyvd-kqCTEGLIQVNVP 106
EGT49170      85 IPNYCAS--SLvgd-krCTEGLIQLNVP 109
O01517        84 APNYCKPvdNFvfadreCTDSALQILIP 111 Caenorhabditis elegans
XP_002635432  86 VPNYCLA--ETyng-lkCTTGAMMIQIP 110
EFO87925      86 VPNYCGAv-RSpd--giCTVKAMMVRIP 110
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