2P6T,2DJW,1I1G


Conserved Protein Domain Family
AsnC_trans_reg

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pfam01037: AsnC_trans_reg 
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Lrp/AsnC ligand binding domain
The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Statistics
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PSSM-Id: 426007
Aligned: 217 rows
Threshold Bit Score: 38.2751
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2P6T_E  74 IRVSI--RKakdAREDFAASVRKWPEVLSCFALTGETDYLLQAFFTDXNAFSHFVLDTLLSHHGVQDAQSSFVLKE 147 Neisseria meningitidis MC58
Q5KVS2  71 IDVKVtpKRg-vGFDEVAERIYRFPEVKSVYLMSGAYDLSVVIEGRSMAEIAQFVSEKLSTLDSVISTTTHFILKK 145 Geobacillus kaustophilus
O28651  68 INVKVslTRe-kGYDDIAKRIAKFSEVHAVRLVSGEYDFQVVVKGKSLKDIAFFVAEKISTIPEVRDTFTHFVLRT 142 Archaeoglobus fulgidus
Q5V2Q8  69 VELNVtlDRe-tSYDDISDRIAKFPEVTSLRLVSGDYDFDLEVEGDSMREVSHFISDKIAPIPEITQTVTHYIMES 143 Haloarcula marismortui
Q92MD2  47 LLVTLkrTP----SLGVLDRLAGFSSVRRVFSVSGQLDLVVEVKVASINALNELRNE-VAQLDNVEDLTTSIVLRR 117 Sinorhizobium meliloti
Q5LX25  67 VLLEVqqKE----TTRIVKRLEAYPEIKLCLSINGEYDLLLSAEAPRIEDLDILVDE-VGAIPGILRTNTFVVFGR 137 Ruegeria pomeroyi
Q88Q35  72 IFVYRydRM---RGEAVLDALRQIPEVIQCEVLSGEFDLMLRVEASSPERVHHVWKE-IAAMPGVENTVTSFVLAA 143 Pseudomonas putida KT2440
Q87GT1  66 FALKFdtSIssyYCESYADELYKIDGVKWCHAISGETDMMVFVEVPNMNRLNDIRDQ-IQRFPELRHLMTHTVLTE 140 Vibrio parahaemolyticus
Q6LS33  66 FEIRHqcAR----CADVVEIFKTLPEVQSCHGVSGDMDLLVFVKADSIQRLHQIRET-LDAHADIVKIKTHVVMSE 136 Photobacterium profundum
Q5Z126  77 VSVVLdqHR----LDAVVDALAEIPEVTEVCGMTGRVDLTVRVVARDAEDLYRLAEE-ILQIPGVERTDMALVMRE 147 Nocardia farcinica
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