1NH3,6Z03


Conserved Protein Domain Family
Topoisom_I

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pfam01028: Topoisom_I (This model is not part of the current CDD release)
Eukaryotic DNA topoisomerase I, catalytic core
Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination.
Statistics
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PSSM-Id: 513940
Aligned: 89 rows
Threshold Bit Score: 173.861
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1NH3_A               230 SSRIKG---------EKDWQKYETARRLKKCVDKIRNQYREDWKSK--EMKVRQRAVALYFIDKLALRAGNEKEEgETAD 298 human
goetting:Ngar_c04450 221 SAALRQ---------ENDRAKYDKAKKLAEQESRVHREVIRRMMKG-----GDKTATVAYLILKLAMRVGDEKDP-DEAD 285
BAJ47816             213 TADIKQ---------KRDKSKYDKAEMLESHIDRVREKIFKGLRSK--EPKMREIALACYLIDRLAMRVGDEKDP-DEAD 280
ABK76827             211 TAGLKQ---------ERDRSKYEKAVALSKKIGEIEAKIVKDMKSK--DPKISKIATACYLIYRTAMRVGDEKDK-DEAD 278
WP_012215705         214 SSDLKQ---------GRDKEKYEKAVKLEKEIEKIKKAMVKDMK----DSKKNNVATACYLIYKTAMRVGDEKDE-DEAD 279 Nitroso...
XP_004347638         391 SAKLIQ---------EATAAKFDQVRKLGEHISEIREQVFKCMRLAkePTVQAQTALGVYLLDQLALRPGTSKI--DTDS 459
WP_256236275         110 AKNRKQyryhpawsnLRDQTKYCRLRDFSHALPEIRARIKEDLCQRg-FPKNKVLAAVVSIMESTSIRVGNSMYE-KLYG 187 Cytopha...
WP_015812644         105 AAGRKQyryhpywnlVRNQAKYYKLLMFSEALPVLREQVEHDLRKRd-FDLSKVIALVIKLMDKTCIRVGNQRYK-VRHG 182 Dyadoba...
WP_014785394         103 ARGRKQsryhphwreVRDETKYERMAHFAKSLPGIRKRVAEDMARGg-LPREKVLATVVRLMEETHIRVGNEEYA-RTNK 180 Terrigl...
6Z03_A               213 TADIKQ---------KRDKSKYDKAEMLENHIDRVREKIFKGLRSK--EPKMREIALACYLIDRLAMRVGDEKDP-DEAD 280 Candida...
1NH3_A               299 TVGCCSLRVEHINLHP---EldgqeYVVEFDFLGKDSIRYYNKVPVE---K----RVFKNLQLFMEN-KQPEDDLFD--- 364 human
goetting:Ngar_c04450 286 TVGASTLRVEHIKFPQaggGr----QMIEFNFLGKDSVPWQKTLEVN---SddtkALYENLKKFMQG-KKPSDPIFD--- 354
BAJ47816             281 TVGATTLRVEHVKLLE---------DRIEFDFLGKDSVRWQKSIDLR---Kep-pEVRQVFEELLEG-KKEGDQIFQ--- 343
ABK76827             279 TVGATTLRKEHIRISD---------GVIEFDFLGKDSIRWNEKLKVT---Gdd-eQFSRNLQGLVKS-IKPKDEIFK--- 341
WP_012215705         280 TVGATTLRKEHIKITS---------DTIEFDFLGKDSVRWQETLKVV---Gdd-kQFQENLKKLIEK-KKPSEEIFH--- 342 Nitroso...
XP_004347638         460 SYGLFTLLPKHVKLVE---P-----RTISFDFPGKDMVQYTNSVEVD---P----SAFKVFKMMMAAaKDPKTPVFD--- 521
WP_256236275         188 SYGLSTMKDRHVK-IQ---G-----QEVQFSFKGKKGVYH----KIS---L----KSKKLAHIVSQCkDIPGKELFQyfd 247 Cytopha...
WP_015812644         183 SSGITTLDARCAT-VT---G-----SRIRFMFKGKKGIQQ----DIT---L----RDKQLARLVKQCkEMPGKRLFQyin 242 Dyadoba...
WP_014785394         181 SYGLTTMRTKHVD-VH---G-----ATVRFSFQGKSRVHH----TID---L----ADKRIARIVKQCsDLPGHDLFQyvd 240 Terrigl...
6Z03_A               281 TVGATTLRVEHVKLLE---------DRIEFDFLGKDSVRWQKSIDLRnepP----EVRQVFEELLEG-KKEGDQIFQ--- 343 Candida...
1NH3_A               365 ------RLNTGILNKHLQDLM-EGLTAKVFRTYNASITLQQQL-KEL--TaPD--ENIPAKILSYNRANRAVAILCNHQR 432 human
goetting:Ngar_c04450 355 ------GINSRKVNAFLQEIM-PGLTAKVFRTCIATRVVQQEL-SKakvD-KN--SSEAQKIYAARKANLEAAIKCNHKK 423
BAJ47816             344 ------NINSRHVNRFLGKIV-KGLTAKVFRTYIATKIVKDFL-AAiprE-KV--TSQERFIYYAKLANLKAAEALNHKR 412
ABK76827             342 ------DIRSSDVNRYYSGIV-KGVTAKVFRTYLASKKVSEYL-RKndkI-RS--KSAFFKLYHAKSANLEAAIMCNHKR 410
WP_012215705         343 ------DITSRDVNKYLSGIV-KGVTAKVFRTYQATTVVKNYL-VNhdnI-KG--KSDNEKLYHAKLANLEAAIMCNHKR 411 Nitroso...
XP_004347638         522 ------SSVGTRVDTFVKSFD-KNFSARSFRTYSASSLFERSLpDC-----RK--VSEVHKKAAFDRANVAVARLCNHQR 587
WP_256236275         248 ekgnnhSIDSGDVNDYIREISgGDFTSKDFRTWTGTVKCLQAF-SNLg---HG--ENNTQVKRLMNEAMDIVAHQLGNTR 321 Cytopha...
WP_015812644         243 enggkcALNAQQVNDYIRRHTgASFSAKDFRTWMGTVTAFEYL-SHQe---KA--ASQRQLTRTLNSCLDAVAAHLGNTR 316 Dyadoba...
WP_014785394         241 edgnphSIDSQAVNDYLREVTgEHFTAKDFRTWAGSVLCCDLL-SEFe---PA--SSITEAKKNVVQAIAQVAAKLGNTP 314 Terrigl...
6Z03_A               344 ------NINSRHVNRFLGKIV-KGLTAKVFRTYIATKIVKDFL-AAI--P-REkvTSQEKFIYYAKLANLKAAEALNHKR 412 Candida...
1NH3_A               433 AP-PKT--FEKSMMNLQTKIDAKKEQLADARRDL 463 human
goetting:Ngar_c04450 424 GVdPKNpaAKKALEKFEESIAKKKEAIAQLKADI 457
BAJ47816             413 AP-PKN--WEQSIQKKEERVKKLMQQLREAESEK 443
ABK76827             411 TV-PKT--FKKALEKKKETLKKAKGATPKTDKQK 441
WP_012215705         412 TI-PKT--FEQSLQKKKDTLKKREREKAWEKTQQ 442 Nitrosopumilus maritimus
XP_004347638         588 IT-TTN--PADDRKKMASAMKAAKASLTKIKDEL 618
WP_256236275         322 SVcKKHyiHPGILADY--ESGKLEKYIKQIQEIE 353 Cytophaga hutchinsonii
WP_015812644         317 AVcKKYyvHPAVFRAY--ENNRIQRFLNKQVEEA 348 Dyadobacter fermentans
WP_014785394         315 SVcRKCyvHPVVLERYLGNISSADAKKEIEREIA 348 Terriglobus roseus
6Z03_A               413 AP-PKN--WEQSIQKKEERVKKLMQQLREAESEk 443 Candidatus Caldarchaeum subterraneum
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