2B9S


Conserved Protein Domain Family
Topoisom_I

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pfam01028: Topoisom_I 
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Eukaryotic DNA topoisomerase I, catalytic core
Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination.
Statistics
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PSSM-Id: 425999
Aligned: 95 rows
Threshold Bit Score: 167.69
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2B9S_A               234 SSSVKG---------QSDMVKFEKARKLKDKVDDIRASYMEDFKSN--DLHVAQRAVAMYFIDRLALRVGNEKGEDEADT 302 Leishma...
goetting:Ngar_c04450 221 SAALRQ---------ENDRAKYDKAKKLAEQESRVHREVIRRMMKG-----GDKTATVAYLILKLAMRVGDEKDPDEADT 286 Candida...
BAJ47816             213 TADIKQ---------KRDKSKYDKAEMLESHIDRVREKIFKGLRSK--EPKMREIALACYLIDRLAMRVGDEKDPDEADT 281 Candida...
ABK76827             211 TAGLKQ---------ERDRSKYEKAVALSKKIGEIEAKIVKDMKSK--DPKISKIATACYLIYRTAMRVGDEKDKDEADT 279 Cenarch...
jgi:Nmar_1322        214 SSDLKQ---------GRDKEKYEKAVKLEKEIEKIKKAMVKDMK----DSKKNNVATACYLIYKTAMRVGDEKDEDEADT 280 Nitroso...
XP_004347638         391 SAKLIQ---------EATAAKFDQVRKLGEHISEIREQVFKCMRLAkePTVQAQTALGVYLLDQLALRPGTSKI-DTDSS 460 Capsasp...
jgi:Dfer_3186        105 AAGRKQyryhpywnlVRNQAKYYKLLMFSEALPVLREQVEHDLRKRd-FDLSKVIALVIKLMDKTCIRVGNQRYKVRHGS 183 Dyadoba...
jgilanl:CHU2291       83 AKNRKQyryhpawsnLRDQTKYCRLRDFSHALPEIRARIKEDLCQRg-FPKNKVLAAVVSIMESTSIRVGNSMYEKLYGS 161 Cytopha...
WP_014221991          94 LRNRKQyryhplwsvMRNETKFHRMAEFGKALPALRQRLESDLSQRs-LTASKVIATVVSLMAQTYIRVGSGEYEKQNGS 172 Niastel...
WP_014785394         103 ARGRKQsryhphwreVRDETKYERMAHFAKSLPGIRKRVAEDMARGg-LPREKVLATVVRLMEETHIRVGNEEYARTNKS 181 Terrigl...
2B9S_A               303 VGCCSLRVEHIQLMP---D-NIVRFDFLGKDSIRYQNDVAVLP----EVYALLQRFTRR-KSPGMDIFD---------QL 364 Leishma...
goetting:Ngar_c04450 287 VGASTLRVEHIKFPQaggGrQMIEFNFLGKDSVPWQKTLEVNSddtkALYENLKKFMQG-KKPSDPIFD---------GI 356 Candida...
BAJ47816             282 VGATTLRVEHVKLLE-----DRIEFDFLGKDSVRWQKSIDLRKep-pEVRQVFEELLEG-KKEGDQIFQ---------NI 345 Candida...
ABK76827             280 VGATTLRKEHIRISD-----GVIEFDFLGKDSIRWNEKLKVTGdd-eQFSRNLQGLVKS-IKPKDEIFK---------DI 343 Cenarch...
jgi:Nmar_1322        281 VGATTLRKEHIKITS-----DTIEFDFLGKDSVRWQETLKVVGdd-kQFQENLKKLIEK-KKPSEEIFH---------DI 344 Nitroso...
XP_004347638         461 YGLFTLLPKHVKLVE---P-RTISFDFPGKDMVQYTNSVEVDP----SAFKVFKMMMAAaKDPKTPVFD---------SS 523 Capsasp...
jgi:Dfer_3186        184 SGITTLDARCAT-VT---G-SRIRFMFKGKKGIQQ----DITL----RDKQLARLVKQCkEMPGKRLFQyinenggkcAL 250 Dyadoba...
jgilanl:CHU2291      162 YGLSTMKDRHVK-IQ---G-QEVQFSFKGKKGVYH----KISL----KSKKLAHIVSQCkDIPGKELFQyfdekgnnhSI 228 Cytopha...
WP_014221991         173 HGLTTLKDKHVV-IA---G-DTIKFSFKGKKGVSH----NITL----KSKRLARIVKNCrEIPGAELFQyyddeghkhPI 239 Niastel...
WP_014785394         182 YGLTTMRTKHVD-VH---G-ATVRFSFQGKSRVHH----TIDL----ADKRIARIVKQCsDLPGHDLFQyvdedgnphSI 248 Terrigl...
2B9S_A               365 NPTQLNDHLKSFM-DGLSAKVFRTYNASITLDRWF-KEkpvDPKWSTADKLAYFNKANTEVAILCNHQKS 432 Leishmania donovani
goetting:Ngar_c04450 357 NSRKVNAFLQEIM-PGLTAKVFRTCIATRVVQQEL-SKakvDKNSSEAQKIYAARKANLEAAIKCNHKKG 424 Candidatus Nitros...
BAJ47816             346 NSRHVNRFLGKIV-KGLTAKVFRTYIATKIVKDFL-AAiprEKVTSQERFIYYAKLANLKAAEALNHKRA 413 Candidatus Caldar...
ABK76827             344 RSSDVNRYYSGIV-KGVTAKVFRTYLASKKVSEYL-RKndkIRSKSAFFKLYHAKSANLEAAIMCNHKRT 411 Cenarchaeum symbi...
jgi:Nmar_1322        345 TSRDVNKYLSGIV-KGVTAKVFRTYQATTVVKNYL-VNhdnIKGKSDNEKLYHAKLANLEAAIMCNHKRT 412 Nitrosopumilus ma...
XP_004347638         524 VGTRVDTFVKSFD-KNFSARSFRTYSASSLFERSLpDC----RKVSEVHKKAAFDRANVAVARLCNHQRI 588 Capsaspora owczar...
jgi:Dfer_3186        251 NAQQVNDYIRRHTgASFSAKDFRTWMGTVTAFEYL-SHq--eKAASQRQLTRTLNSCLDAVAAHLGNTRA 317 Dyadobacter ferme...
jgilanl:CHU2291      229 DSGDVNDYIREISgGDFTSKDFRTWTGTVKCLQAF-SNl--gHGENNTQVKRLMNEAMDIVAHQLGNTRS 295 Cytophaga hutchin...
WP_014221991         240 DSGMINSYIKETTgSDFTSKDFRTWAGSINLLRSL-QAm--gEAVTQTEQKKNIVAALDEVSLKLGNTRT 306 Niastella koreensis
WP_014785394         249 DSQAVNDYLREVTgEHFTAKDFRTWAGSVLCCDLL-SEf--ePASSITEAKKNVVQAIAQVAAKLGNTPS 315 Terriglobus roseus
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