6TLC,6TLC,6WCZ,6MBZ,7ZN7


Conserved Protein Domain Family
STAT_alpha
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pfam01017: STAT_alpha (This model is not part of the current CDD release)
STAT transcription factor, coiled-coil domain
STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STATs share 6 structurally and functionally conserved domains including: an N-terminal domain (ND) that strengthens interactions between STAT dimers on adjacent DNA-binding sites; a coiled-coil STAT domain (CCD) that is implicated in protein-protein interactions; a DNA-binding domain (DBD) with an immunoglobulin-like fold similar to p53 tumour suppressor protein; an EF-hand-like linker domain connecting the DNA-binding and SH2 domains; an SH2 domain that acts as a phosphorylation-dependent switch to control receptor recognition and DNA-binding; and a C-terminal transactivation domain. This entry represents the coiled-coil domain (CCD)
Links
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Statistics
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PSSM-Id: 513931
Aligned: 54 rows
Threshold Bit Score: 101.155
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6TLC_B         21 EQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQgd-----------mqDLNGNNQ----------SVTRQKMQQL 79  human
1_pfamImport    1 AQHVESLRRRTQETGEDLRKMEQEQEAFAISYHECTKLnahlqhf-atqpqnqQNLDMEK----------K-IRRQKEQQ 68 
EFN82765      145 IQQLTALRQKALDCADDIRKMEHEQESFALSYHECTKLnaqmqhl-vtqpqsqQNFDVDK----------K-IRRQREQQ 212
XP_011261579  147 KQQFGILRQNVNANANFIRMIEEQQEAFALLYHDCTKVtvnlqq---llsqnhQNLESEK----------KQLKRQKEHG 213
XP_002427673  184 AQQLEFLRRRTHDTAEDLRKMEQDQEAFALHYHECTKInahlqhl-qtqgqnpQNIELEK----------K-LKRQKDNM 251
XP_969477     146 LHKIDILRRRTQDTADDLRRMEQEQESFALQYHECTKInahiqqlssqqptnaQTTATVQ----------K-LTRQKEML 214
3_pfamImport    1 TQQMDLISNHITHTNEIRITIQSDIDSFNILYSECSKCsqhlqhmrnqrmsipQGPEIER----------K-LKQEKELY 69 
18_pfamImport   1 TQQLDIMRSRTDETAEDLRRMEQEQESFALQYHECTKInahishl-qnqpqnqTNIDLDK----------K-LRRQKEMM 68 
XP_046451783  146 LQQLEILRQRTQETSEDLRRMEQEQEAFALEYHELTKIqanlthl-qnqapsqQKNDFEK----------Q-LRIKKDMS 213
6MBZ_A         14 NQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIq-------------aQFGPLAQlspqerlsreTALQQKQVSL 80  human

6TLC_B         80 EQMLTA-----LDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTR 154 human
1_pfamImport   69 EQLLNHkv-agLMQLRLTLADKLKDTITRLNSLQSRVLDDELIRWKRDQQLGGNGAPFNNNLDSIQEWCESLAELIWLNR 147
EFN82765      213 EQILNHkl-agLMQTRLLLADKLKEIISKLGNLQSRILDDELIRWKRDQQLSGNGIQFVNNLDSIQEWCEGLAEIIWLTR 291
XP_011261579  214 EQSLNNki-ayIFNLRVESVDKMKDTIHRLSMLQSRILDEELISWKRDQQLAGNGATFTSNLDLIQNWCENLADIIWTTR 292
XP_002427673  252 EQMLNQkv-saMVQLRMSLVDKLKETISHLTALQSRILDSELIRWKREQQLAGNGAHFNSNLDSIQEWCENLAEIIWLNR 330
XP_969477     215 EQVLNQkv-agLMQLRLAIVDKFKETIQLLNQLQSNILDDELIRWKREQQLAGNGANFNSNLDTIQDWCESLAELIWLNR 293
3_pfamImport   70 EGQLKTqs-lsLNNALCVYINKLNESLNLLSPVQAHIIDKALIQWKREQQLAGNGYKYMKDIDVIQTWCEKLCDLIWITR 148
18_pfamImport  69 EQMLSQkv-tgLMQQRISLTEKLKVTLGLIVTVQGRILDEELIKWKRDQQLAGNGAKFNNNLDTIQEWCENLAEINWLNR 147
XP_046451783  214 EHKLNVkvlaeLLQMRMALAEKHKETLMLIENLQARVLDDELIRWKREQQLAGNGVPFHSNLDSIQEWCEGLAEIIWLNR 293
6MBZ_A         81 EAWLQRea-qtLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNR 159 human

6TLC_B        155 QQIKKLEELQQKV-SYKGDP-IVQHRPMLEERIVELF 189 human
1_pfamImport  148 QQIKEAERLKQKF-ALE-PPgMQDILPTLNSQITQLL 182
EFN82765      292 QQIKEAELMKQKL-MFN-TTaMQDPFPALNSQITQLL 326
XP_011261579  293 QHIKDGERLKSKFqPFEPQTmLQNIFPTLNSQITQLL 329
XP_002427673  331 QQIKEAERLKQKL-SLD-PPgLVDVLPNLNNLVTQLL 365
XP_969477     294 QQIKEVDRLRQKL-SLD-PPgVADLLPQVLGDVTQLL 328
3_pfamImport  149 SQIKEADRFRVNLgRYFELPqSCEIINTLLDMTTQYL 185
18_pfamImport 148 QQIKGAERLKNKL-PLD-NQgVADILPQLNAQITQLL 182
XP_046451783  294 QQIKEAERLRNKF-PIM-QAnNTDHVPALNTQITQLL 328
6MBZ_A        160 QQIRRAEHLCQQL-PIPG-P-VEEMLAEVNATITDII 193 human
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