6TLC,6WCZ,6MBZ,5OEN


Conserved Protein Domain Family
STAT_alpha

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pfam01017: STAT_alpha 
STAT protein, all-alpha domain
STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain pfam00017.
Statistics
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PSSM-Id: 460026
Aligned: 59 rows
Threshold Bit Score: 95.3697
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6TLC_A        21 EQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQgd------------mqDLNGNNQSVTRQKMQQLEQMLTA--- 85  
XP_011261579 147 KQQFGILRQNVNANANFIRMIEEQQEAFALLYHDCTKVtvnlqq----llsqnhQNLESEKKQLKRQKEHGEQSLNNki- 221 
XP_008184535  17 VQQMELISNHAERTNKIRMTIQSEIDSFNVLYSERAKCaqqleyaksqrmsstsVSPEIECE-LIRKKELHEGQLKAks- 94  
XP_001946645 144 TQQMDLISNHITHTNEIRITIQSDIDSFNILYSECSKCsqhlqhmr-nqrmsipQGPEIERK-LKQEKELYEGQLKTqs- 220 
EFN82765     145 IQQLTALRQKALDCADDIRKMEHEQESFALSYHECTKLnaqmqhl--vtqpqsqQNFDVDKK-IRRQREQQEQILNHkl- 220 
XP_397181    149 AQHVESLRRRTQETGEDLRKMEQEQEAFAISYHECTKLnahlqhf--atqpqnqQNLDMEKK-IRRQKEQQEQLLNHkv- 224 
EFX86742     146 LQQLEILRQRTQETSEDLRRMEQEQEAFALEYHELTKIqanlthl--qnqapsqQKNDFEKQ-LRIKKDMSEHKLNVkvl 222 
XP_028032019 136 ITGLQTVRQKVNIAGEEIRSLQANIESLSLQYHECLKNkghmnyl--qqqtvttERRDLVAC-LRGQIEDTERKLNAlv- 211 
EDS43632     140 INGLQELQMLVRVSENDNRNLVKDYEHLQLEIHEITKNkalle------nldnaALREHARTTLAQQERQVNEMVNL--- 210 
ETN58242     140 FTAVQQLQIMVRTNENDNRNLLKEYEHLLLEVHEMQKNraqle------tiehaEMRQHAHNQLVQHQKMVNDRLQL--- 210 
6TLC_A        86 --LDQMRRSIVSELAGLLSAMEYVQKTLTdEELADWKRRQQIACIGGP-PNI-CLDRLENWITSLAESQLQTRQQIKKLE 161 
XP_011261579 222 ayIFNLRVESVDKMKDTIHRLSMLQSRILdEELISWKRDQQLAGNGAT-FTS-NLDLIQNWCENLADIIWTTRQHIKDGE 299 
XP_008184535  95 liLNNSICVYINKLNELTNLISPVQAYIIdNSLVQWKRQQQFAGNGYK-CMM-DIDVIQTWCEKLCDLIWVTRSQVKEAD 172 
XP_001946645 221 lsLNNALCVYINKLNESLNLLSPVQAHIIdKALIQWKREQQLAGNGYK-YMK-DIDVIQTWCEKLCDLIWITRSQIKEAD 298 
EFN82765     221 agLMQTRLLLADKLKEIISKLGNLQSRILdDELIRWKRDQQLSGNGIQ-FVN-NLDSIQEWCEGLAEIIWLTRQQIKEAE 298 
XP_397181    225 agLMQLRLTLADKLKDTITRLNSLQSRVLdDELIRWKRDQQLGGNGAP-FNN-NLDSIQEWCESLAELIWLNRQQIKEAE 302 
EFX86742     223 aeLLQMRMALAEKHKETLMLIENLQARVLdDELIRWKREQQLAGNGVP-FHS-NLDSIQEWCEGLAEIIWLNRQQIKEAE 300 
XP_028032019 212 aqITQSQMELVDHMKENITNLRQLQSQVLdDELIKWKREQQLSGNGVP-MQS-NLNTIQEWCELLADLIWTTRQQVNNVA 289 
EDS43632     211 --ITGKRLQLVENFRKTIQLTSQVQEKVLhKYLTNWKINQGFAGNGASgMSAsNLDTIQAWCESLAEIIWNTKDQIRLAM 288 
ETN58242     211 --CTGKRLALVDGFRKTILITGEVQTKVLnKYLSQWKINQGFAGNGAStMSAsNLDTIQAWCESLAEIIWSTKDQIRLAI 288 
6TLC_A       162 ELQQKV-SYKGD--P-IVQHRPMLEERIVELF 189 
XP_011261579 300 RLKSKFqPFEPQ--TmLQNIFPTLNSQITQLL 329 
XP_008184535 173 RFRVNLrQYFEL--PqSCEMINTLLNMTTQYL 202 
XP_001946645 299 RFRVNLgRYFEL--PqSCEIINTLLDMTTQYL 328 
EFN82765     299 LMKQKL-MFN-T--TaMQDPFPALNSQITQLL 326 
XP_397181    303 RLKQKF-ALE-P--PgMQDILPTLNSQITQLL 330 
EFX86742     301 RLRNKF-PIM-Q--AnNTDHVPALNTQITQLL 328 
XP_028032019 290 RINSKTiVELRQ--PhLAEMLDDMSKQVTGLL 319 
EDS43632     289 KNKQKL-NIEEPnlP---DFLPQSLVEVTNLL 316 
ETN58242     289 KNKSKL-HVEQDdvP---DLLPQAMVDVTNLL 316 
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