Conserved Protein Domain Family
Troponin
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pfam00992: Troponin (This model is not part of the current CDD release)
Troponin
Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.
Links
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Statistics
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PSSM-Id: 513911
Aligned: 77 rows
Threshold Bit Score: 41.8046
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007228169   11 KHTLKSLMLQVAKDLLEAEAVEKVEERKRYMEEHCPPLS-LPGskADLEALCKELHEKIIVIDEERYNLEHKANMVVEEV 89 
XP_069048856  101 KRLEKDFNELQSLIEMHFESRQKEEDELVALKLRIERRRsERA--EQLRIRTEREKERQTRMTEEKLRKEEEEARRKAEE 178
Q8AVB1        101 KRVEKDFNELQSLINLHFTTRQKEEDELVALKNRIERRRtDRA--DQQRIRTERDRERQARLAEERARREEEAAKLRAEE 178 zebrafish
14_pfamImport   1 KRLEKDYNDLQSLIELHFSSRQKEEEELISLRNRIESRRaDRA--EQQRVRAEQERERQARVAEERSRREEEAAKQRAEE 78 
Q8MKH6         70 KRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRaERA--EQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAED 147 domestic cattle
XP_029692443   64 KRMEKDLLELQTLIDVHFDQRKKDEEELISLKERIERRRaERA--EIQRVRTEKEKDRQNRIAEERQRKEEEEAKKKADD 141 torafugu
XP_003961460   53 KRMEKDLLELQTLIDVHFEQRKKEEEELIGLKDRIERRRsERA--EQQRVRAEKERDRQTRIAEERQRKEDEEAKKRADD 130 torafugu
XP_011600752  101 KRMEKDLMELQTLIEVHFESRKKEEEELIQLKERIENRRaERA--EQQRIRSEREKERQKRLEDERTRKEEEEAKRRAED 178 torafugu
NP_001188470   55 KRQEKDLSELQSLIEAHFIQRKKDEEELIALVNRIEKRRgERA--EQQRIRAEKEKERQARLAEEKERREQEEQRKKHDE 132 zebrafish
NP_001188471   46 KRQEKDLSELQSLIEAHFIQRKKDEEELIALVNRIEKRRgERA--EQQRIRAEKEKERQARLAEEKERREQEEQRKKHDE 123 zebrafish

XP_007228169   90 KDLNIKIVDLKGK-FKKP-PLK------K-VRMSADAMLQALLGSKHK-VNLDLRANLKQVK 141
XP_069048856  179 DAKKKKAFSNMs--FGGY-LQKvek-kaG-KKLTEREKKTKILKERRRpLNIDHLNQEKLAE 235
Q8AVB1        179 DARKKKILSNKg--YGGF-LQKvdq-kkG-KKLTEREKKTKCLLERRKpLNIDHLNQEKLGE 235 zebrafish
14_pfamImport  79 DAKKKMIFSNK-S-FGGY-LQKvdq-kkG-KKLTAREEKKKALMERRKpLNIDHLNQDKLLE 135
Q8MKH6        148 DAKKKKVLSNMGAhFGGY-LVKaeq-krG-KRQTGREMKLRILSERKKpLNIDHMGEEQLRE 206 domestic cattle
XP_029692443  142 EAKKKKVLSGMGAnFGGF-LAKaet-rkG-KRFTGREIKKKTLAERRQpLATDNLREDGLRQ 200 torafugu
XP_003961460  131 EAKKKKVLSNMGAhFGGF-LAKveq-rrG-KRQTAREIKKTTLTERRKpLAIENLREDGLRr 189 torafugu
XP_011600752  179 DAKKKKTLTSL-H-FGGY-MQKltekrsG-KRQTEREKKKKILSERRKsLDIDNLNQERLRD 236 torafugu
NP_001188470  133 DAKKKKALTNMTHqYGGI-QQKgdgrkgA-KKQTEREKKKKILAERKKpLNIDHLSEDKLKE 192 zebrafish
NP_001188471  124 DAKKKKALTNMTH-QYGGiQQKgdg-rkGaKKQTEREKKKKILAERKKpLNIDHLSEDKLKe 183 zebrafish
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