Conserved Protein Domain Family
Rota_NS53
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pfam00981: Rota_NS53 (This model is not part of the current CDD release)
Rotavirus RNA-binding Protein 53 (NS53)
This protein is also known as NSP1. NS53 is encoded by gene 5. It is made in low levels in the infected cells and is a component of early replication. The protein is known to accumulate on the cytoskeleton of the infected cell. NS53 is an RNA binding protein that contains a characteristic cysteine rich region.
Links
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Statistics
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PSSM-Id: 513903
Aligned: 14 rows
Threshold Bit Score: 753.016
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P89055   1 MATFKDACYHYRKLNKLNGLVLKLGANDAWRPAPIAKYKGWCLDCCQHTDLTYCRGCALFHVCQWCSQYNRCFLDEEPHL 80  Rotavirus sp.
Q66773   1 MATFKDACYYYKRLNKLNHAVLKLGVNDAWRPSPPTKYKGWCLDCCQYTDLTYCRGCSIYHVCQWCNQYGRCFLDDEPHL 80  Equine rotavirus
Q65709   1 MATFKDACYHYKKLNKLNGLVLKLGANDAWRPAPVAKYKGWCLDCCQHTDLTYCRGCALFHVCQWCSRYNRCFLDEEPHL 80  Rotavirus A RVA/Cow-t...
A2T3M0   1 MATFKDACYHYRKISKLNSSILKLGANDEWRPAPITKFKGWCLDCCQYTNLTYCRGCALYHVCQWCSQYNRCFLDEEPHL 80  Rotavirus A cow/ZAF/O...
P12475   1 MATFKDACYHYKRLNKLNSLVLKLGANDEWRPAPMTKYKGWCLDCCQYTNLTYCRGCALYHVCQWCSQYNRCFLDEEPHL 80  Bovine rotavirus stra...
Q76II2   1 MATFKDACFFYKKLNRLNNQVLKLGANSVWRPAPLSKYKGWCLDCCQHTDLTYCKGCSLYHVCQWCSQYARCFLDNQPHL 80  Rotavirus G12
Q83444   1 MAAFKDACFHYRRITKLNRELLRIGANSSWTPAPPSNIRGWCLECCQLTNLTYCYGCSLHHVCQWCVQYGRCFLDDEPHL 80  Rotavirus A mouse/Bra...
P15687   1 MATFKDACFHYRRLTALNRRLCNIGANSICMPVPDEKIKGWCLECCQIADLTHCYGCSLPHVCKWCVQNRRCFLDNEPHL 80  Simian rotavirus A/SA...
Q9YKL8   1 MATFKDACFHYRKITKLNRELLRIGANSVWIPVSSNKIKGWCIECCQLTELTFCHGCSLAHVCQWCIQNKRCFLDNEPHL 80  Canine rotavirus K9
O39822   1 MATFKDACFHYRKITKINRELLKIGANSIWTPVRSDKIKGWCIECCQLTELVFCSGCSLAHVCQWCVRNKRCFLDSQPHL 80  Equine rotavirus L338...

P89055  81 LRMRTFRNQISRKDIEGLINMYNTLFPINERIVDKFISNVKQRRCRNEFLIEWYNHLLLPITLQALMVELE-GDVYYIFG 159 Rotavirus sp.
Q66773  81 LRMRTFKNNITKEDLANLIDMYNVLFPVNQKIVNKFINNTKQHKCRNELVPQWYNHLLIPITLQSLSIELD-GDVYYIFG 159 Equine rotavirus
Q65709  81 LRMRTFRNEINKEDVEGLINMYNIIFPINERVVDKFINNVKQRKCRNELLIEWYNHLLLPITLQALSIELE-GDVYYIFG 159 Rotavirus A RVA/Cow-t...
A2T3M0  81 LRMRTFKNTISKEDIENLLNMYDTLFPIHEKIVNKFINNVKQRKCRNEYLLEWYNHLLLPFTLQALTIQLE-NNTYYIFG 159 Rotavirus A cow/ZAF/O...
P12475  81 LRMRTFKDVVTKEDIEGLLTMYETLFPINEKLVNKFINSVKQRKCRNEYLLEWYNHLLMPITLQALTINLE-DNVYYIFG 159 Bovine rotavirus stra...
Q76II2  81 LRMRTLKEPITKEDICNLVSMYSILFPINDKVVRKFSNNVRQHKCRNEYEFEWYNQLLFPITLQALTIKID-DSVYHIFG 159 Rotavirus G12
Q83444  81 LRLRTVKSPITTEKLASIVKMYQLLFPINHSIVKKFVKSTKQHKCRNDFELSWYNQLVLPITLTAAAVHCD-DCIYYIFG 159 Rotavirus A mouse/Bra...
P15687  81 LKLRTVKHPITKDKLQCIIDLYNIIFPINDKVIRKFERMIKQRKCRNQYKIEWYNHLLLPITLNAAAFKFDeNNLYYVFG 160 Simian rotavirus A/SA...
Q9YKL8  81 LKLRTFESPITKEKLQCIIDLYNLLFPINPGIINRFKKIVNQRKCRNEFEQSWYNQLLFPITLNAAVFKFH-SREVYVFG 159 Canine rotavirus K9
O39822  81 LKLRTFEAPITKEKLQCVISMYNMLFPINENIINRFKKNVKQKKCRNEFNATWYNQLLLPITLNAAVFKFQ-SRIVYVFG 159 Equine rotavirus L338...

P89055 160 YFDHMEKENQTPFQFVNMINNYDKLLLDDKNFDRMTNLPVILQQEYAFRYFSKSRFISKTKKSVNRHDFANNLME-EMDN 238 Rotavirus sp.
Q66773 160 YYDDMKNANQTPFSFVNLIDMYDRLLLDDVNFNRMSFLPLVLQQEYALRYFSKSRFISEEKRQINHSHFSINILE-NLHN 238 Equine rotavirus
Q65709 160 YYDCMGKENQTPFHFVNMINRYDRLLLDDKNFDRMMHLPVALQQEYALRYFSKSRFISQIKREMNRHDFSDNLME-ERDN 238 Rotavirus A RVA/Cow-t...
A2T3M0 160 YYDCMEQENQTPFNFVNLVSNYDKLLLDDKNFNRMAYLPPILQQEYALRYFSKSRFLDKPNRGLKRNDFSDNLME-DRHS 238 Rotavirus A cow/ZAF/O...
P12475 160 YYDCMEHENQTPFQFINLLEKYDKLLLDDRNFHRMSHLPVILQQEYALRYFSKSRFLSKGKKRLSRSDFSDNLME-DRHS 238 Bovine rotavirus stra...
Q76II2 160 YYDNMTKVNQTPFSFTNLINRYDKLLLDSINFDRMANLPGALQHQYALRYFSKSRFISHGIKDLCKSHFTEETLE-NKEI 238 Rotavirus G12
Q83444 160 HYEGKANQSNLPYRFVNCVDEYDRLLLDDVNFDRMAFLPGRLQKYYAKRYFIASRIPSAQPAKLTYSDFSVKTLI-NSGA 238 Rotavirus A mouse/Bra...
P15687 161 LYEKSVSDIYAPYRIVNFINEFDKLLLDDINFTRMSNLPIELRTI-MQEYFQLSRLPSSKLKQIYFSDFTKETVIfNTYT 239 Simian rotavirus A/SA...
Q9YKL8 160 LYEGSSSCINLPYRIVNCIDLYDRLLLDQINFERMSSLPASLQSVYANKYFKLSRLPSMKLKQIYYSDFSKQNLI--NKC 237 Canine rotavirus K9
O39822 160 FYEGTTACGYLPYRMVNCIDIYDRLLLDSVNFDRMSALPSDLQALYAQKYFKISRLPSMKLRQVYYSDFTKQNLI--TKY 237 Equine rotavirus L338...

P89055 239 PISLMQVMRNCVNey--mDDKNWNEKCT----LIVDMKSYMELMKSSYTEHYSVSQRCKLFTIYKLNIISKLIKPNYIFS 312 Rotavirus sp.
Q66773 239 PNFKIQITRNCSA-----MLGEWNEACK----LVKDVGTYFEILKTSHVEFYDVSPRCRMFTQHKLKAVSKVIKPNYATS 309 Equine rotavirus
Q65709 239 PMSFMQVTRNCVSah--mNDNDWNERCK----LIGDARNYMELMKSAYTEHYSISNRCKLFTIYKLNIISKLVKPNYIFS 312 Rotavirus A RVA/Cow-t...
A2T3M0 239 PTSLMQVIRNCVAkh--lDDSEWNKACT----QVTNAKNYMEVMNSAYTEHYSVSQRCKLYTKNKLNTLSRLTKPNYILS 312 Rotavirus A cow/ZAF/O...
P12475 239 PTSLMQVVRNCISih--iNDCEWNKACT----LIVDARNYISIMNSSYTEHYSVSQRCKLFTKYKFGIVSRLVKPNYIFS 312 Bovine rotavirus stra...
Q76II2 239 PTSPYELTRNCTVnltsyGVMRWNDECK----KLVNANDYISEMNTSYTEHYTVSQQNLIFVEHKLNLLSKRIQPNYVAS 314 Rotavirus G12
Q83444 239 YARRRIIYRSVTN-------FHWQSHEDplndLLLDKDKILAALMTNERRPFLTHNLNFTSLLHELSELVHHAKPCYLHS 311 Rotavirus A mouse/Bra...
P15687 240 KTPGRSIYRNVTE-------FNWRDELElysdLKNDKNKLIAAMMTSKYTRFYAHDNNFGRLKMTIFELGHHCQPNYVAS 312 Simian rotavirus A/SA...
Q9YKL8 238 KIKSRIVLRNLTE-------FTWDSQISlhydVINNREKILTALSTSSLKRFETHDLNLGRIKADIFELGHHCKPNFISS 310 Canine rotavirus K9
O39822 238 RTKTRITHRNVSK-------INWDTDIElhndLMHNKHRILTALTTAEEKQFEVHDVNLGRIKADMFELGHHCKPNYISS 310 Equine rotavirus L338...

P89055 313 NHGAHALDVHNCKWCQMNNHYKIWDDFRLKKVYNNTMCFIRALMKSNKNVGHRSSQEVVYEYMSNIFIVWKNEKWNKSMQ 392 Rotavirus sp.
Q66773 310 NHRTLATEVRNCRWCSVNTNFIVWNDFRLRNICDNVLNFIRALVKSNTR-RHCSSQEQIHNYIRDVFDVCDENKWNTSVA 388 Equine rotavirus
Q65709 313 NHGLCALDVNNCKWCKIDNHYEIWNDFRLRKIYNNMMNFIRALVKSNTNVGHCSSHELVYKCISSVFIVWKIEKWNDSVR 392 Rotavirus A RVA/Cow-t...
A2T3M0 313 NHETCALNVHNCKWCQITSCYKIWEDFRIKKIYNNVLDFIRALSKSNGMAGHCSSQERIYRYIPKLFLIYDEEQWTESVN 392 Rotavirus A cow/ZAF/O...
P12475 313 SHESCALNVHNCKWCQINNHYKVWEDFRLRKIYNNVMDFIRALMKSNGNVGHCSSQESVYKYIPDLFLICKTEKWNEAVE 392 Bovine rotavirus stra...
Q76II2 315 NHSLRASKMRKCKWCALQPS-TFWDDFRLSDIYDLIMEFIRVLVKSNVNVGHCSSNEWIYPHMQNIFNPCRTQSYNFAIN 393 Rotavirus G12
Q83444 312 FHVQPASKVH-CHSCSVAFDFHTV-DWRIRRIYDDVMYFLRACCRSNVSSGSCSSLDPMDAVVKAALLEMFTESFKHHAH 389 Rotavirus A mouse/Bra...
P15687 313 NHPGNASDIQYCKWCNIKYFLSKI-DWRIRDMYNLLMEFIKDCYKSNVNVGHCSSVENIYPLIKRLIWSLFTNHMDQTIE 391 Simian rotavirus A/SA...
Q9YKL8 311 NHWQPASNVSQCRWCNVKYVFRNM-DWKMESMYNELLSFIQACYKSNVNVGNCSSIENAYPLVKDMIWHSITKYIDQTIE 389 Canine rotavirus K9
O39822 311 NHWQPASRVSLCRWCNIKYAFRNM-DWRMESMYNELMSFIQSCYKSNANVDHCSSIESVYPMVRNVFWHSTTKYIDETLE 389 Equine rotavirus L338...

P89055 393 MIFDYLEPVEISGIEYILLDHELSWEIRGIVMQIMnGE-IPRILTFNDVKKIISAIIYDWFDVRYMREMPLIISTTNELR 471 Rotavirus sp.
Q66773 389 SIFDCLEPVELDSVHYVLLNHEVNWDVANVLIQNI-GK-IPQILTLNDVITALHSMIYDWFDIRYMRNTPTTTFTVDKLR 466 Equine rotavirus
Q65709 393 TLFEYLEPVEINHVEYVLLDHELSWEMSGVIMQIMnGK-VPRILSFDDVKKIMGAIIYDWFDVRYMRETPVIVSTTNELR 471 Rotavirus A RVA/Cow-t...
A2T3M0 393 SLFKCLEPVEISEVEYVLFDHEINWEVRGLILQCMnGS-IPRILNLSDVRLILSSLIYDWFDIRYMRDTPMITSTTNELR 471 Rotavirus A cow/ZAF/O...
P12475 393 MLFNYLEPVDINGTEYVLLDYEVNWEVRGLVMQNMdGK-VPRILNMNDTKKILSAMIFDWFDTRYMRETPMTTSTTNQLR 471 Bovine rotavirus stra...
Q76II2 394 KLFEYLESVEVDGTEYVMFDNNLTIELYDIIRSVMqCR-VPSILSKFDVAAIIKAIISKWFNIDRMRKVPLTLMQTSTLR 472 Rotavirus G12
Q83444 390 LLFHCFDPVQIDDVSYILFNYPVNYDIYDFIIRTLaTErLPFTLSYKQFTTILFALVERWYDLSQIERLPLSIAPTNRLI 469 Rotavirus A mouse/Bra...
P15687 392 EVFNHMSPVSVEGTNVIMLILGLNISLYNEIKRTLnVDsIPMVLNLNEFSSIVKSISSKWYNVDELDKLPMSIKSTEELI 471 Simian rotavirus A/SA...
Q9YKL8 390 KLFNVMNPVEVDGQQVISFHWQIDVALYIHIKMILkTEtLPFALTLYQFGSIIKGIVNQWYDVTELDYLPLCTEQTDKLV 469 Canine rotavirus K9
O39822 390 KLFNMMNPVNIDNQKVISFHWQIDLSLYLHIKMILkTEaLPFMLKVHEFQSIVKGIINQWCDFSKVSELPICVESTDTLL 469 Equine rotavirus L338...

P89055 472 KMNKRNDLMdEYSYELSDTE 491 Rotavirus sp.
Q66773 467 QLCARRKIA-DYDSGVSDVE 485 Equine rotavirus
Q65709 472 KLNKDNNLMdGYDYELSDIE 491 Rotavirus A RVA/Cow-tc/USA/B223/1983/G10P[11]
A2T3M0 472 KLNKKNELIdEYDLELSDIE 491 Rotavirus A cow/ZAF/Offal agent/1965 G8P6[1]
P12475 472 TLNKRNELIdEYDLELSDVE 491 Bovine rotavirus strain RF
Q76II2 473 NLNSSDDLIdEYALMTSDDE 492 Rotavirus G12
Q83444 470 ELQERGNLAeEFDLLLSSSD 489 Rotavirus A mouse/Brazil/EHP/1981 G16Px[20]
P15687 472 EMKNSGTLTeEFELLISNSE 491 Simian rotavirus A/SA11-both
Q9YKL8 470 KLEEEGKISeEYELLISDSE 489 Canine rotavirus K9
O39822 470 RMYEQGELSeEYELLISDSD 489 Equine rotavirus L338/G13
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