1H5Y,2W79,1VZW,4GJ1,1KA9


Conserved Protein Domain Family
His_biosynth
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pfam00977: His_biosynth 
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Histidine biosynthesis protein
Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in this family. Histidine is formed by several complex and distinct biochemical reactions catalyzed by eight enzymes. The enzymes in this Pfam entry are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes. The structure of HisA is known to be a TIM barrel fold. In some archaeal HisA proteins the TIM barrel is composed of two tandem repeats of a half barrel. This family belong to the common phosphate binding site TIM barrel family.
Links
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Statistics
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PSSM-Id: 425971
Aligned: 127 rows
Threshold Bit Score: 121.046
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1H5Y_B   6 RIIPCLDIdgGAKVVV---KGVN------FQGIREVGDPVE---MAVRYEEEGADEIAILDITAAP---EGRATFIDSVK 70  Pyrobaculum aerophilum
2W79_A   2 LVVPAIDL--FRGKVArmiKGRK------ENTIFYEKDPVE---LVEKLIEEGFTLIHVVDLSNAI---ENSGENLPVLE 67  Thermotoga maritima
O29276   3 RVIPAIDL--KDGKVVrlrQGKE------DEVTFEATNPIE---VAKQWVEIGAKVLHVIDLSGAF---QGRLRHEEIIA 68  Archaeoglobus fulgidu...
Q7UQJ1  29 RLIGVIDL--KDGVAVhgiAGNR------SQYQPIAGLSADecsLLHWYRSIGIRRFYVADLNGLMgtgRQRDALLALVT 100 Pirellula sp.
Q8THS7   3 RVVFVMDI--FNRNVVlakGGVRenyrpvSDSSAVCRTSAP---L-EIVEALRPREVYIADLNALQ---GKGPLDINA-- 71  Methanosarcina acetiv...
O26765   3 EIIPVIDL--MDGIAVsgkSGERekyrplESVYSPSPDPVN---IALSLRAAGARSIYIADLDAI----EGTGSNLEAVR 73  Methanothermobacter t...
Q8ZY14   1 MIIPSIDI--EGGRAVkriRGQR-------GNYIFQGDPLE---LAARF--RKAPLVHVVDLDGAE---AGGLVNISVIS 63  Pyrobaculum aerophilu...
O33772   3 EIIPSIDI--SFGKAVkriRGVR------GTGLVL-GNPIE---LANKLYNEGYSRIHVVDLDAA----EGVGNNEMYIK 66  Saccharolobus solfata...
Q970Z2   3 KVVPSIDI--SEGKAVkriRGVK-------GSGLILGNPVK---IAYEIYEEGYDYLHVVDLD-SA---EENGNNEEYVK 66  Sulfurisphaera tokoda...
Q10184   8 lfrPCIDI--HQGQVKqivGGTLgndadvKTNYVSLKPSSY---YAELYKLNHLEGAHVIML--GP---NCEEAAKTALH 77  Schizosaccharomyces p...

1H5Y_B  71 ---RVAEAVS--IPVLVGGG----VRSLEDATTLFRAG----AD----KVSVNTA----AVRNPQLVALLAREFGSQSTV 129 Pyrobaculum aerophilum
2W79_A  68 klsEFAEY------IQIGGG----IRSLDYAEKLRKLG----YR----RQIVSSK----VLEDPSSLKSLREI--DVEPV 123 Thermotoga maritima
O29276  69 ---EIAKM----AEVQVGGG----IRDFRVAERLFELG----VD----RVIFGTI----AVERVEELREFAKKWKG-RVM 124 Archaeoglobus fulgidu...
Q7UQJ1 101 ---EIRQE----ETLWIDSGwtgsISRMD--QEWLSRMnrsiANesnlRWIIATE----TADSLDVQDRMLEFVNSSNLT 167 Pirellula sp.
Q8THS7  72 ---EVIREVSlkADTMLDFG----VSCLGDVDRALSI-----AG----TAVLGTE----TGKLS-VIRDAVARCPG-RIS 129 Methanosarcina acetiv...
O26765  74 ---RVNHV----LPVILDAG----VRDLETFHFMLEF-----AS----RVVVATE----TLESTEELEEILRNYPPERTV 129 Methanothermobacter t...
Q8ZY14  64 ---KIAEILE--GRCELGGG----LRSLEAVERALSL-----CQ----YAVVGSL----PFKNWPLFRRAAE-LYRDRLA 120 Pyrobaculum aerophilu...
O33772  67 ---EICKIGF--DWIQVGGG----IRDVEKAKRLISLD----VN----ALIFSTI----VFTNFNLFYNIVREIGNNRVI 125 Saccharolobus solfata...
Q970Z2  67 ---DICKIGF--KWVQVGGG----IRNVEKAERLLDYD----CS----AIVISTL----PIKDPKSFMDIQKIIGKDKIL 125 Sulfurisphaera tokoda...
Q10184  78 ---TWPGA------LQIGGG----INISN-AQNWLQEG----AS----KVIVTSWlfpdAQFDLDRLKAISSKIGKDRLV 135 Schizosaccharomyces p...

1H5Y_B 130 VAIDAKWn---------GeyyEVYVKGGREATGLDAVKWAKEVEELG-AGEILLTSIDRDGTGLGYDV-EL-IRRVADSV 197 Pyrobaculum aerophilum
2W79_A 124 FSLVTRG----------G---RVAFKGWLAEEEIDPVSLLKRLKEYG-LEEIVHTEIEKVGTLQEHDF-SL-TKKIAIEA 187 Thermotoga maritima
O29276 125 VAIDSKK----------G---RVAVKGWKEVVELTPVQLA-ELYDDL-DVSFLYTNIDVEGLVSGIER-ER-IEEVVKSL 187 Archaeoglobus fulgidu...
Q7UQJ1 168 LSLDFRA----------G------QFVGPET----ASNWVLAALKRN-IREGILLDVASVGSESGPASgEMfSDCVSRFG 226 Pirellula sp.
Q8THS7 130 VSIDVKY----------G---KLLKQDPEIP--EDPFEIVKLLNELP-LKDLIFLDLDRVGTASGFDP-EF-LHKLAETS 191 Methanosarcina acetiv...
O26765 130 VSVDVKDmrlhsrnleiG---------LEELRDLLMGYEV----------DIILLDIGSVGTSSGFNR-EL-L-ELFRPL 187 Methanothermobacter t...
Q8ZY14 121 VSLDYRG----------G---EVLVGGWREK-AASIAEAVRRLEEAGpYAAVIVTSVEVEGTGGGVKA-DIdVKSL-KRI 184 Pyrobaculum aerophilu...
O33772 126 VSID--Ydd-------tK---RVLISGWKER-SMEIIDGIKKVNELE-LLGIILTYVTNEGTVKGIDY-SV--KDYAKLI 188 Saccharolobus solfata...
Q970Z2 126 LSVD--Yds-------sG---YVLIRGWKEK-SIKVLDFLLSYDSLG-Y---IFTYVENEGTKRGIDN-NV-KNYVIRIK 186 Sulfurisphaera tokoda...
Q10184 136 VDVSCRRk--------dNr-wFAAINKWQVMTAFELNEENLDLLSQY-CSEFLIHAADVEGLCKGIDE-DL-VIKLGEWV 203 Schizosaccharomyces p...

1H5Y_B 198 RIPVIASGGAGRVEHFYEAA-----AAGA-DAVLAASLF--HFRVL 235 Pyrobaculum aerophilum
2W79_A 188 EVKVLAAGGISSENSLKTAQkvhteTNGLlKGVIVGRAF--LEGIL 231 Thermotoga maritima
O29276 188 RNPVYVAGGISSIEDIRFAK-----RVGA-AGVVIGSAL--YTKKL 225 Archaeoglobus fulgidus DSM 4304
Q7UQJ1 227 DMSWITGGGIRNVKDVRGLV-----SEGY-SAFLVASAM--LPALG 264 Pirellula sp.
Q8THS7 192 IHDVLLAGGVRGMEDLFTLD-----RLGI-KGALVATAI--HSGEV 229 Methanosarcina acetivorans
O26765 188 IERVIPGGGV-LPEEIPELE-----AMGV-RAALVGRAL--HEGMV 224 Methanothermobacter thermautotrophicus str. Delta H
Q8ZY14 185 ARRVFYAGGVRDCNDVERAY-----ALGF-DGVIVGYAL--YAGDL 222 Pyrobaculum aerophilum str. IM2
O33772 189 RGVKEYAGGVSSDSDITFLK-----NVGF-DYIIVGMAF--YLNKI 226 Saccharolobus solfataricus P2
Q970Z2 187 GLKEYA-GGIGSIEDLYKLN-----EYGI-NYAIIGMSF--YSGSL 223 Sulfurisphaera tokodaii str. 7
Q10184 204 KIPTTYAGGGRSIEDLDLVDk---lSKGK-VDLTIGSALdiFGGVL 245 Schizosaccharomyces pombe 972h-
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