6CAA,7RTM,8GV8,8Y85


Conserved Protein Domain Family
HCO3_cotransp

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pfam00955: HCO3_cotransp (This model is not part of the current CDD release)
HCO3- transporter integral membrane domain
This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.
Statistics
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PSSM-Id: 513882
Aligned: 54 rows
Threshold Bit Score: 521.339
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6CAA_A        397 RFCG-GLIKDIKRKAPFFASDFYDALNIQ------ALSAILFIYLATVTNAITFGGLLGDATDNMQG-VLESFLGTAVSG 468  human
XP_045094394  459 PYFL-GMRQDIKNRSKYFWSDYTDGLNWS------MITVVAYMFAVTVVPTLTFGAILELGTQGALS-VKSCLFSQAFSG 530 
A2AJN7        309 FPFGkGIWMDIMRRFPVYPMDFTDGIIGKsksvgkYVTTTLFLYFACLLPTIAFGSLNDENTNGAID-VQKTIAGQSIGG 387  house mouse
XP_013126766  301 R-FGkGVYDDLRRRLPLYPSDFTDGIIGNdrsllkYTTTAIFLYIAILLPAIAFGSLNDESTRGEID-VQKTIVGQSIGG 378 
EFX89365      259 R-FGqGIREDLSRRLPHYISDYKDGLTGVktp-qkVLSTTLFLYFACILPAIAFGVLNDHNTHGKID-VKKVIIGQTIGG 335 
XP_025016177  267 RIAQ-GLCEDLRRRLSHYISDYIDGVVGHqti-hkTISTIFFLYFACLLPTIAFGVLNDNNTNGKIGdIRKAIIGQTVGG 344 
XP_002110841  491 RLFG-GFINECKKRYPYYVSDFKDGLNFQ------TLAAFIFIYFACISPAITFGGLISSKTDGWIG-VSEMILGTAIIG 562 
XP_002110840  395 KECGsGLLRDMRRRYAHYLSDYTDAFNLQ------CLTASVFIFFACMAPAITFGAILGDYTQGVIG-VSETIVATSICG 467 
8Y85_A        680 svFG-GLVRDVRRRYPHYPSDLRDALHSQ------CVAAVLFIYFAALSPAITFGGLLGEKTEGLMG-VSELIVSTAVLG 751  human
XP_026691613  428 RPFG-GFIKDVKNRYPKYLSDITDAINLQ------CLASIIFIYFAALSPAITFGGLLGEKTNGWMG-VSEMILGCCVCG 499  vase tunicate
6CAA_A        469 AIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLI 548  human
XP_045094394  531 LIWSLFAAQPLLIMSPTGPFLVFEKALSKCAASWDYDYIEVRVYVGMWLFLFTILGTSVNCARFIRYVTVFTEDIFCCLI 610 
A2AJN7        388 LLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFI 467  house mouse
XP_013126766  379 VIYALFAGSPLVIPLTTAPLAIFISVIRGICDDYDLDFDAFYACIGLWNSLFLILGGLFNVSLLMKLFKRSTEEVIALFI 458 
EFX89365      336 LFFFVFGGQPLLILLTTAPLSLYIKVIYSICEDFQLDFYAMYGCVGLWSSFFLVLYSLFDVSRLMRWSTRSTEEIFALFI 415 
XP_025016177  345 LSFGFFGGQPLVIIMTTAPLCLYIKVIYGICEGFGLNFHAMYACVGLWNTFFLVFYAVFDVSRLMKWCTRSTEEIFALFI 424 
XP_002110841  563 LMFAFFAGQPLAIIGSTGPILIFEEIVYELCGQFNIEYIVFRFWIGAWVMIICFVTVALEGSFLVRYFSRFTQEIFSALV 642 
XP_002110840  468 IIYAVLAGQPLLIMGATGPILVFEEALFDFCQLNHVDFLTMRVWVGLWVFLILSLVVLLQGSFLIRYLTRFTEEIFASLI 547 
8Y85_A        752 VLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLI 831  human
XP_026691613  500 CMFGLISGQPLLVVGSTGPLLVFEEAVYNFCMSNGLPFLATRVWIGVWIFVISFVTVAFEGSFLVRFVSRFTQEIFTALI 579  vase tunicate
6CAA_A        549 SFIFIYDAFKKMIKLADYYPIn-----SNFKVG-YNtlfsCTCvppdpanisiSNDTTLAPeylptMSStdmYHNTTFdw 622  human
XP_045094394  611 SVIFFTEVEEFLMRVSVLFQF---------------------------------INTTVTF-----FQQyeeNPIVNLey 652 
A2AJN7        468 SITFVLDAVKGMVKIFGKYYY----------GHhYHt---KRT----------SSLVSLLG-----IGRs-pNSSLHTal 518  house mouse
XP_013126766  459 SIAFVGDAVKGTIKIFHHYYHgpilttTNKTLVlQQi---NEI---------------LDS-----AKNkteTILEHHse 515 
EFX89365      416 SIAFCVDAFRDTVKNFQEn---------------YNa---PSC----------KGDPASLA-----VNVsskANRVDTpt 462 
XP_025016177  425 SIAFVVDAFRDVYKNFNKn---------------YYs---PKC---------------LEP-----KQDfisLLTNNFtn 466 
XP_002110841  643 SIIFIYEAFFNLIKIYENHPLi------------SDy---CTV-------------------------VennLSTTNAti 682 
XP_002110840  548 SLIFIYEAIKNLLKIYATDPVl------------SNy---CNA-----------------------SYVpknYAGSYAny 589 
8Y85_A        832 SLIFIYETFYKLYKVFTEHPLl-----P------FYp---PEG----------ALEGSLDA-----GLEpngSALPPTe- 881  human
XP_026691613  580 SLIFIYETFNKLGKTFQQHPLqafypyPINTSViLSe---YNC----------------SY-----VESiniTNATIGni 635  vase tunicate
6CAA_A        623 -aFLSKKEC-SKYGGNLVGNNC------NFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILI 694  human
XP_045094394  653 -------yTtKAANCTGDPTSCs-----LPAPNSFLIQTILLVLSIAIFHYLRQVGISNFFGRKLRNLCNNFGGIFAVVF 720 
A2AJN7        519 naSLLASP--VEMATTSSPGST------HSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLS 590  house mouse
XP_013126766  516 tgMMSGHA--EGHESIFLPESLv-----LCTRERPILCLLLMLGTLWLGYTLYLIKRSPYLNDKIREVVSDCALPVSVLI 588 
EFX89365      463 aaNNSVVAYlLSQGNASVSEIV------ECNRASSLLFLLLMFGTVWIGVSLYNFNKTPYLQAGKREALADYSLPVAVIT 536 
XP_025016177  467 ---------eTSETIDISDGEC--------RRDATLLFLLLMLGTVWVAVSLYNFNKTPYLQASKRELLADYALPCAVIF 529 
XP_002110841  683 ---------pISFFNSNISNTTsavqviPPRPNTSLLSTILMLGTFGLAMFFRQFRNSQYLGRQARQIISDFGIPISIAA 753 
XP_002110840  590 -------tCmGNYTLLDIDNNGttk-csKPHPNTALLSTMYFLGTFGIIYAWRVFRRSKFLGTWARHMVCDLGIMITIII 661 
8Y85_A        882 ------------------GPPSp-----RNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILV 938  human
XP_026691613  636 tdAVQDTEi-------------------RNQPNTALLSTLLMFGTFIIAYFLRQFKNSKFLRSSVRRTIGDFGVPIAIFA 696  vase tunicate
6CAA_A        695 FCVIDAL-V-G--VDTPKLIVPSEFKPTSP-N-RGWFVPPF-G---E----NPWWVCLAAAIPALLVTILIFMDQQITAV 760  human
XP_045094394  721 VSILYHF-L-FsnVKVAMVQISD-TQNTTSyM-YGFLVIPKlA---P-----DAFLIGGSFMAAVFLYVLIFVEAEIPEQ 788 
A2AJN7        591 FSLIGSY-G-F-----QEIEMSK-FR-YNPsE-SLFEVAQI-H---S----LSFKAIGSAMGLGFLLSLLFFIEQNLVAA 652  house mouse
XP_013126766  589 LSFIGSY-L-F-----IDIQLPVF---SVHdG-PIFKFPPF-E---K----LSGMNALSAVGLGFLLALLIFIDQNIVIS 649 
EFX89365      537 LSFVGSY-L-F-----QDVTVER-FR-YDD-K-NVFMVAPL-E---R----LSWLAVLGAMGMGFSLSLLFFMDQNITSA 597 
XP_025016177  530 LSFVGSY-V-FkdIPVETFRYSNTFEI----G-RAHI-----E---E----LPLSAAFAAMGLGFSLSLLFFMDQNIAAA 590 
XP_002110841  754 MVVVNLL-I-Hg-VYVRTLEVPGGLSTTSPhK-RGWLINPL-G---Lke-pFPVGLMFLAAVPALLVLILLFMETEITLL 824 
XP_002110840  662 MVLINVYgV-GnvVYIKRLDVRPGFLTLSPyR-YSWLVNPF-K---I-----SIGWIFAAFIPAALVSILLFMEIEVTEL 730 
8Y85_A        939 MVLVDYS-ItD--TYTQKLTVPTGLSVTSP-DkRSWFIPPL-GsarP----FPPWMMVAAAVPALLVLILIFMETQITAL 1009 human
XP_026691613  697 MVLLDVL-I-Qd-TYTQKLNVPKGISPTDPsL-RGWFINPF-G---TpdnpMPVWMIFAGILPAFLVFILIFMESHITEM 768  vase tunicate
6CAA_A        761 IVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGE-QPKFLGVREQRVTGTLV 839  human
XP_045094394  789 MALRNKRKLRKGGGLHWDLIVVGFCTLFSSFTGLPWMCPAAVQSLAHITACT-EYEKTQRGE-PKKIKRVLEQRVSGIAT 866 
A2AJN7        653 LVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHiYETIVDVKETRLTALGA 732  house mouse
XP_013126766  650 LTHVPEHKLLKGTAFHWDLMLTGFINILMSCLGLPWMHAAFPHSSLHARQLAKVEQQVENGHlYTTIVSVKETRLTSLVA 729 
EFX89365      598 MVNNPCNKLKKGPAYHWDLFVVALVTAFLSLFGLPWMHATLPHSPLHVRGLADVEERVDQGHvYEIIVKVRETRLTGMIS 677 
XP_025016177  591 MVNNPCNKLKKGCAYHLDLFVVGVLNGFLSLYGFPWMHGVLPHSPLHVRSLADVEERVDGGHvYEIIVKVRETRITSIVS 670 
XP_002110841  825 LVNKKENKMKKGSGFHINLLLVGIGVGITSLIGAPWMCVATVRTLSHTLSVTVMSKSNAPGE-KSQLVEVKEQRVSNLLI 903 
XP_002110840  731 LMNKKNLKMRKGSGFHLDLMLNGLCVGIFSLFGLPWMCSATVRSASHLKSLTVYSKCYAPGE-KPQVLYVREQRLTALLI 809 
8Y85_A       1010 IVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGD-KPQIQEVREQRVTGVLI 1088 human
XP_026691613  769 IISNKERNLKKGTGFHLNLMVLGMLNVLVSFFGMPWVCCAAVRSITHTNSLTVMSKTQAPGD-KPKIEGTKEQRVTVFVV 847  vase tunicate
6CAA_A        840 FILTGLSVFMAP-ILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLA 918  human
XP_045094394  867 YILLLAFAFYGH-FLA-IPSAAIFGVFFYLGVRNLEGNQMIQRASLVCYLPKNRGSHKFLDLAPFWVVQSYTVLQIIFVC 944 
A2AJN7        733 SVLVGLSLLLLPfPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLL 812  house mouse
XP_013126766  730 NILIGLSMFMLPiPLQWIPKPVLYGLFLYIAATSLDGNQMVDRMTLLLKEQTSYPPTHYIRRVPQRKVHYFTGLQIIQLI 809 
EFX89365      678 HFFIGLSLFLLPyPLAYIPTAVLDGLFLYMAVTALNGNQMFERITLLFMEQAAYPPNHYIRRVPQRKIHQFTGCQVTQLL 757 
XP_025016177  671 HILIGLSVFLLPyPLAYIPTAVLDGLFLYMAITALSGSQMFERITLLFMEQAAYPPNHYIRRCPQRKIHLFTFCQLVQLG 750 
XP_002110841  904 HIMIGASLFLTD-VLRLIPIPVLYGVFLYMGFTSLNGVQLIERIKMLIMPSKYHPETIFVRNVPTRKIHLFTLVQIVCIV 982 
XP_002110840  810 HVLMGISLYFTQ-VIEVIPYAVILGVLLYMGIASITGIQLFKRFKLLFMPLKHHNE-IYVKNVPTRKIYSYTLVQVFFLT 887 
8Y85_A       1089 ASLVGLSIVMGA-VLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIA 1167 human
XP_026691613  848 NACLGLSILMQP-VLSEIPLAVLFGIFLYMGVTSLTGVQFIDRIEMLFMPSKHYPDFSYVEVVRHMKIHIFTFIQIICLA 926  vase tunicate
6CAA_A        919 LLWILK-STV--AAIIFPVMILALVAVRK-GM-DYLFSQHDLSFLDDVIP 963  human
XP_045094394  945 GMYVVKsKPT--LGVLFPLFLVITAFFVA-EVlPRVYDEKLLEALDEEDE 991 
A2AJN7        813 LLCAFGmSSLpyMKMVFPLIMIAMIPIRY-NLlPRIIEAKYLDVMDAEHR 861  house mouse
XP_013126766  810 ILCAFGmYPLpyMKMVFPLLMILLVPVRT-SLlPRMIEAKYLDILDSQYM 858 
EFX89365      758 VMCLFGfAPWayMKMVFPLIILFLLPVRH-RLvPQLIEGRFLEALDGEHQ 806 
XP_025016177  751 LMCFFGfSPWpyIKMVFPIVILLLLPVRH-KIiTYVIDAKYLEALDGEHQ 799 
XP_002110841  983 VLWVIK-STD--ASIAFPLFIILTIPVRW-QM-KHFFTRRELIALDNDGK 1027
XP_002110840  888 LLWIVK-LTA--AAIAFPILVLFLIPIRK-AL-GRFYTASELEAVCTETN 932 
8Y85_A       1168 LLWVVK-STA--ASLAFPFLLLLTVPLRHcLL-PRLFQDRELQALDSEDA 1213 human
XP_026691613  927 ILWIVK-STA--AQIAFPFFLVMTIPLRY-FVlPKFFTPKEIAELDSSET 972  vase tunicate
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