4FFJ,6MNZ,1TKS,3MK5,7UEZ,1K49


Conserved Protein Domain Family
DHBP_synthase
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pfam00926: DHBP_synthase (This model is not part of the current CDD release)
3,4-dihydroxy-2-butanone 4-phosphate synthase
3,4-Dihydroxy-2-butanone 4-phosphate is biosynthesised from ribulose 5-phosphate and serves as the biosynthetic precursor for the xylene ring of riboflavin. Sometimes found as a bifunctional enzyme with pfam00925.
Links
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Statistics
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PSSM-Id: 513857
Aligned: 594 rows
Threshold Bit Score: 117.908
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4FFJ_A         7 QEALEALQKGRLVLVIDDKDRENEGDLICSAQAATTENVNFMATYAKGLICMPMSESLANQ---LMLSPMVenNTDNHKT 83  Streptococcus p...
Q9X2E6         2 EELREAFEEGKPVILID-RNRENEADFVFPAQLITEDVVSFFVTYGKGLFCVTADEEDLLKrgfVKLSS-------NYGA 73  Thermotoga mari...
WP_011994567   9 kDLREYFLSGKPLILID-ENREKEGDFVYPAELIDESMVEFFVRYGKGLFCLVAPEGDLLSrgfFKLPT-------NYGA 80  Fervidobacterium
Q5JD32         4 drvrglvLEGKPVVLID-NRREFEADLIYPAEIASPEIVNFMLSM-KGLLCLTMDMDEALKrgfFPLPSK---EGE---T 75  Thermococcus ko...
Q8U4L7         7 EEIRNSFLSGRPAVLID-EERENEADLVFPAEIATPKVVNFMLSA-KGLLCLALDMEEGIKrgfFKLPNN---GGE---T 78  Pyrococcus furi...
O29766         2 EEVSSHVKSGKPVMILDSEK----SAICIPAEVVSGEILNFMMKNCDE-IRLALTWKQILN---LGL------NRFRFQN 67  Archaeoglobus f...
WP_013683543   2 QEIIEAVRAGKPFIIFDDKK----SVLGVPADVVSGRVIALIMKNCDE-YRLAMPWKHITA---LGL------NRFLLYG 67  Archaeoglobus v...
WP_012940533   2 KEVVKAVKSSKPVVIYD-EK----SVLAIPAEVVSVEVVKMMMKHCDE-IRVALPWKRIVE---LGL------NRYKVFN 66  Archaeoglobus p...
9_pfamImport   1 QSIIEAIKMSKPVIVVDDHDLQNTGSLIFNAEKLNLENINFLKEYGDKYIYVAASKQFYEG---LNIDPVY--EVVGSMH 75 
WP_008522440  14 TRARDALRSGGAVLVTEGSGEGDTGAFVLPAGTLTAEKLIAASSFGFSDPFFVLSEPTASR---LGLAVVK--AS-KGGA 87  Jonquetella

4FFJ_A        84 AFTVSIDYKe---TTTGISAEERGL--------TARMCVA--ED--I-TPSDFRRPGHMFPLIAKKGGVLERNGHTEATV 147 Streptococcus p...
Q9X2E6        74 NYFVPVDWg----TGTGISALERAE--------TCRKLAe-gR-----YFHEFRYPGHVTVIGGI--GFQRRKGHTEASL 133 Thermotoga mari...
WP_011994567  81 NYFIPIDFg----DGTGISAYERAV--------TCRALANrdK-----KISEFRYPGHVMLIGSQ--DFSKRRGHSESSV 141 Fervidobacterium
Q5JD32        76 NFLVPVDYk---eTFTGITAEERAL--------TARKIA---EG--L-GVGAFRYPGHLHLLGGI--GLNRRRGHTESSL 136 Thermococcus ko...
Q8U4L7        79 NFLIPVDYk---dVFTGITAEERAL--------TARKVA---EG--L-GIENFRYPGHLPLLGGL--GLNKRKGHTEASL 139 Pyrococcus furi...
O29766        68 GNLIPIDP-----NLEKISAEERAK--------FIRELVS---G--NaG--DIKYPGRIFVEETKEMGVLERPGIAEACV 127 Archaeoglobus f...
WP_013683543  68 GTVIPLDC-----SKNGISAEERAD--------FIRRLVK---G--NvKPEEIVFPGRIFVEEAKEGGVLERPAFGEACI 129 Archaeoglobus v...
WP_012940533  67 GNAIPLD-------FKSLSANDRAE--------FMKILAR---G--KlDLNDVIYPGRIFVEEAKEGGVLERPSFGEASL 126 Archaeoglobus p...
9_pfamImport  76 AF-----------KDTTISLTDTHKddpsnilaTTQSVLN---K----KKVEYHKNGVVFPLITRLGGTLKRVAHPEAIV 137
WP_008522440  88 WFAESFDLAlapeMPTRQYETD-----------VAHVLAD--EStpA---GALLRPGRVRPLVARPGGVVRRASFAEAAS 151 Jonquetella

4FFJ_A       148 DLLKLAGLKECGLCCEIMnHDGK-MMRTDDLIQFSKKHNIPLITIKELQEY 197 Streptococcus pneumoniae
Q9X2E6       134 EISELAGFSRHAVIVEILdEKGN-SHNLDYVLKLSEKFSLPVLEMDDVWRe 183 Thermotoga maritima MSB8
WP_011994567 142 ELMKMCGFKPYSVIVEILnERGD-SHDFDYLSKLAEKFELKTMSIKDVWRl 191 Fervidobacterium
Q5JD32       137 ELMEILGFKRYALMVEILdEKGD-SHNREYALKLAEEHGLPVLTTDDVWKE 186 Thermococcus kodakarensis KOD1
Q8U4L7       140 ELVEMAGFKRYALIIEILdDKGY-SHNLDYAFHFAKEHDLPLIRIREIWKE 189 Pyrococcus furiosus
O29766       128 DLARMAGFAPSAVYAPLMtAEGG-VAGEDYALKFAKEHSMPVFRIKDMIEF 177 Archaeoglobus fulgidus DSM 4304
WP_013683543 130 DIARMAGFSSSALYSTLItPSGD-VADESYAAEFAKENGLPVISIKELIMH 179 Archaeoglobus veneficus
WP_012940533 127 DLARLSGFELAGVYAPLLd-EGN-IADRDFGVKFAKEMGLKAVSINELIEF 175 Archaeoglobus profundus
9_pfamImport 138 DLSELANLKPVGVLSLLLnKD-KqPMKMDEIIAFATKHALPIVSVESIIRY 187
WP_008522440 152 DLAELAGFG-AGVFVPVRtRSGS-PAPLAEAEEAAKQLGAPVLELSRLIAW 200 Jonquetella
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