7UW5,2OAU,6URT,7A46


Conserved Protein Domain Family
MS_channel_2nd
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pfam00924: MS_channel_2nd (This model is not part of the current CDD release)
Mechanosensitive ion channel, beta-domain
This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel beta-sheet (middle/second) domain and a C-terminal alpha/beta-domain. This is the beta domain which adopts a SH3-like barrel structure.
Links
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Statistics
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PSSM-Id: 513855
Aligned: 39 rows
Threshold Bit Score: 64.1133
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7UW5_A  929 EIFGNFVSGLIILFERPVRIGDTVTIG--------SFSGTVSKIRIRATTITDFDRKEVIIPNKAFVTERLINWS 995  Escherichia coli K-12
Q55859  363 SAITNVIGGIILIYTRAFQIGDHIQVG--------DVIGDIIEKNFLVIRICTPTNQIITIPNSSLLISNVINYS 429  Synechocystis sp. PCC 6803
Q58111  124 KPILNFAGWIIILYTRTIKIGDRIFIKnmgagdvfDIDTQHIYLSELTTDTFEPTGRVLIIPNSYIFTASIENLT 198  Methanocaldococcus janna...
P0AAT4  185 DPILGLVAGIQLSANDMLKLGDWLEMPk------yGADGAVIDIGLTTVKVRNWDNTITTIPTWSLVSDSFKNWS 253  Escherichia coli K-12
O05781  130 RLVQDLLAGFFIIVEKQYGFGDLVELSmvg--speNAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIV--KSVNLS 200  Mycobacterium tuberculosis
Q55987  428 SLVKDLVDGFLVLAEDQYAIGDVIDVG--------FAAGGVENLNLRVTQLRSAGGELVTIPNSAIT--QVKNLT 492  Synechocystis sp. PCC 6803
P73148  515 NLIKDLIAGISNLMSDAFAINDFVLIG--------EFEGVVEDTNLFVTRIRCPNGDLVTIPNGAIG--TVCNQT 579  Synechocystis sp. PCC 6803
P72735  566 NVVEDMLNGTLILWTDRYAIGDVVQIG--------DVFGLVENMNIYITQLRGPEGRLSTIPNGKIS--VVQNLT 630  Synechocystis sp. PCC 6803
O34897  110 GLVSDIVTGFFILLEKQLDVGDYITVS--------TFDGIVEQVGLRTTQIRSFDGTLHYIPNRNIT--NVSNHS 174  Bacillus subtilis subsp....
P75783  557 TLVKDIITGVFIQFENGMNTGDLVTIG--------PLTGTVERMSIRSVGVRQDTGAYHIIPWSSIT--TFANFV 621  Escherichia coli K-12
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