4HWA


Conserved Protein Domain Family
MS_channel
?
pfam00924: MS_channel 
Click on image for an interactive view with Cn3D
Mechanosensitive ion channel
Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.
Links
?
Statistics
?
PSSM-Id: 425948
Aligned: 35 rows
Threshold Bit Score: 124.247
Created: 16-Apr-2021
Updated: 29-Sep-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
4HWA_D  92 LVRYGIIAFTLIAALGRVGVQ---TASVIAVLGAAGLAVGLALQGSLSNLAAGVLLVMFR-PFRAGEYVDLG-------- 159 Escherichia coli K-12
O05781  89 VSIVLIYVVVVYEVIDVLPVP---VGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEK-QYGFGDLVELSmvg----- 159 Mycobacterium tubercu...
Q55987 387 MVTVVISASGLLTALIILGIP---TGSVVAIGGLLALAISFGAQSLVKDLVDGFLVLAED-QYAIGDVIDVG-------- 454 Synechocystis sp. PCC...
P72735 526 GISVLLTILGILGTIWLFGIN----PLVLASFGGVAFVLAFLGRNVVEDMLNGTLILWTD-RYAIGDVVQIG-------- 592 Synechocystis sp. PCC...
P73148 474 INLVVCIFTAFVFSLSLFDVP---VATVLAGAGIIGFAVSFGSQNLIKDLIAGISNLMSD-AFAINDFVLIG-------- 541 Synechocystis sp. PCC...
Q58111  83 IFKYLVYVCVTLMIFGVIYQN---VSSLVVSVGLIGAAVTYALQKPILNFAGWIIILYTR-TIKIGDRIFIKnmga---- 154 Methanocaldococcus ja...
O25059 265 AINFVNVSVIILIFLFSYLEN---VTYLVTVLGFASAGLAIAMKDLFMSLLGWFIILIGG-SVHVGDRVRIAkgtdifig 340 Helicobacter pylori
Q55882 109 CKALILLFTISYLLNLFFNLS---EGNLLALTGTIAVALGFAFKDYISSIIAGVVALFEA-PYRVGDRIQIG-------- 176 Synechocystis sp. PCC...
O14050 445 LDRVGLGVVGIIAVLTFISFLdtsFATILAAFGTTLLSLSFVFSTSAQELMSSIIFLFSKhPFDISDVVIVN-------- 516 Schizosaccharomyces p...
P71915 117 VARFALIGIGLAVILSYIWGVr--VGGLFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQ-PFRIDDWLETP-------- 185 Mycobacterium tubercu...

4HWA_D 160 -------GVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSR--EPVRRNEFIIGVAYDSD---IDQVKQILTN 227 Escherichia coli K-12
O05781 160 ----speNAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIV--KSVNLSK---DWARAVVDIPVPTSADlgrVNEVLHQECE 230 Mycobacterium tubercu...
Q55987 455 -------FAAGGVENLNLRVTQLRSAGGELVTIPNSAIT--QVKNLTR---SWSRANLSVNVAYDTDpvkAINVLRQVGE 522 Synechocystis sp. PCC...
P72735 593 -------DVFGLVENMNIYITQLRGPEGRLSTIPNGKIS--VVQNLTK---DWSRAEFIVEIDQSSNvdkALNLIRVVSE 660 Synechocystis sp. PCC...
P73148 542 -------EFEGVVEDTNLFVTRIRCPNGDLVTIPNGAIG--TVCNQTK---DWSRVDYSVMVAADADpkkAIAVLQQVAL 609 Synechocystis sp. PCC...
Q58111 155 ---gdvfDIDTQHIYLSELTTDTFEPTGRVLIIPNSYIFTASIENLTKg-SPYIWDNIVVHFTLNSNinkAEKIVFESAD 230 Methanocaldococcus ja...
O25059 341 dvldismLHITILEDVTFTTYSNNRRAGRIIFVPNNYIFTTMFANYSHfgMKTVWDGVDFCITFDSDfkkASKIALNIAT 420 Helicobacter pylori
Q55882 177 -------DHYGEVTGYGLRGICLQTPDDNNVTIPHNKTWTEPISNANGg-NLEAQVATSFYFDHSVD---VEQVIRILYQ 245 Synechocystis sp. PCC...
O14050 517 -------NIKYEVVSLSLLFTVFRTMGGSTVQAPNSLLNTLFIENLRR--SQPQSETITIVSPFATDfkqLERLRDLLLT 587 Schizosaccharomyces p...
P71915 186 -------TARGRVVEVNWRAVHIDTGSG-LQIMPNSMLATTAFTNLSR---PAGAHECSITTTFSTSd-pPDKVCAMLNR 253 Mycobacterium tubercu...

4HWA_D 228 IIQSEDRILKd------------REMTVRLNELGASSINFVVRVWSNS-------GDLQNVYWDVLER---------IKR 279 Escherichia coli K-12
O05781 231 HARHDSLLGEl-----------lLDEPTVMGVERIEVDTVTLRLVARTl-----pGKQFEAGRQLRVL---------VIR 285 Mycobacterium tubercu...
Q55987 523 DLYNDPEWHDk-----------mLAVPDVLGIDSLTHEGMTITIWIQTa-----pAQQWSVGRELRFR---------VRQ 577 Synechocystis sp. PCC...
P72735 661 QMREDPLWQEk-----------iLEPAAILGVDDIASKGIRLQVWIKTq-----aGQHWPVGREFRLR---------MKK 715 Synechocystis sp. PCC...
P73148 610 GLYHDPWWHPk-----------mLQAPELKGIEEVSHQGILIRIWLKTl-----pGEQWDVARELRLR---------VKV 664 Synechocystis sp. PCC...
Q58111 231 EVIGNLMRELyekwskrkylisrKLSDKPVVRVGITRSSFYIKALYLVn-----vYEKAKIRSEINKRi--------LEK 297 Methanocaldococcus ja...
O25059 421 ELSKEYTDITy------------KQLNKMRDRYSLRSLSVKPRCFLMPenngikiSVWYQTNSYATLSlrskivaeiVEA 488 Helicobacter pylori
Q55882 246 AAYSSRYTQL-------------SIPIVVVMKEHIWGTEFKLRSYPMDa------RDEFAYQTDLIRR---------AKR 297 Synechocystis sp. PCC...
O14050 588 FVKENERDFRp------------IIDLNVSDFSTLDSLKFTVTYYYKS--------NWQNVSLQCVRR---------NKF 638 Schizosaccharomyces p...
P71915 254 AASALPHVK----------------PGVVPATIARGAAEYRTTVRLTSp------ADEGPTQATFLRW---------VWY 302 Mycobacterium tubercu...

4HWA_D 280 EFDAAGIS 287 Escherichia coli K-12
O05781 286 ALTRAGIV 293 Mycobacterium tuberculosis
Q55987 578 ALTENNIE 585 Synechocystis sp. PCC 6803
P72735 716 AFELAGIA 723 Synechocystis sp. PCC 6803
P73148 665 AFESQEIA 672 Synechocystis sp. PCC 6803
Q58111 298 VNKENDVK 305 Methanocaldococcus jannaschii DSM 2661
O25059 489 FLKEENIH 496 Helicobacter pylori
Q55882 298 AFGQQGLP 305 Synechocystis sp. PCC 6803
O14050 639 MCALKNAI 646 Schizosaccharomyces pombe 972h-
P71915 303 AARREGLH 310 Mycobacterium tuberculosis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap