5YM0,6OVT


Conserved Protein Domain Family
ILVD_EDD_N

?
pfam00920: ILVD_EDD_N (This model is not part of the current CDD release)
Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal
This is the N-terminal domain of Ilv/ED dehydratase protein family which includes dihydroxy-acid/6-phosphogluconate dehydratases, and pentonate dehydratases. Members of this entry are involved in various biosynthetic and carbohydrate metabolic pathways. Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid. 6-Phosphogluconate dehydratase catalyzes the first step in the Entner-Doudoroff pathway, the dehydratation of 6-phospho-D-gluconate into 6-phospho-2-dehydro-3-deoxy-D-gluconate. They consist of two domains, N- and C-terminal. This domain is composed of a beta-sheet with four parallel beta-strands surrounded by four alpha-helices and forms a binding site for a [2Fe-2S] cluster and a Mg2+ ion.
Statistics
?
PSSM-Id: 513852
Aligned: 672 rows
Threshold Bit Score: 352.027
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5YM0_A        111 PQIGISSVWYEGNTCNMHLLK-LSEAVKEGVENAGMVgFRFnTIGVSDAIS-MGTRGMCFSLQSRDLIADSIETVMSAQW 188 thale cress
WP_012610956   39 PLIAVANSQTDINPGHMHLQN-LALRVKEGVHAAGGLpFEFnVPAPCDGIT-EGHEGMRYVLAQRDLIADMIETHVRSMR 116 Desulfatibacil...
CCZ45963       35 PVIGIVNSFTDVNPGHRAFKE-LVGYVKEGVWAAGGTpAEFnVPAPCDGMA-QG-EGMHFILPSRDLIAGSIEAMVSAHG 111
WP_015261319   39 PIIGVVSSWSEIHPGSYPNKE-LAQFVKAGVWAAGGTpVEFhTIAVCDAIA-QG-VGMHYSLPSREIVAAEIELMVGSGG 115 Desulfitobacte...
BAK68344       28 PKIAVVNSSSELAVCYAHLDG-IAKIVKEAVRAAGGVpFEVrTTAPSDFITgAGKQGS-YILSARDLVTNDIEAQVEAAM 105
jgi:Tlie_0144  35 PLIGIVNTANDAGLGHVHLDK-LVERVKAGIWQAGGTpFEFrTIATCGAVP-IGTPHLRYELVIRDVIASSVEIMANVQL 112
WP_021844501   37 PHIGIANTFSEASPGHAHFRP-LVEAVKAGIWEAGGIpFEFgVPSTCGNIA-IGTNCLRYEMAVRDVVCSSIEIVSKIQL 114 Blautia hydrog...
36_pfamImport   2 PHIGIPNSYMAGSPGTAHLRQ-VTEAVKEGIWAAGGIpVEFgIPATCGNVA-NGADEMKYEQVGRDIVAMSIEFVSRIHN 79 
CDD08595       32 PHIGVPNSYMAGSPGSAHLRQ-IAEAVKEGIWAAGGIpVEFgIPATCGNIA-NGAEELKYEQVGRDIVAMSVEFVTRVHN 109
31_pfamImport   2 PVIGLVNSWNEMNPGHFPFDKtVIQEMKDEIYKAGGLaLELpVTGICDGIC-SNTPGDRYTLPARDLVSSEVEMVAELNM 80 
5YM0_A        189 YDGNISIPGCDKNMPGTIMAMGRLNRPGIMVYGGTIKPghfq-----dktyDIVsafQSYGEFVSGS-ISDEQRKT---- 258 thale cress
WP_012610956  117 YDGIVFIAGCDKIIPGMLMAAARLDLPSIFLTGGPns-------------wSIRhtpQMNGSVNHQS-Y--DDLEA---- 176 Desulfatibacil...
CCZ45963      112 FDGLVFLCSCDKIVPGMLMAAAALNKPCMFLTAGSMLPyeadeg--tyvtpDLK---ESIGQRNIDA-ISEETFTR---- 181
WP_015261319  116 FDGLVLLPSCDKSPGGMLMAAARLNLPTIFLPPGPMLPhfddqg-qqwvmsDIK---EAMGAFTKQR-MDDKLFEA---- 186 Desulfitobacte...
BAK68344      106 LDGMVCLTSCDKTPPGHMMAAGRLNIPTILVIGGYQASgmig-----nehvDLEdlwSGSIATRFGKpFPHDE-QE---- 175
jgi:Tlie_0144 113 FDGLVLLASCDSIIPGVFIGALRTGLPAIFLSGGPQDTcefegrqvvlselDQL---VFGAQY--DH-SSSQEVKEkiry 186
WP_021844501  115 FDGVVMTCGCDNIVPGTLMAAARLDIPSLLLTAGPMLAgnrkgkelvlsdvNER---VFGRAAAKKE-GNSQELLE---- 186 Blautia hydrog...
36_pfamImport  80 FDAICCVASCDLIIAGCYLAACRLDIPALVVTGGSMQAgnycgktvveadlDAA---RFSG-------ASEAELFE---- 145
CDD08595      110 FDGLAMIASCDNIIAGCYMAAMRLDIPSMIVTGGSMQPgqycgktvveadlDAA---RFSG-------ASEEELMD---- 175
31_pfamImport  81 LEGMVIMATCDKVVPGMLMGAFRVNIPTTMLTGGYMAAgcye-----drmlTLThtkQAYAAYVEGD-MSREEYKA---- 150
5YM0_A        259 VLHHSC---PGAGACGGMYTANTMASAIEAMGMSLPYSSSIPAEDPLKLDECRLAGKYLLELLKMDLKPRDIITPKSLRN 335 thale cress
WP_012610956  177 K--MSCataATCGACEVMGTANTFQCIAEALGMTLPGSSNVPAFLSEKLTFARKTGMRIVSLVEEGVNARQVLNQKSLLN 254 Desulfatibacil...
CCZ45963      182 FRENIC---FSCGTCSMYGTANTMGVFAEVIGLCPIDSTTMLFCSSAKYKQARNVGERIVTLTKEGVRFSDIVTEASLKN 258
WP_015261319  187 IETDTC---TTVGVCGMMGTGNTMGCLIEALGMSLPGTSTTPSVYAKKRHQAKETGKRIVEMVKENLRSHQILNEGSLAN 263 Desulfitobacte...
BAK68344      176 MIRQAV---RGPGVCAGMATANTMHCVVEALGLSLPGSAPVRANSEKMKDAARRSGARIVEMVnegLTPRQILTPAAFRN 252
jgi:Tlie_0144 187 LEDHVC---PGPGACALMGTANTMQILMEALGLSLPGSATVPATSAEKLRFATQTGRKIVELTKKGITPKDILSRSSFLN 263
WP_021844501  187 MEQKAC---ASFGACPVMGTANTMQIIAEAMGMTLPGTSVIPGVVTDKFVSARKTGRQIVEMVKNDRRVSSIITEGALKN 263 Blautia hydrog...
36_pfamImport 146 MEESVC---PSFGACPSMGTANTMQMLGEVLNLVMPGTSTIPASDNARLRAARTAGKYMVQLARSGKTPKDLITKDVLEN 222
CDD08595      176 MEDNVC---PSFGACPSMGTANTMQMLGEVLNLVLPGTSTIPASDNAKLRKAREAGMCMVEMAKAGRKPSDLITKEVLMN 252
31_pfamImport 151 IVRHAC---PTPGACPFMGTANTMCAMAEILGFSPHGNASVRSQSEKWHQMAREAARKVVEAVKEEKRPSDFVTQKSLEN 227
5YM0_A        336 AMVSVMALGGSTNAVLHLIAIARSVGLELT-LDDFQKVSDAVPFLADLKP-SGKYVMEDIHKIGGTPAVLRYLLeLGLMD 413 thale cress
WP_012610956  255 AVMVDLAIGGSTNSTLHLPALARAMELELP-LETFNEYSAKIPTLTSIAP-NGPHGIIDLYMAGGVQGVMKVLE-Hd-LN 330 Desulfatibacil...
CCZ45963      259 GLRHVAATGGSTNAQLHICALARVMGIPMD-LAAFDAIQRDVPCVAKFKP-SSKFNMYDYYKAGGVGATMKAIE-Ry-LD 334
WP_015261319  264 AVRLVMAIGGSTNAVLHLPAIAREAGVELT-LDDIDRLSEQTPCVAKYKP-SSKYTLWDFYQAGGVGAILKIIS--PLLH 339 Desulfitobacte...
BAK68344      253 AVATVLAVSGSINAIKHLQAVAVEAQVDVDiFAMWDEVGRKVPVLSAVRP-NGEVRIEEFEDAGGAAAILKQLApL--ID 329
jgi:Tlie_0144 264 AVKVLLATAGSTNGVLHLLSFARELEIELT-LDDFDRFSRQVPVISEVIP-TGKATVKDLNRAGGVPAILGELL--PLLD 339
WP_021844501  264 AIMADLAIGGSTNAVLHILSIAKELELPVT-LQDFDELSRRTPTITNLRP-AGEYTVDKLYLAGGVPAILKQLE--NLIN 339 Blautia hydrog...
36_pfamImport 223 AIMFDMAVAGSTNAVLHILAYAYELGIKLT-LADFEKYAKEIYCINAVIP-SGPYTVVDFHYAGGVKQVMKQLA--GKIH 298
CDD08595      253 AIMFDMAVAGSTNAVLHILSYAYELGIKLT-LADFEKYAKEIPCINAVVP-SGPYTVVDFHYAGGVMNVMKMLE--SKLY 328
31_pfamImport 228 VVRYMMATGGSTNSLLHIPALARQMGFDIT-PETFDAISREVPLISTIYPnHPVYTMEEFDRAGGLGAVVKEMVkAGKID 306
5YM0_A        414 GDCMTVTGq-----TLAQN 427 thale cress
WP_012610956  331 TDAMTVVGg-----PLKDV 344 Desulfatibacillum aliphaticivorans
CCZ45963      335 PDARLATGg-----TVGEF 348
WP_015261319  340 KEVLTVTGk-----TIEGY 353 Desulfitobacterium dichloroeliminans
BAK68344      330 TGALTCTGr-----TLAEN 343
jgi:Tlie_0144 340 GSAATLSGm-----TVGQI 353
WP_021844501  340 TQAQVCTGq-----TWEEI 353 Blautia hydrogenotrophica
36_pfamImport 299 TDAPTIYGd----tTWGEL 313
CDD08595      329 TDVPSMYGn-----TWADM 342
31_pfamImport 307 ADADGMFGtirqkaELAEN 325
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap