1H6F,4A04,1XBR,5T1J


Conserved Protein Domain Family
T-box

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pfam00907: T-box 
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T-box
The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.
Statistics
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PSSM-Id: 425940
Aligned: 112 rows
Threshold Bit Score: 160.797
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1H6F_A         7 VHLEAKELWDQFHKRGTEMVITKS-GRRMFPPFKVRCSGLDKKAKYILLMDIIAAD-DCRYKFHNSRWMVAGK-AD-PEm 82  human
Q9U2C9        12 VSLNKPEIWEKFYPK-TEMIVTRKrGRVIFPHLDYNVKGLDPDSLYSIYIHLERVD-GIKYKFDAGEWKEAGK-GD-PI- 86  Caenorhabditis ...
Q9XVD5        12 VSLSTPEIWEEFYPK-TEMIVTRNrGRVIFPHLDYIIKGLDPGSLYSIYIHLERVD-GIKYKFDAGEWKEFAK-GD-PI- 86  Caenorhabditis ...
5_pfamImport   1 LALHEPKTWQEFHPN-TEMIVTRKrGRVIFPHLDYLISGLEPTSLYSVFVHLERVD-NVKYKFDQGEWQYATK-GD-PI- 75 
EFP03381       9 VSLSNQDQWEKFHPM-TEMIVTRKaGRRLFPHLNYILKGLDPNELYGVFIHFERVD-KNRYQFLRNKWNVFGK-SD-EV- 83  Caenorhabditis ...
XP_003103799   9 VSLSNQDQWEKFHPM-TEMVVTRKaGRRLFPHLKYILKGLDPDAKYGLFLHFERMD-NIKYKFSVNKWKEFAK-GD-EI- 83  Caenorhabditis ...
XP_003095069  14 VSLSNQEQWEKFYPH-TEMVVTRKsGRLLFPHLKYILKGLDEDTEYSVFLHFERID-NWKYKFLSRGWDKWTE-GD-KK- 88  Caenorhabditis ...
6_pfamImport   1 VALQDRQLWKEFDTLCNEMIITKI-GRNLFPIIEYAFKGLQEHVEYQVGVTMQLTNcQ-KLKFTAGKWDPLDVpEEvF-- 76 
Q1T6W8         5 VALMEKSLWREFDSQCNEMIITKI-GRNLFPILEFAFKGLCEHLNYKIGVTMEPISyQ-KLKFTAGRWESLDIqEEmV-- 80  Caenorhabditis ...
XP_003103922 146 VALLDKALWREFDAQCNEMIITKI-GRNLFPILEVSFKGLNEHLHYRIGVTMEPTViQ-KLKFTGGRWEKLDVmEDmV-- 221 Caenorhabditis ...
1H6F_A        83 PK-RMYIHPDSPAT----------GEQWMSKVVTFHKLKLTNNISDK--H--GFTILNSMHKYQPRFHIvR---ANDILK 144 human
Q9U2C9        87 LPiQYKEHPRGKRT----------GTEWMSEPVSFAHLKITNDPENKd-Q--KLILAQSLHKYIPVLHIkQldpYK-GTF 152 Caenorhabditis ...
Q9XVD5        87 LPiQYKEHPRGKRT----------GAEWMSEPVSFAHIKITNNPEIKd-Q--KVILVQSMHKHIPVVTVkQvrhYK-TGY 152 Caenorhabditis ...
5_pfamImport  76 REvQYYEHPHGARS----------GEHWMSDPVSFASLKITNDPMCEn-P--KLIIVQSMHKYQPVVTIkK---IGnf-- 137
EFP03381      84 RHiKVEQHLDGWRA----------GSYWMTKPVSFEHVKITNNPDLKk-S--NTFVLQSMHKFKPVIGVqK---MGds-- 145 Caenorhabditis ...
XP_003103799  84 RPiERKLHKDGWRL----------GGHWMENPVSFEYFKITNDPEMDk-D--DAVLVQSMHKHIPVLSIqR---ENae-- 145 Caenorhabditis ...
XP_003095069  89 LPiDMKQHKDEWKC----------GRDWMKDPVSFDYIKITNNTEAKk-E--NEILLQSMHRYLPVISIqK---KGgm-- 150 Caenorhabditis ...
6_pfamImport  77 ------------QPneifmakpksGRELMQRGLKLDKLKLTNTKEAVvkNdqM-IRVQSMRQYIPVLHIy------EVVA 137
Q1T6W8        81 ------------QPnevf--lmksGRELLQRGLKLEKLKLTNSKDALqkSdqM-IRVQSMRQYMPVLNIy-----EISPV 140 Caenorhabditis ...
XP_003103922 222 ------------QSnevf--yvksGRELLQRGLKLEKLKLTNSKDALqkSdqM-IRVQSMRQYVPVLNIy-----EATPT 281 Caenorhabditis ...
1H6F_A       145 LpystfRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 187 human
Q9U2C9       153 QmdfhgVEFRLEATQFIVVTAYQNEELTKLKVHHNKFASGFRS 195 Caenorhabditis elegans
Q9XVD5       153 QedfsgEQFRLEATEFMVVTAYQNEILKNLKVHHNKFASGFRS 195 Caenorhabditis elegans
5_pfamImport 138 ----rgEEFRLKVTEFMVVTAYQSNHVNDLKKKHNKFASGFRA 176
EFP03381     146 ----kiEGFRLDVTEFMAVTAYQNNDIKELKIQMNRFASGFKE 184 Caenorhabditis remanei
XP_003103799 146 -----kEEFRFGVTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183 Caenorhabditis remanei
XP_003095069 151 ----ekEEFRLGITEFMAVTTYQNNSIASLKVELNQHASGFRQ 189 Caenorhabditis remanei
6_pfamImport 138 TgvrlvGKYEFAETKFVAVTAYQSERVKQLKVQRNKFAQGFRE 180
Q1T6W8       141 GahnqiGKFQFPETKFIAVTAYQSELVKQLKVQKNKFAQGFRE 183 Caenorhabditis elegans
XP_003103922 282 GatvhvGRFPFVEAKFIAVTAYQSEQVKCLKVQKNKFAQGFRE 324 Caenorhabditis remanei
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