6NYA,1Y8Q,3KYC


Conserved Protein Domain Family
ThiF

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pfam00899: ThiF 
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ThiF family
This domain is found in ubiquitin activating E1 family and members of the bacterial ThiF/MoeB/HesA family. It is repeated in Ubiquitin-activating enzyme E1.
Statistics
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PSSM-Id: 425935
Aligned: 51 rows
Threshold Bit Score: 76.5281
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6NYA_A        410 YDNQIA---VF-GLDFQKKIANS-KVFLVGSGAIGCEMLKNWALLGLgsgsdGYIVVTDNDSIEKSNLNRQFLFRPKDV- 483  Saccharomyces...
XP_025324659   55 YSRQLY---VL-GHEAMKRLQTS-SVLVSGLRGLGVEIAKNIILGGV-----KAVTLHDQGTAQWADLSSQFYLREEDI- 123  dingo
1Y8Q_A         19 YDRQIR---LW-GLEAQKRLRAS-RVLLVGLKGLGAEIAKNLILAGV-----KGLTMLDHEQVTPEDPGAQFLIRTGSV- 87   human
CBZ11876       22 VSPSAQf-aTAdFDPALKDWSFV-KPLVVGAGGIGCELLHLLALSGF-----AHLTVIDMDLIELSNLNRQFLFTHSDI- 93   Leishmania ma...
O65041         25 HGNLVDp-gFVpGPGLRDDIRDYvRILVIGAGGLGCELLKDLALSGF-----RNLEVIDMDRIEVTNLNRQFLFRIEDV- 97   thale cress
P41226        415 YDGQIA---VF-GAGFQEKLRRQ-HYLLVGAGAIGCELLKVFALVGLgagnsGGLTVVDMDHIERSNLSRQFLFRSQDV- 488  human
3KYC_B         31 LAEAVA--------GG--------RVLVVGAGGIGCELLKNLVLTGF-----SHIDLIDLDTIDVSNLNRQFLFQKKHV- 88   human
Q8I553          2 HKTIRK---LF-SDEVCDKIENM-KILLVGAGGIGSEFLKNIITIGC-----KNIDIIDIDTIDITNLNRQFLFKKKDV- 70   Plasmodium fa...
P52488          4 ETSLVT---II-GEDSYKKLRSS-RCLLVGAGGIGSELLKDIILMEF-----GEIHIVDLDTIDLSNLNRQFLFRQKDI- 72   Saccharomyces...
O95352        335 LNLKLMcwrLV-PTLDLDKVVSV-KCLLLGAGTLGCNVARTLMGWGV-----RHITFVDNAKISYSNPVRQPLYEFEDCl 407  human
6NYA_A        484 --GKNKSEVAAEAVCAMNPDLKgkINAKIDK-----VGPe----------TEeifNDSFWESLDFVTNALDNVDARTYVD 546  Saccharomyces...
XP_025324659  124 --GKNRAEVSQPRLAELNSYVP--VSAYTGP-----L------------------VEDFLSGFQVVVLTNTPLEDQLRVG 176  dingo
1Y8Q_A         88 --GRNRAEASLERAQNLNPMVD--VKVDTED-----IEKk----------PE-----SFFTQFDAVCLTCCSRDVIVKVD 143  human
CBZ11876       94 --GKAKSTTAAAAVQARCPGVS--VTAVVGC-----L-E-----------DQ---PDDFYRSFDAVLLAVDSIPARRWIN 149  Leishmania ma...
O65041         98 --GKPKAEVAAKRVMERVSGVE--IVPHFSR-----IED-----------KE----IEFYNDFNIIALGLDSIEARKYIN 153  thale cress
P41226        489 --GRPKAEVAAAAARGLNPDLQ--VIPLTYP-----LDPt----------TEhiyGDNFFSRVDGVAAALDSFQARRYVA 549  human
3KYC_B         89 --GRSKAQVAKESVLQFYPKAN--IVAYHDS-----IMN-----------PDy--NVEFFRQFILVMNALDNRAARNHVN 146  human
Q8I553         71 --KKYKSLVAKERALMHKKDLN--INAYTFD-----VCT------------M---KSSDIKKYDYVINALDNIKARKYVN 126  Plasmodium fa...
P52488         73 --KQPKSTTAVKAVQHFNNSK---LVPYQGN-----VM------------DIstfPLHWFEQFDIIFNALDNLAARRYVN 130  Saccharomyces...
O95352        408 ggGKPKALAAADRLQKIFPGVN--ARGFNMSipmpgHPVnfssvtleqarRDveqLEQLIESHDVVFLLMDTRESRWLPA 485  human
6NYA_A        547 R-RCVF------------YRKP------------------------------------LLESGTLGTKGNTQ-------- 569  Saccharomyces...
XP_025324659  177 E-FCHS------------RGIK------------------------------------LVVADTRGLFGQLFcdfgeemi 207  dingo
1Y8Q_A        144 Q-ICHK------------NSIK------------------------------------FFTGDVFGYHGYTF-------- 166  human
CBZ11876      150 R-KVAEiatrvivptpasASPPaarsaappedavaasaaqapaavyrignyviedaklIIDTGTEGFEGHCR-------- 220  Leishmania ma...
O65041        154 GvACGFleyneddtpkreTIKP------------------------------------MVDGGTEGFKGHAR-------- 189  thale cress
P41226        550 A-RCTH------------YLKP------------------------------------LLEAGTSGTWGSAT-------- 572  human
3KYC_B        147 R-MCLA------------ADVP------------------------------------LIESGTAGYLGQVT-------- 169  human
Q8I553        127 K-LCIM------------EKKV------------------------------------LIEAGSTGYNGQVY-------- 149  Plasmodium fa...
P52488        131 K-ISQF------------LSLP------------------------------------LIESGTAGFDGYMQ-------- 153  Saccharomyces...
O95352        486 V-IAAS------------KRKL------------------------------------VINAAL-GFDTFVV-------- 507  human
6NYA_A        570 ------------VI--I----PRLTE------------------------------SYSS-------------SRD---- 584  Saccharomyces...
XP_025324659  208 ltdsngeqplsaMVsmVtkdsPGVVT------------------------------CLDEarhgfesgdyvsfSEVqgmv 257  dingo
1Y8Q_A        167 ------------ANlgEhefvEEKTK------------------------------VAKVs-----------qGVEdgpd 193  human
CBZ11876      221 ------------VIhmA----HNRTP------------------------------CIECemy--------lyNNG---- 242  Leishmania ma...
O65041        190 ------------VI--L----PGVTP------------------------------CFECtiy----------------- 204  thale cress
P41226        573 ------------VF--M----PHVTE------------------------------AYRApa----------sAAA---- 590  human
3KYC_B        170 ------------TI--K----KGVTE------------------------------CYECh------------PK----- 184  human
Q8I553        150 ------------PI--Y----YNHTK------------------------------CYSCee------------------ 163  Plasmodium fa...
P52488        154 ------------PI--I----PGKTE------------------------------CFEC-------------TKK---- 168  Saccharomyces...
O95352        508 ------------MR--HglkkPKQQGagdlcpnhpvasadllgsslfanipgyklgCYFCndv--------vaPGDs--- 562  human
6NYA_A        585 ------------PPEKSIPLCTLRSFpnkidhtiawakslfqgyftdsaenvnmyltqpnfveqtlkqsgdvkgvlesis 652  Saccharomyces...
XP_025324659  258 elngsqpmeikvLGPYTFSICDTSNFsdyirggivsqvkvpkkisfksllaslaepdfvmtdfakysrpaqlhlgfqalh 337  dingo
1Y8Q_A        194 tkrakldssettMVKKKVVFCPVKEAlevdwssekakaalkrttsdyfllqvllkfrtdkgrdpss-------------- 259  human
CBZ11876      243 ------------ATRETVPLCTLESVprapehcvlyvqlkewpehhrhrsrrrsqggdgdgavagggceedskdgd---- 306  Leishmania ma...
O65041        205 ----------lfPPQVKFPLCTLAETprnaahcieyahliqwetvhrgktfdpdepehmk-------------------- 254  thale cress
P41226        591 ------------SEDAPYPVCTVRYFpstaehtlqwarhefeelfrlsaetinhhqqahtsladmdepqtltllkpvlgv 658  human
3KYC_B        185 ------------PTQRTFPGCTIRNTpsepihcivwakylfnqlfgeedadqevspdradpeaawepteaeararacned 252  human
Q8I553        164 -----------kPKNKTYAICTIRQTpslpehcvawgrlifetffckndnetlidiknhieeeskkrnmdkkeiiififn 232  Plasmodium fa...
P52488        169 ------------ETPKTFPVCTIRSTpsqpihcivwaknflfnqlfasetsgneddnnqdwgtddaeeikrikqetnely 236  Saccharomyces...
O95352        563 -----------tRDRTLDQQCTV--------------------------------------------------------- 574  human
6NYA_A        653 dslsskphnfedcikwarlefekkfnhdikqllfnfpkdaktsngepfwsgakraptplefdiynndhfhfvvagaslra 732  Saccharomyces...
XP_025324659  338 q------------------------------------------------------------------------------- 338  dingo
1Y8Q_A            --------------------------------------------------------------------------------      human
CBZ11876          --------------------------------------------------------------------------------      Leishmania ma...
O65041            --------------------------------------------------------------------------------      thale cress
P41226        659 lrvrpqnwqdcvawalghwklcfhygikqllrhfppnkvledgtpfwsgpkqcpqplefdtnqdthllyv---------- 728  human
3KYC_B        253 gdikristkewakstgydpvklftklfkddirylltmdklwrkrkppvpl------------------------------ 302  human
Q8I553        233 ylfndtikeliylkkdyttipipihfewdeniidlfedesehnqneinidklndnk------------------------ 288  Plasmodium fa...
P52488        237 elqkiiisrdasripeilnklfiqdinkllaienlwktrtk--------------------------------------- 277  Saccharomyces...
O95352            --------------------------------------------------------------------------------      human
6NYA_A        733 ynygiksddsnskpnvdeyksvidhmiipeftpnanlkiqvndddpdpnanaangsdeidqlvsslpdpstlagfklepv 812  Saccharomyces...
XP_025324659  339 -----------------------------------------------------------------------fcaqhgrpp 347  dingo
1Y8Q_A            --------------------------------------------------------------------------------      human
CBZ11876      307 -----------------------------------------------------------------------------rde 309  Leishmania ma...
O65041            --------------------------------------------------------------------------------      thale cress
P41226        729 --laaanlyaqmhglpgsqdwtalrellkllpqpdpqqmapifasnlelasasaefgpeqqkelnkalevwsvgpplkpl 806  human
3KYC_B        303 ----------------------dwaevqsqgeetnasdqqnepqlglkdqqvldvksyarlfsksietlrvhlaekgdga 360  human
Q8I553        289 -----------------nnmgdnkyycnnfkceekdrekddnvlmlssqniwdkkkciemyiktflklykylninkkeee 351  Plasmodium fa...
P52488        278 -------------------------------pvplsdsqintptktaqsasnsvgtiqeqisnfinitqklmdrypkeqn 326  Saccharomyces...
O95352            --------------------------------------------------------------------------------      human
6NYA_A        813 dfekdddtnhhiefitacsncraqnyfietadrqktkfiagriipaIATTTSLVTGLVNLELYKLI----------DNKt 882  Saccharomyces...
XP_025324659  348 rprneedatelvalaravnaralravqqdsldedlirklayvaagdLAPINAFIGGLAAQEVMKAC----------SGK- 416  dingo
1Y8Q_A        260 -------dtyeedselllqirndvldslgispdllpedfvrycfseMAPVCAVVGGILAQEIVKAL----------SQR- 321  human
CBZ11876      310 llnpdnaehvrwvterararqaafgiggapiddlftvgviknvvpaVGFTNAYVAGQAVTELMKWL----------TGCa 379  Leishmania ma...
O65041        255 -------------wvydeairraelfgipgvtysltqgvvkniipaIASTNAIISAACALETLKIV----------SAC- 310  thale cress
P41226        807 mfekdddsnfhvdfvvaaaslrcqnygippvnraqskrivgqiipaIATTTAAVAGLLGLELYKVV----------SGPr 876  human
3KYC_B        361 eliwdkddpsamdfvtsaanlrmhifsmnmksrfdiksmagniipaIATTNAVIAGLIVLEGLKIL----------SGK- 429  human
Q8I553        352 ylifdkdddecinfitsisnirmlnfcisqkskfdiqsiagniipaISSTNAIVASLQAFQLIHVIeyfetlknknNKK- 430  Plasmodium fa...
P52488        327 hiefdkddadtlefvataanirshifnipmksvfdikqiagniipaIATTNAIVAGASSLISLRVLn--------lLKYa 398  Saccharomyces...
O95352        575 ----------------------------------------------SRPGLAVIAGALAVELMVSV----------LQHp 598  human
6NYA_A        883 --------------DIEqYKN----GFVNLALPFFGfsEPIASPkGEYNNKk-----YDK 919  Saccharomyces cerevisiae S288C
XP_025324659  417 ----------------FmPIM----QWLYFDALEC---LPEDKE-ALTEDK------CHP 446  dingo
1Y8Q_A        322 --------------DPPhN------NFFFFDGMKGNgiVE-----------------CLG 344  human
CBZ11876      380 --------------PELnNYA----FYNGATEAGVHtnVEPCRG-SPMHGSgdvagrCLV 420  Leishmania major strain Friedlin
O65041        311 ----------------SkTLV----NYLTYNGGEGL--YTEVTK-FERDTE------CLV 341  thale cress
P41226        877 --------------PRSaFRH----SYLHLAENYLIryMPFAPAiQTFHHL------KWT 912  human
3KYC_B        430 ----------------IdQCR----TIFLNKQPNPRkkLLVPCAlDPPNPN------CYV 463  human
Q8I553        431 --------------NNNnNKK----NNNNNNNNNNEnnVSYCDE-EENKTDhfnirnSKA 471  Plasmodium falciparum 3D7
P52488        399 --------------PTTkYTDlnmaFTAKASNLSQNryLSNPKL-APPNKN------CPV 437  Saccharomyces cerevisiae S288C
O95352        599 eggyaiasssddrmNEPpTSL----GLVPHQIRGFLsrFDNVLPvSLAFDK------CTA 648  human
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