3RIO,6TWR,4R6I,4R6I


Conserved Protein Domain Family
PRD

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pfam00874: PRD 
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PRD domain
The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator such as BglG, SacY and LicT, as well as in activators such as MtlR and LevR. The PRD is phosphorylated on one or two conserved histidine residues. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterized by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators pfam03123) or DNA (for activators), and a duplicated PRD module which is phosphorylated by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations modify the conformation and stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain. The structure of the LicT PRD domains has been solved in both the active (pdb:1h99) and inactive state (pdb:1tlv), revealing massive structural rearrangements upon activation.
Statistics
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PSSM-Id: 459973
Aligned: 164 rows
Threshold Bit Score: 32.9953
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3RIO_A        89 NDVIYHI-SNRTNHSL----NEHIHIALTDHIAFAIKR-QQQGf--DMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGL 160  Bacillus subtilis
Q837K8        21 QSIIKQTsARLAEAQIe--pTELQWTILINHLNEMLNR-SREGt--TLAGVDRTLFTELTPETLKIAEETTEAIGQ---- 91   Enterococcus f...
4R6I_B       182 TDLINKX-EKILNVQX----YTYSKHKLCVLFAITISR-LLSGn--TIDNVSGLILVNKNDDHYKTVASITSELQNSFGV 253  Bacillus anthr...
Q82ZR7       475 QEAIVFF-EQLIQEKL----TEDFQNILIVHLYSAVFYsAQMNe--TFYSDTKNIYSGK-VTQYQAAKTMVDFLQTLFGI 546  Enterococcus f...
Q82YX2       282 QKMMKKI-HHSVVVEFd---EDFLFSEMKDHLRNVMNR-LVFHv--ECHDLFYGEIERQYPLAYELAKIGLQELGRLLNR 354  Enterococcus f...
WP_002262909 282 QSFVKKV-KDTLLVNFd---EQRLFAEIQTHLKFLINR-LIFHv--QANDIFHREIQNKYPLAFEMAKVAGDDLKNHFGC 354  Streptococcus ...
Q8Y9A2       298 NSLITSM-SEELNLPFl--eDAILYKGLLNHVAPLIER-VRGNv--QIYEDTFDVIPTEFLYILQATSKVVKTIPL-LES 370  Listeria monoc...
Q8Y8M4       286 TGICEKM-GEIYQVDFvh-gDTDFYTQIKAHIKLMIRR-VRAGv--IIENPIFNEFMRDNREIFMRVKESLEALKPLLPI 360  Listeria monoc...
Q839Y1       855 IDLLWSF-AKNIQTQLampeEYTFYINLIMHTSGMLER-ILRNdtlTVSEKELGRLVQ--EPIYPVIVSSIETMEEALNM 930  Enterococcus f...
P54901       130 qALVNLC-SRRLQKRF----ESRDIHFLCLYLQYCLLQ-HHAGi--TPQFNPLQRRWAESCLEFQVAQEIGRHWQRRALQ 201  Escherichia co...
3RIO_A       161 CLPEGEIGFIALHIHSA 177  Bacillus subtilis
Q837K8        92 -LSEDEWYVLAVHFEVA 107  Enterococcus faecalis
4R6I_B       254 TLHETEISFLAL---AL 267  Bacillus anthracis str. 'Ames Ancestor'
Q82ZR7       547 SFADTEILFFDLFIRKV 563  Enterococcus faecalis
Q82YX2       355 CVPTVEFGYLALYFELA 371  Enterococcus faecalis
WP_002262909 355 QLELSEMSYLALYFEmi 371  Streptococcus mutans
Q8Y9A2       371 VENESEISLLAIHFLAS 387  Listeria monocytogenes
Q8Y8M4       361 SVSSQEISFLAIYFASE 377  Listeria monocytogenes
Q839Y1       931 DVPAEEVYFIAQLVKNA 947  Enterococcus faecalis
P54901       202 PVPPDEPLFMALLFSml 218  Escherichia coli K-12
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