5WW0,1N3J,3QXY,4LDG,6A5K


Conserved Protein Domain Family
SET
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pfam00856: SET 
SET domain
SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.
Links
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Statistics
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PSSM-Id: 459965
Aligned: 257 rows
Threshold Bit Score: 36.347
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5WW0_A        25 GRGVFALEPIPAQTCI-------------E--IS----------------PVLMFSKEEYEQHG--QYTVL--------- 62   Schizosaccharo...
O46040        66 GRGVFATRDIAAGELI----------------FQ----------------ERALVTGPTARKGQlsSCICChetlpqtgf 113  fruit fly
Q0UEF6       373 GRGLFATRNLATGEVI----------------MC----------------EKAFCVVWGYEREAmtAMTYDlrddrirvs 420  Parastagonospo...
Q2HEQ8       345 GRGLFATRALRAGDLV----------------FA----------------EKATLMPNQYEPARasAALYAlmvrqlcdn 392  Chaetomium glo...
Q9LQX6       623 GRGLFATKNIVAGTLVlvtkavaiergilGngECg---------------EKAQLIMWKNFVEEvtESVRKcgrtrrvvs 687  thale cress
XP_001269014 364 GRGLFTTAPVRAGDLL----------------FCekafthvfydtessdgGLTLLINVQEDAMTigAQASLialiaqkly 427 
CAK96264     360 GRGLFTTQAVRAGDLLicekafahafhddG--DNt---------------NVSILVYADTNSMKvgTQAELnsliarklq 422 
Q0CYZ2       363 GKGLFTTEAVKAGDLLfcekalayafhdeT--APk---------------ELSLLLNAETDNVTlgKQGELieaivqrly 425  Aspergillus te...
Q10E90        26 GRGLFAARSFFPGEVVisqe------pyaS--TP----------------NKISVGSNCDNCFAsrNLRKCsvcrvawyc 81   Japanese rice
Q5BJI7        18 GRGLKAIKHFKVGDLVfacp---------ayaYVltvne------rggrcECCFTRKEGLSKCGkcKQAYYcnvecqrgd 82   zebrafish

5WW0_A        63 ------------------------------------------NEYTYV-WS----------------------------- 70   Schizosaccharo...
O46040       114 lcrhrct-------------------lpvcetcsdseehqaeCEHFRR-WQpkdvdaeqeqvnpmslriltavrvfhlgk 173  fruit fly
Q0UEF6       421 piglsralvqklis-----npsqipavmdlygdwagsdsneeVVDVFR-IHdimsrna---------------------- 472  Parastagonospo...
Q2HEQ8       393 pslagpvlrl-------------fdggyergggvgemvdgvpVVDVFL-VEairtrncf--------------------- 437  Chaetomium glo...
Q9LQX6       688 alstgqgedsleip-----eialfrpdeafetcgdwkqsldtEKLLSI-LDvnslved---------------------- 739  thale cress
XP_001269014 428 ktpslmptftdl----------yhgsykpvkvsevdgtpvvdTFLIERtMSlnvfgcplssre----------------- 480 
CAK96264     423 knpslip--------------------afndlyhgsytpvgvSERIMS-LNgfgcsttsr-------------------- 461 
Q0CYZ2       426 knpsllpsfa-------------dhhhgtykpvnvqeadglpIIDSFL-VErivqlncfgcpl----------------- 474  Aspergillus te...
Q10E90        82 ---------------------------------gsacqreewKLHQLE-CRaiaaltedrkkmltptirlmvrlvlrrkl 127  Japanese rice
Q5BJI7        83 wpmhklecsamcaygenwcpsetvrlvariilkqkhqtertpSERVLT-LReleahldkldneknemndtdiaalhhf-- 159  zebrafish

5WW0_A        71 ----------------------------------------------------------------------EG------KQ 74   Schizosaccharo...
O46040       174 eqrhlvdamqan-----------------aerayrreiiqaaqcfrnfpttdrvfmdqlfrivgvlntnaFE------AP 230  fruit fly
Q0UEF6       473 ----------------------------------------------------------------fgpgnqFGee---nAR 485  Parastagonospo...
Q2HEQ8       438 ---------------------------------------------------------------saprstwEDtrpsapEG 454  Chaetomium glo...
Q9LQX6       740 ----------------------------------------------------------------avsgkvMG------KN 749  thale cress
XP_001269014 481 ----------------------------------------------------------shiramrkmtpqVK------GR 496 
CAK96264     462 --------------------------------------------------------------tahiarvnAD------NR 473 
Q0CYZ2       475 -----------------------------------------------------------lsrdshigamsSD------DT 489  Aspergillus te...
Q10E90       128 qddkaipssgtdnynlvdaleshisevdknqlvlyaqmanlvqlilpsfeldlkeithtfskfacnahtiCD------PE 201  Japanese rice
Q5BJI7       160 --------------------------------------------ysrhldfpdnaalteliaqvncngftIEd-----EE 190  zebrafish

5WW0_A        75 GLALGLGS-----------MFNHdrhpNV--YWKKdnrNNYISYYTLREIKTNEELCISYG 122  Schizosaccharomyces pombe 972h-
O46040       231 CRSGGHETllrgl-fpltaIMNHectpNAshYFEN---GRLAVVRAARDIPKGGEITTTYT 287  fruit fly
Q0UEF6       486 NASTGLWVya--------aYINHscipNAtkEYI----GDMMILRATRAIAAGEEIFHAYD 534  Parastagonospora nodorum SN15
Q2HEQ8       455 RQCKGLWVha--------sYMNHdcvaNTmrSFV----GDMLVSRATRDIEEGEELFQQYV 503  Chaetomium globosum CBS 148.51
Q9LQX6       750 KEYYGVGLwtl------asFINHscipNAr-RLHV---GDYVIVHASRDIKTGEEISFAYF 800  thale cress
XP_001269014 497 DAFHSCGVwal------asYINHscysNAq-RSFI---GDMMIVRATQDLPANTEIAFWYQ 547 
CAK96264     474 EPHTEEEHfyssgvwrlasYVNHscypNTh-RAFI---GDMMVVRATQDLPANTELKFWYR 530 
Q0CYZ2       490 AQKADKKFnscgf-whmasYINHsclsNAr-RSFI---GDMMVVRATQDLAPNTELTFWYK 545  Aspergillus terreus NIH2624
Q10E90       202 LRPLGTGLypv------lsIINHscvpNAv-LIFE---GRTAYVRALQPISKNEEVSISYI 252  Japanese rice
Q5BJI7       191 LSHLGSALfpd------vaLMNHscspNVivTYKG----TVAEVRAVQEINPEEEIFNSYI 241  zebrafish
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