6BOX,2G46,4RZ0,3EP0


Conserved Protein Domain Family
SET

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pfam00856: SET (This model is not part of the current CDD release)
SET domain
SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.
Statistics
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PSSM-Id: 513801
Aligned: 255 rows
Threshold Bit Score: 37.1218
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6BOX_A       152 GWGVRSLRFAPAGTFITcYL--GE-VITSAEAAKRDKNYDDDGI------------------------------------ 192 Schizosaccharom...
Q98RN8        99 GRGLIASRNILKNEKIIeIS--ENlMFDKFEHNLEINSNGSDNYsdlaikllvelfknkk-------------------- 156 Guillardia theta
Q803K4        48 EYGMLAKEDIEEGHVLFtIP--REaLLHQGTTKVKKVLEEGKKClesasgwvpllls----------------------- 102 zebrafish
Q8TBK2        74 GYGMVARESVQAGELL--FVvpRAaLLSQHTCSIGGLLERERVAlqsqsgwvpllla----------------------- 128 human
EDO37756      44 RYGMVAMEDISPDECLFkVP--RGlLLEPKTCGISKILTGKVIQnmlsqhegwvplll---------------------- 99 
A4QNG5        50 QYGMLAREDLSDGELLFsIP--RSaILSQNTTRIRDLIEKEQDSlqscsgwvpllis----------------------- 104 tropical clawed...
Q55XR7        42 GYRIVAERDIEIGELLLsLP--KHsILSHQTASLSAITHLSSAShtilnlslcllh------------------------ 95  Cryptococcus ne...
O42925        37 GDGIFSTFDIDELEVLAkIP--RRiILSPRNSRFGDSLYTHFNEsnrsddinfdnrdqvglv------------------ 96  Schizosaccharom...
XP_001417799  54 GRGVRATRDLRVGEVVVsVP--DDaVLTVDACAVKKELGEFVGDgddeapsprldkellv-------------------- 111
Q57UB6        33 GHGVIATENLPSNTVIVkIP--ESsMITAQKARNHLNFWISQQKqerlgwtpfdgrsrretsvdilgdldqmlspgsmii 110 Trypanosoma brucei
6BOX_A       193 --------------------------TYLFDldmfdd------------------------------------------- 203 Schizosaccharom...
Q98RN8       157 ----------sfwfpyigilpeeydlKLLFRwplkelffikgsrlskasdylk--------------------------- 199 Guillardia theta
Q803K4       103 -------------lmyeytsstshwkPYLSLwpdfrtldqpmfwseeecdkllkgtgipesvitdlrklq---------- 159 zebrafish
Q8TBK2       129 -------------llhelqapasrwrPYFALwpelgrlehpmfwpeeerrcllqgtgvpeavekdlanir---------- 185 human
EDO37756     100 ------------almyeytnptslwkPYMDIvpgidildqpmfwpdetrqsllqgtgfeddveddkqrier--------- 158
A4QNG5       105 -------------llyeatdssshwaPYFGLwpeldppdmpmfwseeeqtkllqgtgileavhkdlkniekey------- 164 tropical clawed...
Q55XR7        96 ---------------eirlsvnskfyGYLQSlprdmgaglplfwqtgegvevedgerglqwlksteaekelrks------ 154 Cryptococcus ne...
O42925        97 ---------mlvitvilenitdspwnAYLNTldetcmpdspllwkdktclegtsmldvintnlrvy-------------- 153 Schizosaccharom...
XP_001417799 112 ----------iavmcemcagkssawcEYLETvheavrvghsvlawddeqvtalfgtdawrdayenddetldl-------- 173
Q57UB6       111 fsllvaagqcgrfsnnafhkkagsasEVMFTvstgggnadlgpffihrwmrtwllslptkydnllellehthldstcvgv 190 Trypanosoma brucei
6BOX_A       204 ------------------------------------------------------------------------------as 205 Schizosaccharom...
Q98RN8       200 --------------------------------------------------------------kklkaqyemvnkevfqrn 217 Guillardia theta
Q803K4       160 --------------------------------------------deynsvvlpfmkshpdlwdpekhnlelykslvafvm 195 zebrafish
Q8TBK2       186 --------------------------------------------seyqsivlpfmeahpdlfslrvrslelyhqlvalvm 221 human
EDO37756     159 --------------------------------------------qyftvavpimkkfkkffdlkrhslslykhmaafima 194
A4QNG5       165 -----------------------------------------nsivlpfirrnpekfcpmkhtldlykrlvafvmaysfqe 203 tropical clawed...
Q55XR7       155 -----------------------------------------erqglslsdvyafylrtshllpptptdplpspflafvha 193 Cryptococcus ne...
O42925       154 -------------------------------------------------knqydqlvrpyfykhadlkqlcpkwnqylet 184 Schizosaccharom...
XP_001417799 174 ------------------------------------------pmmteehfenvvtlffklfpklasglsvealrelhfaa 211
Q57UB6       191 arshdcegggaclrnflcferhrrkvleermqlekefnivmsilslhlplvqpsggctmscatpftmqqfiwayntlmsr 270 Trypanosoma brucei
6BOX_A       206 eytVD--AQNYGDVSr-------------------------fFNHS-----Cs------------pNIAIYSAVR----- 236 Schizosaccharom...
Q98RN8       218 rllYPskIFNYQNWEwsmsillsrtislqetkkvvlipyidlLNHNp-------------------FSSSFISYRki--- 275 Guillardia theta
Q803K4       196 aysFQepVEDDDEDEeddekkpnl---------pmmvpmadmLNHI-----Sk------------hNANLEYTP------ 243 zebrafish
Q8TBK2       222 aysFQepLEEEEDEKepnspvm--------------vpaadiLNHl-------------------aNHNANLEY------ 262 human
EDO37756     195 ysfTEdsPSFHGNNVpvmvp------------------madiLNHh-------------------sNNNARLEF------ 231
A4QNG5       204 pqeEDeeEDIEKDILppmmv-----------------pvadlLNHV-----Aq------------hNAHLEFTP------ 243 tropical clawed...
Q55XR7       194 ytlIStrAFLIDLYHltalc-----------------pfadlLNHSavphtClasddfvcyicgslNVCEHDLSRpdgld 256 Cryptococcus ne...
O42925       185 cvlVQsrCFYVNSYYglsli-----------------pffdiFNHK-----Sgpai-------aslHCQESNDHK----- 230 Schizosaccharom...
XP_001417799 212 tamVAgySFTLGDDEiqamv-----------------pfwdmLNHa-------------------pPCEASVRLHh---- 251
Q57UB6       271 gfsYDpeVWAVIPWVd-------------------------yFNHS-----Lt------------nNATMRFDR------ 302 Trypanosoma brucei
6BOX_A       237 --------------------NHGFRtiydLAFFAIKDIQPLEELTFDY 264 Schizosaccharomyces pombe 972h-
Q98RN8       276 ------------------plSDSKE----IVVYSDKNCNKFDQLYISY 301 Guillardia theta
Q803K4       244 -----------------------EC----LKMVSIRRIGKGEEVFNTY 264 zebrafish
Q8TBK2       263 ---------------------SANC----LRMVATQPIPKGHEIFNTY 285 human
EDO37756     232 ---------------------GEEE----LSMVSTQHILKGGEVFNTY 254
A4QNG5       244 -----------------------EC----LRMITTKSVCAGQELFNTY 264 tropical clawed frog
Q55XR7       257 engtprrlahlsqmeitrlkNENDN----IEMRLERPVRKGEEVFNTY 300 Cryptococcus neoformans var. neoformans B-3501A
O42925       231 ---------------------GDIK----IEFISFQYIRKMSEIFNSF 253 Schizosaccharomyces pombe 972h-
XP_001417799 252 -------------------dQKNGC----LQMITVRGVKKGEEVFNTY 276
Q57UB6       303 ---------------------CMGA----YIFVTTAPVSKGDQVFLQY 325 Trypanosoma brucei
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