1C3S,5ZOP


Conserved Protein Domain Family
Hist_deacetyl

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pfam00850: Hist_deacetyl 
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Histone deacetylase domain
Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins.
Statistics
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PSSM-Id: 425906
Aligned: 68 rows
Threshold Bit Score: 200.54
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1C3S_A                           21 HPLKIPRVSLLLRFKDA------M-N----LIDEKEL--IKSRPATKEELLLFHTEDYINTL------------------ 69  Aquifex aeolicus...
jgi:OSTLU_40681                  34 HRFPMTVFQRVHDILREeg--viArGqtncFVPG--------RAPSVDELCRAHDEDYVRDV------------------ 85  Ostreococcus lucimarinus CCE9901...
dbos:1099484000100_PB2503_04457  17 HRFPAIKYQLLKTALIEer--llPaEr---LAPS--------PAAREGEIKVAHTESYIASL------------------ 65  Parvularcula bermudensis HTCC2503...
EDW39156                         39 HPFNAAKGKHIHKALCAel--slVeGs--fYEP---------EELTKHQLRRIHTREYLRSL------------------ 87  Drosophila persimilis...
Q4QAJ4                          102 HLMRPSRVR-ALHALVH------SlG----LDNAECMtvCHARPATAEEMGAFHRSAYLECL------------------ 152 Leishmania major...
EDO32559                         33 LPKVTGRAS-LTSSLIE------AyG----LLKDRNIrvIAPRKATASELAAFHSSEYVNCM------------------ 83  starlet sea anemone...
Q6C3Y5                           64 RPSNEGRAA-LVDSLLValqlhkSyK----LIPI--------TPATAAELQRYHSLEYVSAV------------------ 112 Yarrowia lipolytica...
XP_001386791                     31 LPSNKGRQS-LISSLLS------AyG----LR-ERCYgiIGEYRASRQELASYHDENFVDFLlqdrl------------- 85  Scheffersomyces stipitis CBS 6054...
XP_001642860                     20 LPCNKYKKSQLTYSLLV------SyG----LL-DGFDviIDDPCCNKKDLLQFHSRDYIDLLldpvynriiqydddeskw 88  Vanderwaltozyma polyspora DSM 70294...
Q6FWB7                           19 LPCNKRQKSQLIYSMLE------SyG----LL-ECFDhiIDVPSCQRKDLEKFHSKDYLNVIldeqlnwnpqidgnedql 87  [Candida] glabrata...
1C3S_A                           70 ------------------------------------MEAERSQsvpkg----arekyNi--------------------- 88  Aquifex aeolicus...
jgi:OSTLU_40681                  86 ------------------------------------RASALDAkrere-------------------------------- 97  Ostreococcus lucimarinus CCE9901...
dbos:1099484000100_PB2503_04457  66 ------------------------------------REGTIDPramrr-------------------------------- 77  Parvularcula bermudensis HTCC2503...
EDW39156                         88 ------------------------------------RWSLNVAriaevs------------------------------- 100 Drosophila persimilis...
Q4QAJ4                          153 ------------------------------------RQAPVICgnpldemslafqkeFdv-------------------- 176 Leishmania major...
EDO32559                         84 ------------------------------------RRAAEAVsdgsee--cedlveF---------------------- 103 starlet sea anemone...
Q6C3Y5                          113 ------------------------------------LKKGQSEkt-----------lDk--------------------- 124 Yarrowia lipolytica...
XP_001386791                     86 -------------------------------rldrtVTSL-ASnhdtindeisisesQr--------------------- 112 Scheffersomyces stipitis CBS 6054...
XP_001642860                     89 sqlhpyirdwldshpeevptsgmiekragllefykkY---NRFkkkrsis-eafsesEsesesgsgsgseaneyfqinns 164 Vanderwaltozyma polyspora DSM 70294...
Q6FWB7                           88 melrkawn---dittsneaskpdfktysellhyyrdHIEVSEHnkkrtaleaelsdvEsgdevt---------------- 148 [Candida] glabrata...
1C3S_A                           89 ------G-------GYeNPVSYAMFTGS-----SLATGSTVQAIEEFL-----KGnVAFNPA--GGMHHAFKSRANGFCY 143 Aquifex aeolicus...
jgi:OSTLU_40681                  98 ---------------iglpwSDALVERT-----LMEVSGTMLTVDLAMk-------VGLCVNtaGGTHHAHRDRGSGFCI 150 Ostreococcus lucimarinus CCE9901...
dbos:1099484000100_PB2503_04457  78 ---------------igfpwSPHIHRRG-----QRTVGGALAAARRALk-------EGLSGQlaGGTHHAHAEAGSGYCI 130 Parvularcula bermudensis HTCC2503...
EDW39156                        101 ---------------lmafvPNKYLQQAylrpmRFQAAGSILAGKLALd-------YGWAINlgGGFHHCCSNRGGGFCP 158 Drosophila persimilis...
Q4QAJ4                          177 ----pfAsq----dSD-CPLFPEVWALV-----SSQAGASLACAEALV-----RGdATVAMNwaGGMHHAAAAHASGFCF 237 Leishmania major...
EDO32559                        104 ------Gl-----gYD-CPPFEDMYDCV-----SMIAGATLLAADMLK-----TGqAKVAVNwqGGWHHAQRDEAAGFCY 161 starlet sea anemone...
Q6C3Y5                          125 -----mGl-----iHD-CPIFPGLDAYV-----KLVAGSTLSCARQLM-----SGqHQLCINwyGGRHHGKRSAASGFCY 183 Yarrowia lipolytica...
XP_001386791                    113 -----yGl-----vHD-CYIFPFIGEYV-----RAVGGSSIASAKTLIreassSIqNVV-VNwyGGRHHCTKSRAAGYCY 175 Scheffersomyces stipitis CBS 6054...
XP_001642860                    165 rerqqdVykkfnleGD-CPLFSFLPLYC-----EVISGASLMLSDFIEk---sSSqRTIAINwdGGRHHAIKNKASGFCY 235 Vanderwaltozyma polyspora DSM 70294...
Q6FWB7                          149 rrstlaKfn---llDD-CPIFPYLPLYC-----YVSTGATLSLAQYILe----GSeRTIAINwdGGRHHSMKTKASGFCY 215 [Candida] glabrata...
1C3S_A                          144 INNPAVGIEYL--RKkGF-K---RILYIDLDAHHCDGVQEAFYDTDQVFVLSLHQSPEYAFPfEKGFLEEIGEGKGKG-- 215 Aquifex aeolicus...
jgi:OSTLU_40681                 151 VNDLAVSALRA--ID-SGaVs--RVMIIDLDVHQGDGTAAILANEPGVFTFSAHA--KSNFP----ARKQQ--------- 210 Ostreococcus lucimarinus CCE9901...
dbos:1099484000100_PB2503_04457 131 YNDFAVVARTL--LN-EGvVd--RIAIVDLDVHQGDGNAAMLTDHPGVYILDVFG--EKNFP----FRKVP--------- 190 Parvularcula bermudensis HTCC2503...
EDW39156                        159 YADISLLIVRL--FE-QEpCrvrRIMIVDLDAHQGNGHERDFNNWETVFILDIYN--AFIYP-RDHAAKLS--------- 223 Drosophila persimilis...
Q4QAJ4                          238 VNDIVLCIRRLl-RY----Yq--RVLYVDLDVHHGDGVEGAFYGNHRVMTLSLHQFGNGFFP-GTGDYPTR--ETADS-- 305 Leishmania major...
EDO32559                        162 INDIVLGILKL--RE--K-Yd--RVLYVDLDVHHGDGVEDAFSFTPKVMTVSFHKYSSGFFP-GTGSCCQVGHGKGRY-- 231 starlet sea anemone...
Q6C3Y5                          184 VNDVVLGIQEM--RK--Q-Yq--KIMYIDVDLHHGDAVSAAFLHSKNVLCVSLHHYDTGFFP-GTGALSDC--GSGPGey 253 Yarrowia lipolytica...
XP_001386791                    176 INDVVLAIGVLr-KK----Fr--RIFYLDLDLHHGDGVESGYEHSKNVFTCSIHRYDLGFYP-GTGRM-----ADSKS-- 240 Scheffersomyces stipitis CBS 6054...
XP_001642860                    236 INDIVILIQKLrkKG----Is--KVSYIDFDLHHGDGVEKAFRYSSNIQTISMHMYEPGFFP-CTGSLEDT--LNGK--- 303 Vanderwaltozyma polyspora DSM 70294...
Q6FWB7                          216 INDIALLIMTLrrGG----Vd--RISYVDFDLHHGDGVEKAFKYSKQVQTISLHMYETGFFP-CSGSLEDN--SSGK--- 283 [Candida] glabrata...
1C3S_A                          216 YNLNIPLPKGLNDNEFLFALEKSLeIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVREVFGEG----VY 291 Aquifex aeolicus...
jgi:OSTLU_40681                 211 STRDVELPRGMTDDAYMAVVAAAMrESLEDFRPELVIYDAGVDVTSNDTLGHLDLTVEGLYRRERMVMDTVLGAgiplAG 290 Ostreococcus lucimarinus CCE9901...
dbos:1099484000100_PB2503_04457 191 ATLDVPLPDRTEDGAFLAAIEAHLpQVWA-FEPDLLLYQAGVDPLASDKLGRLDISFAGLMDRDRMVLGGAWQRgipvSM 269 Parvularcula bermudensis HTCC2503...
EDW39156                        224 IRCGVELQNQTEDAYYLRQLSRCLmQSLADFRPDVVIYNAGTDVLKGDPLGNLDISAEGVLERDRLVFSTFRALgipvVM 303 Drosophila persimilis...
Q4QAJ4                          306 FAINVPLPTRTGDAAYLLSFRTALsSVVQCFDPEAMVVQCGADTIAGDLIGRLCVTTLAHTQCVADVLSLERp----tVL 381 Leishmania major...
EDO32559                        232 YTLNVPLKDGITDRPFVEVFTRVMsRVKAKFKPDAIVCQCGVDSLAGDPMKAFNLTQFAVGRCVKYLQGWNLp----mLV 307 starlet sea anemone...
Q6C3Y5                          254 HTANVPLRKGFGDQSLDRVFHSIVeGYYEAYQPTAVVLLLGCDGLATDEHKKWNLSVPGLGEIVRKVASWKKp----tLV 329 Yarrowia lipolytica...
XP_001386791                    241 KKVNIPTRRGLSDNSLLYIIKNIVvPLIMGFEPEVIIIQAGCDGLGTDTHKEWNLTIKGFSQVLDFLLKEFEPIp--fLI 318 Scheffersomyces stipitis CBS 6054...
XP_001642860                    304 NIVNVPLYHGVDDNYMTEIVNELIkPLIERHSPEVLVIQCGGDGLIGDKFEEWQLTISGLTRNIQNLIEWFPKSd--iIL 381 Vanderwaltozyma polyspora DSM 70294...
Q6FWB7                          284 SIVNIPLLHGLDDSTLQDIAKRIIvPSISKHQPNVIVIQCGGDGLKGDKYSEWQLSIKGLTSTITSLIEQFNCh---iVL 360 [Candida] glabrata...
1C3S_A                          292 LGGGGYHPYALARAWTLIWCEL 313 Aquifex aeolicus
jgi:OSTLU_40681                 291 VVGGGYSPDIDELASRHAVLHR 312 Ostreococcus lucimarinus CCE9901
dbos:1099484000100_PB2503_04457 270 AIGGGYADPIGDSVRAYANTYK 291 Parvularcula bermudensis HTCC2503
EDW39156                        304 LLSGGYTKASAHVIADSIVNLR 325 Drosophila persimilis
Q4QAJ4                          382 LGGGGYHVFHTARCWAIHTATA 403 Leishmania major
EDO32559                        308 LGGGGYNMVNTSRCWTYVTGVI 329 starlet sea anemone
Q6C3Y5                          330 LGGGGYNHTDTARCWTYSTAVC 351 Yarrowia lipolytica
XP_001386791                    319 LGGGGYNHTETAKCWAHATRTI 340 Scheffersomyces stipitis CBS 6054
XP_001642860                    382 LGGGGYNELVMSRFYTYLTYQI 403 Vanderwaltozyma polyspora DSM 70294
Q6FWB7                          361 LGGGGYNNLLMSRFYTYLTWSI 382 [Candida] glabrata
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