2XR8


Conserved Protein Domain Family
Ring_hydroxyl_A

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pfam00848: Ring_hydroxyl_A 
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Ring hydroxylating alpha subunit (catalytic domain)
This family is the catalytic domain of aromatic-ring- hydroxylating dioxygenase systems. The active site contains a non-heme ferrous ion coordinated by three ligands.
Statistics
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PSSM-Id: 425905
Aligned: 42 rows
Threshold Bit Score: 105.23
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2XR8_U            183 LE-TYLGDARPYMDvmldrtpagtvaiggmqkwvIPCNWKFAA---EQFCSdMYHAGtTTHLSGILAGIPPEMDlsqa-- 256 Paraburkho...
WP_011906730      190 LE-TWYYHKSKAMK---------------------GANWKVAY---DGYLE-GYHFQ-AAHTNT-----VATRS------ 231 Novosphing...
jgi:Saro_3490     189 FG-NWSYMGSRVIE---------------------GANWKIAY---DGYLE-GYHFA-SLHPQT-----IFPRT------ 230
Q3S4D0            157 lM-DYLGDAAWYLEpifkhsggle-lvgppgkvvIKANWKAPS---ENFVGdAYHVG-WTHASSLRSGQSIFTPlagn-- 228 Polaromona...
P0ABR5            163 LR-DYLGDIAWYLDgmldrreggteivggvqkwvINCNWKFPA---EQFASdQYHAL-FSHASAVQVLGAKDDGsdkrlg 237 Escherichi...
zhongguo:Q91_1785 169 LD-EYLSDSKPYIDvmfnrteagteaiggiqkwvIPTNWKFAA---EQFCSdMYHAAtMSHLSGFTAGLPEELNlndi-- 242
jgi:Swit_0336     245 LGeRSPRLAARTVD--------------------YRHNVRDFVlmlEQDLK----ASiPPHMAGLMDRLVEELP------ 294
jgi:Swit_2271     192 ME-RMAWVRDITVE--------------------WDCNWKASV---DAFSE-VYHVQ-GIHPQLQWYLDDTNAQidvyer 245
WP_011906783      180 LD-NWVRVLNVSAD--------------------CDFNWKIIR---DNFNE-SYHLP-TIHPELATFINDGLPTtvfemy 233 Novosphing...
WP_011906752      182 MD-TAVRVAWYRIE--------------------LNANWKFVT---DNFSE-SYHTR-TAHPQVPPWIDQDVDSarhemw 235 Novosphing...
2XR8_U            257 -------------------------qipTKGNQFRAAWGGHGSGWyvdepgsLLAVMGPKVTQYWTEgPAAELAEqrlgh 311 Paraburkho...
WP_011906730      232 ----------------------------PSNRASYEGFGPHIRLG--------FPQ-NTIT-RLHEL----PRDE----- 264 Novosphing...
jgi:Saro_3490     231 ----------------------------PSNCMHYEGFGPHQRIG--------FPQHRIAE-ALKDV----PREE----- 264
Q3S4D0            229 -------------------------amlPPEGAGLQMTSKYGSGMgvlwdaySGVHSADLVPDMMAFgGAKQEKLakeig 283 Polaromona...
P0ABR5            238 dg------------------qtarpvweTAKDALQFGQDGHGSGFfftekpdANVWVDGAVSSYYREtYAEAEQR----- 294 Escherichi...
zhongguo:Q91_1785 243 -------------------------dipTQGNQFRAKWGGHGTGYyvdqpglLQCIMGPAITEYITTsPQAEIASkr--l 295
jgi:Swit_0336     295 -----------------------------AEASLLDVLMKYGQIA-----------------YEAAGeRGIPFPA----- 323
jgi:Swit_2271     246 hsrylvpfa----cvsgrvalpssippaIHDIMVKAGMDPADYDGrv---sdIRRDVQLFKREHGAS-QGKDYSA----- 312
WP_011906783      234 enghnamwmighqatsrkdyvsgdvppgLYEAAEAWGIDPKEYRGrt---adIREAVIKAKRERGAE-AGYD-YS----- 303 Novosphing...
WP_011906752      236 paghgrtvqp--mrpsltdrpadgtehmFAHILRAWDIDPAKYSSyeefalqGWKDLKQAKRRLWRE-RGYVHYE----- 307 Novosphing...
2XR8_U            312 TGMPVRRMVGQHMTIFPTCSFL--PTFNNIRIWHP--RGPNEIEVWAFTLVDAD------------APAEIKEEYRRHNI 375 Paraburkho...
WP_011906730      265 WGRQENKGYDFIRMLFPNMSFFlaPEMGQLAQLFP--GPQANQNTTVMNYIFPVk----------pETEEGLAALDQMCD 332 Novosphing...
jgi:Saro_3490     265 WGTQENNGFDFVRIMFPNVSAFiaPEITQIAQLFP--GPTPGENRTVLNYLRREp----------iRDEEDRANVEAAMN 332
Q3S4D0            284 DVRARIYRSHLNCTVFPNNSIL--TCSGVFKVWNP--IDENTTEVWTYAIVEKD------------MPEELKIRLADAVQ 347 Polaromona...
P0ABR5            295 LGEVRALRLAGHNNIFPTLSWL--NGTATLRVWHP--RGPDQVEVWAFCITDKA------------ASDEVKAAFENSAT 358 Escherichi...
zhongguo:Q91_1785 296 GPMFGQRMMGQHMTIFPTCSFL--PGVNTIRTWHP--RGPNEIEVWAFIVVDAD------------APDHIKEEFRKQNI 359
jgi:Swit_0336     324 LTPEEIARAGADWHLFPNMVFLpaPDAMLAYRARPdrDDPERCIFEVYSLLLYPe----------gEEPPLERQCFADWK 393
jgi:Swit_2271     313 -LNDDQLTDDYHYTIFPNVSLNvhADDVMMFRQRPhpTDPDKMLYDIWMLELVPe----------gEEWP-ERPRHKRFR 380
WP_011906783      304 TMTDQQLVDYFHCTLFPNLTITmsPEQCQILRTEPhpTDPEKCVFQHWCLYPPNakmaev-vtpvgPAPLRHDAIHRHSV 382 Novosphing...
WP_011906752      308 NMDDEEITDSPHTVIFPNVTISflPDNLILFRSEPhaTDPEKCYFDLWCMAFPVegqsevesimagVRPLREVAECEHRV 387 Novosphing...
2XR8_U            376 RNfsa-----ggvFEQDDGENWVEIQKGLRGykaksq----------plnaqMGLgrsQTGhPDfpgn-vgyVYAEEAAR 439 Paraburkho...
WP_011906730      333 FFfd--------vVEEEDYFLGLKVQNGLES---------------------GAM---THQ-TF--------GRNEPGNQ 371 Novosphing...
jgi:Saro_3490     333 FFrd--------vTYTEDYLIGLEIQKGLES---------------------GAH---DDL-VF--------GRNERGNQ 371
Q3S4D0            348 RTfgp-----agfWESDDNDNMETESQNAKKyqssnsdllanlgfgkdvygdE----------VypgvvgksSIGETSYR 412 Polaromona...
P0ABR5            359 RAfgp-----agfLEQDDSENWCEIQKLLKGhrarns----------klcleMGLgqeKRRdDGipgi-tnyIFSETAAR 422 Escherichi...
zhongguo:Q91_1785 360 RTfsa-----ggvFEQDDGENWIEVQKLFRGnkarktklnmqmglgdsttdhPDF---PGR-ISg-------VYSEDAAR 423
jgi:Swit_0336     394 DHdgw------glILEQDFQNMTEVQRGMRS---------------------RGFtgsRTN-----------PVQEKSVS 435
jgi:Swit_2271     381 HGeks-----igqVLDQDAFNLPTVQKGMQS---------------------DAF---PGL-WI--------GDQELRIR 422
WP_011906783      383 YGdgvs----lgfVADQDLSIGTTQQQGLNS---------------------RGF---KGC-LL--------PGQEKRVQ 425 Novosphing...
WP_011906752      388 FDggrgipelagqIVYQDMELAENMQAGMHS---------------------RGY---SDA-YL--------SDQETRIR 434 Novosphing...
2XR8_U            440 GMYHHWMRMMsepSW 454 Paraburkholderia xenovorans LB400
WP_011906730      372 FFHKWVAYYL---DE 383 Novosphingobium aromaticivorans
jgi:Saro_3490     372 YFHEWLDWYL---QD 383
Q3S4D0            413 GFYRAYQAHI---Ss 424 Polaromonas naphthalenivorans CJ2
P0ABR5            423 GMYQRWADLLsseSW 437 Escherichia coli K-12
zhongguo:Q91_1785 424 GMYQHWLRMM---Te 435
jgi:Swit_0336     436 NFHRALREFI---SE 447
jgi:Swit_2271     423 HFHKVLDDHV---YG 434
WP_011906783      426 RFHEKLNDMV---LG 437 Novosphingobium aromaticivorans
WP_011906752      435 FFHEVLNDWI---EG 446 Novosphingobium aromaticivorans
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