2G38,6UUJ


Conserved Protein Domain Family
PPE
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pfam00823: PPE 
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PPE family
This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.
Links
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Statistics
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PSSM-Id: 425887
Aligned: 115 rows
Threshold Bit Score: 78.3906
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2G38_B         5 AYP--PEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLM-DAWAGPVVMQLMEAAKPFVRWLTDLCVQ 81  Mycobacterium t...
Q07297         6 VYS--PEVNAFLMSRGPGSTPLWGAAEAWISLAEQLMEAAQEVSDTIVVAVpASFAGETSDMLASRVSTFVAWLDGNAEN 83  Mycobacterium l...
Q745G2         8 ART--PEDNDMLLKAGVGVGTHVANQTAWTTLAATHHASGVASAINTAATS-ASWLGAGSAASAANVTMLNASLHGLAGW 84  Mycobacterium a...
Q50702         4 MIP--AEYISNVIYEGPRADSLYAADQRLRQLADSVRTTAESLNTTLDELH-ENWKGSSSEWMADAALRYLDWLSKHSRQ 80  Mycobacterium t...
P9WHY1         4 MIP--AEYISNIIYEGPGADSLSAAAEQLRLMYNSANMTAKSLTDRLGELQ-ENWKGSSSDLMADAAGRYLDWLTKHSRQ 80  Mycobacterium t...
WP_012392255   2 AIP--PEVHSALLSAGQGPGSLLAAAAQWQELSAQYSAAVVELTQLLAEVQaTSWQGYAAHQWLAAHGPYLIWLEQAAID 79  Mycobacterium m...
P9WI49         2 AIP--PEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQLLGEVQaSSWQGTAATQYVAAHGPYLAWLEQTAIN 79  Mycobacterium t...
Q741E7         8 AFP--PEVHSAALSSGPGPGSLLAAEQAWQALSAEYASAAAELGDLLAAVQaGTWQGPSAEAFVAAHVPYLAWLLQNSTN 85  Mycobacterium a...
Q5Z3L3        10 WLPrmAEANSIALNAGAHAVPISAAATAWGALTAAWVDATATVTRVMAELG-VGMQGVNGIAALSRLVGFTGWAEQQGVM 88  Nocardia farcinica
WP_012393643   5 kLP--PEVNSGR----ARPGSLQATAVALRGLTAGMRQIGAECSSIAAGLT-SGWRGPAAVPVMRVIAPHWALLTALARH 77  Mycobacterium m...

2G38_B        82 LSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQI--LIDNNALGQFTAQ-------IADLDQ-EY-DDFWDEDGEVM 150 Mycobacterium t...
Q07297        84 AGLIARVLHAVAYAFEEARAGMVPLLTVLGNIIHTMA--LKAINWFGQVSTT-------VAALEA-DY-DLMWVQNSTAM 152 Mycobacterium l...
Q745G2        85 VDVKPAVVATAISAYQMAYGSMRPAPECIANRTETATdyGINPLVLGALTPR-------IASLEL-EYyGSMWPNNSAVG 156 Mycobacterium a...
Q50702        81 ILRTARVIESLVMAYEETLLRVVPPATIANNREEVRR--LIASNVAGGKHSSnrrprgtIRAVPGrKYpSNGPLSKLDPI 158 Mycobacterium t...
P9WHY1        81 ILETAYVIDFLAYVYEETRHKVVPPATIANNREEVHR--LIASNVAGVNTPA-------IAGLDA-QY-QQYRAQNIAVM 149 Mycobacterium t...
WP_012392255  80 SSVTAAQHRIAAAGYSSAVAAMPTLAELAANHAIHGV--LVVTNFFGINAIP-------IALNEA-DY-VRMWIQAAETM 148 Mycobacterium m...
P9WI49        80 SAVTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGV--LIATNFFGINTVP-------IALNEA-DY-VRMWLQAADTM 148 Mycobacterium t...
Q741E7        86 STAAAREAETVAAAYTAALSAMPTLEQLATNHAVFAQ--LVATNFFGVNTIP-------IAQNEI-EY-LQMWLQAATTM 154 Mycobacterium a...
Q5Z3L3        89 AAAMGSKAAANATAYTVASLAMPSLPEILATNAAV----VASANPAGAVSGA-------FEAAEL-AK-HAMDLRAALVM 155 Nocardia farcinica
WP_012393643  78 ASQTAVQAETAAQAYEQAAAKMTSAQLIAPNRMMRKW--LSANNFLGQASPV-------IAELEA-EY-DRVWVHCADAV 146 Mycobacterium m...

2G38_B       151 RDYRLRVSDAL 161 Mycobacterium tuberculosis H37Rv
Q07297       153 TTYRDTVLRET 163 Mycobacterium leprae TN
Q745G2       157 ASYGAVLTALA 167 Mycobacterium avium subsp. paratuberculosis
Q50702       159 CAIEAAPMAGA 169 Mycobacterium tuberculosis H37Rv
P9WHY1       150 NDYQSTARFil 160 Mycobacterium tuberculosis H37Rv
WP_012392255 149 TTYQAVSEVAA 159 Mycobacterium marinum
P9WI49       149 AAYQAVADAAT 159 Mycobacterium tuberculosis H37Rv
Q741E7       155 AIYEAVSETAM 165 Mycobacterium avium subsp. paratuberculosis
Q5Z3L3       156 ETYEAATTAVV 166 Nocardia farcinica
WP_012393643 147 HDFAGALAisp 157 Mycobacterium marinum
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