6LQS,7AM1


Conserved Protein Domain Family
RNB

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pfam00773: RNB 
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RNB domain
This domain is the catalytic domain of ribonuclease II.
Statistics
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PSSM-Id: 459934
Aligned: 56 rows
Threshold Bit Score: 175.165
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6LQS_R4  531 RKDLRD---KLICSIDPPGCVDI-----DDALHAKKLpn-gnWEVGVHIADVTHFVKPGTALDAEGAARGTSVYLVDKRI 601 
O74454   614 QHE---------SNINSSSATDFv----SSAFHIRPTst--gYHVGIHVTDVSRVIEPGSPLDRELQRRSIAVNLCQKSV 678  Schizosaccharomyce...
Q46363   245 RTWITA---KLQLVTFGDGPRGEtlpwqEVALSLEsqa--nqWQVGIHITDIAHYIAEDSLLDQLARKRGTTVYLEEQIC 319  Synechocystis sp. ...
Q8YXH3   245 klDLRN---LFTFTITGINSDTKv---iENAISLEKTia-gnWQLGFHIADVSHYVQPDEPLDREAIKRGRSVYLGDLVL 317  Nostoc sp. PCC 7120
Q2JH83   252 RRDLRD---WFCITLEPLDLQHPhglepNVAVSLQRQen-dhWLLGIHIADVAHWLDPDHPLEQEAQQRTATVYLDTMVL 327  Synechococcus sp. ...
Q8DHS2   247 RQDLRE---LVTITLVAPGQEP------QVAFSLDGLgp-dlWQLGIHISDVGGLLPRDELLDRTARRQGMSLATPELSL 316  Synechococcus elon...
Q31LX8   247 RLDLRS---VFTVAIAADDSRPL-----DVALSLQPGes-ggWQVMVHTVEVAPYLPLQSDLDLEAQRHGIDLRLGETAL 317  Synechococcus elon...
Q7V7I0   239 RQDLSS---QPALLLRSWQVSDAp---pLPAVYVE-Pha-ggTRLWIHAPAVAERLTIGNNLDLWLRDRAEALCLGEVWH 310  Prochlorococcus ma...
Q7VBV4   238 RNNLES---QPCILFKSWSSKNCp---lLPALY--SEpsnggMTLWIHIPTIGERLNYGSKLDEWIRNRSNSICFGEEWQ 309  Prochlorococcus ma...
7AM1_A   355 RRNFTDtneYNIFAISELGWVS------EFALHVRNNgn-gtLELGCHVVDVTSHIEEGSSVDRRARKRSSAVFMPQKLV 427 
6LQS_R4  602 DMLPMLLGTDLCSLKPYVDRFAFSVIWELDD-S-ANIVNVNFMKSVIRSREAFSYEQAQLRIDdKTQNDE---------- 669 
O74454   679 PLFPTTLGEAL-SLREDKDCYTMSLLLDVSS-T-GKIRGTWIGWAVIRPRKAYTMKEADELLQ----------------- 738  Schizosaccharomyce...
Q46363   320 PLFPEGLIGR-CSLIPDEDRLALSFFLTVDD-R-GEVTGFEYHSSVVKVDHQLDFSEVQTALAdIES------------- 383  Synechocystis sp. ...
Q8YXH3   318 SMLPDTVADRA-SFVTGSDRLALSFLITISS-QlGEVLEWEIQPSVINVDNNVSKQQAEAILQgAATKKDsp-------q 388  Nostoc sp. PCC 7120
Q2JH83   328 PLFPPEVHNRL-ALLPQQERLAYSLLVTLDP-E-GVVQNFEIYPSLVQSRAHLSYGQVQALLAtTADLGPdee----vpe 400  Synechococcus sp. ...
Q8DHS2   317 PLLPQELET--LRLLPGGDRAAISLLIVLNT-A-GEVQSYRIYRSCIRVDACVTSEQVAATLAlGDS------------- 379  Synechococcus elon...
Q31LX8   318 PFLPPVLTQGVGRFAVGEDRRAVSLLIRVDA-T-GAVQDYELQPSLVQLDQVLSPAEATDLLAdSKAKGE---------- 385  Synechococcus elon...
Q7V7I0   311 PLLGQILSKA-CSFKVGEINDAVSVALDISA-D-GEVTNWHFSLSSIKPVAEIGPKTLTALSNrKPKARTvpaalkpvkd 387  Prochlorococcus ma...
Q7VBV4   310 CFLGDKLNKE-AGFEIGKSNSAITLELFIDK-N-GKCQSWEFYLSTIKPVAKVSQKNLDDILKrKKRSRIvpaslkllkd 386  Prochlorococcus ma...
7AM1_A   428 NLLPQSFNDEL-SLAPGKESATLSVVYTLDSsT-LRIKSTWVGESTISPSNILSLEQLDEKLStGs-------------- 491 
6LQS_R4  670 LTMGMRA----LLKLSVKL----K----------------QKRLEA-GALNL-ASPEVKVHM----DsetsdpneVEI-- 717 
O74454   739 TDARLRL----FHTVSSRL----RthhlgtdvplsrycrlVRRWDE-ESCSFdPNETNLFIS------------------ 791  Schizosaccharomyce...
Q46363   384 VSGELKPygglLQELFFQIcpliK----------------SQRLQR-GSFNL-QTETASPRL----Degr--lgvIMT-- 437  Synechocystis sp. ...
Q8YXH3   389 IIERLQN----LTTIGQAI----K----------------ESRLAR-GSLQLnLPSNQNPYY----Degs--lgaVLVn- 436  Nostoc sp. PCC 7120
Q2JH83   401 LMALLQN----LLRLSQIL----R----------------AKRHQA-GGFDL---PLLDLLTphsaDesg--ygpLLI-- 448  Synechococcus sp. ...
Q8DHS2   380 SGDWLRA----LIHLANAV---------------------SQRRQArGSIEV--TPAEALRLayadE------------- 419  Synechococcus elon...
Q31LX8   386 GIKALKE----LQTIADLW----R----------------TQRRER-GGFELtVTPAIGN------Dega--lgvI---- 428  Synechococcus elon...
Q7V7I0   388 HLAQLET----LIFCARTL---------------------QMGEQAsGSIELdlav---------------pelqCLGdl 427  Prochlorococcus ma...
Q7VBV4   387 YINNIED----LLYISKII---------------------NENLIKaGLIQLdlpv---------------pvieNLEdl 426  Prochlorococcus ma...
7AM1_A   492 PTSYLST----VQEIARSF----Y----------------ARRIND-PEATLlPTLSLLESL----Ddekv-kvdLNI-- 539 
6LQS_R4  718 ---------------KKLLATNSLV-------EEFMLLANISVARKI-YdAFPQTAMLRRHAAPPSTNFEILNEMLntrk 774 
O74454   792 ------------------SAVEVLR-------ETLLDAANRAVASHLrQ-EFRENAFLRTQRLPSRENCRILQSMA---- 841  Schizosaccharomyce...
Q46363   438 ---------------QETLPIRSLL-------AELMVVLQREVALQL-Q-ALGIPGLYCGQVAPEGEDLTDIVKLAgnld 493  Synechocystis sp. ...
Q8YXH3   437 ---------------D--SPVRSLL-------MELVLLVNELIATHL-S-ALGIPAIWRTQGTPDSEDVQEMLKLAinlg 490  Nostoc sp. PCC 7120
Q2JH83   449 ---------------SDRLGAHALM-------TEILLLANQILGHHL-R-QLGIPSLARVQPAPAAEALQSFLRLAnamk 504  Synechococcus sp. ...
Q8DHS2   420 ------------------GLAPAIFlpkvtpwTSLVILANELLGRHL-A-KLGVPALYRTQPVPELYGVQDFLKLCqnln 479  Synechococcus elon...
Q31LX8   429 ---------------SRSPAIAGAV-------QEILIQANRLVTEHL-Q-ALELPVLYVGQRSPDLGSIQDAQRLAaglg 484  Synechococcus elon...
Q7V7I0   428 rwadpdsyhhqwalpLDQTDPQSVL-------SPMIRAAHRAWAQHA-Q-NLQLPGLVIEASEADNNTLNDVAKSAl--- 495  Prochlorococcus ma...
Q7VBV4   427 dktvpggefngwsdtYKDKDPQSII-------SVFTKYANIILKDHF-I-SYNISFIALKFKQPDNIQLNDVIKSAl--- 494  Prochlorococcus ma...
7AM1_A   540 ---------------LDRTLGFVVI-------NEIKRKVNSTVAEKI-YtKLGDLALLRRQMQPIATKMASFRKKIqnfg 596 
6LQS_R4  775 nm--------sisleSSKAL----------ADSLDRCVD----P--EDpyfntLVRIMSTRCMMAAQyfysgaY----S- 825 
O74454   842 ---------------IQMGCvldlsstkslLRSLSLIED----DtvRN-----ILQLYYYKVTPRAV------Y----E- 886  Schizosaccharomyce...
Q46363   494 lgvki-dlegdiipqHYHHL----------SQGFESLPA-------KA-----VLNHLLANTLKIEK------Y----F- 539  Synechocystis sp. ...
Q8YXH3   491 velal-epevdieplDYQQL----------TRAFAESPS-------EQ-----VLTYLLQDTLKPAV------Y----S- 536  Nostoc sp. PCC 7120
Q2JH83   505 ldlnl-qdpavvtlaDWQRI----------CARITAPDVlasgAs-PA-----LVAQMLA-TLPPVE------YrlqpL- 559  Synechococcus sp. ...
Q8DHS2   480 lplsl-dhpsqvtprDYQRF----------MAQLATSDL-------AA-----LLQELLLDKLKPAS------D----S- 525  Synechococcus elon...
Q31LX8   485 laievdenetelnrlALQQL----------SDATQTSEL-------AS-----LLDHLLLQTFKPSF------Y----S- 531  Synechococcus elon...
Q7V7I0   496 --------------aLDIALeldeegrpaaTELAKAFST----TacRR-----VLDQQLRHALPETL------L------ 540  Prochlorococcus ma...
Q7VBV4   495 --------------vLDTKInvneegiisfKDLILSLKE----SpnKR-----LIEKIISNTILDKY------Y----S- 540  Prochlorococcus ma...
7AM1_A   597 y---------nfdtnTADEL----------IKGVLKIKD----DdvRV-----GIEILLFKTMPRAR------Y----Fi 638 
6LQS_R4  826 -----YPDFR------HYGLAVDI----------------------YTHFTSPIRRYCDVVAHRQLAGAI 862 
O74454   887 -----MQKYKgnlasqMMSLGIEDes------------------ddLTHFTAPLERYGDIVVHYQLQLLL 933  Schizosaccharomyces pombe 972h-
Q46363   540 -----SHPAP------HFALAYDSg---------------------YTHCVSPAQRYGDLVIQRLLKLVL 577  Synechocystis sp. PCC 6803 s...
Q8YXH3   537 -----TTKAS------HFGLALLQ----------------------YTHFTAPLRRYPDLLMQRVYYQLL 573  Nostoc sp. PCC 7120
Q2JH83   560 -----EEQLG------HFGLGLKEp---------------------YATFTAPLRRYADLLNLRALHLAL 597  Synechococcus sp. JA-2-3B'a(...
Q8DHS2   526 -----PVVLT------HFGLATAEg---------------------YGHFCSPLQRYTDIVNQRILHLLL 563  Synechococcus elongatus
Q31LX8   532 -----TLAVP------HFSLGLET----------------------YGHFVAPSQRYADLWLQRVILALF 568  Synechococcus elongatus PCC ...
Q7V7I0   541 ------------------RLGINDsqkengniesdhedtktkdsnlQSPWCCPTIHYTDLVNQEIIVTLL 592  Prochlorococcus marinus str....
Q7VBV4   541 -----IPTSN------SDDLGLSKedstnl-----------isadiEAPWSSPGMNYADVINQFILLKLL 588  Prochlorococcus marinus
7AM1_A   639 agkvdPDQYG------HYALNLPI----------------------YTHFTAPMRRYADHVVHRQLKAVI 680 
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