4UAS,3SKX,1QH9,1QQ5,1X42,1TE2,1F5S,3NUQ,6HYJ,3M1Y


Conserved Protein Domain Family
Hydrolase

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pfam00702: Hydrolase (This model is not part of the current CDD release)
haloacid dehalogenase-like hydrolase
This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.
Statistics
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PSSM-Id: 513678
Aligned: 237 rows
Threshold Bit Score: 31.0042
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4UAS_A   2 IEAILFDVDGTLAETE---ELHRRAFNETf-------------------aALGVDW---FWDR--EEYRE---------- 44  Cereibacter sphaeroides
O06480   4 YRTLLFDVDDTILDFQaaeALALRLLFEDqnipl-----------tndmkAQYKTInqgLWRAfeEGKMT---------- 62  Bacillus subtilis sub...
P0A8Y1   3 WDWIFFDADETLFTFD--------SFTGLq--------------------RMFLDY---SVTFtaEDFQD---------- 41  Escherichia coli K-12
O86530   3 IKAVVWDVDDTLFDYT---TADREGMRAHlvae--------------gllAGYGSA---EEAL--VRWREiteq-----q 55  Streptomyces coelicolor
P64636  10 VDTVLLDMDGTLLDLAfdnYFWQKLVPETwgakn-----------gvtpqEAMEYM---RQQY--HDVQH---------- 63  Escherichia coli K-12
Q48389   2 IRAIVTDIEGTTSDIR---FVHNVLFPYArerlagf-------vtaqqfvEPVKTI---LDNL--REEIA---------- 56  Klebsiella oxytoca
O67786   2 VKAILLDIEGTIAPLS---FVKEVMFPYSkkklrefleknwekpeikkivQEVEKI---EGRE--LSLEE---------- 63  Aquifex aeolicus VF5
Q21012   8 FNALLLDIEGTITSIS---FVKDELFPYAfenvgnyleehydnpatqiivEDLRHI---ADQQaeNDVAVvrireprkec 81  Caenorhabditis elegans
P32626   5 YSTYLLDIEGTVCPIS---FVKETLFPYFtnkv--------------pqlVQQDTR---DSPV--SNILS---------- 52  Saccharomyces cerevis...
O27821   1 MKTIIFDIDKTLLVGS---HCHFYSFRLA------------------------------FREL--FDVDV---------- 35  Methanothermobacter t...
4UAS_A  45 --LLTTtgGKERiarflrhq-----kgdpaplPIADIHRAKT----------ERFVALMAEge--iaLRPGIA-DLIAEA 104 Cereibacter sphaeroides
O06480  63 --RDEV--VNTRfsal-------------lkeYGYEADGALL----------EQKYRRFLEeg--hqLIDGAF-DLISNL 112 Bacillus subtilis sub...
P0A8Y1  42 --YQAV--NKPLwvdyqng-------aitslqLQHGRFESWAerlnvepgklNEAFINAMAei--ctPLPGAV-SLLNAI 107 Escherichia coli K-12
O86530  56 waRFSA--GEVDfvtqrrdrt--rvflgrpelTDAEADDWFQ----------RYVTHYEAAw----sLFPDVM-PVLDAL 116 Streptomyces coelicolor
P64636  64 --TLNW--YCLDyws-----------------eqLGLDICAMt---------TEMGPRAV-------LREDTI-PFLEAL 105 Escherichia coli K-12
Q48389  57 --QPAA--GAEEliatlfafm---dedrkstaLKALQGIIWRd--------gYVHGDFTGH------LYPDVL-PALEKW 114 Klebsiella oxytoca
O67786  64 --AVQL--FSRwided-----------rkitpLKELQGHIWE----------EGFKSGELKa----pLYEDAY-EKIKEW 113 Aquifex aeolicus VF5
Q21012  82 ieDVTK--NVRHwikrdk--------kltpmkALQGLIWEEA----------YQRGDVKGH------VYPDVL-PVLKIV 134 Caenorhabditis elegans
P32626  53 --QFHI--DNKEqlqah----------ilelvAKDVKDPILK----------QLQGYVWAHgyesgqIKAPVYaDAIDFI 108 Saccharomyces cerevis...
O27821  36 --RIDI--GNMQgmtdkeiifrtaaehgleidEDDFRRIVDRi--------sYNYRLNLGRdn--irPLDGAG-AVLEHL 100 Methanothermobacter t...
4UAS_A 105 KRA-GI-RLAVATTTSL--------PNVE-ALCRAcFGhpareif-dviaagDMVA---EKKP------SPDIYRLALRE 163 Cereibacter sphaeroides
O06480 113 Q---QQfDLYIVTNGVS--------HTQY-KRLRD-SGlfpffk---difvsEDTG---FQKP------MKEYFNYVFER 167 Bacillus subtilis sub...
P0A8Y1 108 R---GNaKIGIITNGFS--------ALQQ-VRLER-TGlrdyfd---llvisEEVG---VAKP------NKKIFDYALEQ 162 Escherichia coli K-12
O86530 117 A---GShRHAVLSNSSL--------TVQD-RKLRV-LGvhdrfe---ailcaAELG---VSKP------EAGAFLAACDA 171 Streptomyces coelicolor
P64636 106 KAS-GK-QRILLTNAHP--------HNLA-VKLEH-TGldahld---lllstHTFG---YPKE------DQRLWHAVAEA 161 Escherichia coli K-12
Q48389 115 KSQ-GI-DLYVYSSGSV-------------AAQKLlFGysdeg-----dithLFNG---YFDTlvgakrEAQSYRNIAEQ 171 Klebsiella oxytoca
O67786 114 KEK-GI-PVYIYSSGSV--------KAQNlFFGHSvYGdi----------rnLFSG---FFDTkigskrERSSYEKIAKE 170 Aquifex aeolicus VF5
Q21012 135 ENR-KI-PIYIYSSGSV--------HAQKlLFANSiEGdmtkilygyfdtniGLKG-------------ESNSYTKISER 191 Caenorhabditis elegans
P32626 109 KRKkRV--FIYSSGSVKaqkllfgyVQDPnAPAHDsLDlnsyid---gyfdiNTSG----KKT------ETQSYANILRD 173 Saccharomyces cerevis...
O27821 101 RDA-GI-PLGVVTGNIE--------PVAWlKLREAsFDth-----------fRFGGfgnEGCS------RASILRLALER 153 Methanothermobacter t...
4UAS_A 164 LD-----VP--PERAVALEDSLN-GLRAAKGAG 188 Cereibacter sphaeroides
O06480 168 I------PQfsAEHTLIIGDSLTaDIKGGQLAG 194 Bacillus subtilis subsp. subtilis str. 168
P0A8Y1 163 A------GNpdRSRVLMVGDTAEsDILGGINAG 189 Escherichia coli K-12
O86530 172 LA-----LG--PAEVAYVGDHPEiDGRGAADAG 197 Streptomyces coelicolor
P64636 162 TG-----LK--AERTLFIDDSEA-ILDAAAQFG 186 Escherichia coli K-12
Q48389 172 LG-----QP--PAAILFLSDIHQ-ELDAAEEAG 196 Klebsiella oxytoca
O67786 171 IG-----LP--PHEILFISDNPE-ELKAAKEAG 195 Aquifex aeolicus VF5
Q21012 192 IK-----IP--PSEILFLTDVEA-EAAAAKKAG 216 Caenorhabditis elegans
P32626 174 IG-----AK--ASEVLFLSDNPL-ELDAAAGVG 198 Saccharomyces cerevisiae S288C
O27821 154 ASgiygnLK--AGDVIAVGDTPR-DIAAGREVG 183 Methanothermobacter thermautotrophicus str. Delta H
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