8VSD


Conserved Protein Domain Family
TGFb_propeptide

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pfam00688: TGFb_propeptide (This model is not part of the current CDD release)
TGF-beta propeptide
This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.
Statistics
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PSSM-Id: 513666
Aligned: 56 rows
Threshold Bit Score: 146.32
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8VSD_E          1 LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPS-Q---GEVPP---GPLP-EAVLALYNSTR--DRVAgesaepepep 70  human
XP_031797081   43 EGCPVCVWRQHSKELRLESIKSQILSKLRLKEAPN-Isr-evVKQllpKAPPlQEILDLHDFQG--DALQ---------- 108
NP_001266976   20 MSTCKTLDLEMVKKKRIEAIRSQILSKLRLPKEPEpDqsqDE------ENIP-TPLLSLYDSVKemLKEQrtedqtr--- 89 
13_pfamImport   1 MSTCKTLDLEMVKKKRIEAIRSQILSKLRLPKEPEpDqdkDG------GEIP-TPLLSLYNSTKemLNEQqtqgqtr--- 70 
XP_032235827   22 ESSSQRAKHEVRNSADFQMMEQRFLDTMGMRSRPR-Pkr--------gTRIP-QYMLDLYNSH------Kahpdwistq- 84 
11_pfamImport   1 SLLSPPAAPSLKPS-LAETIQSLLLSRLGLQSQPD-Prp--------gVPVP-RYLLDLYRFHQqqYHLVedpsfsf--- 66 
XP_005873648   43 GGRRSGQSHE-----LLRDFEATLLQMFGLRRRPQ-Psk--------sAVIP-EYMRDLYRLQs--GEEEeeeqihsial 105
Q804S2         37 GKQSPQQSEG-----FLNEFELRLLNMFGLKRRPT-Psk--------qAVVP-QYMVDLYRMHSanGDHSakrpksmgr- 100 spotted green ...
XP_007670286   37 GRSTPQRSED-----ILSEFELRLLNMFGLKRRPN-Psk--------gAVIP-PYMLDLYRLHs--GQLeepamdyr--- 96 
Q90YD7         37 GRSSPQHSQS-----VLNQFELRLLNMFGLKRRPT-Pgk--------nIVIP-PYMLDLYHLHs--GQLAadqdsspmd- 98  tropical clawe...
8VSD_E         71 E------------ADYYAKEVTRVLMveTHNE-IYdkfkqsTh------------sIYMFFNTSElreaV----PEPVLL 121 human
XP_031797081  109 PedfleedeyhatTETVISMAQETDPavQTDGsPH------C--------------CHFHFSPKV----M------FTKV 158
NP_001266976   90 ------isveqeeMEYFAKVPHKFNMsiNSTAimg------------------nknVAVPFNISE----IrqsvGKYHQL 141
13_pfamImport  71 ------lsteqeeMEYFSKVLHRFNIsnPENAkk---------------------vIAMSVDISE----MrqsiGEYHLL 119
XP_032235827   85 ----frfgdkwigANTIRAF-------------HH------Tdndgida-sensnlTRIIFDLST----L----PMYETV 132
11_pfamImport  67 ------prqhiqqANTVRSF-------------HH------NelsddnslpdnpqrVHISFNISS----I----PEDERV 113
XP_005873648  106 ----eyperpasrANTVRSF-------------HH------EehlenipgtsensaFRFLFNLSS----I----PENEVI 154
Q804S2        101 -----haeraaskANTIRSF-------------HH------EesmealarlkgkttQQFYFNLTS----I----PKEELI 148 spotted green ...
XP_007670286   97 ------leraasrANTVRSF-------------HH------EesleelpeasgttaRRFFFNLTS----V----PNEEFI 143
Q90YD7         99 ----yqieraasrANTVRSF-------------HH------EesmeeipesgektiQRFFFNLSS----V----PNEELV 147 tropical clawe...
8VSD_E        122 SR-----A---------------ELRLLRLKLK-VEQHVELYQ--------KYSNNSWRYLSNRL------LaP-SDSPE 165 human
XP_031797081  159 LKaqlwvYl-------------rPVPRPATVYL-QILRLKPLSgegtagsgGGGRRHIRIRSLKI------E-LhSRSGH 217
NP_001266976  142 TSaelriHikkp-------------------milEDQRVELY---------YGLDPSARYLTTRL------I-NnKMKDK 186
13_pfamImport 120 TSaelrmFiket-------------------riqTEKRVELY---------YGLGASARYLATRF------I-NnKMKKT 164
XP_032235827  133 TSaelrlStrsgdl--------------kqpsnsTQLWIRVYQvllp--gmgDTPALRRLLDSRE------V-D-ARVAG 188
11_pfamImport 114 LSaelrlLrssra-----------------fwgpGVHRLNIYLv------eSHGDPEPTLLETRLfttannT-H-ESSSL 168
XP_005873648  155 SSaelrlFreqvdq--------------gpdweqGFHRINIYEvmkppaelVSGHLITRLLDTRL------V-H-HNVTR 212
Q804S2        149 TSaelriYrdqvmgaastnnsstNSSTSDKAHAgGFHRINIYEifg---vpQGREPLARLLDTRL------V-Q-DSLTR 217 spotted green ...
XP_007670286  144 TSaelqvFreqvrea-------------ldnnsgYHHRINIYEiikp-ataISKDPVTRLLDTRL------V-N-HNASK 201
Q90YD7        148 TSaelriFregvqep-------------fegdssKLHRINIYDivkp-aaaASRGPVVRLLDTRL------I-H-HNESK 205 tropical clawe...
8VSD_E        166 WLSFDVTGVVRQWLSRgGEIEGFRLSAHCSc----dSrDNT-LQVDING-----FtTGRRG-------DLATihgmnRPF 228 human
XP_031797081  218 WQSIDFKQVLHSWFRQpQSNWGIEINAFDP------S-GTD-LAVTSLG-----P--GAEG----------L-----HPF 267
NP_001266976  187 WISFDVTEPLRKWLETsDDEQGFQLRLFCEcsktteDs----FSFYIDG-----F-SSERGdtgvvqqLTQQ-----PPY 251
13_pfamImport 165 WLSFDVTEPLQNWLKGnDNKQVFQLRAFCDcsqvteCv----LDFDIDG-----K-SVNREdtgrlkeMTKQ-----PPY 229
XP_032235827  189 WESFNVELAIQHWVKNpEQNYGLDIQVTT-------------KEGHSIKdavrtR-EHHAEe-----dWHEE-----RPL 244
11_pfamImport 169 WEAFPLSSDILLEVLGgTGTLGFLLENVYaa---agK-EDA-EKEGHLRvr-rsV--GQDEy-----sWTQE-----RPL 230
XP_005873648  213 WETFDVSPAVLRWTQEkQPNYGLAIEVTHl-----hQ-TRT-HQGQHVRis-rsL--PQGSg-----dWAQL-----RPL 272
Q804S2        218 WESFDVSSAVFQWTSGkGHNHGFMIEVLHPeegeveQ-ERAdKHSRHVRvs-rsL--HQDRd-----sWPQA-----RPL 283 spotted green ...
XP_007670286  202 WESFDVTPAVTRWIAQgQPNHGFVVEVVHl-----eD-ERG-VSERHVRis-rsL--HQDEq-----sWPQI-----RPL 261
Q90YD7        206 WESFDVTPAITRWIAHkQPNHGFVVEVTHl-----dN-DKN-VPKKHVRis-rsL--VPDKd-----sWPRI-----RPL 265 tropical clawe...
8VSD_E        229 LLLM 232 human
XP_031797081  268 M-EL 270
NP_001266976  252 ILTM 255
13_pfamImport 230 ILTM 233
XP_032235827  245 IVTY 248
11_pfamImport 231 LVTY 234
XP_005873648  273 LVTF 276
Q804S2        284 LVTY 287 spotted green pufferfish
XP_007670286  262 LVTF 265
Q90YD7        266 LVTF 269 tropical clawed frog
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