6JZB,7ZHS


Conserved Protein Domain Family
DnaJ_CXXCXGXG
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pfam00684: DnaJ_CXXCXGXG (This model is not part of the current CDD release)
DnaJ central domain
The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found.
Links
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Statistics
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PSSM-Id: 513663
Aligned: 1127 rows
Threshold Bit Score: 29.4726
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6JZB_A       155 CRTCNGSGakpGTSPvT-CGRCHGAGViNVDTqtplGMM-RRQVTCDVCHGRGKEIK--YPCTTCHGTG 219 Streptococcus pneumoniae
XP_001647330 194 CVLCMGQG---SMKK-SkCFTCNGLGS-LTQTrrmgPMIqTFSQSCPDCQGSGMFVKrsDTCQSCSGNG 257
XP_056084722 210 CQVCDGHG---GLKK-YaCKTCKGQGV-QTQTnrmgPLVqSWSQTCADCGGAGIFVEskDICQQCQGLG 273
XP_003677524 181 CLPCNGFG---GLQR-TtCESCQGDGF-QTQTrrmgPMVqTWTQTCASCDGAGCFIKpnDVCPHCHGEG 244
XP_003680535 165 CKACKGRG---SMKV-RtCKACRGRGQ-QSRSrqmgPMMqTWTQTCSDCNGMGTFTKdsDVCRDCEGEG 228
XP_003646956 182 CHRCSGHG---SMTS-SvCGECRGQGV-YSQTrrhgPLVqTWSSSCRNCSGAGTFVKsnDVCQTCRGTG 245
Q6CP33       192 CQRCQGYG---GKKA-TqCRGCQGTGL-FTTTkrmgPMVqTWQTTCKECSGTGKYIRskDACTECSGNG 255 Kluyveromyces lactis
XP_002555414 168 CKKCKGEG---GLKA-SqCYTCGGRGI-RTETkrhgPMVqTWSSTCSDCAGRGSFMKqkDICRDCNGQG 231
XP_003670806 200 CHSCNGMG---GMNT-IiCNECQGKGI-NTETkmlgPMVqSWSSTCFNCSGMGYFIDsqSGCKECQGEG 263
Q6FNN5       178 CSSCDGKG---GMRV-AsCRTCKGQGE-VVKTrrvgPMVqTMSSTCNSCHGTGTFIKdsDLCFVCKGSG 241 [Candida] glabrata
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