7Z0H


Conserved Protein Domain Family
rve
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pfam00665: rve (This model is not part of the current CDD release)
Integrase core domain
Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.
Links
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Statistics
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PSSM-Id: 513647
Aligned: 66 rows
Threshold Bit Score: 41.9205
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7Z0H_W        80 YEPFQYLHTDIFg-PVHNLpns----apSYFISFTDETTKFRWVYPLHDRredSILDVFTTILAFIKNQFQAsVLVIQMD 154 Saccharomyces c...
Q50700        55 YGRLGMWFDPAT--ARRVA---------VWAFVMVLAFSRHLFVRPVIRM---DQTAWCACHVAAFEFFDGV-PARLVCD 119 Mycobacterium t...
WP_279649919 129 HRVGEKLFVDYAgqTVPVIdrhsgeirqAQVFVAVLGASSYTFAEATWSQ---QLPDWLGSHTRCFAFLGGV-PEIVVPD 204 Stutzerimonas s...
O69924       156 AQVDWGDEGKILa-HVGIPk--------VYSFHMTLSYSRDPFCCFTTSQ---DLATFFDCHRKAFAHFGGV-PMSVVYD 222 Streptomyces co...
Q7ARN5       118 TEPGRQMQVDWG--TMRngr------spLHVFVAVLGYSRMLYIEFTDNM---RYDTLETCHRNAFRFFGGV-PREVLYD 185 Yersinia pestis
Q9RI04        31 TQPGYQLQHDWGevELEVAgqr----ckVNFAVNTLGFSRRFHVFAAPKQ---DAEHTYESLVRAFRYFGGS-VKTVLVD 102 Yersinia pestis
P0CF90       228 RRSLGHWEGDLV---SGtk--------nSHIATLVDRKSRYTIILRLRGKd--SVSVNQALTDKFLSLPSELr-KSLTWD 293 Escherichia col...
Q5HK26        67 KKAYYKWRIDET--YIKIKgk------wSYLYRAIDAEGHTLDIWLRKQR---DNHSAYAFIKRLIKQFGK--PQKVITD 133 Staphylococcus ...
P71644       138 PKVPGVIEADTVa-HCGPSlig----efARTLTMTDLVTGWTENASIRNNa--AKWILEGIKECQQRFPFPMt--VFDSD 208 Mycobacterium t...
Q45618       115 tlpgEQMQVDWKe-VGEVViegk--kvkLSLFVATLGYSRMKYAVFTTSQd--QEHLMECLIQ-SFKYFGGV-PKKVLFD 187 Geobacillus ste...

7Z0H_W       155 RGSEYTNR-------------TLHKFLEKNGITPCYTTTADS 183 Saccharomyces cerevisiae S288C
Q50700       120 NLRTGVDKpdlyd---pqinrSYAELASHYATLVDPARARKP 158 Mycobacterium tuberculosis H37Rv
WP_279649919 205 NLRSAVSKshrye---pdinpSYRDLAEHYGVAVVPARARKP 243 Stutzerimonas stutzeri
O69924       223 RTKTVVrrhvapg-eavplhpEAVAFAGHYDFDIDVLAAYRP 263 Streptomyces coelicolor
Q7ARN5       186 NMKTVVLQrdayqtgqhrfhpSLWQFGKEMGFSPRLCRPFRA 227 Yersinia pestis
Q9RI04       103 NQKAAVLKnnngk---vvfnsGFLLLAEHYDFLPRACRPRRA 141 Yersinia pestis
P0CF90       294 RGMELA---------------RHLEFTVSTGVKVYFCDPQSP 320 Escherichia coli K-12
Q5HK26       134 QAPSTK-V-------------AMAKVIKAFKLKPDCHCT-SK 160 Staphylococcus epidermidis RP62A
P71644       209 CGGEFINH-------------DVAGWLQARDIAQTRSRPYQK 237 Mycobacterium tuberculosis
Q45618       188 NMKTVTDGreqgv---vkwnqRFSEFASYYGFIPKVCRPYRA 226 Geobacillus stearothermophilus
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