2POP,1M4M,5YUD


Conserved Protein Domain Family
BIR
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pfam00653: BIR 
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Inhibitor of Apoptosis domain
BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.
Links
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Statistics
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PSSM-Id: 425801
Aligned: 73 rows
Threshold Bit Score: 44.9578
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2POP_B        24 RLKTF-ANFPsGSpvsAS--TLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFIN 89  human
Q8UVF8       267 RIQTF-LAWIyPVn--KE--HLAEAGFYSTGNGDHVVCFHCGGGLQEWKENEDPWDQHAKWFPGCKFLR 330 chicken
Q7QHS1        26 RIRSF-ESWRfGHmqnPT--RLAVAGFYYTGTDDEVRCFQCDAGLRDWLVTDDPWQEHARCFAECTFLR 91  Anopheles gambiae str. PEST
Q91EW1        84 RLKTFkK-WPvg--lgQSkeEMVEAGLCYSGRGDQVECFCCGESICDWRVGDDPWRRHIEANMGCQFVV 149 Cydia pomonella granulovirus
Q8B9M2       134 RMDTFvNFWPgALr--DMitNIAEAGFFYTGRGDETVCFFCDCCVRDWHTNEDAWQRHVTENPQCYFVl 200 Rachiplusia ou MNPV
Q6JPG0       162 RQSSF-EEWPiSLkslKT--QLAYTGFFYTQKGDVTICFHCGLVLKDWYIHDTPINEHAKWFDKCKYLT 227 Neodiprion lecontei nucleo...
Q6R7D0        13 RVNSF-GGWSkQLrpnKD--TLAPAGFFYTGMGDKVKCFACGLEVIDWDPTDNPWTEHGKFSGDCLYLK 78  Ostreid herpesvirus 1 (iso...
P41436       111 RVKSF-HNWPrCMkqrPE--QMADAGFFYTGYGDNTKCFYCDGGLKDWEPEDVPWEQHVRWFDRCAYVQ 176 Cydia pomonella granulosis...
Q9EN27       110 RLKTY-KEWPiSMpisTE--KLAEAGFFYTGKSDKVKCFYCDGGLNKWETDDDPWIQHARWFDKCDYVK 175 Amsacta moorei entomopoxvirus
5_pfamImport   1 RLATF-KEWPkSMpqtPE--RMADAGFFYTGKSDVVACFYCGGNLRDWLAEDDPWVEHVRNFSECPYVK 66
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