1C4Z,9B55,8PWL,6JX5,8EWI


Conserved Protein Domain Family
HECT

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pfam00632: HECT (This model is not part of the current CDD release)
HECT-domain (ubiquitin-transferase)
The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Statistics
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PSSM-Id: 513617
Aligned: 89 rows
Threshold Bit Score: 133.881
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1C4Z_A         59 QLVVEEifn----------pdiGMFt--------Y-DESTklfwfNPSsfETeG-----QFTLIGIVLGLAIYN-NCILD 113  human
Q4E2E5       2646 TMMCDElnyreeddgrrvdpllPFFrltghttmaGvVPNMdfyreNPE--HR-Llf-veVFTWLGKLIGNATMSgYLMFS 2721 Trypanosoma c...
XP_001324201  658 SEVSLDlrn----------pncGFVcptpnsisqVgYYRDkfifvPTN--NE-LrsnkkLYKSIGGLLLLIIRT-GLVQE 723 
XP_001317166 2209 NEIAISifq----------sqsKLFilspngrnhSgGMRDvyipfSSL--RP-Fts-rsLFYAVGVFIGIVIRN-GYFQD 2273
XP_001311958 2273 TECATSife----------ktsCLCfpvpnarhhRgQFKDlfvpyDE---TN-Gey-sdIYRGIGIYIGMVVRT-GFVQD 2336
XP_001583488  133 IELANSifq----------ptsHLFiqspngrnhCgSFRDayvpsTT---LG-Kds-ydQYKAIGTFLGIIIRN-GFPQD 196 
XP_001324632 2634 LDAINEsii----------psiGLFiqcpnskfpNsENFDclipvPDP--NN-Mhs-edMYKMLGVLFGISTRC-GLTKP 2698
XP_001318457 2501 SELAKDicd----------pniGLFvstpnfvnhRgSFREcivpnPIS--EW-Grt-shIYESVGCLIAISIRT-GMVQP 2565
XP_001307101 2545 TEACMEimd----------psmQLFiqtpnkrrkIaTAQDylipnPSP--LT-Pqs-rdFFFYAGVLMTICYTS-RLPEP 2609
XP_001469357 3812 SEMCRElms----------grlPFFvptanhvhnTgSHREayvpaASA--RS-Ayd-leAFAFIGKLMGGALRS-EDPLD 3876
1C4Z_A        114 VHFPMVVYRKLMGkKGTFRD-LGDSH----PVLYQS-L----KDLLEYEGNved----------------dmMI---TFQ 164  human
Q4E2E5       2722 FTFPRLLWKFLTFdNLTIEDyHADIDdtvrGALNDDeF----------------------------------ILndeFFY 2767 Trypanosoma c...
XP_001324201  724 FDFAPVVWRFLVSnKVSIED-IYEID----VNYKNT-I----ESLKDAINSrisede----------fnkqfNL---YFV 780 
XP_001317166 2274 FPFAPFVWKYLANePLDKND-ILCLD----EHFANM-A----NSLVTINEHdfnktyanm-------------------- 2323
XP_001311958 2337 MPFVPFVWKFIAGgELSSND-ILMVD----KMLSDQ-F----AQLRQAEADkdfqrcavpw-kieqwngqqaML------ 2399
XP_001583488  197 IPFAPFIWKHLAGeLLQEND-IMMVD----EQVKTL-F----DRLRQSKNDldftsrfqqkwtyiswtgeivNL------ 260 
XP_001324632 2699 LPFPDFFWKYIAQgILTIED-IYSID----TPYKEL-MisleNNIQNITDEkvfssrfslff------------------ 2754
XP_001318457 2566 FTFPPFFWTCLVTgEITIDD-VFSID----NEYKDF-V----TNLEKDSKEktpqqfqel-------------------- 2615
XP_001307101 2610 FKFARFVWNSLTQrPVTLDD-IYEID----SNFKQF-I----LSIENSSSMspqdf------------hstyML---NFT 2664
XP_001469357 3877 LFLPPLVWRYLCAyPITEAE-VEQVDvicvQCVREFrVlsatHAAAAVADAdesg-------------gtetELfedVF- 3941
1C4Z_A        165 isqtdlfGNPm---------MYD-----------LKEN--GDK------IPI--------TNENRKEFV----------- 197  human
Q4E2E5       2768 si-----------------pGIEwsgesvtdtmgMVRStrGYP------VVT--------PTRSTADMAsifptdghees 2816 Trypanosoma c...
XP_001324201  781 ----------------------Vkdslg--qdhsLNQN--GTS------CKV--------SISNANEYI----------- 809 
XP_001317166 2324 -------------------------------kwavtdwddSTNwlkskdQIV--------GYNDIKNYL----------- 2353
XP_001311958 2400 ------------------------------------PGhsADS-------TV--------GPGEVENFI----------- 2417
XP_001583488  261 ------------------------------------PSqhHTD-------YV--------TGESVEQFI----------- 278 
XP_001324632 2755 -------------------------vvkdslgqerpLSeyGRT------RPV--------TLQNVREYI----------- 2784
XP_001318457 2616 ----------------------------ygnnhnkiKNirGEE------VSVfsfsskslNQGSAGRFI----------- 2650
XP_001307101 2665 aens-------------lgsIVE-----------LIPG--GSL------VPV--------TFDRRLEFL----------- 2693
XP_001469357 3942 -------GEEffvtqlsdhsTKE-----------LIEG--GAQ------TRV--------TLARSSEYA----------- 3976
1C4Z_A        198 ------NLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKyLFRPEEIELLICGSR----N--LDFQALEETTEY---DGg 262  human
Q4E2E5       2817 vtvaqrRKEAERALLHQYDELLLAMLSGITFVLPASSLQ-LIRWDDLQQRVCGNScataEdvISSLDLSLLSE------- 2888 Trypanosoma c...
XP_001324201  810 ------ALSNEFRI-KELQKYLNWVRIGFLKNIKEGIPN-SLDPDTLEFSCCGDPecsyEnlVKIVRFEEISE------- 874 
XP_001317166 2354 ------NMCVGARI-NSVKANLENMKRGFYDNLGFSNPS-IFNSNLISYLAQGSRt------VTTQAFKSITSMlapTN- 2418
XP_001311958 2418 ------IECINFRI-NSIKPTLQLIRQGFIDNTKIDSHP-LLTGARLSHMAQGSNv------ITTQQLRSITQVndyKG- 2482
XP_001583488  279 ------DEFVQARI-NEISQYLDLIRSGFAINIGFETHP-MMNATLIALLVQGSNv------ITTAQLRQITTFdgfNK- 343 
XP_001324632 2785 ------SLSKDFRI-KELKSNLDIIRQGYWENLGLKPPP-FVTGDIIRSCCSPPNeltaEaiLSVTEFDHGLPK------ 2850
XP_001318457 2651 ------SSANSLRIQKLLTPLLL-IRNGFWKALDLAPPP-FVTPQLLEFLACGDRt------ISVSKLRALTEFqgaPR- 2715
XP_001307101 2694 ------AKIKKFRV-KEFNESLEQLRRGFNFFFPAPAAS-ILAPWELELIICGDNe------CPIEDMKRNCSF---P-- 2754
XP_001469357 3977 ------EALLQARL-HEFDLQLHKMREGLLSVVPEVAVL-LLTPEELELRVCGQAd------YTPEELRKGASYeglT-- 4040
1C4Z_A        263 ytRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGk-L----KMIIAK-Ng---PDTERLPTSHTC--FNVLL 331  human
Q4E2E5       2889 -----ELCHMLKEVVHAWPQQRRSQFLLFCSGQRRIPLPe---------KVQVACgD-----DPIAIPTAHTCspISLLL 2949 Trypanosoma c...
XP_001324201  875 -----DQQSIFFKVIQKFTPEQRACLIKFATGRSRLPPSGSSnqF----KFTVDSnG----AQIDKLPTSSTC--FHTLH 939 
XP_001317166 2419 -----QQERYFWEAVDRMTNEQRSLLLKFATTMTRIPNPAINlgF----KLFVNFeAq---LSDSSLPKASTC--FNRLY 2484
XP_001311958 2483 --LEDKNIRWFFNAVDRFNPDQRKLLLKFITTLTRLPNSSINssF----VLKIDKlEr--eNPDQSLPTASTC--FNRLH 2552
XP_001583488  344 --SNEYVISNYWAAVDRMSNEQRSLLLKFVTTLTRFPNKELNptF----HIQIKSsG----GTEDRLPHAQTC--FCRLH 411 
XP_001324632 2851 -----ELKDLFIEILNEMNKSQLSLLLKFATARENLPFN-----PpskpLLNICYmNd--sAWRDGLPKARTC--FGEFD 2916
XP_001318457 2716 -----KMIDIFWTVISRLSEQEKRKFLQFATGTTQIPSN-----Aky-pFLIVDYnRv--pAPDTNLPSASTC--FYRLH 2780
XP_001307101 2755 --ANDPSSTMLWDALEGFTPEERMLFIKFGTGRMGLPPPGSKwmT----PLQIQFkMseaqDAQKPLPTAMTC--NSTMI 2826
XP_001469357 4041 --SEDRRVQLLWKALEEATPLQRRLFLRFVSGRDRMPVK-----------LRILPlTtq-aDADTVLPRAATC--FFAIE 4104
1C4Z_A        332 LPEYSSKEKLKERLLKAITYA-KGFgM 357  human
Q4E2E5       2950 HP-YPSVAVLREKLEVCLRHVyE-FgF 2974 Trypanosoma cruzi
XP_001324201  940 MPRYTSFDNAYKMISIAVENT-ESFeN 965 
XP_001317166 2485 LPLYSSSEVMYNKLVTAIEFC-DTMeN 2510
XP_001311958 2553 LPPYSSEEITYQKLLIAIQYC-QTMeN 2578
XP_001583488  412 LPNYTTPDIAYNKISLAIEIC-TTMeN 437 
XP_001324632 2917 MPIYTSKEIAKKKILLAIEIS-GTFeN 2942
XP_001318457 2781 IQEYSSAEVFHRKLLQAIEYT-GTFeN 2806
XP_001307101 2827 IPRYSSVEMMAKKIRTAIT-----FgA 2848
XP_001469357 4105 VPDYSTLEVMKRKLYYSIENCaD-MdT 4130
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