5L73,7AQ1,8A1F,7UAC,8H3U,2V5Y,7T4S


Conserved Protein Domain Family
MAM

?
pfam00629: MAM (This model is not part of the current CDD release)
MAM domain, meprin/A5/mu
An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.
Statistics
?
PSSM-Id: 513614
Aligned: 58 rows
Threshold Bit Score: 106.303
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5L73_A         23 CEFGWGShktFCH-W-EHDNHVQL-KWsv------lTSKTGPIQDHT---GDGNFIYSQAD-En-QKGK--VARLVSPVV 86   human
Q6UXC1        493 TDFESPE---AGG-W--EDASVGRlQWrrv----saQESQGSSAAAA-----GHFLSLQRAwG--QLGA--EARVLTPLL 553  human
A2AJA7        494 TDFESAS---AGG-W--EDISVGKlQWqwv----eaQEKSKPAGDANr-dAPGHFLSLQKAwG--QLRS--EARALTPAL 558  house mouse
Q9UM73        480 CNFEDG----FCG-WtQGTLSPHTpQWqv------rTLKDARFQDHQ-----DHALLLSTT-DvpASES---ATVTSATF 539  human
A2AJA7         67 CNFEQD----SCG-W--QDISTSGyRWlrdr-agavLHGPGPHSDHThgtDLGWYMAVGTH-SgkEPST---ATLRSPVM 134  house mouse
2_pfamImport    1 CSFNWG----LCGgW---SASSAHlDWff-----spSVNTSTLREHTg--NGGYYAGVLAV-AgrPHGS--TAVLTSPPI 63  
Q63191        273 TDFETG----LGP-W-TQLE-----GWtrnfsagsmVSPAWPHRDHSrnsAYGFFLVSVA-----KPGT--TAVLYSPEF 334  Norway rat
Q6UXC1        271 TDFETG----LGP-W-NRSE-----GWsrnhraggpERPSWPRRDHSrnsAQGSFLVSVA-----EPGT--PAILSSPEF 332  human
NP_035871     217 CTFDTLNd--LCG-WsWVPTATGA-KWtqkk-gptgKQGVGPAEDFSn-pGNGYYMLLDST-Na-RPGQ--KAVLLSPLS 286 
XP_029688610  499 CSFEDG----DCS-W--KPIAGRTlSWkrlqspaktSRQSCPSSGVSfsvEGGH-----------AKGQrsPAVLRSPLF 560  torafugu
5L73_A         87 YSQNSa-HC--MTFWYHMSGSH-VGTLRVKLRYQKpEE--YDQLVWMAI-GHQG--DHWKEGRVLLHKS-LKLYQVIFEG 156  human
Q6UXC1        554 GPSGP--SCe-LHLAYYLQSQP-RGFLALVVVDNG-SR----ELAWQAL-SSSA--GIWKVDKVLLGAR-RRPFRLEFVG 620  human
A2AJA7        559 GPSGP--HCe-LHMAYYFQSHP-QGFLALVVVENG-FR----ELLWQAP-GGGS--GSWTEEKIILGAR-RRPFQLEFVS 625  house mouse
Q9UM73        540 PAPIKssPCe-LRMSWLIRGVL-RGNVSLVLVENK-TGkeQGRMVWHVA-AYEGl-SLWQWMVLPLLDV-SDRFWLQMVA 613  human
A2AJA7        135 REAAP--TCe-LRLWYHIASRD-VAELRLDLTHGV-ET----LTLWQTS-GPWG--PGWQELAVNTGRI-QGDFKVTFSA 201  house mouse
2_pfamImport   64 PLTAEqvYC--VDYWVRTSSDYsRARVRVNSKLPG-NT-----TLLSRC-QVQT--PNWKNCGALITPNvTDVYQIEFDV 132 
Q63191        335 QGSVSy-NCs-FTFYYYLHGSE-ANQFQLFVQAQG-LNttQPPVLLRSRhGELG--TAWVRDRVNIQS--AHPFRILLAG 406  Norway rat
Q6UXC1        333 QASGTs-NCs-LVFYQYLSGSE-AGCLQLFLQTLG-PGapRAPVLLRRRrGELG--TAWVRDRVDIQS--AYPFQILLAG 404  human
NP_035871     287 HSR----GCmtLSFHYIMHGQGhEEGLFVYATFLG-NI--RKYTLFS---GHPG--PDWQAVSVNYTG--QGQIQFMVVG 352 
XP_029688610  561 PPPLRnsPCt-VRFWLCSGGSH-KGLLSLWLLENS-TGpeEPRQLWNSA-SEAKseKSWKLITLPLYGL-ADWFWLQFST 635  torafugu
5L73_A        157 E--IgkGNLGGIAVDDISINNhisqEDCA 183  human
Q6UXC1        621 LvdLdgPDQQGAGVDNVTL------RDCS 643  human
A2AJA7        626 LvdLdgPGQQGAGVDNVTL------RDCN 648  house mouse
Q9UM73        614 W--WgqGSRAIVAFDNIS-IS----LDCY 635  human
A2AJA7        202 T--RnaTHRGAVALDDVEF------RDCG 222  house mouse
2_pfamImport  133 I--FetVPEFTFLFDDITIYP----GRCR 155 
Q63191        407 Et----GPGGFVGLDDLI-MS----NHCI 426  Norway rat
Q6UXC1        405 Qt----GPGGVVGLDDLI-LS----DHCR 424  human
NP_035871     353 M--FgnIPEPAIAVDAISI------APCG 373 
XP_029688610  636 E--NgpGPGSSISLDNIS-FS----MDCF 657  torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap