7KFZ,4L9M,6AXF,6AXG


Conserved Protein Domain Family
RasGEF

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pfam00617: RasGEF 
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RasGEF domain
Guanine nucleotide exchange factor for Ras-like small GTPases.
Statistics
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PSSM-Id: 459872
Aligned: 623 rows
Threshold Bit Score: 44.1201
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7KFZ_B                    225 EIARQLTLLES-DLYRAVQPSELVGS----VWTKEDKeIn---------S--PN--LL----Km-------IRHTTNL-- 273 
XP_001750942              603 QLSDHMTLHNA-ALFARVQPSELV---------TAVLlNh---------Ns-PS--LQr---L--------IRRYDLE-- 647 
EGD78457                 1227 DLAEQLTLFNA-RLYQRVDAIDLI---------ESVVqNv---------Ts-KP--LSr---V--------INRFDEE-- 1271
NP_001294200              118 VAQQLTHIEME-RFSMVGVDEIVQSL----A--SDPLsEigrhsknkegTisSI--SF----Yi-------EWFNRLS-- 175 
WGS:AAFB:cds.EHI_152200A  322 VVAKQIIMFNQ-RLWNTV-------------------------------------------------------HFSEFfy 345 
XP_654773                 758 ALAETL-NSFNlVLFSRVTYEELIVM----NY----N------------Kq-ENkpLTpniqNm-------IERFN---- 804 
XP_653455                 682 YFSDMMTYVHT-VLFSRITEAEIVQ-----FFTK-KP-T----------At-PN--IK----Fm-------TTSFNWL-- 727 
XP_001024825             1073 IIAQQICLIDH-SLFYNINIYELFQDkrlkSFNLFTQyG----------Qk-KNlnLV-------------KRRFNLF-- 1125
EJT42565                  382 SLAKTLTLLES-ALYLNI----------------------------------ETiqFTrhfkHkdtvidsvFMFSNQL-- 424 
XP_025223683               93 VAEQLTLMDLE-LFSKVRPYECLGSV----WSQRDRPgAag------asP--TV--RA----Tv-------AQFNTVT-- 144 
7KFZ_B                    274 T-------LWFE-----KcIVET--E-N-----LEERVAVVSRI-IEILQV-FQELNNFN------GVLEV-VSAMNSS- 323 
XP_001750942              648 Y-------YWIEs----E-MLAC--K-D-----PQLQTLMLDKF-IAAATH-CRQQNNFF------SVFTI-ISCLDTA- 697 
EGD78457                 1272 Y-------FWVEq----E-VLDA--G-D-----PKLQAVIIDKF-IQAAAH-CKALNNFY------SVFTI-IGALDTA- 1321
NP_001294200              176 A-------FAAI-----EvLKQT--K-K-----RNRVAVFEFMI-DIAKEC-CEIGNFNS------MMAIV-AGLSLPA- 225 
WGS:AAFB:cds.EHI_152200A  346 SkntptldNYVNkiqfiEkLTKA--SlE-----YDPSSKMLNFY-IKVSYHcMI-LGDFNsscliySVLSIfCSDIRNK- 415 
XP_654773                 805 ---------WIG-----StIVNcfnecpkgdka------qfiqglilfmkR-LQQLKDIH------FLVSV-VY--TLP- 853 
XP_653455                 728 -----------------SeTL----S-SmikdcSMSFQSAFFNFiMKTAER-FYEQRNFF------GLCAI-VFALHKIq 777 
XP_001024825             1126 T-------YFII-----FiILLQ--H-S-----QSETLQMYEKL-LHLSERaLE-YQNYN------LCLQI-YSSFNSS- 1175
EJT42565                  425 S-------YYVL-----EtTIQQ--T-R-----------TISYW-LRVAFG-CLYLRNLN------SLATI-ITSLQNH- 468 
XP_025223683              145 G-------CVLG-----SvLGAPglT-A-----PQRAQRLEKWI-RIAQRC-RELRNFSS------LRAIL-SALQSNP- 196 
7KFZ_B                    324 PVY-R-L-------DHT----FEQIPSRQKKILE---EAHE---L--SEDHYKKYLAKLRSIN----------------- 365 
XP_001750942              698 KMH-KhC-------QQA----FENISKECRRAFQ---RLVQ---FtsPDRNMRAYRNAL-KALs---------------- 742 
EGD78457                 1322 KIR-K-L-------KQA----WDGVPKESRKLMQ---RLQS---LtsTDKNMKAYRSAY-KKLa---------------- 1365
NP_001294200              226 VSR-L-K-------KTW----CRVEK------AKleiLQHQ---LdpSGNFLSYRATIKAAQWradsa---------rgn 274 
WGS:AAFB:cds.EHI_152200A  416 KIF-NeLksetkkkYRSlenvYS-IS-----------------------MQHANYRNAYADHh----------------- 453 
XP_654773                 854 RLD-L-D-------SIK----SKKISEEDKNYLN---ETEE---LcsFKQNYKYLRAYLSQLe----------------- 897 
XP_653455                 778 DFD-Y-L-------KSN----LSKET-----QVS----IEKfdvLcsFNDNYKALRTEISKSq----------------- 818 
XP_001024825             1176 IIYeK-I-------KQV----QQVSSQLTKKRFS---VLEK---AieFNRSFHSLKESMSKAn----------------- 1220
EJT42565                  469 SVE-R-Ls------FP--------LSVKEGELFE---RLKV---IvhPSNNYNVYRDIIQQIAh---------------- 510 
XP_025223683              197 IYR-L-K-------RSW----GAVSREPLSTFRK---LSQI---FsdENNHLSSREILFQEEAtegsqkedntpgslpsk 257 
7KFZ_B                    366 -P--PCV-PFFG-IYLTNI--------LK---TE-------EG------NPevlkRHg--KELINFSKRR 404 
XP_001750942              743 -KkqPRV-YFLP-LFMKDL--------RF---LA-------DG------NEk---KI---GSLYNVDRLR 779 
EGD78457                 1366 -SkaPRV-AFLP-IVMKDL--------RF---IA-------DG------NQk---KV---QGLLNFDRLR 1402
NP_001294200              275 qQk-iVIpFFVL-LLKDLF--------LI---YH-------GHprilpnAHl-----------NFMAFNQ 313 
WGS:AAFB:cds.EHI_152200A  454 ---dPKI-PVLAlLLGENIrsd--mmeTYiqsNQ-----------------------------LNVLKIR 488 
XP_654773                 898 ---tPYI-PFIG-ILSKDL--------ML---ID-------EG------NPd---KLg-dGT-INLYKWR 933 
XP_653455                 819 ---tPLI-PFIG-ILTKDLlvgdemyaSF---IA-------KSg------------------hFNFNKLR 855 
XP_001024825             1221 ---pPLV-PALN-IITRDLtlldqikdDF---IQvqhqqqiD--------------------LVKFEEIS 1262
EJT42565                  511 -NelPCV-PFTS-LLIRDI--------TF---IR-------DG------NDt---FAkdgTG-VNMQKFH 549 
XP_025223683              258 pppgPVP-YLGT-FLTDLV--------ML---DT-------AL------PDm---LEg--DLINFEKRRK 296 
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