3FAY


Conserved Protein Domain Family
RasGAP

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pfam00616: RasGAP (This model is not part of the current CDD release)
GTPase-activator protein for Ras-like GTPase
All alpha-helical domain that accelerates the GTPase activity of Ras, thereby "switching" it into an "off" position.
Statistics
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PSSM-Id: 513603
Aligned: 50 rows
Threshold Bit Score: 90.4249
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FAY_A         67 LFKTALQEEI----------------KSkVDQIQEIVtGNPTVIKXVVSFNRGaRGQNALRQILAPVVKEIxdDKSLNIK 130  human
6_pfamImport    1 WFQALIEKELakfdksil-tnnqnsaPS-THIYNSLFrGNSILSKSIEKYFNR-IGQEYLDKSIGGIIRRIv-AEEDMCE 76  
Q6CW67        546 WFQALIDREFqgldksit-msnsnhqSS-NHIYNTLFrGNSILTKTMETYCYR-VGQEYLDKCIGTVIRQLv-EEDESYE 621  Kluyveromyces...
P33314        541 TVSRINQKNL----------------DS-KHVFNSLFrGNSILTKSIEQYFFR-VGNEYLSKALSAILKEIi-ESNKSCE 601  Saccharomyces...
Q6FNM9        542 WCTILINKELedfskqsgsrpgidgqYM-PSRVNSLFrGNSILTKTLELYFLR-IGREYLEKAFGTLIRNLl-NEEVSFE 618  [Candida] gla...
XP_011391329  677 RISHFIELESas-------------wGE-KMEPELLFrANTLLSRSIDHFQRL-LTLSWLDDCLGPTVRKIc--QDPHVP 739 
O43374        323 FLDLLFQLEL----------------SR-TSETNTLFrSNSLASKSMESFLKV-AGMQYLHGVLGPIINKVf-EEKKYVE 383  human
NP_001092921  319 FLDVLFKLEL----------------DK-TTEPNTLFrSNSLASKSMESFLKV-AGMQYLHRLLGPIINRIf-EEKKYVE 379 
XP_017948045  327 FLDKLNQREV----------------KR-TVDPNTLFrSNSLASKSMEQYMKI-VGMPFLHEILRPIISKIf-EEKRYIE 387 
Q9Z268        321 FLDYLTRREV----------------AR-TNDPNTLFrSNSLASKSMEQFMKL-VGMRYLHEVLRPVISRVf-EEKKYME 381  house mouse
3FAY_A        131 TDPVDIYKSwvnqxesqtgeasklpydvtpeqalAHEEVKTRLD------SSIRNXRAVTDKFLSAIVSSVdKIPYGXRF 204  human
6_pfamImport   77 LDPARIKe-------------------------pDEIKKRVILE------TNQAKLISWAKEIWHIIYKTSnDLPDAIKV 125 
Q6CW67        622 IDPNRIKES-------------------------ELTEKEKIIE------TNFQKLLSLAERTWKLIFETSnDLPQGIKT 670  Kluyveromyces...
P33314        602 LDPARVKEK-------------------------DEVKKRKIIA------DNYKRLYSWVTKIWKRLYATSnDLPIEIRN 650  Saccharomyces...
Q6FNM9        619 MDPMRISAK-------------------------DDIERRQIIQ------HNSEDLKQWVCTIWNRIIETSnDLPKKIKK 667  [Candida] gla...
XP_011391329  740 SRPDTAASIssagsvggdda----pfdfstsirsPPSFPDNIIEtipdgpITINALRKLSESMWQNIYRQRhSCPPDLRT 815 
O43374        384 LDPSKVEVKdvgc-----------------sglhRPQTEAEVLE------QSAQTLRAHLGALLSALSRSVrACPAVVRA 440  human
NP_001092921  380 LDPSKVELKeagc-----------------aglhRQQTESDVIQ------QSSSLLQSYLSELLTSILQSAsYCPLLICQ 436 
XP_017948045  388 LDPCKIDLNrsrr-----------------isfkGSMSEHHILE------SSLETLRGYLSDIIDAILRSVeQCPSGMRL 444 
Q9Z268        382 LDPCKMDLNrsrr-----------------isfkGTPTEEQVRE------TSLGLLTGYLGSVVDAIVSSTgRCPLALRL 438  house mouse
3FAY_A        205 IAKVLKDSLHEKFPDAGe---DEL--LKIIGNLLYYRYXNPAIVAPDAFDIIdlsagGQLTTDQRRNLGSIAKXLQHAAS 279  human
6_pfamImport  126 QLTHIRKKLEIVCGDSNl---KTV--LNCISGFLFLRFFCPVLLNPKLFHIVe---dHP-DEQKRRLFTLLTKVLMNLST 196 
Q6CW67        671 QLKCFRKKLEIIEPDEKis-sKSL--LNCISGFLFLRFFCPVILNPKIF-NFve--hHP-GENARRSLTLLAKVVMNLST 743  Kluyveromyces...
P33314        651 VLKIFRQKLEIICIDDTl---QII--LNGISGLLFLRFFCPVILNPKLFKYVs----QNLNETARRNLTLISKVLLNLST 721  Saccharomyces...
Q6FNM9        668 QLHELRKGFEIICLEKGq---QSI--LNCISAFLFLRFFCPLILNPKLF-KFte--sHL-TMKQTRNMLLITKVLQNIST 738  [Candida] gla...
XP_011391329  816 VLHKVRTKVNERYRGTK----STRpgIQGVGAFVFLRLFCAALNSPQLYGLAp----CQPSRSASRKLLLLSKVLLALAS 887 
O43374        441 TFRQLFRRVRERF--PGaqheNVP--FIAVTSFLCLRFFSPAIMSPKLFHLRe---rHA-DARTSRTLLLLAKAVQNVGN 512  human
NP_001092921  437 VFHQLYLRVQERF--PDpeyrKVK--FIAVTSFLCLRFISPAIMSPKLFHLRe---kHA-DARTSRTLLLLAKAVQTIGN 508 
XP_017948045  445 CFKQLHKRVEEQFPGAVy---QDVk-YAAISGFLFLRFFAPAILTPKLFHLRe----HHADPRTARTLLLIAKAVQSIGN 516 
Q9Z268        439 AFKQLQRCVEKRFSGIEh---QDVk-YLAISGFLFLRFFAPAILTPKLFDLRd---qHA-DPQTSRSLLLLAKAVQSIGN 510  house mouse
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