4WPC,5C1F,2EFK


Conserved Protein Domain Family
FCH

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pfam00611: FCH 
Click on image for an interactive view with Cn3D
Fes/CIP4, and EFC/F-BAR homology domain
Alignment extended from. Highly alpha-helical. The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins. These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerizes into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localize to actin-rich structures.
Statistics
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PSSM-Id: 459868
Aligned: 520 rows
Threshold Bit Score: 31.4709
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4WPC_A          28 AINALLSRLKQSLLTCEEFMKFIRKKYAFEEEHVQELSKQYKHFFNiQG-ST-NSSLKKMIHEVLGFDGKMAQVKQS 102 Saccharomyces ce...
Q6FU67          16 GVNVLLEHVGNGIKSMDGLTTFFKLRAELEKDYARRLGAAIDLYDKsYC-EE-YGALFKTIQSFFPLERSRALAHSK 90  [Candida] glabrata
CCH62563        16 GATILLQHIANGLKSTQSIVNLFKWQSELDKDFTRRASAANDKFIKdTQaAPeYGNLSSIYNKLSTYQSMKSKSYAK 92 
XP_004181650    17 GVEVLLSHLANGLQTCQTIVNFFKQKSELEKDYSRRLGAINENLSKnLVeTSdFGHLNETINCLQNLEFKNAQYHSK 93 
CAR22646        18 GTRILLEHVSQGLESCEGLIDFFEERSKLEKDYARRLSAITAKFNSnIQsQPdYGKLGLSVKSLHSSQERLSQSHSK 94 
Q75DE5          18 GVRILLRHVAQGLDACKNMVTFFEERSKLEKDYSRKLGAIANRLEQqLEsTPdYGNMQKCAELCRAEQSKLAQSHSK 94  Eremothecium gos...
ybcl:Ecym_2308  18 GVRILLRHVAQGLEVCKNLSVFFEERSKLEKDYSRKMGAIVHHLEKqLKnTPdYGNMQRSLELCKVEQTKVAQSHSK 94 
Q6CTI1          18 GVTVLLQHVGRGICTCELLLDCFTKRSELEMDYARRLGALSARIMNnLErYAdYNNMSESLKYFQSSQQTIANGHSK 94  Kluyveromyces la...
XP_003384235    32 HYETVREQIDVLLRSAKGLLGLVKKRISLEKDRVKSLGKLSSSILDdCKfISfEGVLKESWDHIKQHSLQEGMYRSK 108
XP_002128806    22 GFETVVTHVKEGQRACKWLEDYLKLRSKAEDEFAKALLKASKLELPtME-YS--GTLKSSLDTYRTEAEEEANFHSN 95 
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