pfam00610: DEP (This model is not part of the current CDD release)
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.
Jiyao W et al.(2023). "The conserved domain database in 2023.",