Conserved Protein Domain Family
TP_methylase

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pfam00590: TP_methylase 
Tetrapyrrole (Corrin/Porphyrin) Methylases
This family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function. This family includes the methylase Dipthine synthase.
Statistics
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PSSM-Id: 425769
Aligned: 79 rows
Threshold Bit Score: 88.5537
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q3A6A0         39 HFYLVSVGCGDADNITLKAMRTIQSADIVycskkNRE-N--YPELIKDKTVYPrpgihihrylqslkgnfgfgksKGEDL 115 Pelobacter car...
jgi:Mvan_0376   8 RILGVGMGP---QHVTPEVADALRTVDYVlaaekADDdRllALRRAIVRAHGGael----------------valPDPPR 68 
WP_011748822    3 ELALIGIGTGSPGHLTREGIAAMADADLIlipakGDDkA--DLADLRRALCQQvla----------------sppPLAVF 64  Paracoccus den...
Q6N807          3 KILLIGIGPGGPNYLTFQAVEALNRATVFfipdkGDEkA--ELRLAREQICERfita--------------pgyrFVTID 66  Rhodopseudomon...
O27558          2 TLNIVGIGPGSPDYITPAAKNVVMNSEVVf----GSR-R--ALELFP--------------------------------- 41  Methanothermob...
Q6LXW9         39 VIYIVGIGPGSRDYVTEKAFDTVETSDFVl----GSK-R--SLEIFEI-------------------------------- 79  Methanococcus ...
WP_011698981   16 LVVLVGMGMGA-EDLSPRVLSWIERADVLv----GGK-R--LLDCFPDH------------------------------- 56  Syntrophobacte...
Q8DME6          3 PIHVVGIGLDGLPGLAAAVQQIIDSATLLv----GSD-R--HLQLIPQ-------------------------------- 43  Synechococcus ...
jgi:Nmar_0005   3 KVIAVGVGPGSPKYVTEVVKDIVQNCDIVi----GYK-Y--TLKTIE--------------------------------- 42 
Q9HKE1        352 HISFIGVGPSDPDLMTMKARRAIVASDIVa----GYQmPldIAKSML--------------------------------- 394 Thermoplasma a...
Q3A6A0        116 AAK---AKPELEN--------FV---RTV--TTAVRAGKN--VCLLDGGDPCIF--GPYIWTV-E--VLQD--Ld--PVI 168 Pelobacter car...
jgi:Mvan_0376  69 DRS---ERLSAGGyesavsdwHDaraAQYagVLKERGGT---AAFLVWGDPSLY--DSTIRVVeKvrALLEphValdFDV 140
WP_011748822   65 DMP---ARDAADGyrqgveawHDaiaERWeqVIRAHGAIR--PALLVWGDPSLY--DSTLRIA----ERVArrLplnLRV 133 Paracoccus den...
Q6N807         67 IPK---REAQPQDyratvddwHAriaDRFaqAMTEQLPEGscGAFLVWGDPSLY--DSTIRILd---RLRLrgMeidYEI 138 Rhodopseudomon...
O27558         42 -SA---RKTVVLG--------ARdmdEKLgrAAELAIAME--VSVLSTGDPGFS--GVLKPLK-R--IISSrgLpvrVKV 102 Methanothermob...
Q6LXW9         80 NGK---RMELTLNl-------KNelyDFLknYKNSNSKEK--VSILSTGDPCFS--GLLKTIF-SfdFIDQn----dFEV 140 Methanococcus ...
WP_011698981   57 TGE---RIPLLSS--------LDetiERLrsVARNRR-----TAVLASGDPFFF--GIGRRLV-Q--ALGKe----hVFA 111 Syntrophobacte...
Q8DME6         44 GDT---PRLSLGN--------FNaslKAIqtHLDTTANPQ--VVILTSGDPLFY--GLGRWLL-E--VFAPd----qLTF 101 Synechococcus ...
jgi:Nmar_0005  43 -HLlegKEIHEIT--------MNnqeESYqeVFPRLGDKT--LVIPFTGDVNFSesEVVDRLI-E--IFGE------VEI 102
Q9HKE1        395 -WN---KPKVVFH--------WKeqqRYVdeVIDLYEKGYr-IAYLFTGDSCFTesELIRRFT----SKCRn-----FDI 452 Thermoplasma a...
Q3A6A0        169 IPGVSCLNAANAALHRGLTFGVAAHSAIltnaadTKPGygGSDTIARMAAtRASMVVFtm--fsD-------MEKLVAEL 239 Pelobacter car...
jgi:Mvan_0376 141 LPGISAPQLLAARHRIVLHEVGKPVHVT--------TGrrLQEAVAAGM---DNIVAM--------------LNPPPERL 195
WP_011748822  134 IPGITAIQALCAAHAIPLNAVAAPVLIT--------TGrrIRDHGWPGTV--DRLVVM--------------LDGECSFQ 189 Paracoccus den...
Q6N807        139 IPGITAVQALTARHGIALNGIGEPVTVT---------TgrKLAATGRWSG--ETMVVM--------------LDGEETFA 193 Rhodopseudomon...
O27558        103 VPGISSIQLCAARLLIPWDDADVITLHG------RGEEgiLDVIDNG-----RPTIILps----------rnPSKTAAFL 161 Methanothermob...
Q6LXW9        141 IPGISSIQMAAAKAKISWEDYNILTIHGk----eENLKklLDFVKND-----EKVIFLpn-----------nLKNDIKFL 200 Methanococcus ...
WP_011698981  112 LPNVTSVQALFARLLEPWDDVKVVSLHG------RSETanAGRWLDDLRH-CSRMAFFtdp--------rrtPAWIAREM 176 Syntrophobacte...
Q8DME6        102 HPHLSAVQLAFSRLKLPWQDAVIYSAHG------RDLAglVPLLQRGV----EKIAIYtdg--------eanIAAISRLY 163 Synechococcus ...
jgi:Nmar_0005 103 VPGISSIQVAASRAQVPLDKSRVITMHVt-----TPIEdkKLELQKALID-GFSVVLVprp-wpKqpdkhfmPSEIAVYL 175
Q9HKE1        453 IPGISSVQAASSITGMAIEMAGIISFHVt-----GDIEdrKADLLRTISE-RKRAIIIprpydfM-------PKDIAKFL 519 Thermoplasma a...
Q3A6A0        240 GRFy--PPDTPVAIVARAGYAKdEQVIRGTLEsIL 272 Pelobacter carbinolicus DSM 2380
jgi:Mvan_0376 196 df--tgLDDWTIWWGANLGAPG-ERLVTGRLRdVL 227
WP_011748822  190 sl---dSEGLHIWWGAFLGMPN-QILIRGPLPeVA 220 Paracoccus denitrificans
Q6N807        194 ki---dAEGAEIFWAANLGMDD-EVLVTGKLPeIA 224 Rhodopseudomonas palustris
O27558        162 IECgldP-ERRVAVCERLSYPD-ERVLKSTLRdVS 194 Methanothermobacter thermautotrophicus str. Delta H
Q6LXW9        201 IENgisD-EKEITVLENLSYSN-ERIITNKISnLV 233 Methanococcus maripaludis
WP_011698981  177 LAAgy--aHHTMIVAEDIGLPT-ERIGRFTLReAA 208 Syntrophobacter fumaroxidans
Q8DME6        164 QALh-iPVTYRAWVCQALGSAE-EAILPWDLAqPV 196 Synechococcus elongatus
jgi:Nmar_0005 176 RECgfdTTRIKVHVFEAITTEN-ETSFEGTVKdLE 209
Q9HKE1        520 TDRg--FGDLPAVVIERATAAD-ERRTASFLKdLI 551 Thermoplasma acidophilum
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