2H1X,4Q14,7KCN,2G2N,2GPZ,8UW4,5Z5M,2H0E,3QVA


Conserved Protein Domain Family
Transthyretin

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pfam00576: Transthyretin (This model is not part of the current CDD release)
HIUase/Transthyretin family
This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyze the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolyzis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.
Statistics
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PSSM-Id: 513567
Aligned: 288 rows
Threshold Bit Score: 107.928
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2H1X_A          9 LSTHVLNIAQGVPGANMTIVLHRldpvsSaWNILTTGITNDDGRCPGLIt-kENFIAGVYKMRFETGKYWDALGEt---- 83  zebrafish
WP_016493489    4 ITTHVLDLANGRPMAGVRIELFDlg-ttP-PTLLAQALSNADGRTDEPMlaaQAARPGDFELRFAVGEHFKDsn------ 75  Metapseudomona...
WP_015190554    5 ISIHVVDVTRGLPAAGMKVEIFKv----G-GEKIAAGVLSHQGLLDHSVvrgENVELGNYKVVFHIGQFYCQLGYalpee 79  Gloeocapsa sp....
WP_012170495    7 ISIHGVDIAQGVAARGLQVKVYAld-peR--RLITEGVLGANGVFDDPIitgAGITAGTYEVEFALGAWLKANGYgar-e 82  Azorhizobium c...
WP_011924042    5 ISVHAVDVANGRPALGLRVAIWRva-pdR--TLLAEGLLGADGTLQAPVvkgDGVTAGEYEVLFHIGEFFGAEARt---- 77  Bradyrhizobium...
WP_015322328    5 LTTHVLDTGREGPATGVDVELQRld-stGeSETIARGTTNDDGRLDEPLltpDQMESGTYQLVFDVESYYRKgps----e 79  Natronococcus ...
WP_015410474    5 LTTHVLDTSREGPAEGVDVTLQRvg-ddGdVEPIAEGTTNDDGRLDEPLltpKSIEEGTYELLFDVGEYYRSgps----g 79  Natronomonas m...
35_pfamImport   1 LTTHVLDVSCGRPAQGMRVELRRlt-eeGdWELLKSAETNDDGRLEEPLlegDSMQAGRYELLFLAGAYFRRggsggdas 79 
Q9KET9          5 VTTHVLDTSCGKPAAGVVVELWRiv-egGeSELLTKAVTNQDGRLDKPLlteNKMARGVYELRFQVGDYFLRngfvn-qa 82  Halalkalibacte...
2H0E_A         11 LTTHILDLTCGKPAANVKIGLKRlg-esIx----KEVYTNNDGRVDVPLlagEELXSGEYVXEFHAGDYFASKNXnaa-d 84  Bacillus subtilis
2H1X_A         84 -cFYPYVEIVFTI-T-NTsQHYHVPLLLSRFSYSTYRG 118 zebrafish
WP_016493489   76 -aLAEVVPVRFTV-FdPT-QHYHVPLLCSPWCFSTYRG 110 Metapseudomonas resinovorans
WP_015190554   80 fpFLYVVPFRFGV-S-DVeQHYHLPLKVSPWGFSLFRG 115 Gloeocapsa sp. PCC 7428
WP_012170495   83 aaFLDIVPFRFVV-T-RVeEHYHLPFKFTPWGIQLFRG 118 Azorhizobium caulinodans
WP_011924042   78 -kFLTTVPFRFAI-D-KVeEHFHLPLKFTPWGYSIFRG 112 Bradyrhizobium sp. ORS 278
WP_015322328   80 stFLEIVPVRFVI-DdPE-EHYHVPLLLSPGGYTTYRG 115 Natronococcus occultus
WP_015410474   80 stFLETVPVRFVV-DdAE-EHYHVPLLLSPGGYTTYRG 115 Natronomonas moolapensis
35_pfamImport  80 ypFLEEVPVRFGI-EdPQ-AHYHVPLLAAPGGYSTYRG 115
Q9KET9         83 ypFLHVIPVRFGL-EdVN-EHYHVPLLVAPGGYSTYRG 118 Halalkalibacterium halodurans C-125
2H0E_A         85 qpFLTIVTVRFQLaD-PD-AHYHIPLLLSPFGYQVYRG 120 Bacillus subtilis
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