2H1X,5Z5M,4Q14,2H0F,2IGL,3QVA


Conserved Protein Domain Family
Transthyretin

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pfam00576: Transthyretin 
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HIUase/Transthyretin family
This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyze the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.
Statistics
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PSSM-Id: 425761
Aligned: 330 rows
Threshold Bit Score: 102.92
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2H1X_A             9 LSTHVLNIAQGVPGANMTIVLHRLDPVSSa-----WNILTTGITNDDGRCPGLITk-ENFIAGVYKMRFETGKYWDAlge 82  zebrafish
Q5WBJ4             4 LTTHVLDIGHGVPARGVTVALYRLQKGE-------WKAIATAATNADGRIDSPFLt-VEPLPGEYQLVFHIGEYYAKrev 75  Bacillus cl...
jgi:Pjdr2_3314     6 ITTHVLDTSKGKPAVGIKVELYLIESAESsalpegRTLLRTAATNEDGRLEAPLLgsEEMLAAVYEIVFCAGDYFRDeqr 85  Paenibacill...
jgi:Btus_2018      5 LTTHVLDVACACPAAGLAVELFRIMEDGR------KQSAARAVTGADGRLERPLLagEAMRSGFYEIVFFPGDYYRGkgg 78  Kyrpidia tu...
WP_025333856       5 LTTHVLDLVQGIPASGVFLQLRRLENGE-------SLLLREAVTNEDGRLVAPLLedAEMKPGEYELLFHAGDYFRKkdq 77  Paenibacill...
jgi:Natoc_3148     5 LTTHVLDTGREGPATGVDVELQRLDSTGE------SETIARGTTNDDGRLDEPLLtpDQMESGTYQLVFDVESYYRKgps 78  Natronococc...
KHU:HacjB3_16056   5 LTTHVLDTSREGPASGVDVTLQRLDRSGS------VETINQGTTNDDGRLDEPLLtaDQMETGTYQLLFDVGVYYRQaqs 78  Halalkalico...
ADE01435           5 VTTHVLDTSSEGPAAGVDVTLQKLDSSGE------AETVGRGTTNDDGRVDEPLLsgDAMETGTYQLLFEVGPYYRDgpt 78  Haloferax v...
Q9KET9             5 VTTHVLDTSCGKPAAGVVVELWRIVEGGE------SELLTKAVTNQDGRLDKPLLteNKMARGVYELRFQVGDYFLRngf 78  Bacillus ha...
WP_013916954       6 LTTHVLDVSCGRPAQGMRVELRRLTEEGD------WELLKSAETNDDGRLEEPLLegDSMQAGRYELLFLAGAYFRRggs 79  Paenibacill...
2H1X_A            83 ------tcFYPYVEIVFTITnTSQHYHVPLLLSRFSYSTYRG 118 zebrafish
Q5WBJ4            76 ------etFLSTVPVRFVLSsPQEHYHVPLLVSPWGYQTYRG 111 Bacillus clausii KSM-K16
jgi:Pjdr2_3314    86 rhildsdpVFDRIPIRFSVAdANSHYHIPLLVAPGGYSTYRG 127 Paenibacillus sp. JDR-2
jgi:Btus_2018     79 al--aeavFFDRVSVSLRIAdPEEDLHIPLLIAPGGYSVYRG 118 Kyrpidia tusciae DSM 2912
WP_025333856      78 g----tsgFLDLIPIRFHIGgEGGHYHVPLLLAPGGYSTYRG 115 Paenibacillus sabinae
jgi:Natoc_3148    79 -----estFLEIVPVRFVIDdPEEHYHVPLLLSPGGYTTYRG 115 Natronococcus occultus SP4
KHU:HacjB3_16056  79 -----essFLGTVPVRFIIDdVDEHYHVPLLLSPGGYTTYRG 115 Halalkalicoccus jeotgali B3
ADE01435          79 -----essFLETVPVRFVVDdANEHYHVPLLLSPGSYTTYRG 115 Haloferax volcanii DS2
Q9KET9            79 vn--qaypFLHVIPVRFGLEdVNEHYHVPLLVAPGGYSTYRG 118 Bacillus halodurans C-125
WP_013916954      80 gg-dasypFLEEVPVRFGIEdPQAHYHVPLLAAPGGYSTYRG 120 Paenibacillus mucilaginosus
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