2RHF,1YT3,5C0W


Conserved Protein Domain Family
HRDC
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pfam00570: HRDC 
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HRDC domain
The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.
Links
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Statistics
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PSSM-Id: 425755
Aligned: 102 rows
Threshold Bit Score: 48.6862
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2RHF_A    4 NADLSEALRELRRELX-KETG-YSAFVVFTNATLEALAAR-QPRTLAELAEV---PGLGEKRIEAYGERILDAI 71   Deinococcus radiodurans R1
Q9RUU2  655 HPGVLGALRELRRTLA-AEQG-RSLSWVFPEATIDELARK-LPTRSEELKDV---FGLGGQRIQAFGDRILATI 722  Deinococcus radiodurans
Q4CPU1 1091 EADLLTQMEALVQSLAeRSEG-GRRYNVMPKKTMQMLVATlAEPGWGSVSQLgdlEGLGKNKVRKFGADILRLY 1163 Trypanosoma cruzi
Q54DM3 1085 DANLVARLEKLRQDLA-LIEN-IQETYIFSRDTIDDILRV-KPKTIKELKGL---TGLPSQKIDRYGKSIIQAI 1152 Dictyostelium discoideum AX4
Q9FT73  594 FSGLELKLDELRKEIS-AADGsILPHTVLSTQQIGSISSQ-KPVSLQELESI-----IGKLKTEKYGDRILEEV 660  thale cress
Q6ALQ9  627 HPKLFASLRKWRTVKA-KEEK-IPAFQVLHQSAMVQITVS-LPKSDKELLKL---KGVGPRTVEKYGEELLSLV 694  Desulfotalea psychrophila
Q5LD80  637 HPELYKQLIAWRNSEA-AKAG-LPVYTIIQQKAILGIVNL-LPNDAASLIRI---PYFGKRGAEKYGDALLEMV 704  Bacteroides fragilis NCTC...
Q8A9U4  646 HPELYRALSEWRTAKT-REVN-MPAYVIMQQKALMGIVNL-LPDTPVALEAI---PYFGAKGVEKYGLEILGIV 713  Bacteroides thetaiotaomicron
Q5F644  614 EQQLRQKLEAWRYEQA-RAEN-CALHTVLSDESLADMLAA-TPETETDLEAV---HGLGSVRAAKYGRDILAVC 681  Neisseria gonorrhoeae FA ...
Q73KF1   76 EFAFFPYLRDERKKLA-EQAG-IPIYAVLNNAQLSQIAVE-KPKSISELSKI---EGIGQGKCEKFGEAFLQAV 143  Treponema denticola
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