1MKE,1EGX,1EVH


Conserved Protein Domain Family
WH1
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pfam00568: WH1 
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WH1 domain
WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homolog. A subset of WH1 domains has been termed a "EVH1" domain and appear to bind a polyproline motif.
Links
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Statistics
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PSSM-Id: 395450
Aligned: 8 rows
Threshold Bit Score: 142.203
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1MKE_A  33 FSFLGKKC-VTMSSAVVQLYAA--DRNCmWSK-----KCSGVACLVKDNPQRSYFLRIFDIK-DGKLLWEQELYNNFVYN 103 synthetic construct
Q12446  13 KRALPKASnKIIDVTVARLYIAypDKNE-WQYt----GLSGALALVDDLVGNTFFLKLVDINgHRGVIWDQELYVNFEYY 87  Saccharomyces cerevis...
P42768  36 FEMLGRKC-LTLATAVVQLYLAlpPGAEhWTK-----EHCGAVCFVKDNPQKSYFIRLYGLQ-AGRLLWEQELYSQLVYS 108 human
Q9VAT0  31 FKLLGKKC-QTLNTAVVQIYKTegSAHAhWKK-----RHTGVVCFVKDSAIRSYFMRAYCLI-KNELIWEHEIYDGMEVV 103 fruit fly
O96607   1 MG-E-----QPIFTCQAHVFHIdpKTKRtWITa---sMKAVNVSFFYDSSRNLYRIISVE---GTKAVINSTITPNMTFT 68  fruit fly
Q9Z2X5   3 TARE-----QPIFSTRAHVFQIdpATKRnWIPa---gKHALTVSYFYDATRNVYRIISIG---GAKAIINSTVTPNMTFT 71  Norway rat
1EGX_A   1 MS-E-----TVICSSRATVMLYddGNKR-WLPagtgpQAFSRVQIYHNPTANSFRVVGRKMQpDQQVVINCAIVRGVKYN 73  human
1EVH_A   1 MS-E-----QSICQARAAVMVYddANKK-WVPag-gsTGFSRVHIYHHTGNNTFRVVGRKIQ-DHQVVINCAIPKGLKYN 71  house mouse

1MKE_A 104 SPRGYFHTFAGDTC--QVALNFANEEEAKKFRKAVTDLL 140 synthetic construct
Q12446  88 QDRTFFHTFEMEEC--FAGLLFVDINEASHFLKRVQKRE 124 Saccharomyces cerevisiae S288C
P42768 109 TPTPFFHTFAGDDC--QAGLNFADEDEAQAFRALVQEKI 145 human
Q9VAT0 104 KSRPFLLTFEGSDG--HVGLNFVSEEECDSFFRIVDATI 140 fruit fly
O96607  69 QTSQKFGQWSDVRAntVYGLGFASEAELTKFVEKFQEVK 107 fruit fly
Q9Z2X5  72 KTSQKFGQWADSRAntVYGLGFGSEQQLTQFAEKFQEVK 110 Norway rat
1EGX_A  74 QATPNFHQWRDARQ--VWGLNFGSKEDAAQFAAGMASAL 110 human
1EVH_A  72 QATQTFHQWRDARQ--VYGLNFGSKEDANVFASAMMHAL 108 house mouse
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