Conserved Protein Domain Family

pfam00533: BRCT 
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BRCA1 C-terminus (BRCT) domain
The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
PSSM-Id: 425736
Aligned: 80 rows
Threshold Bit Score: 33.4212
Created: 16-Apr-2021
Updated: 29-Sep-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1Z56_C    1 PISNIFAGLLFYVlsdyvtedTGIRITRAEL---EKTIVEHGGKLiynviLKRHSIGDVRLI------------------ 59   baker's yeast
O97209  317 KVRELFRGLTFFI---------SREVPAKHF---ALVINACGGRVa----TDYVPSNITHVVvdr--------------- 365  Leishmania major
1CDZ_A    1 ELPDFFQGKHFFLy------gEFPGDERRKL---IRYVTAFNGEL-----EDYMSDRVQFVIta---------------- 50   human
Q93161  972 NVPQKFPTTSFHI----------WIDERTDInitNQFMEKFQAIT-----SDEANSNTTHVIvktd-------------e 1023 Caenorhabditis elegans
P41882  930 CVPEKFPVSSFHI----------YIEDRTDDnvtNEFTTKFQSIT-----SDEAMITTTHVVvktt-------------e 981  Caenorhabditis elegans
6J0Y_A    2 STSLLFEQLNFLIl-------VAAEAELPIAhstRKLLMDNSCNNcq--iYELYNENLKDVKtdkdwfmnkfgpqtvhfv 72   Saccharomyces cerev...
Q09615  251 NVSRIMEGFSVFVn-------GYTDPPALVI---RDLMISHGGEY-----HCYYQHGITSYTia---------------- 299  Caenorhabditis elegans
Q20129  496 GLGDLFENCMFYIc-------GVDESRMEKW---RRFLNETGATR-----VAKFTSATNVVVvs---------------- 544  Caenorhabditis elegans
O44844  154 KRPPLFYGFNFTIlpt---tnRRMQATREFW---NRIIEGFGGTCsmspiPGEAGKIPYHLVkrnlkvpsas--idssvv 225  Caenorhabditis elegans
O14079  485 HRRTCFNGKRLYItk-----aIRDSMVGDSIhglYSILETSGAEIvg--dIKRAQEKDTIILaqp--------------- 542  Schizosaccharomyces...
1Z56_C   60 ---SCKTTTECKALIDRGYDILHPNWVLDCI 87   baker's yeast
O97209  366 -paLP-----PGMKKHDQLEYVQPQYIFDCL 390  Leishmania major
Q93161 1024 ngaLETDSLDLLLWVFNGAIIVKEQWMVDCL 1054 Caenorhabditis elegans
P41882  982 dgiLETDDLNLLIWIFHGSIIVRDTWMVDCL 1012 Caenorhabditis elegans
6J0Y_A   73 isnTINFPFYKIVYFDLLIPVVSHTWVQDSV 103  Saccharomyces cerevisiae S288C
Q09615  300 ----ssIATAKINRIRENEIFIKADWITESI 326  Caenorhabditis elegans
Q20129  545 -pnQQERITIRKHLHQEDIAIVTVGWVVECV 574  Caenorhabditis elegans
O44844  226 lyfNDSVLHEKWTFANNCISFLGMGWLVECI 256  Caenorhabditis elegans
O14079  543 dndQEGRNMSATGLNVYKIELVALSILRDRI 573  Schizosaccharomyces pombe 972h-
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