4I3H


Conserved Protein Domain Family
DNA_topoisoIV

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pfam00521: DNA_topoisoIV (This model is not part of the current CDD release)
DNA gyrase/topoisomerase IV, subunit A
This entry represents a domain found in type IIA topoisomerases, such as bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA), and mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth .
Statistics
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PSSM-Id: 513521
Aligned: 72 rows
Threshold Bit Score: 360.715
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4I3H_A        676 RALPDIRDGLKPVQRRILYSMNKdsNTFdKSYRKSAKSVGNI--MGNFHpHGDSSIYDAMVRMSQNWKN--REILVEMHG 751  Streptococcus...
P34534        720 RSIPSLIDGLKPSQRKILWTLLN--NMDeSTEIKVSQLAGAVahRQSYH-HGEESLVRTIIRMGQTFCGssNLPLLQPIG 796  Caenorhabditi...
Q6C7Z9        783 RSIASVCDGFKPGQRKVLFGSFK--RKF-TVSIRVAQLVGYIseHTGYH-HGEASLGSTIMAMAQDFAGsnNIYLMKPDG 858  Yarrowia lipo...
Q5KP97        785 RSIPSVADGLKPGQRKVLFGCFK--RNL-TKEIKVAQLAGYVseKTAYH-HGEASLTSTIVGLAQNFVGsnNINLLDPNG 860  Cryptococcus ...
Q4WLF7        731 RSIPSVVDGLKPGQRKVLYTCFR--RNL-RKDMKVVELAGHVsgMTAYQ-HGDASLQQTIVGLAQTFVGsnNINCLEPSG 806  Aspergillus f...
P90520        808 RSIPSLIDGLKPGQRKILFASFK--RRL-TNEIKVSQLSGYVaeQTSYH-HGEQSLNSTIVKMAHNFVGsnNLPLLTPSG 883  Dictyostelium...
Q4UEG9        681 RSIPSVIDGFKPGQRKVLFGCFK--RNL-KNECKVAQLTGYIaeHSAYH-HGENSLQQTIINMAQDYVGsnNINLLLPCG 756  Theileria ann...
O41065        651 RSIPSVVDGFKPSQRKVLYCAFK--RNL-TSDVKVAQFSGYVaeHSAYH-HGEVSLQGTIVNLAQDYVGsnNINWLLPEG 726  Paramecium bu...
XP_001566276  679 RSIPSAIDGFKPGQRKILFSCFK--RNL-VNSIKVVQLAGYVseHSAYH-HGEQSLVQTIVGMAQDFVGsnNVPLLRKDG 754 
Q383C4        683 RSIPSVVDGLKPGQRKIMFSAFK--RNL-VRSLKVAQLAGYVseHAAYH-HGEQSLVQTIVGLAQDYVGanNVPLLYRDG 758  Trypanosoma b...
4I3H_A        752 NNGSM-DGDPP-AAMRYTEARLSEIAGYLLQDIEKKTVPFAWNfDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPH 829  Streptococcus...
P34534        797 QFGTRhEGGNDaASARYIFTALAPTTRLLFPQADDDLLQKNVE-EGMVVEPTWLCPIVPLILINGTEGIGTGWSTKIANR 875  Caenorhabditi...
Q6C7Z9        859 GFGSRsQGGKDaAAMRYAQTELMDITKAIFNKQDEPLYNYVTD-DDTPVEPEYYLPVLPMLLVNGCEGIGSGWSTSIPPY 937  Yarrowia lipo...
Q5KP97        861 QFGTRlAGGKDaASARYIFTNLPRMTRAIFHPADDGLLNYLVE-DGMSIEPDYFMPTVPMVLINGADGIGTGWSTAIPNY 939  Cryptococcus ...
Q4WLF7        807 NFGSRlQGGQDcASARYIYTRLSPFARRVFHAADDPLLTYNED-DGKKIEPEVYVPVVPMILINGADGIGTGWSSSIPNY 885  Aspergillus f...
P90520        884 QFGTRlQGGSDsASARYIFTKLEPVARYLFNELDDPLLNYLEE-EGESIQPDYYIPIIPMLLVNGSEGIGVGMSTSIPLF 962  Dictyostelium...
Q4UEG9        757 QFGSRkEGGKDaAAARYIFTKLSPLTRYIFLQEDDPILDYQND-DGQIIEPYYYLPIIPMVLVNGAEGIGTGFSTFIPSY 835  Theileria ann...
O41065        727 QFGSRlQGGKDhASARYIFTKLNPKTRQVFVDTDDNLLKYLYD-DGDKIEPECYVPIIPSILVNGSSGIGTGSSTNIPSY 805  Paramecium bu...
XP_001566276  755 QFGTRlHGGKDhAAGRYIFTRLMHVARAIFHPADDFVVEYKDD-DGLSVEPFYYIPVIPMVLVNGTTGIGTGFSTSIPNY 833 
Q383C4        759 QFGTRlQGGKDhAAGRYIFTRLTDIARRIYHPSDDFIVEYRDD-DGLSVEPFYYVPVIPMVLVNGTAGIGTGFATNIPNY 837  Trypanosoma b...
4I3H_A        830 NLAEVIDAAVYMIDHPtAkidklMEfLPGPDFPTGAIIQ---GRDEikkaYETGkGRVV-VRSKtEieklkggkeQIVIT 905  Streptococcus...
P34534        876 NPIDIIDMIRRKIDSIsT------EyEIPPFYEEFRGKL----EVVtptkFISS-GKIQlIRPErKnas----tfSIEIV 940  Caenorhabditi...
Q6C7Z9        938 NPLDIVDNLRRMLKDE-P-----PV-PMIPWFRGWHGEVepvGDGR----YKVK-GLIE-QVDE-R---------TLCIT 994  Yarrowia lipo...
Q5KP97        940 NPVDIVENLRRMMRGE-E-----PE-KMTPWFRGFKGFIeriDQDK----YKVS-GIIE-KIND-T---------TLEIT 996  Cryptococcus ...
Q4WLF7        886 NPEDIVDNLKRLMDGQ-P-----VK-PMQPWFRGFTGEV---TALGgd-rFKFS-GIIK-ETGDk----------EVEIT 942  Aspergillus f...
P90520        963 SPIDIIDQLMLRLNNQvA-----LK-KLIPWYRGFKGTI---SPDRh--tYRTN-GVIK-LVGR-----------NLEIT 1018 Dictyostelium...
Q4UEG9        836 NPIDIIDNIVNFLDNK-D-----MN-DMIPWYRNFKGTVtrnSKLG----YDII-GNYE-LNHSiN---------QLVIT 893  Theileria ann...
O41065        806 NPKDIVDNVKRLISGEdLv-------EMKPWYKGFKGKI---METSpg-vYVTK-GLYM-PNGK-----------TIVVS 861  Paramecium bu...
XP_001566276  834 NPLEVIRNLERLMRGE-E-----VH-KMQPWYFGFTGTMeekEPGK----FISH-GRYE-VRPD-G---------VVCIT 890 
Q383C4        838 SPLDVIDNLNRLLSGE-E-----LQ-PMKPWYFGFTGTIeerEKGK----FVSS-GCAT-VRPD-G---------VVHIT 894  Trypanosoma b...
4I3H_A        906 EIPYEINKANLVKKIDDVR-VNn----KVAgi-aEVRDE-SDRdGLRIAIELKk---DAN---TELVLNYLFKyTDLQIN 972  Streptococcus...
P34534        941 ELPIGIWTSKYKEKLSKIV-ETl----PVL----EFSERhTEK-RVHFRITLDr---KKSsrfLQKSNSDLLNyFKLRTS 1007 Caenorhabditi...
Q6C7Z9        995 ELPARMWTISMKEFLLSSLiDSknekgWIE----DFTEDhGF--RVKFNITLSe--kEME---KTRQIG-LRErFKLISS 1062 Yarrowia lipo...
Q5KP97        997 ELPIRRWTQDFKEMLEEMTtGTdkvpqTIK----DYEEHhTDT-TVHFRVHMTe--kNLA---DAEKEG-FDKrFKLTTS 1065 Cryptococcus ...
Q4WLF7        943 ELPIRTWTQDFKDKLEEII-KAe----KTPsfikDYKDYnTHT-KVHFVIQMDe---KNL---QSAREEGLEEkFKLSKT 1010 Aspergillus f...
P90520       1019 ELPIGRWTSDYKEVLNDLI-DKd----VIK----SFQES-NTEnSVHFTILLNnnqlEQM---EDLTENELIKlFKLSAS 1085 Dictyostelium...
Q4UEG9        894 ELPINRWTNDYREYLNSIMaTNkedegYIT----DYGDFsSNE-FIKIKIKLNd--------sGPDITDDIEKvFKLKTT 960  Theileria ann...
O41065        862 ELPVGKWTHDYKEHLDGLL-EKk----IIS----YFREKhSDT-DVLFEIDFV--------------GNPNIDiLKLETT 917  Paramecium bu...
XP_001566276  891 ELPIGVWTQTYKKFLEDMReKE-----LVV----QYREHtTDV-TVDFEVFLHp--qVLE---QWVAQDVVEErLQLKEY 955 
Q383C4        895 ELPIGTWTQQYKKFLEDLReRE-----IVI----QYREHnTDV-TVDFEVFIHp--eVLR---QWVAQGCVEErLQLREY 959  Trypanosoma b...
4I3H_A        973 YNFNMVAIDNF-T--PRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEglirviSILDEVIALIRASEN-KAD 1048 Streptococcus...
P34534       1008 LTENRVLFDRNgEl-KEFGNISEIAAEFFEVRRDLYEKRLKIQKEECEAKLIYVE------NQLNFIEMVTNGTIEiRSM 1080 Caenorhabditi...
Q6C7Z9       1063 LSTSNMVAFDPeGriKKYDSPEAIMKEYFPVRLEFYQKRKDRLVSDFEQQLEKLT------AQARFIKLIIDKKLNiNNK 1136 Yarrowia lipo...
Q5KP97       1066 LGTGNMVCFDLnGkiKKYASPEEILEEFFHKRLEFYGHRKQHLADELNRQFERLS------NQARFVHMIITKELVvSGK 1139 Cryptococcus ...
Q4WLF7       1011 IATTNLVAFDPeGriTKYASVDDILKEFYAVRLKFYERRKQYQLNELQKELDKLT------NQARFVQMIIDGDLViSKK 1084 Aspergillus f...
P90520       1086 LNFHLTCFDENsKi-QKLESVEEIIDQFYKVRLQFYGKRREYLLKSLDNQIKRLT------TTIQFLEVIASGKLKiQGR 1158 Dictyostelium...
Q4UEG9        961 ISTSNMILFDCnKriKKYNGAIDILKDFITTRVKYYTKRREYMIKQLQLQLQQLS------NQIRFINMIINNELViFRK 1034 Theileria ann...
O41065        918 IRSTNMHAFDPsGkiKKYDTPLDIIRDWFEVRKDLYVKRKAYLLEDLTHRTNIAQ------NKHRFITMVNNDEIIiNKK 991  Paramecium bu...
XP_001566276  956 VHATNIIAFNKeGqiTKYWDAESVLKDFYLVRLDYYAKRKDYLLGELRRLTSKLE------NMVRFVREVVEGTLVvTKR 1029
Q383C4        960 IHATNIIAFDReGkiTKYLDAESVLKEFYLVRLEYYARRREFLLEQLQRAALKLE------NMVRFVNEVIDGTFIvTRR 1033 Trypanosoma b...
4I3H_A       1049 AKENLKVsyDFTE------------------------------------------------------------------- 1061 Streptococcus...
P34534       1081 GRNQLEE--KLQEmgfrvdpma--------------------------------------------------tiaknskk 1108 Caenorhabditi...
Q6C7Z9       1137 GRKVLIA--ELSElkfprygkngerlasdakaaiaed-------------------eeapsdevaedlaeaeeihgkipt 1195 Yarrowia lipo...
Q5KP97       1140 RRPDIVA--ELRSlkfkpfpkkerakeege-----------------------------------neaaeeeedgdegqa 1182 Cryptococcus ...
Q4WLF7       1085 KKPALVA--ELKKhgfkafpkvidavkageda-----------------------------pvveeeedesgndetevls 1133 Aspergillus f...
P90520       1159 SKQDLIK--ELESgeivgfe-----------------------------------------------------nfgthpp 1183 Dictyostelium...
Q4UEG9       1035 SKKQIVS--ELKRlnfntykpeee------------------------------------------------edeedndi 1064 Theileria ann...
O41065        992 HESVISA--ELEKlnfy------------------------------------------------------------kvd 1009 Paramecium bu...
XP_001566276 1030 KKKELLE--DLQGrlylpfpphakkklssttveeeggeaepttq-----nseedvlgmgsaadggvddgdaetpevrrat 1102
Q383C4       1034 SMKDVLK--DLKQrgytpfppqqkkkmssttivdeedndgarkilpdvfefesvplceqvigkilctaepeeinmwkgvl 1111 Trypanosoma b...
4I3H_A       1062 EQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDertmyNLMKKELR 1116 Streptococcus pneumoniae TIGR4
P34534       1109 ANYGYLLEMPVSRLTSDEMKRLEERKSRRRTELEAAESADWK-----SVWRSELD 1158 Caenorhabditis elegans
Q6C7Z9       1196 NGYDYLLGMALWSLTKERYEKLLRERDGKEEELIELLKKSAK-----DIWMDDLD 1245 Yarrowia lipolytica
Q5KP97       1183 sdYDYLLGMAIWSLTSEKVEKLLAERDAKEQELIELLKLSPN-----NIWDRDLD 1232 Cryptococcus neoformans
Q4WLF7       1134 SAYDYLLGMPLWSLTHERVEKLRRQIGEKEVEIDALIKLSKE-----DIWKRDLD 1183 Aspergillus fumigatus
P90520       1184 EVYQHLFSLSILDITKERIDNLTNQLTKRKSEHQSISSSDPK-----SLWTADLQ 1233 Dictyostelium discoideum
Q4UEG9       1065 egFNYLLKMSLLSLTLDHINKLNNEYNSKQVQLKELINTTPI-----QLYKKDLV 1114 Theileria annulata
O41065       1010 GKYDYLLNMRISSLTLERATELEREAVKLNKELDDLSKTTET-----DMWNNDLQ 1059 Paramecium bursaria Chlorella virus 1
XP_001566276 1103 RNYDYLLGMKLWSLTAEMIARLEAQLARARHDTATMEARTPK-----DMWMEDLQ 1152
Q383C4       1112 VEYDYLLSLRMVDLTVEMAMYFRTKREQMLNKHNFVLSASSK-----DLWREDLD 1161 Trypanosoma brucei
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