8X93,8HLP,8HLP,8HLP,8EPM,8EPM,7UHF,7UHF,7DTC,7DTC,6KZO,6KZO,6KZO,7WEL,7WEL,7WEL,7JPK,7JPK,7JPK,7XMF,8FHD,5XSY,5XSY,5XSY,8TEO,7TJ8,7TJ8,7TJ8,7WSW,7SX4,7SX4,7SX4,7FHO,7FHO,8IZY,7YID,7VNP,7O4H,7XNI,8WUI,7WM1,7PXH,7A6U


Conserved Protein Domain Family
Ion_trans

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pfam00520: Ion_trans (This model is not part of the current CDD release)
Ion transport protein
This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Statistics
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PSSM-Id: 513520
Aligned: 286 rows
Threshold Bit Score: 56.5118
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8X93_A  529 QAFYWTVLSLVALNTLCVAIvhynQP--------------------------Ew--------------------lSDfly 562  human
Q25376  170 RVIAIVSVSVIVISIVTFCLetlpEFkryellnd----------tiivddamPk--------------------fGTpff 219  Doryteuthis opalescens
P08510  227 RVVAIISVFVILLSIVIFCLetlpEFkhykvfnttt------ngtkieedevPd--------------------iTDpff 280  fruit fly
P17659  231 DSYAFPG----SIPSGGLGTggtsSFstl---------------------ggSf--------------------fTDpff 265  Norway rat
Q09470  167 RVIAIVSVMVILISIVIFCLetlpELkddkdftgtvh----ridnttviynsNi--------------------fTDpff 222  human
G5EFC3  204 KLIAGISVLFIFISIFSFCLkthqSFrlpvligqnitmpggvvqpsiervstEp---------------------LPifg 262  Caenorhabditis elegans
O76457  174 KIIAVISVFFIVISILSFCLkthpEMrvpvlknatsrtvngtytwrlekketEp---------------------HEaff 232  California sea hare
P17972  174 KTIGVVSVFFICISILSFCLkthpDMrvpivrnitvkta-ngsngwfldktqTn--------------------aHIaff 232  fruit fly
O76266  210 YAVAFISVIMTTISIILFCVetleRFakshc----------------vadeaPn--------------------fLDpff 253  medicinal leech
8TEO_A  229 RVVAIISVFVILLSIVIFCLetlpEF--------------------------KhykvfntttngtkieedevpdiTDpff 282  fruit fly
8X93_A  563 YAEFIFLGLFMSEMFIKMYGLG-TRPYFHSSFNCFDCGVIIGSIFEV------------I-------------------- 609  human
Q25376  220 IIETGCIIWFTMELLIRFASCPgKLDFFKDSMNAIDVVSIMPYFITL------------G-------------------- 267  Doryteuthis opalescens
P08510  281 LIETLCIIWFTFELTVRFLACPnKLNFCRDVMNVIDIIAIIPYFITL------------A-------------------- 328  fruit fly
P17659  266 LVETLCIVWFTFELLVRFSACPsKAAFFRNIMNIIDLVAIFPYFITLgtelvqrheqqpV-------------------- 325  Norway rat
Q09470  223 IVETLCIIWFSFELVVRFFACPsKTDFFKNIMNFIDIVAIIPYFITL------------G-------------------- 270  human
G5EFC3  263 QIEMLCNIWFTLELIIRFVFCPsKIRFFKSPLNMIDLVATLSFYADAm----------mV-------------------- 312  Caenorhabditis elegans
O76457  233 YIECASNAWFTFEIIIRFVVAPnKLDFLKAPVNIIDIVATLSFYLDFmlt------elkQ-------------------- 286  California sea hare
P17972  233 YIECVCNAWFTFEILVRFISSPnKWEFIKSSVNIIDYIATLSFYIDL------------V-------------------- 280  fruit fly
O76266  254 IIETICTAWFTFEAIVRFISCPnKIMFWFGFQNLIDVTAVVPYYVTL------------F-------------------- 301  medicinal leech
8TEO_A  283 LIETLCIIWFTFELTVRFLACPnKLNFCRDVMNVIDIIAIIPYFITL------------Atvvaeeedtlnlpkapvspq 350  fruit fly
8X93_A  610 ---Wavi-----------------------kpGtsFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLL 663  human
Q25376  268 ---Tviqndtnt-------------qdkqnmsL--AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASLRELGLLIFFL 329  Doryteuthis opalescens
P08510  329 ---TvvaeeedtlnlpkapvspqdkssnqamsL--AILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFL 403  fruit fly
P17659  326 ---Sggsgqn----------------rqqamsL--AILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFL 384  Norway rat
Q09470  271 ---Teiaeqegn------------qkgeqatsL--AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFL 333  human
G5EFC3  313 ---Rvve----------------------depK--DVVEFLSMIRIFRLFKLTQHHQGLQILIHTFRASAKELILLVFFL 365  Caenorhabditis elegans
O76457  287 ---E----------------------------S--DMLEFFSIIRIMRLCKLTRHSAGLKILIHTFKASAKELILLIFFL 333  California sea hare
P17972  281 ---Lqrfas-------------------hlenA--DILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFL 336  fruit fly
O76266  302 ---Nvvstms----------------cstaksS--ASLAFLRVIRLVRVFKLTKHSTGLQVLILTIKASSEELGLFLVVL 360  medicinal leech
8TEO_A  351 dksSnqa-----------------------msL--AILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFL 405  fruit fly
8X93_A  664 FLFIVVFALLGMQLFgGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSqggvQggmvfsiYFIVLTLFG 743  human
Q25376  330 VIGVVLFSSAV--YFa-----EVDTEQSHFKSIPDSFWWAVVTMTTVGYGDMSPVGVYG----K-------LVGSLCAIA 391  Doryteuthis opalescens
P08510  404 FIGVVLFSSAV--YFa-----EAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWG----K-------IVGSLCAIA 465  fruit fly
P17659  385 FIGVILFSSAV--YFa-----EADDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGG----K-------IVGSLCAIA 446  Norway rat
Q09470  334 FIGVILFSSAV--YFa-----EAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGG----K-------IVGSLCAIA 395  human
G5EFC3  366 ILGIVIFAALV--YYaEKME---ANPNNQFQSIPLGLWWAICTMTTVGYGDMTPHTSFG----R-------LVGSLCAVM 429  Caenorhabditis elegans
O76457  334 VLGIVIFAALI--YYaERIQ---YNPENDFESIPVGLWWAIVTMTTVGYGDMAPKTYVG----M-------FVGALCALA 397  California sea hare
P17972  337 VLGIVIFASLV--YYaERIQ---PNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIG----M-------FVGALCALA 400  fruit fly
O76266  361 LVCMLVYSSAIYYAElGVPK-------SNIHSIPDAFWWAIITMTTVGYGDTFPVGPFG----K-------VIGAACAIS 422  medicinal leech
8TEO_A  406 FIGVVLFSSAVYFAEaGSENSf-------FKSIPDAFWWAVVTMTTVGYGDMTPVGVWG----K-------IVGSLCAIA 467  fruit fly
8X93_A  744 NYTLLNVFLAIAVDNLANAQELTK 767  human
Q25376  392 GVLTIALPVPVIVSNFNYFYHRDA 415  Doryteuthis opalescens
P08510  466 GVLTIALPVPVIVSNFNYFYHRET 489  fruit fly
P17659  447 GVLTIALPVPVIVSNFNYFYHRET 470  Norway rat
Q09470  396 GVLTIALPVPVIVSNFNYFYHRET 419  human
G5EFC3  430 GVLTIALPVPVIVSNFAMFYSHNQ 453  Caenorhabditis elegans
O76457  398 GVLCIALPVPVIVSNFALFYSHTQ 421  California sea hare
P17972  401 GVLTIALPVPVIVSNFAMYYSHTQ 424  fruit fly
O76266  423 GVLTLAMPVPILTGHFNKFYAHKT 446  medicinal leech
8TEO_A  468 GVLTIALPVPVIVSNFNYFYHREt 491  fruit fly
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