Conserved Protein Domain Family
PPV_E1_C
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pfam00519: PPV_E1_C 
Papillomavirus helicase
This is the C-terminal ATPase/helicase domain of Papillomavirus E1 protein, a DNA helicase that is required for initiation of viral DNA replication. This protein forms a complex with the E2 protein pfam00508. The domain architecture of E1 is similar to that of the SV40 T-antigen.
Links
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Statistics
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PSSM-Id: 459841
Aligned: 11 rows
Threshold Bit Score: 532.703
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q705G8 327 VLKFDFSHMVQWALDNEMMDESSIAFHYAQMADHDSNARAWLGLSNQAKIVKDVCTMVHHYQRAIMRSMTMSAYVHKMCE 406 Bos taurus papillomav...
P03114 352 DCTFELSQMVQWAYDNDIVDDSEIAYKYAQLADTNSNASAFLKSNSQAKIVKDCATMCRHYKRAEKKQMSMSQWIKYRCD 431 Human papillomavirus 16
Q89536 300 EKTFDLSEMVQWAYDNDLKDESEIAYKYAALAETDENALAFLKSNNQPKHVKDCATMCRYYKKAEMKRLSMSQWIDERCK 379 Canine oral papilloma...
P03111 315 ESPFELCKMVQWAYDNGHTEECKIAYYYAVLADEDENARAFLSSNSQAKYVKDCAQMVRHYLRAEMAQMSMSEWIFRKLD 394 Human papillomavirus ...
P03112 306 EKPFQLSVMVQWAYDNHLQDESSIAYKYAMLAETDENARAFLASNSQAKYVRDCCNMVRLYLRAEMRQMTMSAWINYRLD 385 Papillomavirus sylvil...
P27551 316 TDTFELSRMVQWALDNDLQDEHMLALEYALLAESDGNARAFLKQNNQPMIVKNCSIMVRHYKTALVAKMSISQYVNKRCL 395 Human papillomavirus ...
Q07846 303 AETFELSRMVQWAYDNNYVDECDIAYHYAMYAEEDANAAAYLKSNNQVKHVRDCSTMVRMYKRYEMRDMSMSEWIYKCCD 382 Human papillomavirus 4
P06920 309 ASTFDFSAMVQWAFHNHLLDEADIAYQYARLAPEDANAVAWLAHNNQAKFVRECAYMVRFYKKGQMRDMSISEWIYTKIN 388 Human papillomavirus 5
Q8QQC0 319 EVKFDFSQFVQWAYDNEYQEEHEIAYNYASIADEDSNAAAWLGLTGQAKVVKDVATMVRYYRRAEMNRMSMSNWIHNRKK 398 Equus caballus papill...
Q84356 304 ETKFDLSEMVQWAYDNNYEDESQIAFEYARTATESPNANAWLASNAQAKHVRDCATMVRHYKRAEMKAMSMSQWVWKCCR 383 Mastomys natalensis p...
Q8UZ18 346 AATFSLSAMVQWAYDNGLEGESEIAYGYAQLAEEDTNAEAFLRSNAQAKHVKDCAIMVRHYRRAEMCKMNIAQWIKLRCS 425 Omikronpapillomavirus 1

Q705G8 407 RV-N-VTGSWLVIMQFLKFHGIEPIRFVNALRPWLQGVPKKNCLAFIGPPDTGKSLFTNSLMSFLKGKVLNFANSASHFW 484 Bos taurus papillomav...
P03114 432 RV-D-DGGDWKQIVMFLRYQGVEFMSFLTALKRFLQGIPKKNCILLYGAANTGKSLFGMSLMKFLQGSVICFVNSKSHFW 509 Human papillomavirus 16
Q89536 380 ATdD-GPGDWKEVVKFLRHQGIEFILFLADFKRFLRGRPKKNCLVFWGPPNTGKSMFCMSLLSFLHGVVISYVNSKSHFW 458 Canine oral papilloma...
P03111 395 NV-E-GSGNWKEIVRFLRFQEVEFISFMIAFKDLLCGKPKKNCLLIFGPPNTGKSMFCTSLLKLLGGKVISYCNSKSQFW 472 Human papillomavirus ...
P03112 386 GM-N-DDGDWKVVVHFLRHQRVEFIPFMVKLKAFLRGTPKKNCMVFYGPPNSGKSYFCMSLIRLLAGRVLSFANSRSHFW 463 Papillomavirus sylvil...
P27551 396 DHgEaDENSWRGIVHFLRYQGQEFLPFMCKMHNFLHHRPKKSTLVLCGPSDTGKSYFANGLNKFLDGHVLSFVSNGSHFW 475 Human papillomavirus ...
Q07846 383 EC-S-EEGDWKPISQFLKYQGVNILSFLIVLKSFLKGIPKKNCIVIHGPPDTGKSLFCYSFIKFLKGKVVSYVNRSSHFW 460 Human papillomavirus 4
P06920 389 EV-E-GEGHWSDIVKFIRYQNINFIVFLTALKEFLHSVPKKNCILIYGPPNSGKSSFAMSLIRVLKGRVLSFVNSKSQFW 466 Human papillomavirus 5
Q8QQC0 399 K--S-KPGQWQPIVNFLKYQGVAMVTFINALKSFLKGTPKKNCLVIWGPPNTGKSWFCMSLMHFLGGRVLSHVNSNSHFW 475 Equus caballus papill...
Q84356 384 EEpE--EGTWTPISLYLASEGVEVIRFLSAMKSWLRGIPKKNCLVFYGPPNTGKSLFTMSLIKFLRGRVISFANSKSHFW 461 Mastomys natalensis p...
Q8UZ18 426 KV-E-GEGDWRPIMKFLKFQKVEILAFLTFMRHFLRGTPKRNCMVLLGPPNTGKSLFGMSLMHFLGGKIISHVNSGSHFW 503 Omikronpapillomavirus 1

Q705G8 485 LAPLTEAKVALIDDATHACLKYCDTYLRNFFDGYSVCIDRKHKNAVQIKAPPMLLTSNIDIQAEEKYSYLKSRVTCFYFN 564 Bos taurus papillomav...
P03114 510 LQPLADAKIGMLDDATVPCWNYIDDNLRNALDGNLVSMDVKHRPLVQLKCPPLLITSNINAGTDSRWPYLHNRLVVFTFP 589 Human papillomavirus 16
Q89536 459 LQPLTEGKMGLLDDATRPCWLYIDTYLRNALDGNTFSVDCKHKAPLQLKCPPLLITTNVNVCGDEKFKYLRSRCSFFHFP 538 Canine oral papilloma...
P03111 473 LQPLADAKIGLLDDATKPCWDYMDIYMRNALDGNTICIDLKHRAPQQIKCPPLLITSNIDVKSDTCWMYLHSRISAFKFA 552 Human papillomavirus ...
P03112 464 LQPLADAKLALVDDATSACWDFIDTYLRNALDGNPISVDLKHKAPIEIKCPPLLITTNVDVKSDDRWRYLFSRICVFNFL 543 Papillomavirus sylvil...
P27551 476 LSPLRGARCCLIDDATLTFWRYADQNMRALLDGYEISIDAKHRNPMQTRAPPLIITTNEDIMRLDEFKYLQTRTMYVYFN 555 Human papillomavirus ...
Q07846 461 LQPLMDCKVGFMDDATYVCWTYIDQNLRNALDGNPMCIDAKHRAPQQLKLPPMLITSNIDIKQEQSLMYLHSRIQCFNFP 540 Human papillomavirus 4
P06920 467 LQPLSECKIALLDDVTDPCWIYMDTYLRNGLDGHYVSLDCKYRAPTQMKFPPLLLTSNINVHGETNYRYLHTTIKGFEFP 546 Human papillomavirus 5
Q8QQC0 476 LQPLGDAKVALLDDATTVVWDYFDRYMRNACDGNPISLDMKHKAPVQIKCPPLLITSNIDVKADDRWLYLHSRLVTFHFP 555 Equus caballus papill...
Q84356 462 MQPLAEAKVVLLDDATRATWDYVDTYMRNAMDGNPLSIDCKYRTPVQVKCPPMLVTTNEDVHLNDRWRYLHSRIQVFHLK 541 Mastomys natalensis p...
Q8UZ18 504 LQPLLECKVAMLDDATTSTWDYMDIYLRNMLDGNTVCLDAKHKAPMQLKCPPLIVTTNVDVTANDKWKYLHSRLKVFTFP 583 Omikronpapillomavirus 1

Q705G8 565 DKCPLNEDGKPLFQITDPDWKSFFERLWQRLELSDQEEEE-EgdENGSRGTFIC 617 Bos taurus papillomavirus 5
P03114 590 NEFPFDENGNPVYELNDKNWKSFFSRTWSRLSLHEDEDKE-N--DGDSLPTFKC 640 Human papillomavirus 16
Q89536 539 QEFPLDDNGNPGFQLNDQSWASFFKRFWKHLDLSDPEDGE----DGETQRGLRL 588 Canine oral papillomavirus (strain Y62)
P03111 553 HEFPFKDNGDPGFSLTDENWKSFFERFWQQLELSDQEDEG-N--DGKPQQSLRL 603 Human papillomavirus type 1a
P03112 544 QELPIR-NGTPVYELNDANWKSFFKRFWSTLELSDPEDEG-D--DGGSQPALRl 593 Papillomavirus sylvilagi (STRAIN KANSAS)
P27551 556 KPFPLKGNGQPLYYIDGYTWNSFFRKFWRHLNLKDPEDES----DGETPGTIRL 605 Human papillomavirus type 41
Q07846 541 NKMPILDDGSPMYTFTDGTWKSFFQKLGRQLELTDPEEEN----NGVPSRTFRC 590 Human papillomavirus 4
P06920 547 NPFPMKADNTPQFELTDQSWKSFFTRLWTQLDLSDQEEEG-E--DGESQRAFQC 597 Human papillomavirus 5
Q8QQC0 556 NLFPFEDDGSPVYQFNDENWNSLFTRLWRALDLSDQEDEG-D--DGDPAPAFRC 606 Equus caballus papillomavirus 1
Q84356 542 EPMPIDTAGNPEYSFSNRHWKAFFEKLQKPLDLSEDEGDPkD--NGEHTQPFSC 593 Mastomys natalensis papillomavirus (isolate Afr...
Q8UZ18 584 NLCPLNCRGDPEFQLTPENWKAFLEKCWTSLGLEDLLKDG----DGEPLQPLRC 633 Omikronpapillomavirus 1
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