4FID,2XTZ,6K41


Conserved Protein Domain Family
G-alpha

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pfam00503: G-alpha (This model is not part of the current CDD release)
G-protein alpha subunit
G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA .
Statistics
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PSSM-Id: 513508
Aligned: 130 rows
Threshold Bit Score: 111.613
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FID_B          1 SNAKPITVXL-------------------LGSG-----ESGKs----TIAKQLKILFGGGFPEQERa------tHKSsi- 45   Entamoeba his...
XP_002679780  137 PRFSTGIPSP-------------------RLSVq---sSALQvyqshIRFIFLASGESGRKTLSKLirynlepeVIEkq- 193 
XP_002677043   42 KKERDGYDEDnlncvniesvdattaaasaITEQq---mNNKR-----MNVLCLGGSDSGKSTFVNTl------tEQY--- 104 
XP_002671918   15 STITIHQEQL-------------------LSTE--------D------EWIILGTADSGTSTFYYMi------eRILrkn 55  
XP_002674060   13 SQIGESIT---------------------IQQEq---sTREE------SWIILGTADSGTSTFYYMi------eRILsnn 56  
XP_002679518   15 SNNTPLLQQT-------------------KHSNn---nDNHQ------RIVLLGNTSSGKSTICEMi--------qYqk- 57  
XP_002676985   45 NSTNSNSNNS-------------------NVSNn---nTINN------NIYCVGCSDGGKTSFHNQlk-----sKFHmk- 90  
XP_002672578   26 QRRGSNVGQI-------------------HATSp---pTSTTtf--gANLLFSSRSDDL----FDEleddds-----kss 72  
XP_002674728  785 PNFARYVD---------------------LEAEnktndELNTsiaepFSLLFIGEDKSGLTSYLQQi------rTMFrq- 836 
XP_002676158  155 SKLISGISHQ-------------------EHLKr---lQDCK------LVLILGGVDSGKNLI-QQfq-----nMIHpe- 199 
4FID_B         46 -cSNVVt-cXR-TLI-------EQSAILNHPXKYQPKSKEF--T----TEDP--------------VTLPFSPELVGDVE 95   Entamoeba his...
XP_002679780  194 -aFDLNqsySTlY---------FFFSNTIILLEQFYQMLFElkF----PNQCinelppilanvepqIIQEILKDLKEIED 259 
XP_002677043  105 --QSNS---KAvSTS-------EHFECLCRHMSQIAKSYRQ--D----GHERwpec-------semTNKILFGGEESTED 159 
XP_002671918   56 rnYSNRdefNH-DLQ-------IVCSLMIKRLWTILEESER--NriidMIPKsf-----------gPCLENLNDKSNIDD 114 
XP_002674060   57 rhYSNRnefNH-DLQ-------LVCFLMIKNLWTILESERS--R----IIDLipk--------sfgPCLENLNDKSNIDQ 114 
XP_002679518   58 -qHQADk-sCNtYNL-------FYKVDSNTISKTIIEQILF--A----SKDIsi----------eaIIREYTNDCNNFDN 112 
XP_002676985   91 -iHKNEkirAT-----------LIIKTCLSSIQDIIFIVMSd-----------------------qERNDFIHKIKKSDP 135 
XP_002672578   73 qsFQTS---TQ-FLS-------LLGHNILDQAKKVNDLHTT--Q----VQSIpiy---------gnNRKDSVDLSKAPKL 126 
XP_002674728  837 -sVSLQe-aKT-YKQhiqaftaWLFHQFIS-LKQLLQALDK--E----EPLIvlsp-------dlsKNCEALFDILDNSD 899 
XP_002676158  200 -sVSPR---INyLSN-------SSMNTNVNSTNGKTSPNGN--Q----SPSNifsln-----pqtsQNSNNGSSSMTVNS 257 
4FID_B         96 A----------------LWADEGi-----------QATYEESAK-F--QL-------PDCAKYL--FEn-VKR--I---- 129  Entamoeba his...
XP_002679780  260 IpmdrefsvdqvnklsnNIPMASnckvvlklitkqVYNNLILFF-ErqDVk-----lLIRKYHDllQTq-QHGtiF---- 328 
XP_002677043  160 Vss------------pkDDEIQI------------IITDFERIW----ST-------CLKSYYEknKDakHFT------- 197 
XP_002671918  115 Sq---------------ISEFDYcgllmyiwnipfFRESFETKW-NaiSP-------NISENIKdpNIvmNLL--I---- 165 
XP_002674060  115 Sq---------------ISEFDYcellmyiwnipfFRDLFETKW-NaiSP-------NISENFKdpNIn-YYHvlS---- 166 
XP_002679518  113 S-------------------------------------TLFALW-N--DQ-------KFRNIYQ--SCqdSLN--L---- 137 
XP_002676985  136 Qiydflln---ltnitrKWEFTKses-------iqYGQYIRMIW-S--Ky------kIIQELYY--LYk-DSH--H---- 187 
XP_002672578  127 VlvgtgssdsidnilgdTTFLSDe-----------ICERLVDFWmD--EP-------IIQMCYFfaSIayKFI------- 179 
XP_002674728  900 Kh--------------aCTFLIPq-----------VRDSIVALS-T--NkefvkiftNLSSIYG--KLsnKYY--Ftslp 947 
XP_002676158  258 Sd--------------nNSVSSSqqilrrlwkqkeFFKVMDQLW-K--HP-------FVQKSYR--ERn-SRKtpI---- 306 
4FID_B        130 -----A---XEDYV---------PTEE---------DLIHNRTk--TTG------------------------------- 150  Entamoeba his...
XP_002679780  329 ---------DRIEIlksvs-------------hetlCEILEKPsnsFTK------------------------------- 355 
XP_002677043  198 ---------ENMNQ---------VFK----------NGKLCLQkckYQL------------------------------- 218 
XP_002671918  166 -----L---ENLEE---------L------------ISRIKSKs-eFFP------------------------------- 184 
XP_002674060  167 -----LlilENLEE---------L------------ISRIKSKt-eFFP------------------------------- 188 
XP_002679518  138 -----F---ENVDI---------F------------VRKLKNHe-sFIP------------------------------- 156 
XP_002676985  188 -----Li--DNIDV---------LCNEmnii--isqLSDHQKNq--FLKntkrrlnqrlnstteivtsnslncnqlennl 247 
XP_002672578  180 -----E---GYGDYsrnraeksvYIRHlnlenlptlIDQLEDVl-sYETegddlqs------------------------ 226 
XP_002674728  948 hdihkLfftANIAY---------FLNEap------rIL---QEn--YLP------------------------------- 976 
XP_002676158  307 -----PllgENIEY---------FLNDgrv----ekLKKITEL------------------------------------- 331 
4FID_B        151 ------------------------------------------------------------IH------------------ 152  Entamoeba his...
XP_002679780  356 ------------------------------------------------------------EE------------------ 357 
XP_002677043      --------------------------------------------------------------------------------     
XP_002671918      --------------------------------------------------------------------------------     
XP_002674060      --------------------------------------------------------------------------------     
XP_002679518      --------------------------------------------------------------------------------     
XP_002676985  248 ydqddeedgeeqqqqdaedlyqldnhinnimnskkkskkisifsskfksnfnssqqnnnnTSlnnennnennntshydky 327 
XP_002672578  227 -----------------------------------------------------kfssaikDD------------------ 235 
XP_002674728  977 ------------------------------------------------------------TE------------------ 978 
XP_002676158  332 ------------------------------------------------------------TK------------------ 333 
4FID_B        153 EYDFVV---K--DI--PFHLIDVGG-------QR------------------S-ERK---------------------XW 178  Entamoeba his...
XP_002679780  358 EELILRlffIsrQK--LTGCSQFTL-------QL------------------G-PHK---------------------LS 388 
XP_002677043  219 YNSTNS----------TQRETIRRF---------------------------StSHE---------------------LN 240 
XP_002671918  185 MALSYT---S------SMGVRDFKY---------------------------N-NIL----------------------- 204 
XP_002674060  189 LALSYE---I------TKGVREFRY---------------------------N-NIL----------------------- 208 
XP_002679518  157 DIYIKG---N------SSGITEYDI-------NF------------------D-DKK---------------------VT 180 
XP_002676985  328 SPLIKF---L------TIGKNETKF-------QF------------------DsKNL---------------------FT 352 
XP_002672578  236 SHIVTElivStyVK--TTGIIEIPV-------KF------------------GdNNL---------------------IG 267 
XP_002674728  979 FDIVAY---PekTHfhPLNIIENELasremteEVrrssikttssqsisddmfTeDLSqyrnnyeslnmstekaplefmFR 1055
XP_002676158  334 QDIVRAkilS--LE--SMPVKDITKptlenreLV------------------TrKLL----------------------- 368 
4FID_B        179 --VSFFSDVD-CAIFVTSL-A-E----YDXKLYEDGNTSRLTES-------------IAVFKDI---------XTNEFLK 227  Entamoeba his...
XP_002679780  389 --FCLVAGQR-AERKKYP--R-Ym--eQGFEYVIFCMNLSEYNR-------------NLYENDT---------ITRFRDT 438 
XP_002677043  241 --LVTAGGKK-MERRRWNS-LdL----EGTNVLLLFVSLSEFNQ-------------QSIEDSK---------TNRMDES 290 
XP_002671918  205 --VKNVGGSR-SQRKKWIN-C-F----NGQSLAILLVSLAELDQ-------------YTVEDAR---------TLRMQES 253 
XP_002674060  209 --VKNAGGSR-GQRKKWL--CcF----NNQSIAIFIISLAELDQ-------------YTVEDTQ---------TLRIQES 257 
XP_002679518  181 --FVTAGGKT-SERKKWNF-ClQ----GNVSVLVYVVSLAEFNQ-------------SGYGDEK---------VNRMDES 230 
XP_002676985  353 --ILDLGGRG-AEKKKWEF-F-Ln--eTNADFVLFFVSMSEFNQ-------------NLIESDN---------INRLHES 403 
XP_002672578  268 --LYDTGGQR-NERKKWKN-I-MndnsQTLSGVLFLVPLSEYNQ-------------ICYEDDS---------INRTIES 320 
XP_002674728 1056 rtPYTIFSTRtSVDEKKVTsA-Ik--eLSIDAIVITVSLEDIDQqnnsvvgsssiptLNFL--KkqvivngksSASIVNI 1130
XP_002676158  369 --LLETFGWK-EKRALYLP-Y-Le--kQNLKCIIFTVSLSDIDM-------------LSFEDLIspsksetkpGNRLLDS 428 
4FID_B        228 GAVKLIFLNKXDL-F--EEK---LTKVPLNTIFPEYTG--GDN----AVXG--AQ-----YIQQ---------------L 273  Entamoeba his...
XP_002679780  439 IYMAHEYCCQDCK-KygNMS---VIPVFTHLDQLMRQI---------------YY------------------------G 475 
XP_002677043  291 LKTFKELLTKKQL-K--NSR---KVVIFSKPDILQEKL--SVEa---RYQRqvC------DSMK---------------E 338 
XP_002671918  254 KMLLGELINSNFL-R--RAR---KIVIFTKPDILIKKLqkGHSi---NLGN---Fkm--rPEFKd-------------iI 306 
XP_002674060  258 KLLMEELINTRFL-K--TAR---KIVIFTKPDILIKKLqkGHSi---HLGN--Ykm---rPEFKe-------------iI 310 
XP_002679518  231 LKLYKELMTRVSN-SgnNTR---VVLLFTKPDIMMRKL--RSYi---EFGR--LFetetlTDLS---------------R 284 
XP_002676985  404 LTIYRDIINRALLrN--TKD---IILIFTKPDIFLHKM--ENNi---EFKL---------PNIEglnipkmetirpellK 464 
XP_002672578  321 LNLFSELVNRNTF-G--SLP---FFLIFTKKLVMEEKL---------KLYDltYV-----PFKT---------------E 365 
XP_002674728 1131 FKILEKLLMAEEF-A--DTQ---ICFIFTHLDIFNQKLsqDPS----LLTK--VF-----PKYS---------------- 1177
XP_002676158  429 LTYFEQVFSKKEL-G--ESSirkIVLF-TKVDSFIRKV--SKGeasnALSQ--YF-----SDFN---------------G 480 
4FID_B        274 -FTG------KLQT--EEXNI----SGADGTANie------gAVNekvytnptnatdgsN----IKRVFXLA-VDVIXKN 329  Entamoeba his...
XP_002679780  476 nVPN------SANV----WIPm--cEEIAKLHNsr-----rsNVM--------------D----FIFSSLIP-VKEVLNK 519 
XP_002677043  339 eLKSmsnlnlERSV--LNSTI----NEYENLFQqy------cKDS--------------K------FDYHVCnTTNEEEV 386 
XP_002671918  307 nKHE------LKKV--VNSIV----SHYLDF-----------ENEme-----------fN----KIHSFHIVnTTEMEEV 348 
XP_002674060  311 nKHE------LKKV--VNSIV----SHYLNF-----------ENEie-----------fK----KIHSFHIVnTTELEEV 352 
XP_002679518  285 iVND------YHERdvLNTII----SSFLT------------ETN-------------------NIYGK----IPEYHII 319 
XP_002676985  465 lKDN------IKLE--INNLI----NLFENIHLns------fNNI-------------------TFKYHIVN-IINIKEC 506 
XP_002672578  366 lPQD------LKVE--LKLNEenkkDLLVNILKmknsqidnlTPR--------------EiqliDRFSSDTR-YSPSQLL 422 
XP_002674728 1178 -PSP------KKPP--IKYLE----ETFELFNSk-------hKRR--------------R----RFHYSFVN-TFDKEDV 1218
XP_002676158  481 nRKN------PKQV--FNYIL----ERFKQIQNry-----siSYHshyy------geseAeyesSITFHAIN-TLDEFDV 536 
4FID_B        330 XAAN-GKX-RPT---K 340  Entamoeba histolytica
XP_002679780  520 LKYF-AFI-VGY---P 530 
XP_002677043  387 QSCM-QRI-VSN---N 397 
XP_002671918  349 NSVL-ERI-LDH---N 359 
XP_002674060  353 NCVM-ERI-LDH---N 363 
XP_002679518  320 QSISeLDI-SQLaklM 334 
XP_002676985  507 QEFI-EILlRQT---I 518 
XP_002672578  423 KIIGgDKT-------I 431 
XP_002674728 1219 RKSF-KNI-HEV---V 1229
XP_002676158  537 NQVMnSML-FNVresF 551 
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