3KHJ,7RFG


Conserved Protein Domain Family
IMPDH

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pfam00478: IMPDH (This model is not part of the current CDD release)
IMP dehydrogenase / GMP reductase domain
This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.
Statistics
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PSSM-Id: 513485
Aligned: 393 rows
Threshold Bit Score: 320.905
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3KHJ_C          1 GSHMGTKNIGKGLT--FEDILLVPNYSEVL----PR------EVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARL 68  Cryptosporidiu...
CDC21338        9 SHTFSEYLLVPGYSssECTPANASLKTPLVk--fKKgee-saITMNIPMVSAIMQSVSGEKLAIALAKEGGISFIYGSQT 85 
CCX49611        9 SHTFSEYLLVPGYSsaECTPANTSLKTPIVr--yKAgee-paLSMNIPLVSAVMQSVSGDKLAVALAREGGISFIFVSQP 85 
Q73JB0          9 SHTFSEYLLVPRLSgvEHIPQAVSLKTPLTk--yKKgee-pkISLNIPLVSSIMQSVSDHNMAVALAREGGLSFIFGSQS 85  Treponema dent...
WP_015613807    9 SHTFSEYLLVPGYSssKCIPANVSLKTPVVk--fKKgen-ssIEMNIPLVSAIMQSVSDDEMAIALAKEGGISFIYGSQS 85  Clostridium pa...
WP_013702273    9 SHTFGEYLLIPGYTsaECIPENVSLKTPVVrfnkKSgek-psLSMNIPLVSAVMQSVSDDKMAIALAKEGGISFIFGSQT 87  Treponema succ...
WP_013758950    9 SHTFGEYLLVPGYSsaDCIPANVNLKTPVVk--fRRgee-spLSMNIPMVSAVMQSVSNDTMAIALAKEGGISFIYGSQT 85  Treponema bren...
WP_015042729    9 SHTFGEYLLVPGYSsaDCTPTNVSLKTPVVk--yKKgee-ssINTNIPLVSAIMQSVSDDKMAIALAREGGISFIYCSQP 85  unclassified D...
31_pfamImport   1 SHTFSEYLLVPGFTseECIPDNVSLKTPLVk--yRKgeedcpISLNIPMVSAIMQAVSNDTLAVALAKEGGLSFIYGSQS 78 
CDE02777        9 SHTFSEYLLIPGYTspECIPTNVSLRTPLVk--fRRget-sdINLNIPLVSAVMQSVSDDRMAIALAREGGISFIYGSQS 85 
3KHJ_C         69 GGIGIIHKNMDMesqvnevLKVK---------NSGGLRvgaaig------------------------------------ 103 Cryptosporidiu...
CDC21338       86 IEAQAAMVKRVK-------SYKAgfvtsvsniKPDQTLadilalkektghstvavtddgsangkligivtsrdyrvsrmd 158
CCX49611       86 IESQAAMVSRVK-------KYKAgfamsdssiRPDQTMadilalkertghstvavtddgsatgkllgvvtsrdyrpsrmd 158
Q73JB0         86 IESEAKMVTKVK-------NYRAgfvesdsnlTPEHHLsdvldlkdrtdhttvavthdgtghgkllgvvtgrdyrightd 158 Treponema dent...
WP_015613807   86 IENEAAMVSRVK-------NHKAgfvisdsniRPDQKLqdvldlkkktghstvavtedgtatgkllgivtsrdyrvsrms 158 Clostridium pa...
WP_013702273   88 IENQAAMVARVK-------SYKAgfvtsdsniRPDQTLeevvslieqtghstiavtddgtahgklegiiterdfridhvp 160 Treponema succ...
WP_013758950   86 IERQADMIRRVK-------SYKAgfvtsdsniKPDQSLqdvvdlkartghstvavtadgspngkllgiitsrdfrinkvd 158 Treponema bren...
WP_015042729   86 IDTQAQMIARVK-------NYKAgfvtsdsniTPDSTLanilalktktdhstvavtsdgtatgkllglvttrdyrvsrms 158 unclassified D...
31_pfamImport  79 IEDEAAMVRRVK-------SSKAgfvisasnlTPDATLadvlalkekngfstvaitedatptgkllglvtsrdyritrms 151
CDE02777       86 IEDEAAMVARVK-------SYKAgfvvsdsnlTPDNTLadvlelvernghgtiaitddgthnghllgivtgrdyrvsrms 158
3KHJ_C        104 --------------------------vneierAKLLV------------------------EAGVDVIVLDSAHGHSLNI 133 Cryptosporidiu...
CDC21338      159 patkvsefmtpienlvyaeegtslkeanniiwDNKLNalpivdkngnlvsfvfrkdydshkENPMELLDKSKRYVVGAGI 238
CCX49611      159 patkvsefmtpidrlvfayegvslkeandiiwEHKLNslpvitkegnmvafvfrkdydahkENPTELLDKQKRYVVGAGI 238
Q73JB0        159 lntkvkefmtpierlhvaeegislkkaqdiiwEFKLNslpildkkgclvafvfrkdyesntENPLELLDEKKRYMVGAGI 238 Treponema dent...
WP_015613807  159 pdckisdfmtpfeklvstkkgtslkeanniiwDYKLNslpivdddqhlvymvfrkdydsnkENKLELLDSSKRYIVGAGI 238 Clostridium pa...
WP_013702273  161 anskvneymtpfaklvtgkdgitlsaandliwAHKVNqlpiiddknhlvsivfrkdfdnheTHPNELMDTNHRYIVGAGI 240 Treponema succ...
WP_013758950  159 paakvrdymtrfddlivgqdgitlseaneliwAHKLNslpiigksgnlvsmvfrkdyasheEHPLELLDSRQRYVVGAGI 238 Treponema bren...
WP_015042729  159 kdtkvkefmtkfedlicgsdqitlseandiiwDHKLNalplidkdqnlkylvfrkdydshkEYERELLDASKRYIVGAGI 238 unclassified D...
31_pfamImport 152 tdipvrefmtpreklitapaattlkeandiiwDNKLNalpvvddqdhlmyfvfrkdyaehkEHPLALQDADKRYLVGAGI 231
CDE02777      159 pdlkisefmtprahlvtapanttlkeandiiwDNKLNalpivddedrlcyfvfrkdysehkENPQELLDKQKRFMVGAGI 238
3KHJ_C        134 IRTL-KEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIG-P-GsIC-TTRIVAGVGVPQITAIEKCSSVASKFGIP 209 Cryptosporidiu...
CDC21338      239 NTRDyAERVPALVEAGADVLCIDSSEGFSEWQKLTIDWIREHYgDtV-KVgAGNVVDRDGFRFLAEAGADFIKIGIGGGS 317
CCX49611      239 NTRDyEERVPALVEAGADILCIDSSEGFSEWQTRTLNFIRAKYgDsV-KVgAGNVVDREGFRFLADAGADFVKVGIGGGS 317
Q73JB0        239 NTRDyEERVPALVEAGADVLCIDSSDGFSDWQKQTIQFVKEKYgDsI-PIgAGNVVDADGFNFLADAGADFIKVGIGGGS 317 Treponema dent...
WP_015613807  239 NTRDyKERVPALVEAGADVLCIDSSEGFSEWQKLTLDYIRENYgDkV-KVgAGNVVDREGFLFLAEAGADFVKIGVGGGS 317 Clostridium pa...
WP_013702273  241 NTRDyMERVPALLKAGVDILCLDSSEGYSEWQAKALHDIHEKFgKdV-KVgAGNVVDREGFMFLAENGADFVKIGIGGGS 319 Treponema succ...
WP_013758950  239 NTRDyMERVPALIEAGADVFCLDSSEGFSEWQKRALHDIHKNFgDkV-KVgAGNVVDKEGFLFLAENGADFVKVGIGGGS 317 Treponema bren...
WP_015042729  239 NTRDyEERVPALVNAGADVLCIDSSEGFSEWQKRTIDFIRKKYgEsV-KVgAGNVVDREGFLFLAEAGADFVKVGIGGGS 317 unclassified D...
31_pfamImport 232 NSKDyAERVPALVEAGADVLCIDSSEGYSVWQKKTIDFIREKYgDtV-KVgAGNVVDREGFRYLARAGADFVKVGIGGGS 310
CDE02777      239 NTRDyAERVPALVDAGVDVLCIDASEGYTCWQKQTLDFIRGRYgDsV-KVgAGNVVDRDGFRFLAGAGADFVKVGIGGGS 317
3KHJ_C        210 IIADGGIRYSGDIGKALAVGASS-VMIGS-I----LAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRp 283 Cryptosporidiu...
CDC21338      318 ICITRETKGIGRGQATAVIEVAKaRDEYYeEtgiyIPICSDGGIVHDYHITLALAMGCDFCMLGRYFSRFEESPTNKVIv 397
CCX49611      318 ICITRETKGIGRGQATAVQEVARaRDEYFlEkgiyVPICADGGIVHDYHITLALAMGADFCMLGRYFARCDESPSAKVMi 397
Q73JB0        318 ICITRETKGIGRGQATALIEVAKaRDEYFkKkgvyIPICSDGGIVFDYHITLALAMGSDFCMLGRYFARFDESPTNKVLi 397 Treponema dent...
WP_015613807  318 ICITREQKGIGRGQATALIEVAKaRDEYFdKtgiyVPICSDGGIVYDYHVTLALAMGADFIMLGRYFSRFDESPTNKVSi 397 Clostridium pa...
WP_013702273  320 ICITREQKGIGRGQATATIEVAKaRDEYYsKtgiyVPICSDGGIVHDYHITLALAMGADFVMLGRYFARFDESPTNKLIi 399 Treponema succ...
WP_013758950  318 ICITREQKGIGRGQATATIEVAKaRDEYYeKtgvyIPVCSDGGIVHDYHVTLALAMGADFVMLGRYFARFDESPTNKLIv 397 Treponema bren...
WP_015042729  318 ICITREQKGIGRGQATALIEVANaRDQYFkEtgiyIPVCSDGGIVHDYHITLALAMGADFIMLGRYFSRFDESPTNKVNi 397 unclassified D...
31_pfamImport 311 ICITRETKGIGRGQASALIEVAAaRDEYYkEtgvyVPICSDGGIVFDFHMTLALAMGADFLMLGRYFARFDESPTNKLMv 390
CDE02777      318 ICITREQKGIGRGQATALIEVAAaRDEYFeEtgiyVPICSDGGIVHDYHMTLALAMGADFIMLGRYFARFDESPTNRLFv 397
3KHJ_C        284 ENKMVPEGIEGRVKYKGemeGVVYQ--LvgglrscMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK 361 Cryptosporidiu...
CDC21338      398 NGNYMKEYWGEGSARAR---NWQRYdvGga---gkLSFEEGVDSYVPYAGYLHDNVAVTLAKVKHTMCNCGALTIPELQE 471
CCX49611      398 NGNYMKEYWGEGSARAR---NWQRYysGgd---skLSFEEGVDSYVPYAGSLHNNVTVTLSKVRSTMCNCGALTIPELRE 471
Q73JB0        398 NGNYMKEYWGEGSARAR---NWQRYdsGge---kkLSFEEGVDSYVPYAGKLHDNVAVTLNKIRSTMCNCGVLSIPEFQR 471 Treponema dent...
WP_015613807  398 NGTYMKEYWGEGSNRAR---NWQRYdmGgd---skLSFEEGVDSYVPYAGSLKDNVSLTLNKVRSTMCNCGAMTIPELQK 471 Clostridium pa...
WP_013702273  400 NGNYVKEYWGEGSNRAR---NWQRYdlGgk---kgMAFEEGVDSYVPYAGRLHDNVSLSMSKVIHTMCNCGALSIPELQQ 473 Treponema succ...
WP_013758950  398 NGSYVKEYWGEGSNRAR---NWQRYdlGga---kkMAFEEGVDSYVPYAGSLHDNVGMTLSKIRHTMCNCGVLSIAELQK 471 Treponema bren...
WP_015042729  398 NGSYMKEYWGEGSNRAR---NWQRYdlGgd---gkLSFEEGVDSYVPYAGSLKDNVTLSLNKVRSTMSNCGVLTIPELHK 471 unclassified D...
31_pfamImport 391 NGAYVKEYWGEGSNRAR---NWQRYdlGgk---ndLAFEEGVDSYVAYAGSLHDNVEKSLYKVKSTMCNCGVINIPDLQK 464
CDE02777      398 NGQYVKEYWGEGSNRAR---NWQRYdlGgk---ggLNFEEGVDSYVVYAGPLHDNVAKSLYKVKSTMCNCGVNNIPDLQK 471
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