1EEP,6JIG,1VRD,3KHJ


Conserved Protein Domain Family
IMPDH
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pfam00478: IMPDH 
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IMP dehydrogenase / GMP reductase domain
This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.
Links
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Statistics
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PSSM-Id: 425706
Aligned: 440 rows
Threshold Bit Score: 367.856
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1EEP_B           9 ALTFDDVSLIPRKS--SVLPS-EVSLKTQLT----KN-----ISLNIPFLSSAMDTVTESQMAIAIAKEGGIGIIHKNMS 76  Lyme disease ...
jgi:Selsp_0725   9 SHTFGEYLLVPGYSseQCVPA-NVSLQTPLVk--fRRgeepkIKMNIPMTSAIMQAVSNDTMAIALAREGGVSFIYGSQT 85  Selenomonas s...
Q73JB0           9 SHTFSEYLLVPRLSgvEHIPQ-AVSLKTPLTk--yKKgeepkISLNIPLVSSIMQSVSDHNMAVALAREGGLSFIFGSQS 85  Treponema den...
WP_013702273     9 SHTFGEYLLIPGYTsaECIPE-NVSLKTPVVrfnkKSgekpsLSMNIPLVSAVMQSVSDDKMAIALAKEGGISFIFGSQT 87  Treponema suc...
WP_013758950     9 SHTFGEYLLVPGYSsaDCIPA-NVNLKTPVVk--fRRgeespLSMNIPMVSAVMQSVSNDTMAIALAKEGGISFIYGSQT 85  Treponema bre...
Q2RSY7           8 GLSFDDVLLVPGRT--RARSRaDITLASRFS----RR-----IALALPLVSANVPWCTQAPMAIALGRLGGLGVLHRMCA 76  Rhodospirillu...
BGI:SBI_01836   10 GLSFDDVLLVPQRT--PLTSRrQADTSSELL----PG-----VVLRTPVISANTQWCTGDRMALAMALNGGLGVLHRMQT 78  Streptomyces ...
Q2JC64          11 GLSFDDVLLVPHRT--RVRSRaDVDTTVDLA----PG-----VRLWVPVIGANTQWCTGGAMAAALARVGGLGFVHRMQT 79  Frankia casua...
WP_013673146    16 DLTYDDVFLVPSRS--SVASRfDVDLSTTDG----SG-------ATVPVVAANMTAVAGRRMAETLARRGALTVLPQDVD 82  Pseudonocardi...
CBW26846        13 GLTFDDVLLVPRHS--EIASRrIPSLRSKAT----KN-----FEIETPVISANMDTVTGVEMACAMAKLGGLGILHRFMS 81  Halobacteriov...

1EEP_B          77 IEAQRKEIEKVKtykf-----------------------------------------qktINTNGDt----nEQKP---- 107 Lyme disease ...
jgi:Selsp_0725  86 PEQEAAMISRVKnyksgfvssdsnikptttlgevlalkdatghstmavtedgtpngklvgIVTSRDyrvtrmSFDTpvkd 165 Selenomonas s...
Q73JB0          86 IESEAKMVTKVKnyragfvesdsnltpehhlsdvldlkdrtdhttvavthdgtghgkllgVVTGRDyrightDLNTkvke 165 Treponema den...
WP_013702273    88 IENQAAMVARVKsykagfvtsdsnirpdqtleevvslieqtghstiavtddgtahgklegIITERDfridhvPANSkvne 167 Treponema suc...
WP_013758950    86 IERQADMIRRVKsykagfvtsdsnikpdqslqdvvdlkartghstvavtadgspngkllgIITSRDfrinkvDPAAkvrd 165 Treponema bre...
Q2RSY7          77 IEDQERQVALVK-------------------------------------------------------------------- 88  Rhodospirillu...
BGI:SBI_01836   79 VEQQLGHLDAVK-------------------------------------------------------------------- 90  Streptomyces ...
Q2JC64          80 VERQATHIASVK-------------------------------------------------------------------- 91  Frankia casua...
WP_013673146    83 AQAVAGIVAWIKsrhpvwdtpltlhtddavadal----nllpkrahgtvvivddghrpvgTVDEAAch--gvDRFTrlsd 156 Pseudonocardi...
CBW26846        82 PEEQVEDVKKIQ-------------------------------------------------------------------- 93  Halobacteriov...

1EEP_B         108 ------EIFTa--------------KQHLEK---SD---------AYKNAEH-KEDFPNACK----DLNNKLRVGAAVSI 150 Lyme disease ...
jgi:Selsp_0725 166 fmtpfeRLIYadanltlpqandliwEHKLNMlplIDenqrlrymvFRKDYTD-NKENELELI----DERKRYIVGAGINT 240 Selenomonas s...
Q73JB0         166 fmtpieRLHVaeegislkkaqdiiwEFKLNSlpiLDkkgclvafvFRKDYES-NTENPLELL----DEKKRYMVGAGINT 240 Treponema den...
WP_013702273   168 ymtpfaKLVTgkdgitlsaandliwAHKVNQlpiIDdknhlvsivFRKDFDN-HETHPNELM----DTNHRYIVGAGINT 242 Treponema suc...
WP_013758950   166 ymtrfdDLIVgqdgitlseaneliwAHKLNSlpiIGksgnlvsmvFRKDYAS-HEEHPLELL----DSRQRYVVGAGINT 240 Treponema bre...
Q2RSY7          89 ------------------------------AapvD------------------GEDAARATV----DDGGALIAAAAVGA 116 Rhodospirillu...
BGI:SBI_01836   91 ---------------------------------------------------AhRPEEGSADRat-rAADGRLLVGAAVGV 118 Streptomyces ...
Q2JC64          92 -------------------------------------------------------SGPVGTGpatvDPVGRLLVGAAVGT 116 Frankia casua...
WP_013673146   157 --vlapAPVTmpldtap--revfdalGGHGValgLdpdgrvagllTALGAVRaGIYTPTL------DARGRLRTAAAIGI 226 Pseudonocardi...
CBW26846        94 -------------------------------------------------------------Kyi-kDNNLSGPVAASIGV 111 Halobacteriov...

1EEP_B         151 DIDTIERVEELVKAHVDILVIDSAHGHSTRIIELIKKIKTKYp-----N-LDLI-AGNIVTKEAALDLISVGADCLKVGI 223 Lyme disease ...
jgi:Selsp_0725 241 R-DYAERVPALLEAGADVLCIDSSEGYSEWQKKTLEYIHKEFg-----EdV-KVgAGNVVDGEGFRFLADAGADFVKVGI 313 Selenomonas s...
Q73JB0         241 R-DYEERVPALVEAGADVLCIDSSDGFSDWQKQTIQFVKEKYg-----DsI-PIgAGNVVDADGFNFLADAGADFIKVGI 313 Treponema den...
WP_013702273   243 R-DYMERVPALLKAGVDILCLDSSEGYSEWQAKALHDIHEKFg-----KdV-KVgAGNVVDREGFMFLAENGADFVKIGI 315 Treponema suc...
WP_013758950   241 R-DYMERVPALIEAGADVFCLDSSEGFSEWQKRALHDIHKNFg-----DkV-KVgAGNVVDKEGFLFLAENGADFVKVGI 313 Treponema bre...
Q2RSY7         117 KPEDLERADRLVAAGCDALVVDIAHGHADYALDTIAALKSRH------PqIDVI-GGNVATAEGTADLIAAGADAIKVGI 189 Rhodospirillu...
BGI:SBI_01836  119 SGDWRERAERLVEHAVDVLFVDVAHGHSDQVIDAVAKLRAAY------PrLPLA-AGNVATAAGVTDLAEAGADVVKVGI 191 Streptomyces ...
Q2JC64         117 KGDYLDRAALMVEHGADLLLVDVAHGHSDQVIDTVGKLHARH------PrVPIV-AGNVATAGGTNDLLDAGADVVKVGI 189 Frankia casua...
WP_013673146   227 NGDVGTKAKALLEAGVDVLVVDTAHGHQEKMLDALRAVR-RAvtesgtT-VPVV-AGNVVTASGVADLAEAGADIVKVGV 303 Pseudonocardi...
CBW26846       112 KEEGKLRAKLLADIGVDILTIDIAHGDSVMMLETLEYVKKTW------PhIDVI-AGNVATGEGVKRMIDLGADAVKVGI 184 Halobacteriov...

1EEP_B         224 GPGSICTTRIVAGVGVPQITAICDVYE-ACNNT-N----ICIIADGGIRFSGDVVKAIAAGADSVMIGNLFAGTKESPSE 297 Lyme disease ...
jgi:Selsp_0725 314 GGGSICITRETKGIGRGQATAVIDVCRaRDEYFkEkgvyIPVCSDGGIVHDYHMTLALAMGADFMMLGRYFSRFDESPTD 393 Selenomonas s...
Q73JB0         314 GGGSICITRETKGIGRGQATALIEVAKaRDEYFkKkgvyIPICSDGGIVFDYHITLALAMGSDFCMLGRYFARFDESPTN 393 Treponema den...
WP_013702273   316 GGGSICITREQKGIGRGQATATIEVAKaRDEYYsKtgiyVPICSDGGIVHDYHITLALAMGADFVMLGRYFARFDESPTN 395 Treponema suc...
WP_013758950   314 GGGSICITREQKGIGRGQATATIEVAKaRDEYYeKtgvyIPVCSDGGIVHDYHVTLALAMGADFVMLGRYFARFDESPTN 393 Treponema bre...
Q2RSY7         190 GPGGICTTRRVAGAGVPQMTAIADCVG-VARAR-N----VPVIADGGIRFSGDIVKALAVGAASVMLGSLLAGTDESAAV 263 Rhodospirillu...
BGI:SBI_01836  192 GPGGVCTTRLVAGTGVPQLTAVMDCAA-AAAER-G----VRVIADGGIRQSGDIAKSLAAGAHAVMLGSALAGADESAAS 265 Streptomyces ...
Q2JC64         190 GPGGVCTTRLVAGSGVPQLTAIIDCAH-AAAQR-D----ATVIADGGVRQSGDLAKALAAGAAAVMLGSALAGADESEAG 263 Frankia casua...
WP_013673146   304 GPGAMCTTRMMTGVGRPQFSAVAECAA-AGRDH-G----VRIWADGGVRHPRDVALALAAGASAAMIGSWLAGTYESPGD 377 Pseudonocardi...
CBW26846       185 GPGSMCTTRIITGHGVPQLSAIAMCVE-EAIKH-D----VPVIADGGIKTSGDIVKALCAGAQTIMAGSLLSGTLETPGE 258 Halobacteriov...

1EEP_B         298 EIIyN-GKKFKSYVGMGSISAMk--R-------G---SKS--RY--FqlennepkKLVPEGIEGMV----PYSGKLKDIL 356 Lyme disease ...
jgi:Selsp_0725 394 KVKvN-GTYYKEYWGEGSNRAR---------------NWQ--RYdlGgd----rkLSFEEGVDSYV----PYAGSLRDNI 447 Selenomonas s...
Q73JB0         394 KVLiN-GNYMKEYWGEGSARAR---------------NWQ--RYdsGge----kkLSFEEGVDSYV----PYAGKLHDNV 447 Treponema den...
WP_013702273   396 KLIiN-GNYVKEYWGEGSNRAR---------------NWQ--RYdlGgk----kgMAFEEGVDSYV----PYAGRLHDNV 449 Treponema suc...
WP_013758950   394 KLIvN-GSYVKEYWGEGSNRAR---------------NWQ--RYdlGga----kkMAFEEGVDSYV----PYAGSLHDNV 447 Treponema bre...
Q2RSY7         264 FIDhQ-GRRCKATTGFVTLGVGltrKrlrgekiN---AEDldAY-------------VAEGVESTF----EASGPLARLI 322 Rhodospirillu...
BGI:SBI_01836  266 PVTrD-GRSYKVSNGFVSLGMKltlRhaagekiT---REEvdDY-------------VPEGTEATF----PATGPLARTL 324 Streptomyces ...
Q2JC64         264 VVDlPdGSRYRCSRGFATLGMAntlRaaaggrlT---RDDvvGY-------------IPEGVEMTF----APSGPVADTV 323 Frankia casua...
WP_013673146   378 LLRdEaGRPYKESFGMASKRAVsarT-------RgdgDFDraRK-----------SLFEEGISSSRqlldPARPGVEDVL 439 Pseudonocardi...
CBW26846       259 LK----GGM-KEYRGMASKAAQvswRge---lpK---------------------GMAAEGVDTMV----PCKGPVEEVI 305 Halobacteriov...

1EEP_B         357 TQLKGGLMSGMGYLGAATISDLKINSKFVKISHSSLKESHPH 398 Lyme disease spirochete
jgi:Selsp_0725 448 HISLSKIRSTMCNCGALNLSELRDKAKITLVSSTSIVEGGSH 489 Selenomonas sputigena ATCC 35185
Q73JB0         448 AVTLNKIRSTMCNCGVLSIPEFQRDAKITLVSSASIIEGGPH 489 Treponema denticola
WP_013702273   450 SLSMSKVIHTMCNCGALSIPELQQKAKLTLVSSTTISEGSAH 491 Treponema succinifaciens
WP_013758950   448 GMTLSKIRHTMCNCGVLSIAELQKNAKITLVSQASIAEGSSH 489 Treponema brennaborense
Q2RSY7         323 GQLAGGIRSGVSYGGALSIAELQDKARFIRVSEAGRAESRPH 364 Rhodospirillum rubrum ATCC 11170
BGI:SBI_01836  325 RQLMGGVQSAMSYSGARDITGFRERAEFIRVTSAGRAENRPH 366 Streptomyces bingchenggensis BCW-1
Q2JC64         324 YQLVGGLRSAMSYTGAADMAEFRRLAEFIRVTPAGRAENAPH 365 Frankia casuarinae
WP_013673146   440 DAICSGVRSACTYAGARTLAELHDNAVLGVQTVAGFAEGTPH 481 Pseudonocardia dioxanivorans
CBW26846       306 SELTGGLRSGMTYLGVDNIADMKEVGLFMEMSTSGMVESRPH 347 Halobacteriovorax marinus SJ
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